Agonistic tnf receptor binding agents

ABSTRACT

The present invention relates to binding agents binding to receptors of the TNF superfamily, in particular binding agents binding to at least two different receptors of the TNF superfamily, as well as to their use in medicine. The present invention further relates to nucleic acid molecules encoding such binding agents, to cells comprising such nucleic acid molecules and to pharmaceutical compositions and kits.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a divisional of, and claims priority to, U.S. patentapplication Ser. No. 16/582,534, filed on Sep. 25, 2019 and entitled,“Agonistic Tumor Necrosis Factor (TNF) Receptor Binding Agents”. The'534 application is a divisional of, and claims priority to, U.S. patentapplication Ser. No. 15/538,419, filed on Jun. 21, 2017 (now U.S. Pat.No. 10,457,735) and entitled, “Methods Of Inducing T Cell Activation byAdministering an Antibody Comprising CD40 and 4-1BB (CD137) BindingDomains” which is a National Stage entry of International ApplicationNo. PCT/EP2016/050308, filed on Jan. 8, 2016 and entitled, “AgonisticTNF Receptor Binding Agents”, which claims priority to InternationalApplication No. PCT/EP2015/050255, filed on Jan. 8, 2015. All theaforementioned applications are incorporated by reference herein intheir entireties.

INCORPORATION BY REFERENCE

This application incorporates by reference a Sequence Listing submittedwith this application in computer readable form (CRF) as a text fileentitled “61785US03_SeqList” created on Sep. 25, 2019 and having a sizeof 937,759 bytes.

TECHNICAL FIELD OF THE INVENTION

The present invention relates to binding agents binding to receptors ofthe TNF superfamily, in particular binding agents binding to at leasttwo different receptors of the TNF superfamily, as well as to their usein medicine. The present invention further relates to nucleic acidmolecules encoding such binding agents, to cells comprising such nucleicacid molecules and to pharmaceutical compositions and kits.

BACKGROUND OF THE INVENTION

Receptors for tumor necrosis factor (TNF) superfamily ligands areoligomeric, mostly trimeric, type I or type III transmembrane proteinsand contain one to six cysteine-rich domains (CRDs) in theirextracellular domain (Naismith J. H. and Sprang S. R. (1998), TRENDS inBiochemical Sciences 23(2):74-79). Moreover, several receptors for TNFsuperfamily ligands contain death domains (DDs) that recruitcaspase-interacting proteins following ligand binding to initiate theextrinsic pathway of caspase activation.

Numerous receptors of the TNF superfamily have been identified so far,including 4-1BB (CD137), BAPPR, BCMA, CD27, CD30, CD40, DCR3, DR3(TRAMP), DR6, EDAR, Fas (CD95), FN14 (TWEAK-R), GITR, HVEM, LTI3R, NGFR(CD271), OPG, OX40 (CD134), RANK (TRANCE-R), RELT, TALI, TNFR1, TN1R2,TRAIL-R1, TRAIL-R2, TRAIL-R3, TRAIL-R4, TROY and XEDAR (Bodmer, J. L. etal. (2002), TRENDS in Biochemical Sciences, 27(1):19-26).

Through timely expression and intricate signaling, receptors of the TNFsuperfamily and their corresponding ligands act to regulate cellresponses, including activation, proliferation, differentiation, andapoptosis. While critical to the regulation of beneficial processes,such as immune defense and hematopoiesis, TNF signaling is alsoimplicated in tumorigenesis, transplant rejection, virus replication,bone resorption, diabetes and autoimmune diseases.

Agonistic agents specifically binding to one or more receptors of theTNF superfamily are, therefore, considered as potential therapeutics inthe prevention and/or treatment of various diseases and disorders.

Accordingly, it was an object of the present invention to provide novelagonistic binding agents targeting receptors of the TNF superfamily, inparticular agonistic binding agents targeting at least two differentreceptors of the TNF superfamily.

SUMMARY OF THE INVENTION

In one aspect, the present invention relates to a binding agentcomprising at least two binding domains, wherein a first binding domainbinds to a first receptor of the tumor necrosis factor (TNF) superfamilyand a second binding domain binds to a second receptor of the TNFsuperfamily, wherein the first receptor and the second receptor aredifferent.

In one embodiment, the binding agent is an agonistic binding agent.

In one embodiment, the binding agent is a bispecific molecule,preferably a bispecific antibody.

In one embodiment, the binding agent is in the format of a full-lengthantibody or an antibody fragment.

In one embodiment, the first receptor and the second receptor areselected from the group consisting of CD40, CD27, OX40 (CD134) and 4-1BB(CD137).

In one embodiment, the first binding domain or the second binding domainbinds to CD27, wherein the binding agent comprises

-   (a) the heavy chain complementarity determining region(s) HCDR1,    HCDR2 and/or HCDR3, and/or    -   the light chain complementarity determining region(s) LCDR1,        LCDR2 and/or LCDR3 of an antibody selected from the group        consisting of AB27_1 to AB27_186 as shown in Table 7; and/or-   (b) the heavy chain variable domain (VH) or a variant or fragment    thereof and/or the light chain variable domain (VL) or a variant or    fragment thereof    -   of an antibody selected from the group consisting of AB27_1 to        AB27_186 as shown in Table 7.

In one embodiment, the first binding domain or the second binding domainbinds to OX40 (CD134), wherein the binding agent comprises

-   (a) the heavy chain complementarity determining region(s) HCDR1,    HCDR2 and/or HCDR3, and/or    -   the light chain complementarity determining region(s) LCDR1,        LCDR2 and/or LCDR3 of an antibody selected from the group        consisting of AB134_1 to AB134_92 as shown in Table 8; and/or-   (b) the heavy chain variable domain (VH) or a variant or fragment    thereof and/or the light chain variable domain (VL) or a variant or    fragment thereof    -   of an antibody selected from the group consisting of AB134_1 to        AB134_92 as shown in Table 8.

In one embodiment, the first binding domain or the second binding domainbinds to 4-1BB (CD137), wherein the binding agent comprises

-   (a) the heavy chain complementarity determining region(s) HCDR1,    HCDR2 and/or HCDR3, and/or    -   the light chain complementarity determining region(s) LCDR1,        LCDR2 and/or LCDR3 of an antibody selected from the group        consisting of AB137_1 to AB137_12 as shown in Table 9; and/or-   (b) the heavy chain variable domain (VH) or a variant or fragment    thereof and/or the light chain variable domain (VL) or a variant or    fragment thereof    -   of an antibody selected from the group consisting of AB137_1 to        AB137_12 as shown in Table 9.

In one embodiment, the first binding domain or the second binding domainbinds to CD40, wherein the binding agent comprises

-   (a) heavy chain complementarity determining region(s) HCDR1 having    the amino acid sequence of SEQ ID NO: 2323, HCDR2 having the amino    acid sequence of SEQ ID NO: 2324 and/or HCDR3 having the amino acid    sequence of SEQ ID NO: 2325, and/or    -   light chain complementarity determining region(s) LCDR1 having        the amino acid sequence of SEQ ID NO: 2326, LCDR2 having the        amino acid sequence of SEQ ID NO: 2327 and/or LCDR3 having the        amino acid sequence of SEQ ID NO: 2328; and/or-   (b) heavy chain variable domain (VH) having the amino acid sequence    of SEQ ID NO: 2321 or a variant or fragment thereof and/or light    chain variable domain (VL) having the amino acid sequence of SEQ ID    NO: 2322 or a variant or fragment thereof.

In one embodiment,

-   (a) the first binding domain binds to CD40 and the second binding    domain binds to CD27;-   (b) the first binding domain binds to CD40 and the second binding    domain binds to OX40 (CD134);-   (c) the first binding domain binds to CD40 and the second binding    domain binds to 4-1BB (CD137);-   (d) the first binding domain binds to 4-1BB (CD137) and the second    binding domain binds to CD27;-   (e) the first binding domain binds to 4-1BB (CD137) and the second    binding domain binds to OX40 (CD134); or-   (f) the first binding domain binds to OX40 (CD134) and the second    binding domain binds to CD27.

In one embodiment, the binding agent comprises one or more heavy chainconstant domains of an immunoglobulin and/or light chain constantdomains of an immunoglobulin.

In another aspect, the present invention relates to a binding agent thatbinds to CD27, comprising

-   (a) the heavy chain complementarity determining region(s) HCDR1,    HCDR2 and/or HCDR3, and/or    -   the light chain complementarity determining region(s) LCDR1,        LCDR2 and/or LCDR3 of an antibody selected from the group        consisting of AB27_1 to AB27_186 as shown in Table 7; and/or-   (b) the heavy chain variable domain (VH) or a variant or fragment    thereof and/or the light chain variable domain (VL) or a variant or    fragment thereof    -   of an antibody selected from the group consisting of AB27_1 to        AB27_186 as shown in Table 7.

In another aspect, the present invention relates to a binding agent thatbinds to OX40 (CD134), comprising

-   (a) the heavy chain complementarity determining region(s) HCDR1,    HCDR2 and/or HCDR3, and/or    -   the light chain complementarity determining region(s) LCDR1,        LCDR2 and/or LCDR3 of an antibody selected from the group        consisting of AB134_1 to AB134_92 as shown in Table 8; and/or-   (b) the heavy chain variable domain (VH) or a variant or fragment    thereof and/or the light chain variable domain (VL) or a variant or    fragment thereof    -   of an antibody selected from the group consisting of AB134_1 to        AB134_92 as shown in Table 8.

In another aspect, the present invention relates to a binding agent thatbinds to 4-1BB (CD137), comprising

-   (a) the heavy chain complementarity determining region(s) HCDR1,    HCDR2 and/or HCDR3, and/or    -   the light chain complementarity determining region(s) LCDR1,        LCDR2 and/or LCDR3 of an antibody selected from the group        consisting of AB137_1 to AB137_12 as shown in Table 9; and/or-   (b) the heavy chain variable domain (VH) or a variant or fragment    thereof and/or the light chain variable domain (VL) or a variant or    fragment thereof    -   of an antibody selected from the group consisting of AB137_1 to        AB137_12 as shown in Table 9.

In one embodiment, the binding agent is an agonistic binding agent.

In one embodiment, the binding agent is in the format of a full-lengthantibody or an antibody fragment.

In one embodiment, the binding agent comprises one or more heavy chainconstant domains of an immunoglobulin and/or light chain constantdomains of an immunoglobulin.

In another aspect, the present invention relates to a binding agentbinding to the same epitope(s) as a binding agent as defined above.

In another aspect, the present invention relates to a nucleic acidmolecule encoding a binding agent as defined above, wherein, preferably,the nucleic acid molecule is contained in a vector.

In another aspect, the present invention relates to a cell comprising anucleic acid molecule as defined above.

In another aspect, the present invention relates to a pharmaceuticalcomposition comprising, as an active agent, a binding agent as definedabove, a nucleic acid molecule as defined above, or a cell as definedabove.

In one embodiment, the pharmaceutical composition further comprises apharmaceutically acceptable carrier and/or excipient.

In another aspect, the present invention relates to a kit comprising abinding agent as defined above, a nucleic acid molecule as definedabove, a cell as defined above, or a pharmaceutical composition asdefined above.

In another aspect, the present invention relates to a binding agent asdefined above, a nucleic acid molecule as defined above, a cell asdefined above, or a pharmaceutical composition as defined above for useas a medicament.

In another aspect, the present invention relates to a binding agent asdefined above, a nucleic acid molecule as defined above, a cell asdefined above, or a pharmaceutical composition as defined above for usein the treatment of a disease selected from the group consisting ofcancer, infectious diseases, inflammatory diseases, metabolic diseases,autoimmune disorders, degenerative diseases, apoptosis-associateddiseases and transplant rejections.

BRIEF DESCRIPTION OF THE FIGURES

FIGS. 1A-1C show binding curves of reference antibodies against CD27,CD134 and CD137 to the respective recombinant protein, as determined byenzyme-linked immunosorbent assay (ELISA).

FIGS. 2A-2C show the expression of CD27, CD134 and CD137 on the cellsurface of HT1080 cell lines overexpressing CD27, CD134 and CD137,respectively, as determined by fluorescence-activated cell sorting(FACS).

FIGS. 3A-3C show binding curves of reference antibodies against CD27,CD134 and CD137 to CD27, CD134 and CD137 expressed on the cell surfaceof corresponding HT1080 cell lines, as determined by a cellular bindingassay.

FIG. 4 shows the activation curve of an agonistic anti-CD27 referenceantibody with or without cross-linking, as determined by ELISA measuringthe IL-8 concentration in the supernatants of CD27-overexpressing HT1080cells.

FIGS. 5A-5C show exemplary activation curves of agonistic anti-CD27,anti-CD134 and anti-CD137 antibodies under cross-linking conditions, asdetermined by ELISA measuring the IL-8 concentration in the supernatantsof target-overexpressing HT1080 cells.

FIGS. 6A-6B show the expression of CD27, CD40, CD134 and CD137 on thecell surface of stable transfectants of HEK293_NFK_gfp_luc cells (A) andof stable transfectants of K562 cells (B) overexpressing CD27, CD40,CD134 and CD137, respectively, as determined by FACS (white curves:control without antibody; grey curves: antibody staining).

FIGS. 7A-7D show the analysis of two examples (Bispecific Antibody A andBispecific Antibody B) of a bispecific antibody simultaneously targetingCD40 and CD137 (CD137×CD40). Activation of CD137 was measured byluciferase activity (relative light units, RLU) ofHEK293_NFK_CD137_gfp_luc upon incubation with indicated bispecificantibodies and K562_CD40 for trans-presentation or K562_wt for control.Activation of CD40 was measured by luciferase activity (RLU) ofHEK293_NFK_CD40_gfp_luc upon incubation with indicated bispecificantibodies and K562_CD137 for trans-presentation or K562_wt for control.The two parental monospecific, bivalent antibodies (CD137 IgG1 or CD40IgG1) and (ii) the two monovalent antibodies with one irrelevant arm(CD137×control, CD40×control) served as controls for the bispecificCD137×CD40 antibodies. Only bispecific CD137×CD40 antibodies resulted inactivation of CD137 and CD40 upon trans-presentation by CD40 and CD137,respectively. Used sequences of variable domains of anti-CD137 andanti-CD40 antibodies are identified by the abbreviation AB137 and AB40,respectively.

FIGS. 8A-8B show the analysis of a bispecific antibody simultaneouslytargeting CD40 and CD27 (CD27×CD40). Activation of CD27 was measured byluciferase activity (RLU) of HEK293_NFK_CD27_gfp_luc upon incubationwith the indicated bispecific antibody and K562_CD40 fortrans-presentation or K562_wt for control. Activation of CD40 wasmeasured by luciferase activity (RLU) of HEK293_NFK_CD40_gfp_luc uponincubation with the indicated bispecific antibody and K562_CD27 fortrans-presentation or K562_wt for control. The two parentalmonospecific, bivalent antibodies (CD27 IgG1 or CD40 IgG1) and (ii) thetwo monovalent antibodies with one irrelevant arm (CD27×control,CD40×control) served as controls for the bispecific CD27×CD40 antibody.The bispecific CD27×CD40 antibody resulted in superior activation ofCD27 and CD40 upon trans-presentation by CD40 and CD27, respectively.Used sequences of variable domains of anti-CD27 and anti-CD40 antibodiesare identified by the abbreviation AB27 and AB40, respectively.

FIGS. 9A-9D show the analysis of two examples (Bispecific Antibody A andBispecific Antibody B) of a bispecific antibody simultaneously targetingCD40 and CD134 (CD134×CD40). Activation of CD134 was measured byluciferase activity (RLU) of HEK293_NFK_CD134_gfp_luc upon incubationwith the indicated bispecific antibodies and K562_CD40 fortrans-presentation or K562_wt for control. Activation of CD40 wasmeasured by luciferase activity (RLU) of HEK293_NFK_CD40_gfp_luc uponincubation with antibodies and K562_CD134 for trans-presentation orK562_wt for control. The two parental monospecific, bivalent antibodies(CD134 IgG1 or CD40 IgG1) and (ii) the two monovalent antibodies withone irrelevant arm (CD134×control, CD40×control) served as controls forthe bispecific CD134×CD40 antibodies. Bispecific CD134×CD40 antibodiesresulted in superior activation of CD134 and CD40 upontrans-presentation by CD40 and CD134, respectively. Used sequences ofvariable domains of anti-CD134 and anti-CD40 antibodies are identifiedby the abbreviation AB134 and AB40, respectively.

FIGS. 10A-10C show the expression of CD27, CD134 and CD137 on the cellsurface of double transfectants of HEK293_NFK_gfp_luc cellsoverexpressing CD27+CD134 (HEK293_NFK_CD27_CD134_gfp_luc), CD134 CD137(HEK293_NFK_CD134_CD137_gfp_luc) and CD27 CD137(HEK293_NFK_CD27_CD137_gfp_luc), respectively, as determined by FACS(white curves: control without antibody; grey curves: antibodystaining).

FIG. 11 shows the analysis of a bispecific antibody simultaneouslytargeting CD27 and CD134 (CD134×CD27). Activation of CD27 and CD134 wasmeasured by luciferase activity of HEK293_NFK_CD27_CD134_gfp_luc uponincubation with the indicated bispecific antibody; maximum RLUs areshown. The two parental monospecific, bivalent antibodies (CD134 IgG1 orCD27 IgG1) and (ii) the two monovalent antibodies with one irrelevantarm (CD134×control, CD27×control) served as controls for the bispecificCD134×CD27 antibody. The bispecific CD134×CD27 antibody resulted insuperior activation of HEK293_NFK_CD27_CD134_gfp_luc as compared to thefour corresponding controls. Used sequences of variable domains ofanti-CD134 and anti-CD27 antibodies are identified by the abbreviationAB134 and AB27, respectively.

FIGS. 12A-12B show the analysis of two examples (Bispecific Antibody Aand Bispecific Antibody B) of a bispecific antibody simultaneouslytargeting CD134 and CD137 (CD134×CD137). Activation of CD134 and CD137was measured by luciferase activity of HEK293_NFK_CD134_CD137_gfp_lucupon incubation with the indicated bispecific antibodies; maximum RLUsare shown. The two parental monospecific, bivalent antibodies (CD134IgG1 or CD137 IgG1) and (ii) the two monovalent antibodies with oneirrelevant arm (CD134×control, CD137×control) served as controls for thebispecific CD antibodies. Bispecific CD antibodies resulted inactivation of HEK293_NFK_CD134_CD137_gfp_luc, whereas the fourcorresponding controls did not result in measurable activation of thedouble transfectant. Used sequences of variable domains of anti-CD134and anti-CD137 antibodies are identified by the abbreviation AB134 andAB137, respectively.

FIGS. 13A-13B show the analysis of two examples (Bispecific Antibody Aand Bispecific Antibody B) of a bispecific antibody simultaneouslytargeting CD27 and CD137 (CD137×CD27). Activation of CD27 and CD137 wasmeasured by luciferase activity of HEK293_NFK_CD27_CD137_gfp_luc uponincubation with the indicated bispecific antibodies; maximum RLUs areshown. The two parental monospecific, bivalent antibodies (CD137 IgG1 orCD27 IgG1) and (ii) the two monovalent antibodies with one irrelevantarm (CD137×control, CD27×control) served as controls for the bispecificCD137×CD27 antibodies. Bispecific CD134×CD27 antibodies resulted insuperior activation of HEK293_NFK_CD27_CD137_gfp_luc as compared to thetwo control antibodies with one irrelevant arm. Used sequences ofvariable domains of anti-CD137 and anti-CD27 antibodies are identifiedby the abbreviation AB137 and AB27, respectively.

DETAILED DESCRIPTION OF THE INVENTION

Although the present invention is described in detail below, it is to beunderstood that this invention is not limited to the particularmethodologies, protocols and reagents described herein as these mayvary. It is also to be understood that the terminology used herein isfor the purpose of describing particular embodiments only, and is notintended to limit the scope of the present invention which will belimited only by the appended claims. Unless defined otherwise, alltechnical and scientific terms used herein have the same meanings ascommonly understood by one of ordinary skill in the art.

In the following, the elements of the present invention will bedescribed. These elements are listed with specific embodiments, however,it should be understood that they may be combined in any manner and inany number to create additional embodiments. The variously describedexamples and preferred embodiments should not be construed to limit thepresent invention to only the explicitly described embodiments. Thisdescription should be understood to support and encompass embodimentswhich combine the explicitly described embodiments with any number ofthe disclosed and/or preferred elements. Furthermore, any permutationsand combinations of all described elements in this application should beconsidered disclosed by the description of the present applicationunless the context indicates otherwise.

Preferably, the terms used herein are defined as described in “Amultilingual glossary of biotechnological terms: (IUPACRecommendations)”, H. G. W. Leuenberger, B. Nagel, and H. Kölbl, Eds.,Helvetica Chimica Acta, CH-4010 Basel, Switzerland, (1995).

The practice of the present invention will employ, unless otherwiseindicated, conventional methods of chemistry, biochemistry, cellbiology, immunology, and recombinant DNA techniques which are explainedin the literature in the field (cf., e.g., Molecular Cloning: ALaboratory Manual, 2nd Edition, J. Sambrook et al. eds., Cold SpringHarbor Laboratory Press, Cold Spring Harbor 1989).

Throughout this specification and the claims which follow, unless thecontext requires otherwise, the word “comprise”, and variations such as“comprises” and “comprising”, will be understood to imply the inclusionof a stated member, integer or step or group of members, integers orsteps but not the exclusion of any other member, integer or step orgroup of members, integers or steps although in some embodiments suchother member, integer or step or group of members, integers or steps maybe excluded, i.e. the subject-matter consists in the inclusion of astated member, integer or step or group of members, integers or steps.The terms “a” and “an” and “the” and similar reference used in thecontext of describing the invention (especially in the context of theclaims) are to be construed to cover both the singular and the plural,unless otherwise indicated herein or clearly contradicted by context.Recitation of ranges of values herein is merely intended to serve as ashorthand method of referring individually to each separate valuefalling within the range. Unless otherwise indicated herein, eachindividual value is incorporated into the specification as if it wereindividually recited herein. All methods described herein can beperformed in any suitable order unless otherwise indicated herein orotherwise clearly contradicted by context. The use of any and allexamples, or exemplary language (e.g., “such as”), provided herein isintended merely to better illustrate the invention and does not pose alimitation on the scope of the invention otherwise claimed. No languagein the specification should be construed as indicating any non-claimedelement essential to the practice of the invention.

Several documents are cited throughout the text of this specification.Each of the documents cited herein (including all patents, patentapplications, scientific publications, manufacturer's specifications,instructions, etc.), whether supra or infra, are hereby incorporated byreference in their entirety. Nothing herein is to be construed as anadmission that the invention is not entitled to antedate such disclosureby virtue of prior invention.

The term “receptor of the TNF superfamily” preferably refers to areceptor selected from the group consisting of 4-1BB (CD137), BAFFR,BCMA, CD27, CD30, CD40, DCR3, DR3 (TRAMP), DR6, EDAR, Fas (CD95), FN14(TWEAK-R), GITR, HVEM, LTI3R, NGFR (CD271), OPG, OX40 (CD134), RANK(TRANCE-R), RELT, TALI, TNFR1, TNFR2, TRAIL-R1, TRAIL-R2, TRAIL-R3,TRAIL-R4, TROY and XEDAR.

The term “receptor of the TNF superfamily”, as used herein, alsoincludes variants of a given receptor of the TNF superfamily.

The term “variant” according to the invention refers, in particular, tomutants, splice variants, conformation variants, isoforms, allelicvariants, species variants and species homologs, in particular thosewhich are naturally present. An allelic variant relates to an alterationin the normal sequence of a gene, the significance of which is oftenunclear. Complete gene sequencing often identifies numerous allelicvariants for a given gene. A species homolog is a nucleic acid or aminoacid sequence with a different species of origin from that of a givennucleic acid or amino acid sequence. The term “variant” shall encompassany posttranslationally modified variants and conformation variants.

According to the present invention, the first receptor and the secondreceptor of the TNF superfamily are preferably selected from the groupconsisting of CD40, CD27, OX40 (CD134) and 4-1BB (CD137).

CD40, also referred to as tumor necrosis factor receptor superfamilymember 5 (TNFRSF5), is the receptor for the ligand TNFSF5/CD40L. CD40 isknown to transduce TRAF6- and MAP3K8-mediated signals that activate ERKin macrophages and B-cells, leading to induction of immunoglobulinsecretion. In one embodiment, CD40 is human CD40, having UniProtaccession number P25942.

CD27, also referred to as TNFRSF7, is the receptor for the ligandCD70/CD27L. CD27 is believed to play a role in survival of activated Tcells and a role in apoptosis through association with SIVA 1. In oneembodiment, CD27 is human CD27, having UniProt accession number P26842.

OX40 (CD134), also referred to as TNFRSF4, is the receptor for theligand TNFSF4/OX40L/GP34. OX40 (CD134) is a costimulatory moleculeimplicated in long-term T cell immunity. In one embodiment, OX40 (CD134)is human OX40 (CD134), having UniProt accession number P43489.

4-1BB (CD137), also referred to as TNFRSF9, is the receptor for theligand TNFSF9/4-1BBL. 4-1BB (CD137) is believed to be involved in T cellactivation. In one embodiment, 4-1BB (CD137) is human 4-1BB (CD137),having UniProt accession number Q07011.

The term “binding domain” characterizes in connection with the presentinvention a structure, e.g., of an antibody, which binds to/interactswith a given target structure/antigen/epitope. Thus, the binding domainaccording to the invention designates an “antigen-interaction site” or“antigen-binding site”.

The term “antigen” relates to an agent such as a protein or peptidecomprising an epitope against which an immune response is directedand/or is to be directed.

The term “peptide” according to the invention comprises oligo- andpolypeptides and refers to substances comprising two or more, preferably3 or more, preferably 4 or more, preferably 6 or more, preferably 8 ormore, preferably 9 or more, preferably 10 or more, preferably 13 ormore, preferably 16 more, preferably 21 or more and up to preferably 8,10, 20, 30, 40 or 50, in particular 100 amino acids joined covalently bypeptide bonds. The term “protein” refers to large peptides, preferablyto peptides with more than 100 amino acid residues, but in general theterms “peptides” and “proteins” are synonyms and are usedinterchangeably herein.

The term “epitope” refers to an antigenic determinant in a molecule,i.e., to the part in a molecule that is recognized by the immune system,for example, that is recognized by an antibody. For example, epitopesare the discrete, three-dimensional sites on an antigen, which arerecognized by the immune system. Epitopes usually consist of chemicallyactive surface groupings of molecules such as amino acids or sugar sidechains and usually have specific three dimensional structuralcharacteristics, as well as specific charge characteristics.Conformational and non-conformational epitopes are distinguished in thatthe binding to the former but not the latter is lost in the presence ofdenaturing solvents. An epitope of a protein preferably comprises acontinuous or discontinuous portion of said protein and is preferablybetween 5 and 100, preferably between 5 and 50, more preferably between8 and 30, most preferably between 10 and 25 amino acids in length, forexample, the epitope may be preferably 8, 9, 10, 11, 12, 13, 14, 15, 16,17, 18, 19, 20, 21, 22, 23, 24, or 25 amino acids in length.

Mapping of epitopes recognized by binding agents can be performed asdescribed in detail in “Epitope Mapping Protocols” (Methods in MolecularBiology) by Glenn E. Morris ISBN-089603-375-9 and in “Epitope Mapping: APractical Approach” Practical Approach Series, 248 by Olwyn M. R.Westwood, Frank C. Hay.

The term “agonistic binding agent”, as used herein, refers to a bindingagent, which activates the receptor(s) of the TNF superfamily it isbinding to. In one embodiment, the binding agent induces IL-8 releasefrom and/or activates the NF-κB pathway in the cell(s) expressing thereceptor(s) of the TNF superfamily it is binding to. In one embodiment,the binding agent is a trans-activating binding agent, simultaneouslyactivating receptors of the TNF superfamily, e.g., said first and secondreceptor, located on different cells. In another embodiment, the bindingagent is a cis-activating binding agent, simultaneously activatingreceptors of the TNF superfamily, e.g., said first and second receptor,located on the same cell.

The term “binding” according to the invention preferably relates to aspecific binding. A binding agent, such as an antibody or fragmentthereof, is specific for a predetermined target if it is capable ofbinding to said predetermined target while it is not (substantially)capable of binding to other targets.

According to the present invention, a binding agent, such as an antibodyor fragment thereof, is capable of binding to a predetermined target ifit has a significant affinity for said predetermined target and binds tosaid predetermined target in standard assays. “Affinity” or “bindingaffinity” is often measured by equilibrium dissociation constant(K_(D)). Preferably, the term “significant affinity” refers to thebinding to a predetermined target with a dissociation constant (K_(D))of 10⁻⁵ M or lower, 10⁻⁶ M or lower, 10⁻⁷ M or lower, 10⁻⁸ M or lower,10⁻⁹ M or lower, 10⁻¹⁹ M or lower, 10⁻¹¹ M or lower, or 10⁻¹² M orlower.

An agent is not (substantially) capable of binding to a target if it hasno significant affinity for said target and does not bind significantly,in particular does not bind detectably, to said target in standardassays. Preferably, the agent does not detectably bind to said target ifpresent in a concentration of up to 2, preferably 10, more preferably20, in particular 50 or 100 μg/ml or higher. Preferably, an agent has nosignificant affinity for a target if it binds to said target with aK_(D) that is at least 10-fold, 100-fold, 10³-fold, 10⁴-fold, 10⁵-fold,or 10⁶-fold higher than the K_(D) for binding to the predeterminedtarget to which the agent is capable of binding. For example, if theK_(D) for binding of an agent to the target to which the agent iscapable of binding is 10⁻¹⁰ M, the K_(D) for binding to a target forwhich the agent has no significant affinity would be at least 10⁻⁶ M,10⁻⁵ M, 10⁻⁴ M, 10⁻³ M, 10⁻² M, or 10⁻¹ M.

Binding of an agent to a target can be determined experimentally usingany suitable method; see, for example, Berzofsky et al.,“Antibody-Antigen Interactions” In Fundamental Immunology, Paul, W. E.,Ed., Raven Press New York, N Y (1984), Kuby, Janis Immunology, W. H.Freeman and Company New York, N Y (1992), and methods described herein.Affinities may be readily determined using conventional techniques, suchas by equilibrium dialysis; by using the BIAcore 2000 instrument, usinggeneral procedures outlined by the manufacturer; by radioimmunoassayusing radiolabeled target antigen; or by another method known to theskilled artisan. The affinity data may be analyzed, for example, by themethod of Scatchard et al., Ann N.Y. Acad. ScL, 51:660 (1949). Themeasured affinity of a particular antibody-antigen interaction can varyif measured under different conditions, e.g., salt concentration, pH.Thus, measurements of affinity and other antigen-binding parameters,e.g., K_(D), IC₅₀, are preferably made with standardized solutions ofantibody and antigen, and a standardized buffer.

The term “antibody” refers to a glycoprotein comprising at least twoheavy (H) chains and two light (L) chains inter-connected by disulfidebonds. The term “antibody” includes monoclonal antibodies, recombinantantibodies, human antibodies, humanized antibodies, chimeric antibodiesand combinations of any of the foregoing. Each heavy chain is comprisedof a heavy chain variable region (VH) and a heavy chain constant region(CH). Each light chain is comprised of a light chain variable region(VL) and a light chain constant region (CL). The variable regions andconstant regions are also referred to herein as variable domains andconstant domains, respectively. The VH and VL regions can be furthersubdivided into regions of hypervariability, termed complementaritydetermining regions (CDRs), interspersed with regions that are moreconserved, termed framework regions (FRs). Each VH and VL is composed ofthree CDRs and four FRs, arranged from amino-terminus tocarboxy-terminus in the following order: FR1, CDR1, FR2, CDR2, FR3,CDR3, FR4. The CDRs of a VH are termed HCDR1, HCDR2 and HCDR3, the CDRsof a VL are termed LCDR1, LCDR2 and LCDR3. The variable regions of theheavy and light chains contain a binding domain that interacts with anantigen. The constant regions of an antibody comprise the heavy chainconstant region (CH) and the light chain constant region (CL), whereinCH can be further subdivided into constant domain CH1, a hinge region,and constant domains CH2 and CH3 (arranged from amino-terminus tocarboxy-terminus in the following order: CH1, CH2, CH3). The constantregions of the antibodies may mediate the binding of the immunoglobulinto host tissues or factors, including various cells of the immune system(e.g., effector cells) and the first component (Clq) of the classicalcomplement system.

Antibodies may be derived from different species, including but notlimited to mouse, rat, rabbit, guinea pig and human.

Antibodies described herein include IgA such as IgA1 or IgA2, IgG1,IgG2, IgG3, IgG4, IgE, IgM, and IgD antibodies. In various embodiments,the antibody is an IgG1 antibody, more particularly an IgG1, kappa orIgG1, lambda isotype (i.e. IgG1, κ, λ), an IgG2a antibody (e.g. IgG2a,κ, λ), an IgG2b antibody (e.g. IgG2b, κ, λ), an IgG3 antibody (e.g.IgG3, κ, λ) or an IgG4 antibody (e.g. IgG4, κ, λ).

As used herein, “isotype” refers to the antibody class (e.g., IgM orIgG1) that is encoded by heavy chain constant region genes. “Isotypeswitching” refers to the phenomenon by which the class, or isotype, ofan antibody changes from one Ig class to one of the other Ig classes.

The term “monoclonal antibody”, as used herein, refers to a preparationof antibody molecules of single molecular composition. A monoclonalantibody displays a single binding specificity and affinity. In oneembodiment, the monoclonal antibodies are produced by a hybridoma whichincludes a B-cell obtained from a non-human animal, e.g., a mouse, fusedto an immortalized cell.

The term “recombinant antibody”, as used herein, includes all antibodiesthat are prepared, expressed, created or isolated by recombinant means,such as (a) antibodies isolated from an animal (e.g., a mouse) that istransgenic or transchromosomal with respect to the immunoglobulin genesor a hybridoma prepared therefrom, (b) antibodies isolated from a hostcell transformed to express the antibody, e.g., from a transfectoma, (c)antibodies isolated from a recombinant, combinatorial antibody library,and (d) antibodies prepared, expressed, created or isolated by any othermeans that involve splicing of immunoglobulin gene sequences to otherDNA sequences.

The term “recombinant” in the context of the present invention means“made through genetic engineering”. Preferably, a “recombinant object”,such as a recombinant antibody or nucleic acid” is not naturallyoccurring.

The term “naturally occurring”, as used herein, as applied to an objectrefers to the fact that an object can be found in nature. For example, apolypeptide or polynucleotide sequence that is present in an organism(including viruses) that can be isolated from a source in nature andwhich has not been intentionally modified by man in the laboratory isnaturally occurring.

The term “human antibody”, as used herein, is intended to includeantibodies having variable and constant regions derived from humangermline immunoglobulin sequences. Human antibodies may include aminoacid residues not encoded by human germline immunoglobulin sequences(e.g., mutations introduced by random or site-specific mutagenesis invitro or by somatic mutation in vivo).

The term “humanized antibody” refers to a molecule having an antigenbinding site that is substantially derived from an immunoglobulin from anon-human species, wherein the remaining immunoglobulin structure of themolecule is based upon the structure and/or sequence of a humanimmunoglobulin. The antigen binding site may either comprise completevariable regions (VH and VL) fused onto constant domains (e.g., theconstant domains of IgG UK), or only the complementarity determiningregions (CDRs) grafted onto appropriate framework regions in thevariable regions. Antigen binding sites may be wild-type or modified byone or more amino acid substitutions, e.g. modified to resemble humanimmunoglobulins more closely. Some forms of humanized antibodiespreserve all CDR sequences (for example a humanized mouse antibody whichcontains all six CDRs from the mouse antibody). Other forms have one ormore CDRs which are altered with respect to the original antibody.

The term “chimeric antibody” refers to those antibodies wherein oneportion of each of the amino acid sequences of heavy and light chains ishomologous to corresponding sequences in antibodies derived from aparticular species or belonging to a particular class, while theremaining segment of the chain is homologous to corresponding sequencesin another. Typically, the variable region of both light and heavychains mimics the variable regions of antibodies derived from onespecies of mammals, while the constant portions are homologous tosequences of antibodies derived from another. One clear advantage tosuch chimeric forms is that the variable region can conveniently bederived from presently known sources using readily available B-cells orhybridomas from non-human host organisms in combination with constantregions derived from, for example, human cell preparations. While thevariable region has the advantage of ease of preparation and thespecificity is not affected by the source, the constant region beinghuman, is less likely to elicit an immune response from a human subjectwhen the antibodies are injected than would the constant region from anon human source. However, the definition is not limited to thisparticular example.

The antibodies described herein are preferably isolated. The term“isolated antibody”, as used herein, is intended to refer to an antibodywhich is substantially free of other antibodies having differentantigenic specificities. An isolated antibody that specifically binds toan epitope, isoform or variant of a given receptor of the TNFsuperfamily may, however, have cross-reactivity to other relatedantigens, e.g., from other species (e.g., species homologs of saidreceptor). Moreover, an isolated antibody may be substantially free ofother cellular material and/or chemicals.

The term “antibody fragment” refers to one or more fragments of anantibody that retain the ability to specifically bind to an antigen andmay also be referred to as “antigen-binding fragment” of an antibody. Ithas been shown that the antigen-binding function of an antibody can beperformed by fragments of a full-length antibody. Examples of bindingfragments encompassed within the term “antibody fragment” include (i)Fab fragments, monovalent fragments consisting of the VL, VH, CL and CHregions; (ii) F(ab′)₂ fragments, bivalent fragments comprising two Fabfragments linked by a disulfide bridge at the hinge region; (iii) Fdfragments consisting of the VH and CH regions; (iv) Fv fragmentsconsisting of the VL and VH regions of a single arm of an antibody, (v)dAb fragments (Ward et al., (1989) Nature 341: 544-546), which consistof a VH region; (vi) isolated complementarity determining regions (CDR),and (vii) combinations of two or more isolated CDRs which may optionallybe joined by a synthetic linker. Furthermore, although the tworegions/domains of the Fv fragment, VL and VH, are coded for by separategenes, they can be joined, using recombinant methods, by a syntheticlinker that enables them to be made as a single protein chain in whichthe VL and VH regions pair to form monovalent molecules (known as singlechain Fv (scFv); see e.g., Bird et al. (1988) Science 242: 423-426; andHuston et al. (1988) Proc. Natl. Acad. Sci. USA 85: 5879-5883). Suchsingle chain antibodies are also intended to be encompassed within theterm “antibody fragment”. A further example is a binding-domainimmunoglobulin fusion protein comprising (i) a binding domainpolypeptide that is fused to an immunoglobulin hinge region polypeptide,(ii) an immunoglobulin heavy chain CH2 constant region fused to thehinge region, and (iii) an immunoglobulin heavy chain CH3 constantregion fused to the CH2 constant region. The binding domain polypeptidecan be a heavy chain variable region or a light chain variable region.The binding-domain immunoglobulin fusion proteins are further disclosedin US 2003/0118592 and US 2003/0133939. These antibody fragments areobtained using conventional techniques known to those with skill in theart, and the fragments are screened for utility in the same manner asare intact antibodies.

The terms “part” or “fragment” are used interchangeably herein and referto a continuous element. For example, a part of a structure such as anamino acid sequence or protein refers to a continuous element of saidstructure. A portion, a part or a fragment of a structure preferablycomprises one or more functional properties of said structure. Forexample, a portion, a part or a fragment of an epitope or peptide ispreferably immunologically equivalent to the epitope or peptide it isderived from. A part or fragment of a protein sequence preferablycomprises a sequence of at least 6, in particular at least 8, at least12, at least 15, at least 20, at least 30, at least 50, or at least 100consecutive amino acids of the protein sequence.

When used in connection with VH and VL domains, the term “fragment”preferably refers to one or more of the complementarity-determiningregions (CDRs), preferably at least the CDR3 variable region, of theheavy chain variable region (VH) and/or of the light chain variableregion (VL). In one embodiment, said one or more of thecomplementarity-determining regions (CDRs) are selected from a set ofcomplementarity-determining regions CDR1, CDR2 and CDR3. In aparticularly preferred embodiment, the term “fragment” refers to thecomplementarity-determining regions CDR1, CDR2 and CDR3 of the heavychain variable region (VH), i.e. HCDR1, HCDR2 and HCDR3, and/or of thelight chain variable region (VL), i.e. LCDR1, LCDR2 and LCDR3.

The teaching given herein with respect to specific amino acid sequences,e.g., those shown in the sequence listing, is to be construed so as toalso relate to variants of said specific sequences resulting insequences which are functionally equivalent to said specific sequences,e g, amino acid sequences exhibiting properties identical or similar tothose of the specific amino acid sequences. One important property is toretain binding to a target.

For example, the sequences shown in the sequence listing can be modifiedso as to remove one or more, preferably all free cysteine residues, inparticular by replacing the cysteine residues by amino acids other thancysteine, preferably serine, alanine, threonine, glycine, tyrosine,leucine or methionine, most preferably alanine or serine.

It will be appreciated by those skilled in the art that, in particular,the sequences of the CDRs and variable regions can be modified withoutlosing the ability to bind the first and/or the second receptor of theTNF superfamily. For example, CDR regions will be either identical orhighly homologous to the regions of antibodies specified herein. By“highly homologous” it is contemplated that from 1 to 5, preferably from1 to 4, such as 1 to 3 or 1 or 2 substitutions may be made in the CDRs.In addition, the hypervariable and variable regions may be modified sothat they show substantial homology with the regions of antibodiesspecifically disclosed herein.

For the purposes of the present invention, “variants” of an amino acidsequence, in particular variants of a heavy chain variable domain (VH)or of a light chain variable domain (VL), comprise amino acid insertionvariants, amino acid addition variants, amino acid deletion variantsand/or amino acid substitution variants. Amino acid deletion variantsthat comprise the deletion at the N-terminal and/or C-terminal end ofthe protein are also called N-terminal and/or C-terminal truncationvariants.

Amino acid insertion variants comprise insertions of single or two ormore amino acids in a particular amino acid sequence. In the case ofamino acid sequence variants having an insertion, one or more amino acidresidues are inserted into a particular site in an amino acid sequence,although random insertion with appropriate screening of the resultingproduct is also possible.

Amino acid addition variants comprise amino- and/or carboxy-terminalfusions of one or more amino acids, such as 1, 2, 3, 5, 10, 20, 30, 50,or more amino acids.

Amino acid deletion variants are characterized by the removal of one ormore amino acids from the sequence, such as by removal of 1, 2, 3, 5,10, 20, 30, 50, or more amino acids. The deletions may be in anyposition of the protein.

Amino acid substitution variants are characterized by at least oneresidue in the sequence being removed and another residue being insertedin its place. Preference is given to modifications being in positions inthe amino acid sequence which are not conserved between homologousproteins or peptides and/or to replacing amino acids with other oneshaving similar properties. Preferably, amino acid substitutions inprotein variants are conservative amino acid substitutions. Aconservative amino acid substitution involves substitution of an aminoacid with another one of the same family of amino acids, i.e., aminoacids which are related in their side chains (e.g., in terms of theelectrical charge and/or size). Naturally occurring amino acids aregenerally divided into four families acidic (aspartate, glutamate),basic (lysine, arginine, histidine), non-polar (alanine, valine,leucine, isoleucine, proline, phenylalanine, methionine, tryptophan),and uncharged polar (glycine, asparagine, glutamine, cysteine, serine,threonine, tyrosine) amino acids. Phenylalanine, tryptophan, andtyrosine are sometimes classified jointly as aromatic amino acids.

Preferably the degree of similarity, preferably identity between a givenamino acid sequence and an amino acid sequence which is a variant ofsaid given amino acid sequence will be at least about 60%, 65%, 70%,80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%,94%, 95%, 96%, 97%, 98%, or 99%. The degree of similarity or identity isgiven preferably for an amino acid region which is at least about 10%,at least about 20%, at least about 30%, at least about 40%, at leastabout 50%, at least about 60%, at least about 70%, at least about 80%,at least about 90% or about 100% of the entire length of the referenceamino acid sequence. For example, if the reference amino acid sequenceconsists of 200 amino acids, the degree of similarity or identity isgiven preferably for at least about 20, at least about 40, at leastabout 60, at least about 80, at least about 100, at least about 120, atleast about 140, at least about 160, at least about 180, or about 200amino acids, preferably continuous amino acids. In preferredembodiments, the degree of similarity or identity is given for theentire length of the reference amino acid sequence. The alignment fordetermining sequence similarity, preferably sequence identity can bedone with art known tools, preferably using the best sequence alignment,for example, using Align, using standard settings, preferablyEMBOSS::needle, Matrix: Blosum62, Gap Open 10.0, Gap Extend 0.5.

“Sequence similarity” indicates the percentage of amino acids thateither are identical or that represent conservative amino acidsubstitutions. “Sequence identity” between two amino acid sequencesindicates the percentage of amino acids that are identical between thesequences.

The term “percentage identity” is intended to denote a percentage ofamino acid residues which are identical between the two sequences to becompared, obtained after the best alignment, this percentage beingpurely statistical and the differences between the two sequences beingdistributed randomly and over their entire length. Sequence comparisonsbetween two amino acid sequences are conventionally carried out bycomparing these sequences after having aligned them optimally, saidcomparison being carried out by segment or by “window of comparison” inorder to identify and compare local regions of sequence similarity. Theoptimal alignment of the sequences for comparison may be produced,besides manually, by means of the local homology algorithm of Smith andWaterman, 1981, Ads App. Math. 2, 482, by means of the local homologyalgorithm of Neddleman and Wunsch, 1970, J. Mol. Biol. 48, 443, by meansof the similarity search method of Pearson and Lipman, 1988, Proc. NatlAcad. Sci. USA 85, 2444, or by means of computer programs which usethese algorithms (GAP, BESTFIT, FASTA, BLAST P, BLAST N and TFASTA inWisconsin Genetics Software Package, Genetics Computer Group, 575Science Drive, Madison, Wis.).

The percentage identity is calculated by determining the number ofidentical positions between the two sequences being compared, dividingthis number by the number of positions compared and multiplying theresult obtained by 100 so as to obtain the percentage identity betweenthese two sequences.

Binding agents in accordance with the present invention may be at leastbispecific or multispecific, such as trispecific, tetraspecific and soon.

The term “bispecific molecule” refers to a molecule that has twodifferent binding specificities and thus may bind to two different typesof antigen, such as a first and a second receptor of the TNF superfamilySuch bispecific molecule may be in the format of an antibody molecule orof an antibody-like molecule or of a protein scaffold with antibody-likeproperties or of a cyclic peptide with at least two bindingspecificities.

The term “bispecific antibody”, as used herein, refers to an antibodycomprising two antigen-binding sites, a first binding site havingaffinity for a first antigen or epitope and a second binding site havingbinding affinity for a second antigen or epitope distinct from thefirst. In particular, a bispecific antibody is an artificial proteinthat is composed of fragments of two different antibodies (saidfragments of two different antibodies forming two binding domains) andconsequently binds to two different types of antigen.

A bispecific molecule/antibody according to the invention is engineeredto simultaneously bind to a first receptor of the TNF superfamily and toa second receptor of the TNF superfamily, wherein the first receptor andthe second receptor are different and may be located on the same cell(“cis”) or different cells (“trans”).

In one embodiment, the first receptor and the second receptor arelocated on the same cell and are selected from the group consisting ofCD27, OX40 (CD134) and 4-1BB (CD137). In one embodiment, said cell is aT cell.

In another embodiment, the first receptor and the second receptor arelocated on different cells, wherein the first receptor is CD40 and thesecond receptor is selected from the group consisting of CD27, OX40(CD134) and 4-1BB (CD137). In one embodiment, said different cells arean antigen-presenting cell (APC), such as a dendritic cell, expressingCD40 and a T cell expressing the second receptor selected from the groupconsisting of CD27, OX40 (CD134) and 4-1BB (CD137).

Bispecific (full-length) antibodies may be obtained bycovalently/chemically linking two (monoclonal) antibodies or byconventional hybrid-hybridoma techniques. Covalent linking of twomonoclonal antibodies is described, for example, in Anderson (1992),Blood 80:2826-34. In the context of this invention, one of theantibodies is specific for the first receptor of the TNF superfamily andthe other one for the second receptor of the TNF superfamily.

Alternatively, bispecific (full-length) antibodies may be obtained byusing the knobs-into-holes technology, which allows thehetero-dimerization of antibody heavy chains by introducing specificmutations in the CH3 dimer interface, e.g., in the CH3 dimer interfaceof IgG1 or IgG4. This technology is described, for example, in Spiess C.et al. (2013), Journal of Biological Chemistry 288(37):26583-93; LabrijnA. F. et al. (2013), PNAS 110(13):5145-50; and WO 2008/119353 A1.

In one embodiment, the bispecific antibody is a bispecific single-chainantibody.

As used herein, a “bispecific single-chain antibody” denotes a singlepolypeptide chain comprising two binding domains. Each binding domaincomprises one VH region, wherein the VH region of the first bindingdomain specifically binds to the first receptor of the TNF superfamily(REC1), and the VH region of the second binding domain specificallybinds to the second receptor of the TNF superfamily (REC2). The twobinding domains are optionally linked to one another by a short peptidelinker. Each binding domain may additionally comprise one variableregion from an antibody light chain (VL), the VH region and VL regionwithin each of the first and second binding domains being linked to oneanother via a long peptide linker, which is long enough to allow the VHregion and VL region of the first binding domain and the VH region andVL region of the second binding domain to pair with one another.

In one embodiment, the corresponding variable heavy chain regions (VH)and the corresponding variable light chain regions (VL) are arranged,from N-terminus to C-terminus, in the orderVH(REC1)-VL(REC1)-VH(REC2)-VL(REC2), VH(REC2)-VL(REC2)-VH(REC1)-VL(REC1)or VH(REC2)-VL(REC2)-VL(REC1)-VH(REC1). It is, however, also envisagedthat the bispecific single chain antibodies of the invention compriseother domain arrangements, such as VL(REC1)-VH(REC1)-VH(REC2)-VL(REC2),VL(REC1)-VH(REC1)-VL(REC2)-VH(REC2),VH(REC1)-VL(REC1)-VL(REC2)-VH(REC2),VL(REC2)-VH(REC2)-VH(REC1)-VL(REC1),VL(REC2)-VH(REC2)-VL(REC1)-VH(REC1).

Peptide linkers are generally designed to provide flexibility andprotease resistance. In one embodiment, the peptide linker is aglycine-serine-threonine-rich linker or glycine-serine-rich linker,wherein at least 50%, preferably at least 60%, more preferably at least70%, more preferably at least 80%, even more preferably at least 90% ofthe amino acids are a glycine or serine or threonine residue or aglycine or serine residue, respectively. In another embodiment, theamino acids are selected from glycine, serine and threonine, i.e., thepeptide linker is exclusively composed of glycine, serine and threonineresidues (referred to as a glycine-serine-threonine linker). In yetanother embodiment, the peptide linker is exclusively composed ofglycine and serine residues (referred to as a glycine-serine linker).Short peptide linkers may consist of 12 or less such as 11, 10, 9, 8, 7,6, 5, 4, 3 or 2 amino acids, and preferably, 5 or 6 amino acids. Shortpeptide linkers preferably comprise the amino acid sequences SGGGGS orGGGGS. Long peptide linkers may consist of 12 or more, such as 15 to 25or 15 to 20 or 15 to 18 amino acids, and may, for example, be selectedfrom (GGGGS)₃, (GGGGS)₄ and (GGGGS)₅.

In one embodiment, the binding agent of the invention is in the formatof a bispecific antibody fragment.

The binding agent according to the invention may be one of various typesof bivalent and trivalent single-chain variable fragments (scFvs),fusion proteins mimicking the variable domains of two antibodies. Asingle-chain variable fragment (scFv) is a fusion protein of thevariable regions of the heavy (VH) and light chains (VL) ofimmunoglobulins, connected with a peptide linker of ten to about 25amino acids. The peptide linker is usually rich in glycine forflexibility, as well as serine or threonine for solubility, and caneither connect the N-terminus of the VH with the C-terminus of the VL,or vice versa. Divalent (or bivalent) single-chain variable fragments(di-scFvs, bi-scFvs) can be engineered by linking two scFvs. This can bedone by producing a single peptide chain with two VH and two VL regions,yielding tandem scFvs. The invention also includes multispecificmolecules comprising more than two scFvs binding domains. This makes itpossible that the molecule comprises either multiple antigenspecificities and is a trispecific, tetraspecific, or multispecificmolecule, or the molecule is a bispecific molecule comprising more thanone scFv binding domain with specificity for the same antigen. Inparticular, the molecule of the invention may be a multispecific singlechain Fv.

In one embodiment, the binding agent comprises two Fab regions, onebeing directed against the first receptor of the TNF superfamily and theother being directed against the second receptor of the TNF superfamily.In one embodiment, the binding agent is an antigen-binding fragment(Fab)2 complex. The (Fab)2 complex is composed of two Fab fragments, oneFab fragment comprising a Fv domain, i.e. VH and VL domains, binding tothe first receptor of the TNF superfamily, and the other Fab fragmentcomprising a Fv domain binding to the second receptor of the TNFsuperfamily Each of the Fab fragments may be composed of two singlechains, a VL-CL module and a VH—CH module. Alternatively, each of theindividual Fab fragments may be arranged in a single chain, preferably,VL-CL-CH—VH, and the individual variable and constant domains may beconnected with a peptide linker. In general, the individual singlechains and Fab fragments may be connected via disulfide bonds, adhesivedomains, chemical linkage and/or peptide linker(s). The binding agentmay also comprise more than two Fab fragments, in particular, themolecule may be a Fab3, Fab4, or a multimeric Fab complex withspecificity for 2, 3, 4, or more different antigens. The invention alsoincludes chemically linked Fabs.

Another possibility is the creation of scFvs with peptide linkers thatare too short for the two variable regions to fold together (about fiveamino acids), forcing scFvs to dimerize. This type is known asdiabodies. Still shorter peptide linkers (one or two amino acids) leadto the formation of trimers, so-called triabodies or tribodies.Tetrabodies have also been produced. They exhibit an even higheraffinity to their targets than diabodies.

A diabody (Kipriyanov, Int. J. Cancer 77 (1998), 763-772) is a smallbivalent and bispecific antibody fragment. Diabodies comprise a heavychain variable domain (VH) connected to a light chain variable domain(VL) on the same polypeptide chain (VH-VL) connected by a peptide linkerthat is too short to allow pairing between the two domains on the samechain. This forces pairing with the complementary domains of anotherchain and promotes the assembly of a dimeric molecule with twofunctional antigen-binding sites. To construct bispecific diabodies ofthe invention, the V-domains of an antibody binding to the firstreceptor of the TNF superfamily (REC1) and an antibody binding to thesecond receptor of the TNF superfamily (REC2) may be fused to create thetwo chains VH(REC1)-VL(REC2) and VH(REC2)-VL(REC1). Each chain by itselfis not able to bind to the respective antigen, but recreates thefunctional antigen binding sites of an anti-REC1 antibody and ananti-REC2 antibody on pairing with the other chain. To this end, apeptide linker that is too short to allow pairing between the twodomains on the same chain is used. The two scFv molecules, with a linkerbetween heavy chain variable domain and light chain variable domain thatis too short for intramolecular dimerization, are co-expressed and selfassemble to form bi-specific molecules with the two binding sites atopposite ends.

In one embodiment, the bispecific antibody fragment binding to the firstreceptor of the TNF superfamily (REC1) and the second receptor of theTNF superfamily (REC2) is a minibody, preferably, a minibody comprisingtwo single VH-VL-C chains that are connected with each other via theconstant domain (C) of each chain. According to this aspect, thecorresponding variable heavy chain regions (VH), corresponding variablelight chain regions (VL) and constant domains (C) are arranged, fromN-terminus to C-terminus, in the order VH(REC1)-VL(REC1)-(C) andVH(REC2)-VL(REC2)-C, wherein C is preferably a CH3 domain. Pairing ofthe constant domains results in formation of the minibody.

In one embodiment, the bispecific binding agent is in the format of anantibody-like molecule with a heavy chain containing two consecutiveN-terminal variable domains with different specificities and a lightchain with two consecutive variable domains with different specificitiesresulting in four binding domains with two different specificities (Wuet al. (2007), Nat. Biotechnology 25(11))

Binding agents according to the invention may also comprises an aminoacid sequence for facilitating secretion of the molecule, such as aN-terminal secretion signal, and/or one or more labels or tagsfacilitating binding, purification or detection of the molecule.

Preferably, the secretion signal is a signal sequence that allows asufficient passage through the secretory pathway and/or secretion of thebinding agent into the extracellular environment. Preferably, thesecretion signal sequence is cleavable and is removed from the maturebinding agent. The secretion signal sequence preferably is chosen withrespect to the cell or organism wherein the binding agent is producedin.

A “label or tag facilitating binding, purification or detection of themolecule” is meant to include any labels/tags known in the art for thesepurposes. Particularly preferred are affinity tags, such as chitinbinding protein (CBP), maltose binding protein (MBP),glutathione-S-transferase (GST) and poly(His) (e.g., His₆);solubilization tags, such as thioredoxin (TRX) and poly(NANP);chromatography tags, such as a FLAG-tag; epitope tags, such as V5-tag,myc-tag and HA-tag; and fluorescent or luminescent labels or tags, suchas fluorescent proteins (e.g., GFP, YFP, RFP etc.), fluorescent dyes andluciferase.

The amino acid sequence of a (poly)peptide label or tag may beintroduced at any position within the amino acid sequence of the bindingagent, and may, for example, take the shape of a loop within the encodedprotein structure or it may be N-terminally or C-terminally fused. Thelabel or tag may further contain a cleavage site that allows a removalof the label or tag from the binding agent. Similarly, non-peptidiclabels or tags, e.g., fluorescent dyes, may be conjugated to the bindingagent at any suitable site.

Binding agents of the invention may contain, e.g., in addition to saidfirst and second binding domain, a further binding domain which servese.g. to enhance selectivity for a specific cell type. This can beachieved, e.g., by providing a binding domain that binds to anotherantigen expressed on said specific cell type.

Binding agents of the invention may further comprise one or moremodifications increasing the stability of the binding agent. The term“stability” of the binding agent relates to the “half-life” of thebinding agent, e.g., in vivo. “Half-life” relates to the period of timewhich is needed to eliminate half of the activity, amount, or number ofmolecules.

The binding agent may, for example, be conjugated to a half-lifeextension module. Such modules are known to a person skilled in the artand include, for example, albumin, an albumin-binding domain, animmunoglobulin-binding domain, an FcRn-binding motif, and, inparticular, a polymer. Particularly preferred polymers includepolyethylene glycol (PEG), hydroxyethyl starch (HES), polysialic acidand PEG-mimetic peptide sequences.

The binding agents described herein may be conjugated to a therapeuticmoiety or agent, such as a cytotoxin, a drug (e.g., animmunosuppressant) or a radioisotope. A cytotoxin or cytotoxic agentincludes any agent that is detrimental to and, in particular, killscells. Examples include taxol, cytochalasin B, gramicidin D, ethidiumbromide, emetine, mitomycin, etoposide, tenoposide, vincristine,vinblastine, colchicin, doxorubicin, daunorubicin, dihydroxy anthracindione, mitoxantrone, mithramycin, actinomycin D, 1-dehydrotestosterone,glucocorticoids, procaine, tetracaine, lidocaine, propranolol, andpuromycin and analogs or homologs thereof. Suitable therapeutic agentsfor forming conjugates include, but are not limited to, antimetabolites(e.g., methotrexate, 6-mercaptopurine, 6-thioguanine, cytarabine,fludarabin, 5-fluorouracil decarbazine), alkylating agents (e.g.,mechlorethamine, thioepa chlorambucil, melphalan, carmustine (BSNU) andlomustine (CCNU), cyclophosphamide, busulfan, dibromomannitol,streptozotocin, mitomycin C, and cis-dichlorodiamine platinum (II) (DDP)cisplatin), anthracyclines (e.g., daunorubicin (formerly daunomycin) anddoxorubicin), antibiotics (e.g., dactinomycin (formerly actinomycin),bleomycin, mithramycin, and anthramycin (AMC), and anti-mitotic agents(e.g., vincristine and vinblastine). In a preferred embodiment, thetherapeutic agent is a cytotoxic agent or a radiotoxic agent. In anotherembodiment, the therapeutic agent is an immunosuppressant. In yetanother embodiment, the therapeutic agent is GM-CSF. In a preferredembodiment, the therapeutic agent is doxorubicin, cisplatin, bleomycin,sulfate, carmustine, chlorambucil, cyclophosphamide or ricin A.

Binding agents also can be conjugated to a radioisotope, e.g.,iodine-131, yttrium-90 or indium-111, to generate cytotoxicradiopharmaceuticals.

Techniques for conjugating such therapeutic moiety to binding agents,such as antibodies or fragments thereof, are well known, see, e.g.,Arnon et al., “Monoclonal Antibodies For Immunotargeting Of Drugs InCancer Therapy”, in Monoclonal Antibodies And Cancer Therapy, Reisfeldet al. (eds.), pp. 243-56 (Alan R. Liss, Inc. 1985); Hellstrom et al.,“Antibodies For Drug Delivery”, in Controlled Drug Delivery (2nd Ed.),Robinson et al. (eds.), pp. 623-53 (Marcel Dekker, Inc. 1987); Thorpe,“Antibody Carriers Of Cytotoxic Agents In Cancer Therapy: A Review”, inMonoclonal Antibodies '84: Biological And Clinical Applications,Pincheraet al. (eds.), pp. 475-506 (1985); “Analysis, Results, AndFuture Prospective Of The Therapeutic Use Of Radiolabeled Antibody InCancer Therapy”, in Monoclonal Antibodies For Cancer Detection AndTherapy, Baldwin et al. (eds.), pp. 303-16 (Academic Press 1985), andThorpe et al., “The Preparation And Cytotoxic Properties OfAntibody-Toxin Conjugates”, Immunol. Rev., 62: 119-58 (1982).

The present invention provides a binding agent comprising at least twobinding domains, wherein a first binding domain binds to a firstreceptor of the tumor necrosis factor (TNF) superfamily and a secondbinding domain binds to a second receptor of the TNF superfamily,wherein the first receptor and the second receptor are different.

In one embodiment, the first binding domain binds to CD40 and the secondbinding domain binds to CD27, wherein, preferably, the binding agentcomprises one or more CDRs or one or more variable domains of antibodyAB40_1, and one or more CDRs or one or more variable domains of anantibody AB27_X, wherein X is selected from the group consisting of 1 to186, as shown in Table 7.

“AB40_1” refers to an antibody binding to CD40, which comprises

-   (a) heavy chain complementarity determining regions HCDR1 having the    amino acid sequence of SEQ ID NO: 2323, HCDR2 having the amino acid    sequence of SEQ ID NO: 2324 and HCDR3 having the amino acid sequence    of SEQ ID NO: 2325, and    -   light chain complementarity determining regions LCDR1 having the        amino acid sequence of SEQ ID NO: 2326, LCDR2 having the amino        acid sequence of SEQ ID NO: 2327 and

LCDR3 having the amino acid sequence of SEQ ID NO: 2328; and

-   -   (b) heavy chain variable domain (VH) having the amino acid        sequence of SEQ ID NO: 2321 and light chain variable domain (VL)        having the amino acid sequence of SEQ ID NO: 2322.

In various embodiments, the binding agent comprises one or more CDRs orone or more variable domains of antibody AB40_1 and X is 1; the bindingagent comprises one or more CDRs or one or more variable domains ofantibody AB40_1 and X is 2; the binding agent comprises one or more CDRsor one or more variable domains of antibody AB40_1 and X is 3; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 4; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 5; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 6; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 7; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 8; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 9; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 10; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 11; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 12; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 13; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 14; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 15; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 16; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 17; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 18; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 19; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 20; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 21; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 22; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 23; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 24; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 25; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 26; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 27; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 28; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 29; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 30; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 31; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 32; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 33; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 34; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 35; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 36; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 37; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 38; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 39; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 40; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 41; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 42; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 43; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 44; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 45; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 46; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 47; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 48; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 49; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 50; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 51; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 52; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 53; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 54; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 55; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 56; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 57; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 58; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 59; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 60; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 61; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 62; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 63; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 64; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 65; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 66; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 67; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 68; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 69; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 70; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 71; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 72; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 73; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 74; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 75; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 76; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 77; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 78; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 79; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 80; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 81; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 82; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 83; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 84; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 85; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 86; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 87; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 88; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 89; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 90; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 91; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 92; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 93; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 94; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 95; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 96; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 97; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 98; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 99; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 100; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 101;the binding agent comprises one or more CDRs or one or more variabledomains of antibody AB40_1 and X is 102; the binding agent comprises oneor more CDRs or one or more variable domains of antibody AB40_1 and X is103; the binding agent comprises one or more CDRs or one or morevariable domains of antibody AB40_1 and X is 104; the binding agentcomprises one or more CDRs or one or more variable domains of antibodyAB40_1 and X is 105; the binding agent comprises one or more CDRs or oneor more variable domains of antibody AB40_1 and X is 106; the bindingagent comprises one or more CDRs or one or more variable domains ofantibody AB40_1 and X is 107; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 108;the binding agent comprises one or more CDRs or one or more variabledomains of antibody AB40_1 and X is 109; the binding agent comprises oneor more CDRs or one or more variable domains of antibody AB40_1 and X is110; the binding agent comprises one or more CDRs or one or morevariable domains of antibody AB40_1 and X is 111; the binding agentcomprises one or more CDRs or one or more variable domains of antibodyAB40_1 and X is 112; the binding agent comprises one or more CDRs or oneor more variable domains of antibody AB40_1 and X is 113; the bindingagent comprises one or more CDRs or one or more variable domains ofantibody AB40_1 and X is 114; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 115;the binding agent comprises one or more CDRs or one or more variabledomains of antibody AB40_1 and X is 116; the binding agent comprises oneor more CDRs or one or more variable domains of antibody AB40_1 and X is117; the binding agent comprises one or more CDRs or one or morevariable domains of antibody AB40_1 and X is 118; the binding agentcomprises one or more CDRs or one or more variable domains of antibodyAB40_1 and X is 119; the binding agent comprises one or more CDRs or oneor more variable domains of antibody AB40_1 and X is 120; the bindingagent comprises one or more CDRs or one or more variable domains ofantibody AB40_1 and X is 121; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 122;the binding agent comprises one or more CDRs or one or more variabledomains of antibody AB40_1 and X is 123; the binding agent comprises oneor more CDRs or one or more variable domains of antibody AB40_1 and X is124; the binding agent comprises one or more CDRs or one or morevariable domains of antibody AB40_1 and X is 125; the binding agentcomprises one or more CDRs or one or more variable domains of antibodyAB40_1 and X is 126; the binding agent comprises one or more CDRs or oneor more variable domains of antibody AB40_1 and X is 127; the bindingagent comprises one or more CDRs or one or more variable domains ofantibody AB40_1 and X is 128; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 129;the binding agent comprises one or more CDRs or one or more variabledomains of antibody AB40_1 and X is 130; the binding agent comprises oneor more CDRs or one or more variable domains of antibody AB40_1 and X is131; the binding agent comprises one or more CDRs or one or morevariable domains of antibody AB40_1 and X is 132; the binding agentcomprises one or more CDRs or one or more variable domains of antibodyAB40_1 and X is 133; the binding agent comprises one or more CDRs or oneor more variable domains of antibody AB40_1 and X is 134; the bindingagent comprises one or more CDRs or one or more variable domains ofantibody AB40_1 and X is 135; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 136;the binding agent comprises one or more CDRs or one or more variabledomains of antibody AB40_1 and X is 137; the binding agent comprises oneor more CDRs or one or more variable domains of antibody AB40_1 and X is138; the binding agent comprises one or more CDRs or one or morevariable domains of antibody AB40_1 and X is 139; the binding agentcomprises one or more CDRs or one or more variable domains of antibodyAB40_1 and X is 140; the binding agent comprises one or more CDRs or oneor more variable domains of antibody AB40_1 and X is 141; the bindingagent comprises one or more CDRs or one or more variable domains ofantibody AB40_1 and X is 142; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 143;the binding agent comprises one or more CDRs or one or more variabledomains of antibody AB40_1 and X is 144; the binding agent comprises oneor more CDRs or one or more variable domains of antibody AB40_1 and X is145; the binding agent comprises one or more CDRs or one or morevariable domains of antibody AB40_1 and X is 146; the binding agentcomprises one or more CDRs or one or more variable domains of antibodyAB40_1 and X is 147; the binding agent comprises one or more CDRs or oneor more variable domains of antibody AB40_1 and X is 148; the bindingagent comprises one or more CDRs or one or more variable domains ofantibody AB40_1 and X is 149; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 150;the binding agent comprises one or more CDRs or one or more variabledomains of antibody AB40_1 and X is 151; the binding agent comprises oneor more CDRs or one or more variable domains of antibody AB40_1 and X is152; the binding agent comprises one or more CDRs or one or morevariable domains of antibody AB40_1 and X is 153; the binding agentcomprises one or more CDRs or one or more variable domains of antibodyAB40_1 and X is 154; the binding agent comprises one or more CDRs or oneor more variable domains of antibody AB40_1 and X is 155; the bindingagent comprises one or more CDRs or one or more variable domains ofantibody AB40_1 and X is 156; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 157;the binding agent comprises one or more CDRs or one or more variabledomains of antibody AB40_1 and X is 158; the binding agent comprises oneor more CDRs or one or more variable domains of antibody AB40_1 and X is159; the binding agent comprises one or more CDRs or one or morevariable domains of antibody AB40_1 and X is 160; the binding agentcomprises one or more CDRs or one or more variable domains of antibodyAB40_1 and X is 161; the binding agent comprises one or more CDRs or oneor more variable domains of antibody AB40_1 and X is 162; the bindingagent comprises one or more CDRs or one or more variable domains ofantibody AB40_1 and X is 163; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 164;the binding agent comprises one or more CDRs or one or more variabledomains of antibody AB40_1 and X is 165; the binding agent comprises oneor more CDRs or one or more variable domains of antibody AB40_1 and X is166; the binding agent comprises one or more CDRs or one or morevariable domains of antibody AB40_1 and X is 167; the binding agentcomprises one or more CDRs or one or more variable domains of antibodyAB40_1 and X is 168; the binding agent comprises one or more CDRs or oneor more variable domains of antibody AB40_1 and X is 169; the bindingagent comprises one or more CDRs or one or more variable domains ofantibody AB40_1 and X is 170; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 171;the binding agent comprises one or more CDRs or one or more variabledomains of antibody AB40_1 and X is 172; the binding agent comprises oneor more CDRs or one or more variable domains of antibody AB40_1 and X is173; the binding agent comprises one or more CDRs or one or morevariable domains of antibody AB40_1 and X is 174; the binding agentcomprises one or more CDRs or one or more variable domains of antibodyAB40_1 and X is 175; the binding agent comprises one or more CDRs or oneor more variable domains of antibody AB40_1 and X is 176; the bindingagent comprises one or more CDRs or one or more variable domains ofantibody AB40_1 and X is 177; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 178;the binding agent comprises one or more CDRs or one or more variabledomains of antibody AB40_1 and X is 179; the binding agent comprises oneor more CDRs or one or more variable domains of antibody AB40_1 and X is180; the binding agent comprises one or more CDRs or one or morevariable domains of antibody AB40_1 and X is 181; the binding agentcomprises one or more CDRs or one or more variable domains of antibodyAB40_1 and X is 182; the binding agent comprises one or more CDRs or oneor more variable domains of antibody AB40_1 and X is 183; the bindingagent comprises one or more CDRs or one or more variable domains ofantibody AB40_1 and X is 184; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 185; orthe binding agent comprises one or more CDRs or one or more variabledomains of antibody AB40_1 and X is 186.

In one embodiment, the binding agent comprises one or more CDRs or oneor more variable domains of antibody AB40_1 and X is 5.

In one embodiment, the first binding domain binds to CD40 and the secondbinding domain binds to OX40 (CD134), wherein, preferably, the bindingagent comprises

one or more CDRs or one or more variable domains of antibody AB40_1, asdefined above, and one or more CDRs or one or more variable domains ofan antibody AB134_X, wherein X is selected from the group consisting of1 to 92, as shown in Table 8.

In various embodiments, the binding agent comprises one or more CDRs orone or more variable domains of antibody AB40_1 and X is 1; the bindingagent comprises one or more CDRs or one or more variable domains ofantibody AB40_1 and X is 2; the binding agent comprises one or more CDRsor one or more variable domains of antibody AB40_1 and X is 3; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 4; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 5; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 6; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 7; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 8; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 9; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 10; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 11; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 12; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 13; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 14; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 15; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 16; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 17; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 18; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 19; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 20; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 21; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 22; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 23; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 24; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 25; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 26; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 27; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 28; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 29; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 30; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 31; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 32; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 33; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 34; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 35; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 36; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 37; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 38; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 39; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 40; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 41; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 42; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 43; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 44; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 45; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 46; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 47; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 48; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 49; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 50; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 51; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 52; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 53; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 54; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 55; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 56; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 57; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 58; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 59; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 60; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 61; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 62; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 63; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 64; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 65; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 66; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 67; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 68; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 69; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 70; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 71; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 72; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 73; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 74; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 75; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 76; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 77; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 78; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 79; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 80; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 81; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 82; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 83; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 84; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 85; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 86; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 87; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 88; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 89; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 90; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 91; orthe binding agent comprises one or more CDRs or one or more variabledomains of antibody AB40_1 and X is 92.

In one embodiment, the binding agent comprises one or more CDRs or oneor more variable domains of antibody AB40_1 and X is 3. In anotherembodiment, the binding agent comprises one or more CDRs or one or morevariable domains of antibody AB40_1 and X is 81.

In one embodiment, the first binding domain binds to CD40 and the secondbinding domain binds to 4-1BB (CD137), wherein, preferably, the bindingagent comprises

one or more CDRs or one or more variable domains of antibody AB40_1, asdefined above, and one or more CDRs or one or more variable domains ofan antibody AB137_X, wherein X is selected from the group consisting of1 to 12, as shown in Table 9.

In various embodiments, the binding agent comprises one or more CDRs orone or more variable domains of antibody AB40_1 and X is 1; the bindingagent comprises one or more CDRs or one or more variable domains ofantibody AB40_1 and X is 2; the binding agent comprises one or more CDRsor one or more variable domains of antibody AB40_1 and X is 3; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 4; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 5; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 6; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 7; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 8; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 9; thebinding agent comprises one or more CDRs or one or more variable domainsof antibody AB40_1 and X is 10; the binding agent comprises one or moreCDRs or one or more variable domains of antibody AB40_1 and X is 11; orthe binding agent comprises one or more CDRs or one or more variabledomains of antibody AB40_1 and X is 12.

In one embodiment, the binding agent comprises one or more CDRs or oneor more variable domains of antibody AB40_1 and X is 2. In anotherembodiment, the binding agent comprises one or more CDRs or one or morevariable domains of antibody AB40_1 and X is 12.

In one embodiment, the first binding domain binds to 4-1BB (CD137) andthe second binding domain binds to CD27, wherein, preferably, thebinding agent comprises one or more CDRs or one or more variable domainsof an antibody AB137_X, wherein X is selected from the group consistingof 1 to 12, as shown in Table 9, and one or more CDRs or one or morevariable domains of an antibody AB27_Y, wherein Y is selected from thegroup consisting of 1 to 186, as shown in Table 7.

In various embodiments, X is 1 and Y is selected from the groupconsisting of 1 to 186; X is 2 and Y is selected from the groupconsisting of 1 to 186; X is 3 and Y is selected from the groupconsisting of 1 to 186; X is 4 and Y is selected from the groupconsisting of 1 to 186; X is 5 and Y is selected from the groupconsisting of 1 to 186; X is 6 and Y is selected from the groupconsisting of 1 to 186; X is 7 and Y is selected from the groupconsisting of 1 to 186; X is 8 and Y is selected from the groupconsisting of 1 to 186; X is 9 and Y is selected from the groupconsisting of 1 to 186; X is 10 and Y is selected from the groupconsisting of 1 to 186; X is 11 and Y is selected from the groupconsisting of 1 to 186; or X is 12 and Y is selected from the groupconsisting of 1 to 186.

In various embodiments,

X is 1 and Y is 1; X is 1 and Y is 2; X is 1 and Y is 3; X is 1 and Y is4; X is 1 and Y is 5; X is 1 and Y is 6; X is 1 and Y is 7; X is 1 and Yis 8; X is 1 and Y is 9; X is 1 and Y is 10; X is 1 and Y is 11; X is 1and Y is 12; X is 1 and Y is 13; X is 1 and Y is 14; X is 1 and Y is 15;X is 1 and Y is 16; X is 1 and Y is 17; X is 1 and Y is 18; X is 1 and Yis 19; X is 1 and Y is 20; X is 1 and Y is 21; X is 1 and Y is 22; X is1 and Y is 23; X is 1 and Y is 24; X is 1 and Y is 25; X is 1 and Y is26; X is 1 and Y is 27; X is 1 and Y is 28; X is 1 and Y is 29; X is 1and Y is 30; X is 1 and Y is 31; X is 1 and Y is 32; X is 1 and Y is 33;X is 1 and Y is 34; X is 1 and Y is 35; X is 1 and Y is 36; X is 1 and Yis 37; X is 1 and Y is 38; X is 1 and Y is 39; X is 1 and Y is 40; X is1 and Y is 41; X is 1 and Y is 42; X is 1 and Y is 43; X is 1 and Y is44; X is 1 and Y is 45; X is 1 and Y is 46; X is 1 and Y is 47; X is 1and Y is 48; X is 1 and Y is 49; X is 1 and Y is 50; X is 1 and Y is 51;X is 1 and Y is 52; X is 1 and Y is 53; X is 1 and Y is 54; X is 1 and Yis 55; X is 1 and Y is 56; X is 1 and Y is 57; X is 1 and Y is 58; X is1 and Y is 59; X is 1 and Y is 60; X is 1 and Y is 61; X is 1 and Y is62; X is 1 and Y is 63; X is 1 and Y is 64; X is 1 and Y is 65; X is 1and Y is 66; X is 1 and Y is 67; X is 1 and Y is 68; X is 1 and Y is 69;X is 1 and Y is 70; X is 1 and Y is 71; X is 1 and Y is 72; X is 1 and Yis 73; X is 1 and Y is 74; X is 1 and Y is 75; X is 1 and Y is 76; X is1 and Y is 77; X is 1 and Y is 78; X is 1 and Y is 79; X is 1 and Y is80; X is 1 and Y is 81; X is 1 and Y is 82; X is 1 and Y is 83; X is 1and Y is 84; X is 1 and Y is 85; X is 1 and Y is 86; X is 1 and Y is 87;X is 1 and Y is 88; X is 1 and Y is 89; X is 1 and Y is 90; X is 1 and Yis 91; X is 1 and Y is 92; X is 1 and Y is 93; X is 1 and Y is 94; X is1 and Y is 95; X is 1 and Y is 96; X is 1 and Y is 97; X is 1 and Y is98; X is 1 and Y is 99; X is 1 and Y is 100; X is 1 and Y is 101; X is 1and Y is 102; X is 1 and Y is 103; X is 1 and Y is 104; X is 1 and Y is105; X is 1 and Y is 106; X is 1 and Y is 107; X is 1 and Y is 108; X is1 and Y is 109; X is 1 and Y is 110; X is 1 and Y is 111; X is 1 and Yis 112; X is 1 and Y is 113; X is 1 and Y is 114; X is 1 and Y is 115; Xis 1 and Y is 116; X is 1 and Y is 117; X is 1 and Y is 118; X is 1 andY is 119; X is 1 and Y is 120; X is 1 and Y is 121; X is 1 and Y is 122;X is 1 and Y is 123; X is 1 and Y is 124; X is 1 and Y is 125; X is 1and Y is 126; X is 1 and Y is 127; X is 1 and Y is 128; X is 1 and Y is129; X is 1 and Y is 130; X is 1 and Y is 131; X is 1 and Y is 132; X is1 and Y is 133; X is 1 and Y is 134; X is 1 and Y is 135; X is 1 and Yis 136; X is 1 and Y is 137; X is 1 and Y is 138; X is 1 and Y is 139; Xis 1 and Y is 140; X is 1 and Y is 141; X is 1 and Y is 142; X is 1 andY is 143; X is 1 and Y is 144; X is 1 and Y is 145; X is 1 and Y is 146;X is 1 and Y is 147; X is 1 and Y is 148; X is 1 and Y is 149; X is 1and Y is 150; X is 1 and Y is 151; X is 1 and Y is 152; X is 1 and Y is153; X is 1 and Y is 154; X is 1 and Y is 155; X is 1 and Y is 156; X is1 and Y is 157; X is 1 and Y is 158; X is 1 and Y is 159; X is 1 and Yis 160; X is 1 and Y is 161; X is 1 and Y is 162; X is 1 and Y is 163; Xis 1 and Y is 164; X is 1 and Y is 165; X is 1 and Y is 166; X is 1 andY is 167; X is 1 and Y is 168; X is 1 and Y is 169; X is 1 and Y is 170;X is 1 and Y is 171; X is 1 and Y is 172; X is 1 and Y is 173; X is 1and Y is 174; X is 1 and Y is 175; X is 1 and Y is 176; X is 1 and Y is177; X is 1 and Y is 178; X is 1 and Y is 179; X is 1 and Y is 180; X is1 and Y is 181; X is 1 and Y is 182; X is 1 and Y is 183; X is 1 and Yis 184; X is 1 and Y is 185; X is 1 and Y is 186; X is 2 and Y is 1; Xis 2 and Y is 2; X is 2 and Y is 3; X is 2 and Y is 4; X is 2 and Y is5; X is 2 and Y is 6; X is 2 and Y is 7; X is 2 and Y is 8; X is 2 and Yis 9; X is 2 and Y is 10; X is 2 and Y is 11; X is 2 and Y is 12; X is 2and Y is 13; X is 2 and Y is 14; X is 2 and Y is 15; X is 2 and Y is 16;X is 2 and Y is 17; X is 2 and Y is 18; X is 2 and Y is 19; X is 2 and Yis 20; X is 2 and Y is 21; X is 2 and Y is 22; X is 2 and Y is 23; X is2 and Y is 24; X is 2 and Y is 25; X is 2 and Y is 26; X is 2 and Y is27; X is 2 and Y is 28; X is 2 and Y is 29; X is 2 and Y is 30; X is 2and Y is 31; X is 2 and Y is 32; X is 2 and Y is 33; X is 2 and Y is 34;X is 2 and Y is 35; X is 2 and Y is 36; X is 2 and Y is 37; X is 2 and Yis 38; X is 2 and Y is 39; X is 2 and Y is 40; X is 2 and Y is 41; X is2 and Y is 42; X is 2 and Y is 43; X is 2 and Y is 44; X is 2 and Y is45; X is 2 and Y is 46; X is 2 and Y is 47; X is 2 and Y is 48; X is 2and Y is 49; X is 2 and Y is 50; X is 2 and Y is 51; X is 2 and Y is 52;X is 2 and Y is 53; X is 2 and Y is 54; X is 2 and Y is 55; X is 2 and Yis 56; X is 2 and Y is 57; X is 2 and Y is 58; X is 2 and Y is 59; X is2 and Y is 60; X is 2 and Y is 61; X is 2 and Y is 62; X is 2 and Y is63; X is 2 and Y is 64; X is 2 and Y is 65; X is 2 and Y is 66; X is 2and Y is 67; X is 2 and Y is 68; X is 2 and Y is 69; X is 2 and Y is 70;X is 2 and Y is 71; X is 2 and Y is 72; X is 2 and Y is 73; X is 2 and Yis 74; X is 2 and Y is 75; X is 2 and Y is 76; X is 2 and Y is 77; X is2 and Y is 78; X is 2 and Y is 79; X is 2 and Y is 80; X is 2 and Y is81; X is 2 and Y is 82; X is 2 and Y is 83; X is 2 and Y is 84; X is 2and Y is 85; X is 2 and Y is 86; X is 2 and Y is 87; X is 2 and Y is 88;X is 2 and Y is 89; X is 2 and Y is 90; X is 2 and Y is 91; X is 2 and Yis 92; X is 2 and Y is 93; X is 2 and Y is 94; X is 2 and Y is 95; X is2 and Y is 96; X is 2 and Y is 97; X is 2 and Y is 98; X is 2 and Y is99; X is 2 and Y is 100; X is 2 and Y is 101; X is 2 and Y is 102; X is2 and Y is 103; X is 2 and Y is 104; X is 2 and Y is 105; X is 2 and Yis 106; X is 2 and Y is 107; X is 2 and Y is 108; X is 2 and Y is 109; Xis 2 and Y is 110; X is 2 and Y is 111; X is 2 and Y is 112; X is 2 andY is 113; X is 2 and Y is 114; X is 2 and Y is 115; X is 2 and Y is 116;X is 2 and Y is 117; X is 2 and Y is 118; X is 2 and Y is 119; X is 2and Y is 120; X is 2 and Y is 121; X is 2 and Y is 122; X is 2 and Y is123; X is 2 and Y is 124; X is 2 and Y is 125; X is 2 and Y is 126; X is2 and Y is 127; X is 2 and Y is 128; X is 2 and Y is 129; X is 2 and Yis 130; X is 2 and Y is 131; X is 2 and Y is 132; X is 2 and Y is 133; Xis 2 and Y is 134; X is 2 and Y is 135; X is 2 and Y is 136; X is 2 andY is 137; X is 2 and Y is 138; X is 2 and Y is 139; X is 2 and Y is 140;X is 2 and Y is 141; X is 2 and Y is 142; X is 2 and Y is 143; X is 2and Y is 144; X is 2 and Y is 145; X is 2 and Y is 146; X is 2 and Y is147; X is 2 and Y is 148; X is 2 and Y is 149; X is 2 and Y is 150; X is2 and Y is 151; X is 2 and Y is 152; X is 2 and Y is 153; X is 2 and Yis 154; X is 2 and Y is 155; X is 2 and Y is 156; X is 2 and Y is 157; Xis 2 and Y is 158; X is 2 and Y is 159; X is 2 and Y is 160; X is 2 andY is 161; X is 2 and Y is 162; X is 2 and Y is 163; X is 2 and Y is 164;X is 2 and Y is 165; X is 2 and Y is 166; X is 2 and Y is 167; X is 2and Y is 168; X is 2 and Y is 169; X is 2 and Y is 170; X is 2 and Y is171; X is 2 and Y is 172; X is 2 and Y is 173; X is 2 and Y is 174; X is2 and Y is 175; X is 2 and Y is 176; X is 2 and Y is 177; X is 2 and Yis 178; X is 2 and Y is 179; X is 2 and Y is 180; X is 2 and Y is 181; Xis 2 and Y is 182; X is 2 and Y is 183; X is 2 and Y is 184; X is 2 andY is 185; X is 2 and Y is 186; X is 3 and Y is 1; X is 3 and Y is 2; Xis 3 and Y is 3; X is 3 and Y is 4; X is 3 and Y is 5; X is 3 and Y is6; X is 3 and Y is 7; X is 3 and Y is 8; X is 3 and Y is 9; X is 3 and Yis 10; X is 3 and Y is 11; X is 3 and Y is 12; X is 3 and Y is 13; X is3 and Y is 14; X is 3 and Y is 15; X is 3 and Y is 16; X is 3 and Y is17; X is 3 and Y is 18; X is 3 and Y is 19; X is 3 and Y is 20; X is 3and Y is 21; X is 3 and Y is 22; X is 3 and Y is 23; X is 3 and Y is 24;X is 3 and Y is 25; X is 3 and Y is 26; X is 3 and Y is 27; X is 3 and Yis 28; X is 3 and Y is 29; X is 3 and Y is 30; X is 3 and Y is 31; X is3 and Y is 32; X is 3 and Y is 33; X is 3 and Y is 34; X is 3 and Y is35; X is 3 and Y is 36; X is 3 and Y is 37; X is 3 and Y is 38; X is 3and Y is 39; X is 3 and Y is 40; X is 3 and Y is 41; X is 3 and Y is 42;X is 3 and Y is 43; X is 3 and Y is 44; X is 3 and Y is 45; X is 3 and Yis 46; X is 3 and Y is 47; X is 3 and Y is 48; X is 3 and Y is 49; X is3 and Y is 50; X is 3 and Y is 51; X is 3 and Y is 52; X is 3 and Y is53; X is 3 and Y is 54; X is 3 and Y is 55; X is 3 and Y is 56; X is 3and Y is 57; X is 3 and Y is 58; X is 3 and Y is 59; X is 3 and Y is 60;X is 3 and Y is 61; X is 3 and Y is 62; X is 3 and Y is 63; X is 3 and Yis 64; X is 3 and Y is 65; X is 3 and Y is 66; X is 3 and Y is 67; X is3 and Y is 68; X is 3 and Y is 69; X is 3 and Y is 70; X is 3 and Y is71; X is 3 and Y is 72; X is 3 and Y is 73; X is 3 and Y is 74; X is 3and Y is 75; X is 3 and Y is 76; X is 3 and Y is 77; X is 3 and Y is 78;X is 3 and Y is 79; X is 3 and Y is 80; X is 3 and Y is 81; X is 3 and Yis 82; X is 3 and Y is 83; X is 3 and Y is 84; X is 3 and Y is 85; X is3 and Y is 86; X is 3 and Y is 87; X is 3 and Y is 88; X is 3 and Y is89; X is 3 and Y is 90; X is 3 and Y is 91; X is 3 and Y is 92; X is 3and Y is 93; X is 3 and Y is 94; X is 3 and Y is 95; X is 3 and Y is 96;X is 3 and Y is 97; X is 3 and Y is 98; X is 3 and Y is 99; X is 3 and Yis 100; X is 3 and Y is 101; X is 3 and Y is 102; X is 3 and Y is 103; Xis 3 and Y is 104; X is 3 and Y is 105; X is 3 and Y is 106; X is 3 andY is 107; X is 3 and Y is 108; X is 3 and Y is 109; X is 3 and Y is 110;X is 3 and Y is 111; X is 3 and Y is 112; X is 3 and Y is 113; X is 3and Y is 114; X is 3 and Y is 115; X is 3 and Y is 116; X is 3 and Y is117; X is 3 and Y is 118; X is 3 and Y is 119; X is 3 and Y is 120; X is3 and Y is 121; X is 3 and Y is 122; X is 3 and Y is 123; X is 3 and Yis 124; X is 3 and Y is 125; X is 3 and Y is 126; X is 3 and Y is 127; Xis 3 and Y is 128; X is 3 and Y is 129; X is 3 and Y is 130; X is 3 andY is 131; X is 3 and Y is 132; X is 3 and Y is 133; X is 3 and Y is 134;X is 3 and Y is 135; X is 3 and Y is 136; X is 3 and Y is 137; X is 3and Y is 138; X is 3 and Y is 139; X is 3 and Y is 140; X is 3 and Y is141; X is 3 and Y is 142; X is 3 and Y is 143; X is 3 and Y is 144; X is3 and Y is 145; X is 3 and Y is 146; X is 3 and Y is 147; X is 3 and Yis 148; X is 3 and Y is 149; X is 3 and Y is 150; X is 3 and Y is 151; Xis 3 and Y is 152; X is 3 and Y is 153; X is 3 and Y is 154; X is 3 andY is 155; X is 3 and Y is 156; X is 3 and Y is 157; X is 3 and Y is 158;X is 3 and Y is 159; X is 3 and Y is 160; X is 3 and Y is 161; X is 3and Y is 162; X is 3 and Y is 163; X is 3 and Y is 164; X is 3 and Y is165; X is 3 and Y is 166; X is 3 and Y is 167; X is 3 and Y is 168; X is3 and Y is 169; X is 3 and Y is 170; X is 3 and Y is 171; X is 3 and Yis 172; X is 3 and Y is 173; X is 3 and Y is 174; X is 3 and Y is 175; Xis 3 and Y is 176; X is 3 and Y is 177; X is 3 and Y is 178; X is 3 andY is 179; X is 3 and Y is 180; X is 3 and Y is 181; X is 3 and Y is 182;X is 3 and Y is 183; X is 3 and Y is 184; X is 3 and Y is 185; X is 3and Y is 186; X is 4 and Y is 1; X is 4 and Y is 2; X is 4 and Y is 3; Xis 4 and Y is 4; X is 4 and Y is 5; X is 4 and Y is 6; X is 4 and Y is7; X is 4 and Y is 8; X is 4 and Y is 9; X is 4 and Y is 10; X is 4 andY is 11; X is 4 and Y is 12; X is 4 and Y is 13; X is 4 and Y is 14; Xis 4 and Y is 15; X is 4 and Y is 16; X is 4 and Y is 17; X is 4 and Yis 18; X is 4 and Y is 19; X is 4 and Y is 20; X is 4 and Y is 21; X is4 and Y is 22; X is 4 and Y is 23; X is 4 and Y is 24; X is 4 and Y is25; X is 4 and Y is 26; X is 4 and Y is 27; X is 4 and Y is 28; X is 4and Y is 29; X is 4 and Y is 30; X is 4 and Y is 31; X is 4 and Y is 32;X is 4 and Y is 33; X is 4 and Y is 34; X is 4 and Y is 35; X is 4 and Yis 36; X is 4 and Y is 37; X is 4 and Y is 38; X is 4 and Y is 39; X is4 and Y is 40; X is 4 and Y is 41; X is 4 and Y is 42; X is 4 and Y is43; X is 4 and Y is 44; X is 4 and Y is 45; X is 4 and Y is 46; X is 4and Y is 47; X is 4 and Y is 48; X is 4 and Y is 49; X is 4 and Y is 50;X is 4 and Y is 51; X is 4 and Y is 52; X is 4 and Y is 53; X is 4 and Yis 54; X is 4 and Y is 55; X is 4 and Y is 56; X is 4 and Y is 57; X is4 and Y is 58; X is 4 and Y is 59; X is 4 and Y is 60; X is 4 and Y is61; X is 4 and Y is 62; X is 4 and Y is 63; X is 4 and Y is 64; X is 4and Y is 65; X is 4 and Y is 66; X is 4 and Y is 67; X is 4 and Y is 68;X is 4 and Y is 69; X is 4 and Y is 70; X is 4 and Y is 71; X is 4 and Yis 72; X is 4 and Y is 73; X is 4 and Y is 74; X is 4 and Y is 75; X is4 and Y is 76; X is 4 and Y is 77; X is 4 and Y is 78; X is 4 and Y is79; X is 4 and Y is 80; X is 4 and Y is 81; X is 4 and Y is 82; X is 4and Y is 83; X is 4 and Y is 84; X is 4 and Y is 85; X is 4 and Y is 86;X is 4 and Y is 87; X is 4 and Y is 88; X is 4 and Y is 89; X is 4 and Yis 90; X is 4 and Y is 91; X is 4 and Y is 92; X is 4 and Y is 93; X is4 and Y is 94; X is 4 and Y is 95; X is 4 and Y is 96; X is 4 and Y is97; X is 4 and Y is 98; X is 4 and Y is 99; X is 4 and Y is 100; X is 4and Y is 101; X is 4 and Y is 102; X is 4 and Y is 103; X is 4 and Y is104; X is 4 and Y is 105; X is 4 and Y is 106; X is 4 and Y is 107; X is4 and Y is 108; X is 4 and Y is 109; X is 4 and Y is 110; X is 4 and Yis 111; X is 4 and Y is 112; X is 4 and Y is 113; X is 4 and Y is 114; Xis 4 and Y is 115; X is 4 and Y is 116; X is 4 and Y is 117; X is 4 andY is 118; X is 4 and Y is 119; X is 4 and Y is 120; X is 4 and Y is 121;X is 4 and Y is 122; X is 4 and Y is 123; X is 4 and Y is 124; X is 4and Y is 125; X is 4 and Y is 126; X is 4 and Y is 127; X is 4 and Y is128; X is 4 and Y is 129; X is 4 and Y is 130; X is 4 and Y is 131; X is4 and Y is 132; X is 4 and Y is 133; X is 4 and Y is 134; X is 4 and Yis 135; X is 4 and Y is 136; X is 4 and Y is 137; X is 4 and Y is 138; Xis 4 and Y is 139; X is 4 and Y is 140; X is 4 and Y is 141; X is 4 andY is 142; X is 4 and Y is 143; X is 4 and Y is 144; X is 4 and Y is 145;X is 4 and Y is 146; X is 4 and Y is 147; X is 4 and Y is 148; X is 4and Y is 149; X is 4 and Y is 150; X is 4 and Y is 151; X is 4 and Y is152; X is 4 and Y is 153; X is 4 and Y is 154; X is 4 and Y is 155; X is4 and Y is 156; X is 4 and Y is 157; X is 4 and Y is 158; X is 4 and Yis 159; X is 4 and Y is 160; X is 4 and Y is 161; X is 4 and Y is 162; Xis 4 and Y is 163; X is 4 and Y is 164; X is 4 and Y is 165; X is 4 andY is 166; X is 4 and Y is 167; X is 4 and Y is 168; X is 4 and Y is 169;X is 4 and Y is 170; X is 4 and Y is 171; X is 4 and Y is 172; X is 4and Y is 173; X is 4 and Y is 174; X is 4 and Y is 175; X is 4 and Y is176; X is 4 and Y is 177; X is 4 and Y is 178; X is 4 and Y is 179; X is4 and Y is 180; X is 4 and Y is 181; X is 4 and Y is 182; X is 4 and Yis 183; X is 4 and Y is 184; X is 4 and Y is 185; X is 4 and Y is 186; Xis 5 and Y is 1; X is 5 and Y is 2; X is 5 and Y is 3; X is 5 and Y is4; X is 5 and Y is 5; X is 5 and Y is 6; X is 5 and Y is 7; X is 5 and Yis 8; X is 5 and Y is 9; X is 5 and Y is 10; X is 5 and Y is 11; X is 5and Y is 12; X is 5 and Y is 13; X is 5 and Y is 14; X is 5 and Y is 15;X is 5 and Y is 16; X is 5 and Y is 17; X is 5 and Y is 18; X is 5 and Yis 19; X is 5 and Y is 20; X is 5 and Y is 21; X is 5 and Y is 22; X is5 and Y is 23; X is 5 and Y is 24; X is 5 and Y is 25; X is 5 and Y is26; X is 5 and Y is 27; X is 5 and Y is 28; X is 5 and Y is 29; X is 5and Y is 30; X is 5 and Y is 31; X is 5 and Y is 32; X is 5 and Y is 33;X is 5 and Y is 34; X is 5 and Y is 35; X is 5 and Y is 36; X is 5 and Yis 37; X is 5 and Y is 38; X is 5 and Y is 39; X is 5 and Y is 40; X is5 and Y is 41; X is 5 and Y is 42; X is 5 and Y is 43; X is 5 and Y is44; X is 5 and Y is 45; X is 5 and Y is 46; X is 5 and Y is 47; X is 5and Y is 48; X is 5 and Y is 49; X is 5 and Y is 50; X is 5 and Y is 51;X is 5 and Y is 52; X is 5 and Y is 53; X is 5 and Y is 54; X is 5 and Yis 55; X is 5 and Y is 56; X is 5 and Y is 57; X is 5 and Y is 58; X is5 and Y is 59; X is 5 and Y is 60; X is 5 and Y is 61; X is 5 and Y is62; X is 5 and Y is 63; X is 5 and Y is 64; X is 5 and Y is 65; X is 5and Y is 66; X is 5 and Y is 67; X is 5 and Y is 68; X is 5 and Y is 69;X is 5 and Y is 70; X is 5 and Y is 71; X is 5 and Y is 72; X is 5 and Yis 73; X is 5 and Y is 74; X is 5 and Y is 75; X is 5 and Y is 76; X is5 and Y is 77; X is 5 and Y is 78; X is 5 and Y is 79; X is 5 and Y is80; X is 5 and Y is 81; X is 5 and Y is 82; X is 5 and Y is 83; X is 5and Y is 84; X is 5 and Y is 85; X is 5 and Y is 86; X is 5 and Y is 87;X is 5 and Y is 88; X is 5 and Y is 89; X is 5 and Y is 90; X is 5 and Yis 91; X is 5 and Y is 92; X is 5 and Y is 93; X is 5 and Y is 94; X is5 and Y is 95; X is 5 and Y is 96; X is 5 and Y is 97; X is 5 and Y is98; X is 5 and Y is 99; X is 5 and Y is 100; X is 5 and Y is 101; X is 5and Y is 102; X is 5 and Y is 103; X is 5 and Y is 104; X is 5 and Y is105; X is 5 and Y is 106; X is 5 and Y is 107; X is 5 and Y is 108; X is5 and Y is 109; X is 5 and Y is 110; X is 5 and Y is 111; X is 5 and Yis 112; X is 5 and Y is 113; X is 5 and Y is 114; X is 5 and Y is 115; Xis 5 and Y is 116; X is 5 and Y is 117; X is 5 and Y is 118; X is 5 andY is 119; X is 5 and Y is 120; X is 5 and Y is 121; X is 5 and Y is 122;X is 5 and Y is 123; X is 5 and Y is 124; X is 5 and Y is 125; X is 5and Y is 126; X is 5 and Y is 127; X is 5 and Y is 128; X is 5 and Y is129; X is 5 and Y is 130; X is 5 and Y is 131; X is 5 and Y is 132; X is5 and Y is 133; X is 5 and Y is 134; X is 5 and Y is 135; X is 5 and Yis 136; X is 5 and Y is 137; X is 5 and Y is 138; X is 5 and Y is 139; Xis 5 and Y is 140; X is 5 and Y is 141; X is 5 and Y is 142; X is 5 andY is 143; X is 5 and Y is 144; X is 5 and Y is 145; X is 5 and Y is 146;X is 5 and Y is 147; X is 5 and Y is 148; X is 5 and Y is 149; X is 5and Y is 150; X is 5 and Y is 151; X is 5 and Y is 152; X is 5 and Y is153; X is 5 and Y is 154; X is 5 and Y is 155; X is 5 and Y is 156; X is5 and Y is 157; X is 5 and Y is 158; X is 5 and Y is 159; X is 5 and Yis 160; X is 5 and Y is 161; X is 5 and Y is 162; X is 5 and Y is 163; Xis 5 and Y is 164; X is 5 and Y is 165; X is 5 and Y is 166; X is 5 andY is 167; X is 5 and Y is 168; X is 5 and Y is 169; X is 5 and Y is 170;X is 5 and Y is 171; X is 5 and Y is 172; X is 5 and Y is 173; X is 5and Y is 174; X is 5 and Y is 175; X is 5 and Y is 176; X is 5 and Y is177; X is 5 and Y is 178; X is 5 and Y is 179; X is 5 and Y is 180; X is5 and Y is 181; X is 5 and Y is 182; X is 5 and Y is 183; X is 5 and Yis 184; X is 5 and Y is 185; X is 5 and Y is 186; X is 6 and Y is 1; Xis 6 and Y is 2; X is 6 and Y is 3; X is 6 and Y is 4; X is 6 and Y is5; X is 6 and Y is 6; X is 6 and Y is 7; X is 6 and Y is 8; X is 6 and Yis 9; X is 6 and Y is 10; X is 6 and Y is 11; X is 6 and Y is 12; X is 6and Y is 13; X is 6 and Y is 14; X is 6 and Y is 15; X is 6 and Y is 16;X is 6 and Y is 17; X is 6 and Y is 18; X is 6 and Y is 19; X is 6 and Yis 20; X is 6 and Y is 21; X is 6 and Y is 22; X is 6 and Y is 23; X is6 and Y is 24; X is 6 and Y is 25; X is 6 and Y is 26; X is 6 and Y is27; X is 6 and Y is 28; X is 6 and Y is 29; X is 6 and Y is 30; X is 6and Y is 31; X is 6 and Y is 32; X is 6 and Y is 33; X is 6 and Y is 34;X is 6 and Y is 35; X is 6 and Y is 36; X is 6 and Y is 37; X is 6 and Yis 38; X is 6 and Y is 39; X is 6 and Y is 40; X is 6 and Y is 41; X is6 and Y is 42; X is 6 and Y is 43; X is 6 and Y is 44; X is 6 and Y is45; X is 6 and Y is 46; X is 6 and Y is 47; X is 6 and Y is 48; X is 6and Y is 49; X is 6 and Y is 50; X is 6 and Y is 51; X is 6 and Y is 52;X is 6 and Y is 53; X is 6 and Y is 54; X is 6 and Y is 55; X is 6 and Yis 56; X is 6 and Y is 57; X is 6 and Y is 58; X is 6 and Y is 59; X is6 and Y is 60; X is 6 and Y is 61; X is 6 and Y is 62; X is 6 and Y is63; X is 6 and Y is 64; X is 6 and Y is 65; X is 6 and Y is 66; X is 6and Y is 67; X is 6 and Y is 68; X is 6 and Y is 69; X is 6 and Y is 70;X is 6 and Y is 71; X is 6 and Y is 72; X is 6 and Y is 73; X is 6 and Yis 74; X is 6 and Y is 75; X is 6 and Y is 76; X is 6 and Y is 77; X is6 and Y is 78; X is 6 and Y is 79; X is 6 and Y is 80; X is 6 and Y is81; X is 6 and Y is 82; X is 6 and Y is 83; X is 6 and Y is 84; X is 6and Y is 85; X is 6 and Y is 86; X is 6 and Y is 87; X is 6 and Y is 88;X is 6 and Y is 89; X is 6 and Y is 90; X is 6 and Y is 91; X is 6 and Yis 92; X is 6 and Y is 93; X is 6 and Y is 94; X is 6 and Y is 95; X is6 and Y is 96; X is 6 and Y is 97; X is 6 and Y is 98; X is 6 and Y is99; X is 6 and Y is 100; X is 6 and Y is 101; X is 6 and Y is 102; X is6 and Y is 103; X is 6 and Y is 104; X is 6 and Y is 105; X is 6 and Yis 106; X is 6 and Y is 107; X is 6 and Y is 108; X is 6 and Y is 109; Xis 6 and Y is 110; X is 6 and Y is 111; X is 6 and Y is 112; X is 6 andY is 113; X is 6 and Y is 114; X is 6 and Y is 115; X is 6 and Y is 116;X is 6 and Y is 117; X is 6 and Y is 118; X is 6 and Y is 119; X is 6and Y is 120; X is 6 and Y is 121; X is 6 and Y is 122; X is 6 and Y is123; X is 6 and Y is 124; X is 6 and Y is 125; X is 6 and Y is 126; X is6 and Y is 127; X is 6 and Y is 128; X is 6 and Y is 129; X is 6 and Yis 130; X is 6 and Y is 131; X is 6 and Y is 132; X is 6 and Y is 133; Xis 6 and Y is 134; X is 6 and Y is 135; X is 6 and Y is 136; X is 6 andY is 137; X is 6 and Y is 138; X is 6 and Y is 139; X is 6 and Y is 140;X is 6 and Y is 141; X is 6 and Y is 142; X is 6 and Y is 143; X is 6and Y is 144; X is 6 and Y is 145; X is 6 and Y is 146; X is 6 and Y is147; X is 6 and Y is 148; X is 6 and Y is 149; X is 6 and Y is 150; X is6 and Y is 151; X is 6 and Y is 152; X is 6 and Y is 153; X is 6 and Yis 154; X is 6 and Y is 155; X is 6 and Y is 156; X is 6 and Y is 157; Xis 6 and Y is 158; X is 6 and Y is 159; X is 6 and Y is 160; X is 6 andY is 161; X is 6 and Y is 162; X is 6 and Y is 163; X is 6 and Y is 164;X is 6 and Y is 165; X is 6 and Y is 166; X is 6 and Y is 167; X is 6and Y is 168; X is 6 and Y is 169; X is 6 and Y is 170; X is 6 and Y is171; X is 6 and Y is 172; X is 6 and Y is 173; X is 6 and Y is 174; X is6 and Y is 175; X is 6 and Y is 176; X is 6 and Y is 177; X is 6 and Yis 178; X is 6 and Y is 179; X is 6 and Y is 180; X is 6 and Y is 181; Xis 6 and Y is 182; X is 6 and Y is 183; X is 6 and Y is 184; X is 6 andY is 185; X is 6 and Y is 186; X is 7 and Y is 1; X is 7 and Y is 2; Xis 7 and Y is 3; X is 7 and Y is 4; X is 7 and Y is 5; X is 7 and Y is6; X is 7 and Y is 7; X is 7 and Y is 8; X is 7 and Y is 9; X is 7 and Yis 10; X is 7 and Y is 11; X is 7 and Y is 12; X is 7 and Y is 13; X is7 and Y is 14; X is 7 and Y is 15; X is 7 and Y is 16; X is 7 and Y is17; X is 7 and Y is 18; X is 7 and Y is 19; X is 7 and Y is 20; X is 7and Y is 21; X is 7 and Y is 22; X is 7 and Y is 23; X is 7 and Y is 24;X is 7 and Y is 25; X is 7 and Y is 26; X is 7 and Y is 27; X is 7 and Yis 28; X is 7 and Y is 29; X is 7 and Y is 30; X is 7 and Y is 31; X is7 and Y is 32; X is 7 and Y is 33; X is 7 and Y is 34; X is 7 and Y is35; X is 7 and Y is 36; X is 7 and Y is 37; X is 7 and Y is 38; X is 7and Y is 39; X is 7 and Y is 40; X is 7 and Y is 41; X is 7 and Y is 42;X is 7 and Y is 43; X is 7 and Y is 44; X is 7 and Y is 45; X is 7 and Yis 46; X is 7 and Y is 47; X is 7 and Y is 48; X is 7 and Y is 49; X is7 and Y is 50; X is 7 and Y is 51; X is 7 and Y is 52; X is 7 and Y is53; X is 7 and Y is 54; X is 7 and Y is 55; X is 7 and Y is 56; X is 7and Y is 57; X is 7 and Y is 58; X is 7 and Y is 59; X is 7 and Y is 60;X is 7 and Y is 61; X is 7 and Y is 62; X is 7 and Y is 63; X is 7 and Yis 64; X is 7 and Y is 65; X is 7 and Y is 66; X is 7 and Y is 67; X is7 and Y is 68; X is 7 and Y is 69; X is 7 and Y is 70; X is 7 and Y is71; X is 7 and Y is 72; X is 7 and Y is 73; X is 7 and Y is 74; X is 7and Y is 75; X is 7 and Y is 76; X is 7 and Y is 77; X is 7 and Y is 78;X is 7 and Y is 79; X is 7 and Y is 80; X is 7 and Y is 81; X is 7 and Yis 82; X is 7 and Y is 83; X is 7 and Y is 84; X is 7 and Y is 85; X is7 and Y is 86; X is 7 and Y is 87; X is 7 and Y is 88; X is 7 and Y is89; X is 7 and Y is 90; X is 7 and Y is 91; X is 7 and Y is 92; X is 7and Y is 93; X is 7 and Y is 94; X is 7 and Y is 95; X is 7 and Y is 96;X is 7 and Y is 97; X is 7 and Y is 98; X is 7 and Y is 99; X is 7 and Yis 100; X is 7 and Y is 101; X is 7 and Y is 102; X is 7 and Y is 103; Xis 7 and Y is 104; X is 7 and Y is 105; X is 7 and Y is 106; X is 7 andY is 107; X is 7 and Y is 108; X is 7 and Y is 109; X is 7 and Y is 110;X is 7 and Y is 111; X is 7 and Y is 112; X is 7 and Y is 113; X is 7and Y is 114; X is 7 and Y is 115; X is 7 and Y is 116; X is 7 and Y is117; X is 7 and Y is 118; X is 7 and Y is 119; X is 7 and Y is 120; X is7 and Y is 121; X is 7 and Y is 122; X is 7 and Y is 123; X is 7 and Yis 124; X is 7 and Y is 125; X is 7 and Y is 126; X is 7 and Y is 127; Xis 7 and Y is 128; X is 7 and Y is 129; X is 7 and Y is 130; X is 7 andY is 131; X is 7 and Y is 132; X is 7 and Y is 133; X is 7 and Y is 134;X is 7 and Y is 135; X is 7 and Y is 136; X is 7 and Y is 137; X is 7and Y is 138; X is 7 and Y is 139; X is 7 and Y is 140; X is 7 and Y is141; X is 7 and Y is 142; X is 7 and Y is 143; X is 7 and Y is 144; X is7 and Y is 145; X is 7 and Y is 146; X is 7 and Y is 147; X is 7 and Yis 148; X is 7 and Y is 149; X is 7 and Y is 150; X is 7 and Y is 151; Xis 7 and Y is 152; X is 7 and Y is 153; X is 7 and Y is 154; X is 7 andY is 155; X is 7 and Y is 156; X is 7 and Y is 157; X is 7 and Y is 158;X is 7 and Y is 159; X is 7 and Y is 160; X is 7 and Y is 161; X is 7and Y is 162; X is 7 and Y is 163; X is 7 and Y is 164; X is 7 and Y is165; X is 7 and Y is 166; X is 7 and Y is 167; X is 7 and Y is 168; X is7 and Y is 169; X is 7 and Y is 170; X is 7 and Y is 171; X is 7 and Yis 172; X is 7 and Y is 173; X is 7 and Y is 174; X is 7 and Y is 175; Xis 7 and Y is 176; X is 7 and Y is 177; X is 7 and Y is 178; X is 7 andY is 179; X is 7 and Y is 180; X is 7 and Y is 181; X is 7 and Y is 182;X is 7 and Y is 183; X is 7 and Y is 184; X is 7 and Y is 185; X is 7and Y is 186; X is 8 and Y is 1; X is 8 and Y is 2; X is 8 and Y is 3; Xis 8 and Y is 4; X is 8 and Y is 5; X is 8 and Y is 6; X is 8 and Y is7; X is 8 and Y is 8; X is 8 and Y is 9; X is 8 and Y is 10; X is 8 andY is 11; X is 8 and Y is 12; X is 8 and Y is 13; X is 8 and Y is 14; Xis 8 and Y is 15; X is 8 and Y is 16; X is 8 and Y is 17; X is 8 and Yis 18; X is 8 and Y is 19; X is 8 and Y is 20; X is 8 and Y is 21; X is8 and Y is 22; X is 8 and Y is 23; X is 8 and Y is 24; X is 8 and Y is25; X is 8 and Y is 26; X is 8 and Y is 27; X is 8 and Y is 28; X is 8and Y is 29; X is 8 and Y is 30; X is 8 and Y is 31; X is 8 and Y is 32;X is 8 and Y is 33; X is 8 and Y is 34; X is 8 and Y is 35; X is 8 and Yis 36; X is 8 and Y is 37; X is 8 and Y is 38; X is 8 and Y is 39; X is8 and Y is 40; X is 8 and Y is 41; X is 8 and Y is 42; X is 8 and Y is43; X is 8 and Y is 44; X is 8 and Y is 45; X is 8 and Y is 46; X is 8and Y is 47; X is 8 and Y is 48; X is 8 and Y is 49; X is 8 and Y is 50;X is 8 and Y is 51; X is 8 and Y is 52; X is 8 and Y is 53; X is 8 and Yis 54; X is 8 and Y is 55; X is 8 and Y is 56; X is 8 and Y is 57; X is8 and Y is 58; X is 8 and Y is 59; X is 8 and Y is 60; X is 8 and Y is61; X is 8 and Y is 62; X is 8 and Y is 63; X is 8 and Y is 64; X is 8and Y is 65; X is 8 and Y is 66; X is 8 and Y is 67; X is 8 and Y is 68;X is 8 and Y is 69; X is 8 and Y is 70; X is 8 and Y is 71; X is 8 and Yis 72; X is 8 and Y is 73; X is 8 and Y is 74; X is 8 and Y is 75; X is8 and Y is 76; X is 8 and Y is 77; X is 8 and Y is 78; X is 8 and Y is79; X is 8 and Y is 80; X is 8 and Y is 81; X is 8 and Y is 82; X is 8and Y is 83; X is 8 and Y is 84; X is 8 and Y is 85; X is 8 and Y is 86;X is 8 and Y is 87; X is 8 and Y is 88; X is 8 and Y is 89; X is 8 and Yis 90; X is 8 and Y is 91; X is 8 and Y is 92; X is 8 and Y is 93; X is8 and Y is 94; X is 8 and Y is 95; X is 8 and Y is 96; X is 8 and Y is97; X is 8 and Y is 98; X is 8 and Y is 99; X is 8 and Y is 100; X is 8and Y is 101; X is 8 and Y is 102; X is 8 and Y is 103; X is 8 and Y is104; X is 8 and Y is 105; X is 8 and Y is 106; X is 8 and Y is 107; X is8 and Y is 108; X is 8 and Y is 109; X is 8 and Y is 110; X is 8 and Yis 111; X is 8 and Y is 112; X is 8 and Y is 113; X is 8 and Y is 114; Xis 8 and Y is 115; X is 8 and Y is 116; X is 8 and Y is 117; X is 8 andY is 118; X is 8 and Y is 119; X is 8 and Y is 120; X is 8 and Y is 121;X is 8 and Y is 122; X is 8 and Y is 123; X is 8 and Y is 124; X is 8and Y is 125; X is 8 and Y is 126; X is 8 and Y is 127; X is 8 and Y is128; X is 8 and Y is 129; X is 8 and Y is 130; X is 8 and Y is 131; X is8 and Y is 132; X is 8 and Y is 133; X is 8 and Y is 134; X is 8 and Yis 135; X is 8 and Y is 136; X is 8 and Y is 137; X is 8 and Y is 138; Xis 8 and Y is 139; X is 8 and Y is 140; X is 8 and Y is 141; X is 8 andY is 142; X is 8 and Y is 143; X is 8 and Y is 144; X is 8 and Y is 145;X is 8 and Y is 146; X is 8 and Y is 147; X is 8 and Y is 148; X is 8and Y is 149; X is 8 and Y is 150; X is 8 and Y is 151; X is 8 and Y is152; X is 8 and Y is 153; X is 8 and Y is 154; X is 8 and Y is 155; X is8 and Y is 156; X is 8 and Y is 157; X is 8 and Y is 158; X is 8 and Yis 159; X is 8 and Y is 160; X is 8 and Y is 161; X is 8 and Y is 162; Xis 8 and Y is 163; X is 8 and Y is 164; X is 8 and Y is 165; X is 8 andY is 166; X is 8 and Y is 167; X is 8 and Y is 168; X is 8 and Y is 169;X is 8 and Y is 170; X is 8 and Y is 171; X is 8 and Y is 172; X is 8and Y is 173; X is 8 and Y is 174; X is 8 and Y is 175; X is 8 and Y is176; X is 8 and Y is 177; X is 8 and Y is 178; X is 8 and Y is 179; X is8 and Y is 180; X is 8 and Y is 181; X is 8 and Y is 182; X is 8 and Yis 183; X is 8 and Y is 184; X is 8 and Y is 185; X is 8 and Y is 186; Xis 9 and Y is 1; X is 9 and Y is 2; X is 9 and Y is 3; X is 9 and Y is4; X is 9 and Y is 5; X is 9 and Y is 6; X is 9 and Y is 7; X is 9 and Yis 8; X is 9 and Y is 9; X is 9 and Y is 10; X is 9 and Y is 11; X is 9and Y is 12; X is 9 and Y is 13; X is 9 and Y is 14; X is 9 and Y is 15;X is 9 and Y is 16; X is 9 and Y is 17; X is 9 and Y is 18; X is 9 and Yis 19; X is 9 and Y is 20; X is 9 and Y is 21; X is 9 and Y is 22; X is9 and Y is 23; X is 9 and Y is 24; X is 9 and Y is 25; X is 9 and Y is26; X is 9 and Y is 27; X is 9 and Y is 28; X is 9 and Y is 29; X is 9and Y is 30; X is 9 and Y is 31; X is 9 and Y is 32; X is 9 and Y is 33;X is 9 and Y is 34; X is 9 and Y is 35; X is 9 and Y is 36; X is 9 and Yis 37; X is 9 and Y is 38; X is 9 and Y is 39; X is 9 and Y is 40; X is9 and Y is 41; X is 9 and Y is 42; X is 9 and Y is 43; X is 9 and Y is44; X is 9 and Y is 45; X is 9 and Y is 46; X is 9 and Y is 47; X is 9and Y is 48; X is 9 and Y is 49; X is 9 and Y is 50; X is 9 and Y is 51;X is 9 and Y is 52; X is 9 and Y is 53; X is 9 and Y is 54; X is 9 and Yis 55; X is 9 and Y is 56; X is 9 and Y is 57; X is 9 and Y is 58; X is9 and Y is 59; X is 9 and Y is 60; X is 9 and Y is 61; X is 9 and Y is62; X is 9 and Y is 63; X is 9 and Y is 64; X is 9 and Y is 65; X is 9and Y is 66; X is 9 and Y is 67; X is 9 and Y is 68; X is 9 and Y is 69;X is 9 and Y is 70; X is 9 and Y is 71; X is 9 and Y is 72; X is 9 and Yis 73; X is 9 and Y is 74; X is 9 and Y is 75; X is 9 and Y is 76; X is9 and Y is 77; X is 9 and Y is 78; X is 9 and Y is 79; X is 9 and Y is80; X is 9 and Y is 81; X is 9 and Y is 82; X is 9 and Y is 83; X is 9and Y is 84; X is 9 and Y is 85; X is 9 and Y is 86; X is 9 and Y is 87;X is 9 and Y is 88; X is 9 and Y is 89; X is 9 and Y is 90; X is 9 and Yis 91; X is 9 and Y is 92; X is 9 and Y is 93; X is 9 and Y is 94; X is9 and Y is 95; X is 9 and Y is 96; X is 9 and Y is 97; X is 9 and Y is98; X is 9 and Y is 99; X is 9 and Y is 100; X is 9 and Y is 101; X is 9and Y is 102; X is 9 and Y is 103; X is 9 and Y is 104; X is 9 and Y is105; X is 9 and Y is 106; X is 9 and Y is 107; X is 9 and Y is 108; X is9 and Y is 109; X is 9 and Y is 110; X is 9 and Y is 111; X is 9 and Yis 112; X is 9 and Y is 113; X is 9 and Y is 114; X is 9 and Y is 115; Xis 9 and Y is 116; X is 9 and Y is 117; X is 9 and Y is 118; X is 9 andY is 119; X is 9 and Y is 120; X is 9 and Y is 121; X is 9 and Y is 122;X is 9 and Y is 123; X is 9 and Y is 124; X is 9 and Y is 125; X is 9and Y is 126; X is 9 and Y is 127; X is 9 and Y is 128; X is 9 and Y is129; X is 9 and Y is 130; X is 9 and Y is 131; X is 9 and Y is 132; X is9 and Y is 133; X is 9 and Y is 134; X is 9 and Y is 135; X is 9 and Yis 136; X is 9 and Y is 137; X is 9 and Y is 138; X is 9 and Y is 139; Xis 9 and Y is 140; X is 9 and Y is 141; X is 9 and Y is 142; X is 9 andY is 143; X is 9 and Y is 144; X is 9 and Y is 145; X is 9 and Y is 146;X is 9 and Y is 147; X is 9 and Y is 148; X is 9 and Y is 149; X is 9and Y is 150; X is 9 and Y is 151; X is 9 and Y is 152; X is 9 and Y is153; X is 9 and Y is 154; X is 9 and Y is 155; X is 9 and Y is 156; X is9 and Y is 157; X is 9 and Y is 158; X is 9 and Y is 159; X is 9 and Yis 160; X is 9 and Y is 161; X is 9 and Y is 162; X is 9 and Y is 163; Xis 9 and Y is 164; X is 9 and Y is 165; X is 9 and Y is 166; X is 9 andY is 167; X is 9 and Y is 168; X is 9 and Y is 169; X is 9 and Y is 170;X is 9 and Y is 171; X is 9 and Y is 172; X is 9 and Y is 173; X is 9and Y is 174; X is 9 and Y is 175; X is 9 and Y is 176; X is 9 and Y is177; X is 9 and Y is 178; X is 9 and Y is 179; X is 9 and Y is 180; X is9 and Y is 181; X is 9 and Y is 182; X is 9 and Y is 183; X is 9 and Yis 184; X is 9 and Y is 185; X is 9 and Y is 186; X is 10 and Y is 1; Xis 10 and Y is 2; X is 10 and Y is 3; X is 10 and Y is 4; X is 10 and Yis 5; X is 10 and Y is 6; X is 10 and Y is 7; X is 10 and Y is 8; X is10 and Y is 9; X is 10 and Y is 10; X is 10 and Y is 11; X is 10 and Yis 12; X is 10 and Y is 13; X is 10 and Y is 14; X is 10 and Y is 15; Xis 10 and Y is 16; X is 10 and Y is 17; X is 10 and Y is 18; X is 10 andY is 19; X is 10 and Y is 20; X is 10 and Y is 21; X is 10 and Y is 22;X is 10 and Y is 23; X is 10 and Y is 24; X is 10 and Y is 25; X is 10and Y is 26; X is 10 and Y is 27; X is 10 and Y is 28; X is 10 and Y is29; X is 10 and Y is 30; X is 10 and Y is 31; X is 10 and Y is 32; X is10 and Y is 33; X is 10 and Y is 34; X is 10 and Y is 35; X is 10 and Yis 36; X is 10 and Y is 37; X is 10 and Y is 38; X is 10 and Y is 39; Xis 10 and Y is 40; X is 10 and Y is 41; X is 10 and Y is 42; X is 10 andY is 43; X is 10 and Y is 44; X is 10 and Y is 45; X is 10 and Y is 46;X is 10 and Y is 47; X is 10 and Y is 48; X is 10 and Y is 49; X is 10and Y is 50; X is 10 and Y is 51; X is 10 and Y is 52; X is 10 and Y is53; X is 10 and Y is 54; X is 10 and Y is 55; X is 10 and Y is 56; X is10 and Y is 57; X is 10 and Y is 58; X is 10 and Y is 59; X is 10 and Yis 60; X is 10 and Y is 61; X is 10 and Y is 62; X is 10 and Y is 63; Xis 10 and Y is 64; X is 10 and Y is 65; X is 10 and Y is 66; X is 10 andY is 67; X is 10 and Y is 68; X is 10 and Y is 69; X is 10 and Y is 70;X is 10 and Y is 71; X is 10 and Y is 72; X is 10 and Y is 73; X is 10and Y is 74; X is 10 and Y is 75; X is 10 and Y is 76; X is 10 and Y is77; X is 10 and Y is 78; X is 10 and Y is 79; X is 10 and Y is 80; X is10 and Y is 81; X is 10 and Y is 82; X is 10 and Y is 83; X is 10 and Yis 84; X is 10 and Y is 85; X is 10 and Y is 86; X is 10 and Y is 87; Xis 10 and Y is 88; X is 10 and Y is 89; X is 10 and Y is 90; X is 10 andY is 91; X is 10 and Y is 92; X is 10 and Y is 93; X is 10 and Y is 94;X is 10 and Y is 95; X is 10 and Y is 96; X is 10 and Y is 97; X is 10and Y is 98; X is 10 and Y is 99; X is 10 and Y is 100; X is 10 and Y is101; X is 10 and Y is 102; X is 10 and Y is 103; X is 10 and Y is 104; Xis 10 and Y is 105; X is 10 and Y is 106; X is 10 and Y is 107; X is 10and Y is 108; X is 10 and Y is 109; X is 10 and Y is 110; X is 10 and Yis 111; X is 10 and Y is 112; X is 10 and Y is 113; X is 10 and Y is114; X is 10 and Y is 115; X is 10 and Y is 116; X is 10 and Y is 117; Xis 10 and Y is 118; X is 10 and Y is 119; X is 10 and Y is 120; X is 10and Y is 121; X is 10 and Y is 122; X is 10 and Y is 123; X is 10 and Yis 124; X is 10 and Y is 125; X is 10 and Y is 126; X is 10 and Y is127; X is 10 and Y is 128; X is 10 and Y is 129; X is 10 and Y is 130; Xis 10 and Y is 131; X is 10 and Y is 132; X is 10 and Y is 133; X is 10and Y is 134; X is 10 and Y is 135; X is 10 and Y is 136; X is 10 and Yis 137; X is 10 and Y is 138; X is 10 and Y is 139; X is 10 and Y is140; X is 10 and Y is 141; X is 10 and Y is 142; X is 10 and Y is 143; Xis 10 and Y is 144; X is 10 and Y is 145; X is 10 and Y is 146; X is 10and Y is 147; X is 10 and Y is 148; X is 10 and Y is 149; X is 10 and Yis 150; X is 10 and Y is 151; X is 10 and Y is 152; X is 10 and Y is153; X is 10 and Y is 154; X is 10 and Y is 155; X is 10 and Y is 156; Xis 10 and Y is 157; X is 10 and Y is 158; X is 10 and Y is 159; X is 10and Y is 160; X is 10 and Y is 161; X is 10 and Y is 162; X is 10 and Yis 163; X is 10 and Y is 164; X is 10 and Y is 165; X is 10 and Y is166; X is 10 and Y is 167; X is 10 and Y is 168; X is 10 and Y is 169; Xis 10 and Y is 170; X is 10 and Y is 171; X is 10 and Y is 172; X is 10and Y is 173; X is 10 and Y is 174; X is 10 and Y is 175; X is 10 and Yis 176; X is 10 and Y is 177; X is 10 and Y is 178; X is 10 and Y is179; X is 10 and Y is 180; X is 10 and Y is 181; X is 10 and Y is 182; Xis 10 and Y is 183; X is 10 and Y is 184; X is 10 and Y is 185; X is 10and Y is 186;X is 11 and Y is 1; X is 11 and Y is 2; X is 11 and Y is 3; X is 11 andY is 4; X is 11 and Y is 5; X is 11 and Y is 6; X is 11 and Y is 7; X is11 and Y is 8; X is 11 and Y is 9; X is 11 and Y is 10; X is 11 and Y is11; X is 11 and Y is 12; X is 11 and Y is 13; X is 11 and Y is 14; X is11 and Y is 15; X is 11 and Y is 16; X is 11 and Y is 17; X is 11 and Yis 18; X is 11 and Y is 19; X is 11 and Y is 20; X is 11 and Y is 21; Xis 11 and Y is 22; X is 11 and Y is 23; X is 11 and Y is 24; X is 11 andY is 25; X is 11 and Y is 26; X is 11 and Y is 27; X is 11 and Y is 28;X is 11 and Y is 29; X is 11 and Y is 30; X is 11 and Y is 31; X is 11and Y is 32; X is 11 and Y is 33; X is 11 and Y is 34; X is 11 and Y is35; X is 11 and Y is 36; X is 11 and Y is 37; X is 11 and Y is 38; X is11 and Y is 39; X is 11 and Y is 40; X is 11 and Y is 41; X is 11 and Yis 42; X is 11 and Y is 43; X is 11 and Y is 44; X is 11 and Y is 45; Xis 11 and Y is 46; X is 11 and Y is 47; X is 11 and Y is 48; X is 11 andY is 49; X is 11 and Y is 50; X is 11 and Y is 51; X is 11 and Y is 52;X is 11 and Y is 53; X is 11 and Y is 54; X is 11 and Y is 55; X is 11and Y is 56; X is 11 and Y is 57; X is 11 and Y is 58; X is 11 and Y is59; X is 11 and Y is 60; X is 11 and Y is 61; X is 11 and Y is 62; X is11 and Y is 63; X is 11 and Y is 64; X is 11 and Y is 65; X is 11 and Yis 66; X is 11 and Y is 67; X is 11 and Y is 68; X is 11 and Y is 69; Xis 11 and Y is 70; X is 11 and Y is 71; X is 11 and Y is 72; X is 11 andY is 73; X is 11 and Y is 74; X is 11 and Y is 75; X is 11 and Y is 76;X is 11 and Y is 77; X is 11 and Y is 78; X is 11 and Y is 79; X is 11and Y is 80; X is 11 and Y is 81; X is 11 and Y is 82; X is 11 and Y is83; X is 11 and Y is 84; X is 11 and Y is 85; X is 11 and Y is 86; X is11 and Y is 87; X is 11 and Y is 88; X is 11 and Y is 89; X is 11 and Yis 90; X is 11 and Y is 91; X is 11 and Y is 92; X is 11 and Y is 93; Xis 11 and Y is 94; X is 11 and Y is 95; X is 11 and Y is 96; X is 11 andY is 97; X is 11 and Y is 98; X is 11 and Y is 99; X is 11 and Y is 100;X is 11 and Y is 101; X is 11 and Y is 102; X is 11 and Y is 103; X is11 and Y is 104; X is 11 and Y is 105; X is 11 and Y is 106; X is 11 andY is 107; X is 11 and Y is 108; X is 11 and Y is 109; X is 11 and Y is110; X is 11 and Y is 111; X is 11 and Y is 112; X is 11 and Y is 113; Xis 11 and Y is 114; X is 11 and Y is 115; X is 11 and Y is 116; X is 11and Y is 117; X is 11 and Y is 118; X is 11 and Y is 119; X is 11 and Yis 120; X is 11 and Y is 121; X is 11 and Y is 122; X is 11 and Y is123; X is 11 and Y is 124; X is 11 and Y is 125; X is 11 and Y is 126; Xis 11 and Y is 127; X is 11 and Y is 128; X is 11 and Y is 129; X is 11and Y is 130; X is 11 and Y is 131; X is 11 and Y is 132; X is 11 and Yis 133; X is 11 and Y is 134; X is 11 and Y is 135; X is 11 and Y is136; X is 11 and Y is 137; X is 11 and Y is 138; X is 11 and Y is 139; Xis 11 and Y is 140; X is 11 and Y is 141; X is 11 and Y is 142; X is 11and Y is 143; X is 11 and Y is 144; X is 11 and Y is 145; X is 11 and Yis 146; X is 11 and Y is 147; X is 11 and Y is 148; X is 11 and Y is149; X is 11 and Y is 150; X is 11 and Y is 151; X is 11 and Y is 152; Xis 11 and Y is 153; X is 11 and Y is 154; X is 11 and Y is 155; X is 11and Y is 156; X is 11 and Y is 157; X is 11 and Y is 158; X is 11 and Yis 159; X is 11 and Y is 160; X is 11 and Y is 161; X is 11 and Y is162; X is 11 and Y is 163; X is 11 and Y is 164; X is 11 and Y is 165; Xis 11 and Y is 166; X is 11 and Y is 167; X is 11 and Y is 168; X is 11and Y is 169; X is 11 and Y is 170; X is 11 and Y is 171; X is 11 and Yis 172; X is 11 and Y is 173; X is 11 and Y is 174; X is 11 and Y is175; X is 11 and Y is 176; X is 11 and Y is 177; X is 11 and Y is 178; Xis 11 and Y is 179; X is 11 and Y is 180; X is 11 and Y is 181; X is 11and Y is 182; X is 11 and Y is 183; X is 11 and Y is 184; X is 11 and Yis 185; X is 11 and Y is 186;X is 12 and Y is 1; X is 12 and Y is 2; X is 12 and Y is 3; X is 12 andY is 4; X is 12 and Y is 5; X is 12 and Y is 6; X is 12 and Y is 7; X is12 and Y is 8; X is 12 and Y is 9; X is 12 and Y is 10; X is 12 and Y is11; X is 12 and Y is 12; X is 12 and Y is 13; X is 12 and Y is 14; X is12 and Y is 15; X is 12 and Y is 16; X is 12 and Y is 17; X is 12 and Yis 18; X is 12 and Y is 19; X is 12 and Y is 20; X is 12 and Y is 21; Xis 12 and Y is 22; X is 12 and Y is 23; X is 12 and Y is 24; X is 12 andY is 25; X is 12 and Y is 26; X is 12 and Y is 27; X is 12 and Y is 28;X is 12 and Y is 29; X is 12 and Y is 30; X is 12 and Y is 31; X is 12and Y is 32; X is 12 and Y is 33; X is 12 and Y is 34; X is 12 and Y is35; X is 12 and Y is 36; X is 12 and Y is 37; X is 12 and Y is 38; X is12 and Y is 39; X is 12 and Y is 40; X is 12 and Y is 41; X is 12 and Yis 42; X is 12 and Y is 43; X is 12 and Y is 44; X is 12 and Y is 45; Xis 12 and Y is 46; X is 12 and Y is 47; X is 12 and Y is 48; X is 12 andY is 49; X is 12 and Y is 50; X is 12 and Y is 51; X is 12 and Y is 52;X is 12 and Y is 53; X is 12 and Y is 54; X is 12 and Y is 55; X is 12and Y is 56; X is 12 and Y is 57; X is 12 and Y is 58; X is 12 and Y is59; X is 12 and Y is 60; X is 12 and Y is 61; X is 12 and Y is 62; X is12 and Y is 63; X is 12 and Y is 64; X is 12 and Y is 65; X is 12 and Yis 66; X is 12 and Y is 67; X is 12 and Y is 68; X is 12 and Y is 69; Xis 12 and Y is 70; X is 12 and Y is 71; X is 12 and Y is 72; X is 12 andY is 73; X is 12 and Y is 74; X is 12 and Y is 75; X is 12 and Y is 76;X is 12 and Y is 77; X is 12 and Y is 78; X is 12 and Y is 79; X is 12and Y is 80; X is 12 and Y is 81; X is 12 and Y is 82; X is 12 and Y is83; X is 12 and Y is 84; X is 12 and Y is 85; X is 12 and Y is 86; X is12 and Y is 87; X is 12 and Y is 88; X is 12 and Y is 89; X is 12 and Yis 90; X is 12 and Y is 91; X is 12 and Y is 92; X is 12 and Y is 93; Xis 12 and Y is 94; X is 12 and Y is 95; X is 12 and Y is 96; X is 12 andY is 97; X is 12 and Y is 98; X is 12 and Y is 99; X is 12 and Y is 100;X is 12 and Y is 101; X is 12 and Y is 102; X is 12 and Y is 103; X is12 and Y is 104; X is 12 and Y is 105; X is 12 and Y is 106; X is 12 andY is 107; X is 12 and Y is 108; X is 12 and Y is 109; X is 12 and Y is110; X is 12 and Y is 111; X is 12 and Y is 112; X is 12 and Y is 113; Xis 12 and Y is 114; X is 12 and Y is 115; X is 12 and Y is 116; X is 12and Y is 117; X is 12 and Y is 118; X is 12 and Y is 119; X is 12 and Yis 120; X is 12 and Y is 121; X is 12 and Y is 122; X is 12 and Y is123; X is 12 and Y is 124; X is 12 and Y is 125; X is 12 and Y is 126; Xis 12 and Y is 127; X is 12 and Y is 128; X is 12 and Y is 129; X is 12and Y is 130; X is 12 and Y is 131; X is 12 and Y is 132; X is 12 and Yis 133; X is 12 and Y is 134; X is 12 and Y is 135; X is 12 and Y is136; X is 12 and Y is 137; X is 12 and Y is 138; X is 12 and Y is 139; Xis 12 and Y is 140; X is 12 and Y is 141; X is 12 and Y is 142; X is 12and Y is 143; X is 12 and Y is 144; X is 12 and Y is 145; X is 12 and Yis 146; X is 12 and Y is 147; X is 12 and Y is 148; X is 12 and Y is149; X is 12 and Y is 150; X is 12 and Y is 151; X is 12 and Y is 152; Xis 12 and Y is 153; X is 12 and Y is 154; X is 12 and Y is 155; X is 12and Y is 156; X is 12 and Y is 157; X is 12 and Y is 158; X is 12 and Yis 159; X is 12 and Y is 160; X is 12 and Y is 161; X is 12 and Y is162; X is 12 and Y is 163; X is 12 and Y is 164; X is 12 and Y is 165; Xis 12 and Y is 166; X is 12 and Y is 167; X is 12 and Y is 168; X is 12and Y is 169; X is 12 and Y is 170; X is 12 and Y is 171; X is 12 and Yis 172; X is 12 and Y is 173; X is 12 and Y is 174; X is 12 and Y is175; X is 12 and Y is 176; X is 12 and Y is 177; X is 12 and Y is 178; Xis 12 and Y is 179; X is 12 and Y is 180; X is 12 and Y is 181; X is 12and Y is 182; X is 12 and Y is 183; X is 12 and Y is 184; X is 12 and Yis 185; or X is 12 and Y is 186.

In one embodiment, X is 2 and Y is 5. In another embodiment, X is 10 andY is 164.

In one embodiment, the first binding domain binds to 4-1BB (CD137) andthe second binding domain binds to OX40 (CD134), wherein, preferably,the binding agent comprises one or more CDRs or one or more variabledomains of an antibody AB137_X, wherein X is selected from the groupconsisting of 1 to 12, as shown in Table 9, and one or more CDRs or oneor more variable domains of an antibody AB134_Y, wherein Y is selectedfrom the group consisting of 1 to 92, as shown in Table 8.

In various embodiments, X is 1 and Y is selected from the groupconsisting of 1 to 92; X is 2 and Y is selected from the groupconsisting of 1 to 92; X is 3 and Y is selected from the groupconsisting of 1 to 92; X is 4 and Y is selected from the groupconsisting of 1 to 92; X is 5 and Y is selected from the groupconsisting of 1 to 92; X is 6 and Y is selected from the groupconsisting of 1 to 92; X is 7 and Y is selected from the groupconsisting of 1 to 92; X is 8 and Y is selected from the groupconsisting of 1 to 92; X is 9 and Y is selected from the groupconsisting of 1 to 92; X is 10 and Y is selected from the groupconsisting of 1 to 92; X is 11 and Y is selected from the groupconsisting of 1 to 92; or X is 12 and Y is selected from the groupconsisting of 1 to 92.

In various embodiments,

X is 1 and Y is 1; X is 1 and Y is 2; X is 1 and Y is 3; X is 1 and Y is4; X is 1 and Y is 5; X is 1 and Y is 6; X is 1 and Y is 7; X is 1 and Yis 8; X is 1 and Y is 9; X is 1 and Y is 10; X is 1 and Y is 11; X is 1and Y is 12; X is 1 and Y is 13; X is 1 and Y is 14; X is 1 and Y is 15;X is 1 and Y is 16; X is 1 and Y is 17; X is 1 and Y is 18; X is 1 and Yis 19; X is 1 and Y is 20; X is 1 and Y is 21; X is 1 and Y is 22; X is1 and Y is 23; X is 1 and Y is 24; X is 1 and Y is 25; X is 1 and Y is26; X is 1 and Y is 27; X is 1 and Y is 28; X is 1 and Y is 29; X is 1and Y is 30; X is 1 and Y is 31; X is 1 and Y is 32; X is 1 and Y is 33;X is 1 and Y is 34; X is 1 and Y is 35; X is 1 and Y is 36; X is 1 and Yis 37; X is 1 and Y is 38; X is 1 and Y is 39; X is 1 and Y is 40; X is1 and Y is 41; X is 1 and Y is 42; X is 1 and Y is 43; X is 1 and Y is44; X is 1 and Y is 45; X is 1 and Y is 46; X is 1 and Y is 47; X is 1and Y is 48; X is 1 and Y is 49; X is 1 and Y is 50; X is 1 and Y is 51;X is 1 and Y is 52; X is 1 and Y is 53; X is 1 and Y is 54; X is 1 and Yis 55; X is 1 and Y is 56; X is 1 and Y is 57; X is 1 and Y is 58; X is1 and Y is 59; X is 1 and Y is 60; X is 1 and Y is 61; X is 1 and Y is62; X is 1 and Y is 63; X is 1 and Y is 64; X is 1 and Y is 65; X is 1and Y is 66; X is 1 and Y is 67; X is 1 and Y is 68; X is 1 and Y is 69;X is 1 and Y is 70; X is 1 and Y is 71; X is 1 and Y is 72; X is 1 and Yis 73; X is 1 and Y is 74; X is 1 and Y is 75; X is 1 and Y is 76; X is1 and Y is 77; X is 1 and Y is 78; X is 1 and Y is 79; X is 1 and Y is80; X is 1 and Y is 81; X is 1 and Y is 82; X is 1 and Y is 83; X is 1and Y is 84; X is 1 and Y is 85; X is 1 and Y is 86; X is 1 and Y is 87;X is 1 and Y is 88; X is 1 and Y is 89; X is 1 and Y is 90; X is 1 and Yis 91; X is 1 and Y is 92;X is 2 and Y is 1; X is 2 and Y is 2; X is 2 and Y is 3; X is 2 and Y is4; X is 2 and Y is 5; X is 2 and Y is 6; X is 2 and Y is 7; X is 2 and Yis 8; X is 2 and Y is 9; X is 2 and Y is 10; X is 2 and Y is 11; X is 2and Y is 12; X is 2 and Y is 13; X is 2 and Y is 14; X is 2 and Y is 15;X is 2 and Y is 16; X is 2 and Y is 17; X is 2 and Y is 18; X is 2 and Yis 19; X is 2 and Y is 20; X is 2 and Y is 21; X is 2 and Y is 22; X is2 and Y is 23; X is 2 and Y is 24; X is 2 and Y is 25; X is 2 and Y is26; X is 2 and Y is 27; X is 2 and Y is 28; X is 2 and Y is 29; X is 2and Y is 30; X is 2 and Y is 31; X is 2 and Y is 32; X is 2 and Y is 33;X is 2 and Y is 34; X is 2 and Y is 35; X is 2 and Y is 36; X is 2 and Yis 37; X is 2 and Y is 38; X is 2 and Y is 39; X is 2 and Y is 40; X is2 and Y is 41; X is 2 and Y is 42; X is 2 and Y is 43; X is 2 and Y is44; X is 2 and Y is 45; X is 2 and Y is 46; X is 2 and Y is 47; X is 2and Y is 48; X is 2 and Y is 49; X is 2 and Y is 50; X is 2 and Y is 51;X is 2 and Y is 52; X is 2 and Y is 53; X is 2 and Y is 54; X is 2 and Yis 55; X is 2 and Y is 56; X is 2 and Y is 57; X is 2 and Y is 58; X is2 and Y is 59; X is 2 and Y is 60; X is 2 and Y is 61; X is 2 and Y is62; X is 2 and Y is 63; X is 2 and Y is 64; X is 2 and Y is 65; X is 2and Y is 66; X is 2 and Y is 67; X is 2 and Y is 68; X is 2 and Y is 69;X is 2 and Y is 70; X is 2 and Y is 71; X is 2 and Y is 72; X is 2 and Yis 73; X is 2 and Y is 74; X is 2 and Y is 75; X is 2 and Y is 76; X is2 and Y is 77; X is 2 and Y is 78; X is 2 and Y is 79; X is 2 and Y is80; X is 2 and Y is 81; X is 2 and Y is 82; X is 2 and Y is 83; X is 2and Y is 84; X is 2 and Y is 85; X is 2 and Y is 86; X is 2 and Y is 87;X is 2 and Y is 88; X is 2 and Y is 89; X is 2 and Y is 90; X is 2 and Yis 91; X is 2 and Y is 92;X is 3 and Y is 1; X is 3 and Y is 2; X is 3 and Y is 3; X is 3 and Y is4; X is 3 and Y is 5; X is 3 and Y is 6; X is 3 and Y is 7; X is 3 and Yis 8; X is 3 and Y is 9; X is 3 and Y is 10; X is 3 and Y is 11; X is 3and Y is 12; X is 3 and Y is 13; X is 3 and Y is 14; X is 3 and Y is 15;X is 3 and Y is 16; X is 3 and Y is 17; X is 3 and Y is 18; X is 3 and Yis 19; X is 3 and Y is 20; X is 3 and Y is 21; X is 3 and Y is 22; X is3 and Y is 23; X is 3 and Y is 24; X is 3 and Y is 25; X is 3 and Y is26; X is 3 and Y is 27; X is 3 and Y is 28; X is 3 and Y is 29; X is 3and Y is 30; X is 3 and Y is 31; X is 3 and Y is 32; X is 3 and Y is 33;X is 3 and Y is 34; X is 3 and Y is 35; X is 3 and Y is 36; X is 3 and Yis 37; X is 3 and Y is 38; X is 3 and Y is 39; X is 3 and Y is 40; X is3 and Y is 41; X is 3 and Y is 42; X is 3 and Y is 43; X is 3 and Y is44; X is 3 and Y is 45; X is 3 and Y is 46; X is 3 and Y is 47; X is 3and Y is 48; X is 3 and Y is 49; X is 3 and Y is 50; X is 3 and Y is 51;X is 3 and Y is 52; X is 3 and Y is 53; X is 3 and Y is 54; X is 3 and Yis 55; X is 3 and Y is 56; X is 3 and Y is 57; X is 3 and Y is 58; X is3 and Y is 59; X is 3 and Y is 60; X is 3 and Y is 61; X is 3 and Y is62; X is 3 and Y is 63; X is 3 and Y is 64; X is 3 and Y is 65; X is 3and Y is 66; X is 3 and Y is 67; X is 3 and Y is 68; X is 3 and Y is 69;X is 3 and Y is 70; X is 3 and Y is 71; X is 3 and Y is 72; X is 3 and Yis 73; X is 3 and Y is 74; X is 3 and Y is 75; X is 3 and Y is 76; X is3 and Y is 77; X is 3 and Y is 78; X is 3 and Y is 79; X is 3 and Y is80; X is 3 and Y is 81; X is 3 and Y is 82; X is 3 and Y is 83; X is 3and Y is 84; X is 3 and Y is 85; X is 3 and Y is 86; X is 3 and Y is 87;X is 3 and Y is 88; X is 3 and Y is 89; X is 3 and Y is 90; X is 3 and Yis 91; X is 3 and Y is 92;X is 4 and Y is 1; X is 4 and Y is 2; X is 4 and Y is 3; X is 4 and Y is4; X is 4 and Y is 5; X is 4 and Y is 6; X is 4 and Y is 7; X is 4 and Yis 8; X is 4 and Y is 9; X is 4 and Y is 10; X is 4 and Y is 11; X is 4and Y is 12; X is 4 and Y is 13; X is 4 and Y is 14; X is 4 and Y is 15;X is 4 and Y is 16; X is 4 and Y is 17; X is 4 and Y is 18; X is 4 and Yis 19; X is 4 and Y is 20; X is 4 and Y is 21; X is 4 and Y is 22; X is4 and Y is 23; X is 4 and Y is 24; X is 4 and Y is 25; X is 4 and Y is26; X is 4 and Y is 27; X is 4 and Y is 28; X is 4 and Y is 29; X is 4and Y is 30; X is 4 and Y is 31; X is 4 and Y is 32; X is 4 and Y is 33;X is 4 and Y is 34; X is 4 and Y is 35; X is 4 and Y is 36; X is 4 and Yis 37; X is 4 and Y is 38; X is 4 and Y is 39; X is 4 and Y is 40; X is4 and Y is 41; X is 4 and Y is 42; X is 4 and Y is 43; X is 4 and Y is44; X is 4 and Y is 45; X is 4 and Y is 46; X is 4 and Y is 47; X is 4and Y is 48; X is 4 and Y is 49; X is 4 and Y is 50; X is 4 and Y is 51;X is 4 and Y is 52; X is 4 and Y is 53; X is 4 and Y is 54; X is 4 and Yis 55; X is 4 and Y is 56; X is 4 and Y is 57; X is 4 and Y is 58; X is4 and Y is 59; X is 4 and Y is 60; X is 4 and Y is 61; X is 4 and Y is62; X is 4 and Y is 63; X is 4 and Y is 64; X is 4 and Y is 65; X is 4and Y is 66; X is 4 and Y is 67; X is 4 and Y is 68; X is 4 and Y is 69;X is 4 and Y is 70; X is 4 and Y is 71; X is 4 and Y is 72; X is 4 and Yis 73; X is 4 and Y is 74; X is 4 and Y is 75; X is 4 and Y is 76; X is4 and Y is 77; X is 4 and Y is 78; X is 4 and Y is 79; X is 4 and Y is80; X is 4 and Y is 81; X is 4 and Y is 82; X is 4 and Y is 83; X is 4and Y is 84; X is 4 and Y is 85; X is 4 and Y is 86; X is 4 and Y is 87;X is 4 and Y is 88; X is 4 and Y is 89; X is 4 and Y is 90; X is 4 and Yis 91; X is 4 and Y is 92;X is 5 and Y is 1; X is 5 and Y is 2; X is 5 and Y is 3; X is 5 and Y is4; X is 5 and Y is 5; X is 5 and Y is 6; X is 5 and Y is 7; X is 5 and Yis 8; X is 5 and Y is 9; X is 5 and Y is 10; X is 5 and Y is 11; X is 5and Y is 12; X is 5 and Y is 13; X is 5 and Y is 14; X is 5 and Y is 15;X is 5 and Y is 16; X is 5 and Y is 17; X is 5 and Y is 18; X is 5 and Yis 19; X is 5 and Y is 20; X is 5 and Y is 21; X is 5 and Y is 22; X is5 and Y is 23; X is 5 and Y is 24; X is 5 and Y is 25; X is 5 and Y is26; X is 5 and Y is 27; X is 5 and Y is 28; X is 5 and Y is 29; X is 5and Y is 30; X is 5 and Y is 31; X is 5 and Y is 32; X is 5 and Y is 33;X is 5 and Y is 34; X is 5 and Y is 35; X is 5 and Y is 36; X is 5 and Yis 37; X is 5 and Y is 38; X is 5 and Y is 39; X is 5 and Y is 40; X is5 and Y is 41; X is 5 and Y is 42; X is 5 and Y is 43; X is 5 and Y is44; X is 5 and Y is 45; X is 5 and Y is 46; X is 5 and Y is 47; X is 5and Y is 48; X is 5 and Y is 49; X is 5 and Y is 50; X is 5 and Y is 51;X is 5 and Y is 52; X is 5 and Y is 53; X is 5 and Y is 54; X is 5 and Yis 55; X is 5 and Y is 56; X is 5 and Y is 57; X is 5 and Y is 58; X is5 and Y is 59; X is 5 and Y is 60; X is 5 and Y is 61; X is 5 and Y is62; X is 5 and Y is 63; X is 5 and Y is 64; X is 5 and Y is 65; X is 5and Y is 66; X is 5 and Y is 67; X is 5 and Y is 68; X is 5 and Y is 69;X is 5 and Y is 70; X is 5 and Y is 71; X is 5 and Y is 72; X is 5 and Yis 73; X is 5 and Y is 74; X is 5 and Y is 75; X is 5 and Y is 76; X is5 and Y is 77; X is 5 and Y is 78; X is 5 and Y is 79; X is 5 and Y is80; X is 5 and Y is 81; X is 5 and Y is 82; X is 5 and Y is 83; X is 5and Y is 84; X is 5 and Y is 85; X is 5 and Y is 86; X is 5 and Y is 87;X is 5 and Y is 88; X is 5 and Y is 89; X is 5 and Y is 90; X is 5 and Yis 91; X is 5 and Y is 92;X is 6 and Y is 1; X is 6 and Y is 2; X is 6 and Y is 3; X is 6 and Y is4; X is 6 and Y is 5; X is 6 and Y is 6; X is 6 and Y is 7; X is 6 and Yis 8; X is 6 and Y is 9; X is 6 and Y is 10; X is 6 and Y is 11; X is 6and Y is 12; X is 6 and Y is 13; X is 6 and Y is 14; X is 6 and Y is 15;X is 6 and Y is 16; X is 6 and Y is 17; X is 6 and Y is 18; X is 6 and Yis 19; X is 6 and Y is 20; X is 6 and Y is 21; X is 6 and Y is 22; X is6 and Y is 23; X is 6 and Y is 24; X is 6 and Y is 25; X is 6 and Y is26; X is 6 and Y is 27; X is 6 and Y is 28; X is 6 and Y is 29; X is 6and Y is 30; X is 6 and Y is 31; X is 6 and Y is 32; X is 6 and Y is 33;X is 6 and Y is 34; X is 6 and Y is 35; X is 6 and Y is 36; X is 6 and Yis 37; X is 6 and Y is 38; X is 6 and Y is 39; X is 6 and Y is 40; X is6 and Y is 41; X is 6 and Y is 42; X is 6 and Y is 43; X is 6 and Y is44; X is 6 and Y is 45; X is 6 and Y is 46; X is 6 and Y is 47; X is 6and Y is 48; X is 6 and Y is 49; X is 6 and Y is 50; X is 6 and Y is 51;X is 6 and Y is 52; X is 6 and Y is 53; X is 6 and Y is 54; X is 6 and Yis 55; X is 6 and Y is 56; X is 6 and Y is 57; X is 6 and Y is 58; X is6 and Y is 59; X is 6 and Y is 60; X is 6 and Y is 61; X is 6 and Y is62; X is 6 and Y is 63; X is 6 and Y is 64; X is 6 and Y is 65; X is 6and Y is 66; X is 6 and Y is 67; X is 6 and Y is 68; X is 6 and Y is 69;X is 6 and Y is 70; X is 6 and Y is 71; X is 6 and Y is 72; X is 6 and Yis 73; X is 6 and Y is 74; X is 6 and Y is 75; X is 6 and Y is 76; X is6 and Y is 77; X is 6 and Y is 78; X is 6 and Y is 79; X is 6 and Y is80; X is 6 and Y is 81; X is 6 and Y is 82; X is 6 and Y is 83; X is 6and Y is 84; X is 6 and Y is 85; X is 6 and Y is 86; X is 6 and Y is 87;X is 6 and Y is 88; X is 6 and Y is 89; X is 6 and Y is 90; X is 6 and Yis 91; X is 6 and Y is 92;X is 7 and Y is 1; X is 7 and Y is 2; X is 7 and Y is 3; X is 7 and Y is4; X is 7 and Y is 5; X is 7 and Y is 6; X is 7 and Y is 7; X is 7 and Yis 8; X is 7 and Y is 9; X is 7 and Y is 10; X is 7 and Y is 11; X is 7and Y is 12; X is 7 and Y is 13; X is 7 and Y is 14; X is 7 and Y is 15;X is 7 and Y is 16; X is 7 and Y is 17; X is 7 and Y is 18; X is 7 and Yis 19; X is 7 and Y is 20; X is 7 and Y is 21; X is 7 and Y is 22; X is7 and Y is 23; X is 7 and Y is 24; X is 7 and Y is 25; X is 7 and Y is26; X is 7 and Y is 27; X is 7 and Y is 28; X is 7 and Y is 29; X is 7and Y is 30; X is 7 and Y is 31; X is 7 and Y is 32; X is 7 and Y is 33;X is 7 and Y is 34; X is 7 and Y is 35; X is 7 and Y is 36; X is 7 and Yis 37; X is 7 and Y is 38; X is 7 and Y is 39; X is 7 and Y is 40; X is7 and Y is 41; X is 7 and Y is 42; X is 7 and Y is 43; X is 7 and Y is44; X is 7 and Y is 45; X is 7 and Y is 46; X is 7 and Y is 47; X is 7and Y is 48; X is 7 and Y is 49; X is 7 and Y is 50; X is 7 and Y is 51;X is 7 and Y is 52; X is 7 and Y is 53; X is 7 and Y is 54; X is 7 and Yis 55; X is 7 and Y is 56; X is 7 and Y is 57; X is 7 and Y is 58; X is7 and Y is 59; X is 7 and Y is 60; X is 7 and Y is 61; X is 7 and Y is62; X is 7 and Y is 63; X is 7 and Y is 64; X is 7 and Y is 65; X is 7and Y is 66; X is 7 and Y is 67; X is 7 and Y is 68; X is 7 and Y is 69;X is 7 and Y is 70; X is 7 and Y is 71; X is 7 and Y is 72; X is 7 and Yis 73; X is 7 and Y is 74; X is 7 and Y is 75; X is 7 and Y is 76; X is7 and Y is 77; X is 7 and Y is 78; X is 7 and Y is 79; X is 7 and Y is80; X is 7 and Y is 81; X is 7 and Y is 82; X is 7 and Y is 83; X is 7and Y is 84; X is 7 and Y is 85; X is 7 and Y is 86; X is 7 and Y is 87;X is 7 and Y is 88; X is 7 and Y is 89; X is 7 and Y is 90; X is 7 and Yis 91; X is 7 and Y is 92;X is 8 and Y is 1; X is 8 and Y is 2; X is 8 and Y is 3; X is 8 and Y is4; X is 8 and Y is 5; X is 8 and Y is 6; X is 8 and Y is 7; X is 8 and Yis 8; X is 8 and Y is 9; X is 8 and Y is 10; X is 8 and Y is 11; X is 8and Y is 12; X is 8 and Y is 13; X is 8 and Y is 14; X is 8 and Y is 15;X is 8 and Y is 16; X is 8 and Y is 17; X is 8 and Y is 18; X is 8 and Yis 19; X is 8 and Y is 20; X is 8 and Y is 21; X is 8 and Y is 22; X is8 and Y is 23; X is 8 and Y is 24; X is 8 and Y is 25; X is 8 and Y is26; X is 8 and Y is 27; X is 8 and Y is 28; X is 8 and Y is 29; X is 8and Y is 30; X is 8 and Y is 31; X is 8 and Y is 32; X is 8 and Y is 33;X is 8 and Y is 34; X is 8 and Y is 35; X is 8 and Y is 36; X is 8 and Yis 37; X is 8 and Y is 38; X is 8 and Y is 39; X is 8 and Y is 40; X is8 and Y is 41; X is 8 and Y is 42; X is 8 and Y is 43; X is 8 and Y is44; X is 8 and Y is 45; X is 8 and Y is 46; X is 8 and Y is 47; X is 8and Y is 48; X is 8 and Y is 49; X is 8 and Y is 50; X is 8 and Y is 51;X is 8 and Y is 52; X is 8 and Y is 53; X is 8 and Y is 54; X is 8 and Yis 55; X is 8 and Y is 56; X is 8 and Y is 57; X is 8 and Y is 58; X is8 and Y is 59; X is 8 and Y is 60; X is 8 and Y is 61; X is 8 and Y is62; X is 8 and Y is 63; X is 8 and Y is 64; X is 8 and Y is 65; X is 8and Y is 66; X is 8 and Y is 67; X is 8 and Y is 68; X is 8 and Y is 69;X is 8 and Y is 70; X is 8 and Y is 71; X is 8 and Y is 72; X is 8 and Yis 73; X is 8 and Y is 74; X is 8 and Y is 75; X is 8 and Y is 76; X is8 and Y is 77; X is 8 and Y is 78; X is 8 and Y is 79; X is 8 and Y is80; X is 8 and Y is 81; X is 8 and Y is 82; X is 8 and Y is 83; X is 8and Y is 84; X is 8 and Y is 85; X is 8 and Y is 86; X is 8 and Y is 87;X is 8 and Y is 88; X is 8 and Y is 89; X is 8 and Y is 90; X is 8 and Yis 91; X is 8 and Y is 92;X is 9 and Y is 1; X is 9 and Y is 2; X is 9 and Y is 3; X is 9 and Y is4; X is 9 and Y is 5; X is 9 and Y is 6; X is 9 and Y is 7; X is 9 and Yis 8; X is 9 and Y is 9; X is 9 and Y is 10; X is 9 and Y is 11; X is 9and Y is 12; X is 9 and Y is 13; X is 9 and Y is 14; X is 9 and Y is 15;X is 9 and Y is 16; X is 9 and Y is 17; X is 9 and Y is 18; X is 9 and Yis 19; X is 9 and Y is 20; X is 9 and Y is 21; X is 9 and Y is 22; X is9 and Y is 23; X is 9 and Y is 24; X is 9 and Y is 25; X is 9 and Y is26; X is 9 and Y is 27; X is 9 and Y is 28; X is 9 and Y is 29; X is 9and Y is 30; X is 9 and Y is 31; X is 9 and Y is 32; X is 9 and Y is 33;X is 9 and Y is 34; X is 9 and Y is 35; X is 9 and Y is 36; X is 9 and Yis 37; X is 9 and Y is 38; X is 9 and Y is 39; X is 9 and Y is 40; X is9 and Y is 41; X is 9 and Y is 42; X is 9 and Y is 43; X is 9 and Y is44; X is 9 and Y is 45; X is 9 and Y is 46; X is 9 and Y is 47; X is 9and Y is 48; X is 9 and Y is 49; X is 9 and Y is 50; X is 9 and Y is 51;X is 9 and Y is 52; X is 9 and Y is 53; X is 9 and Y is 54; X is 9 and Yis 55; X is 9 and Y is 56; X is 9 and Y is 57; X is 9 and Y is 58; X is9 and Y is 59; X is 9 and Y is 60; X is 9 and Y is 61; X is 9 and Y is62; X is 9 and Y is 63; X is 9 and Y is 64; X is 9 and Y is 65; X is 9and Y is 66; X is 9 and Y is 67; X is 9 and Y is 68; X is 9 and Y is 69;X is 9 and Y is 70; X is 9 and Y is 71; X is 9 and Y is 72; X is 9 and Yis 73; X is 9 and Y is 74; X is 9 and Y is 75; X is 9 and Y is 76; X is9 and Y is 77; X is 9 and Y is 78; X is 9 and Y is 79; X is 9 and Y is80; X is 9 and Y is 81; X is 9 and Y is 82; X is 9 and Y is 83; X is 9and Y is 84; X is 9 and Y is 85; X is 9 and Y is 86; X is 9 and Y is 87;X is 9 and Y is 88; X is 9 and Y is 89; X is 9 and Y is 90; X is 9 and Yis 91; X is 9 and Y is 92;X is 10 and Y is 1; X is 10 and Y is 2; X is 10 and Y is 3; X is 10 andY is 4; X is 10 and Y is 5; X is 10 and Y is 6; X is 10 and Y is 7; X is10 and Y is 8; X is 10 and Y is 9; X is 10 and Y is 10; X is 10 and Y is11; X is 10 and Y is 12; X is 10 and Y is 13; X is 10 and Y is 14; X is10 and Y is 15; X is 10 and Y is 16; X is 10 and Y is 17; X is 10 and Yis 18; X is 10 and Y is 19; X is 10 and Y is 20; X is 10 and Y is 21; Xis 10 and Y is 22; X is 10 and Y is 23; X is 10 and Y is 24; X is 10 andY is 25; X is 10 and Y is 26; X is 10 and Y is 27; X is 10 and Y is 28;X is 10 and Y is 29; X is 10 and Y is 30; X is 10 and Y is 31; X is 10and Y is 32; X is 10 and Y is 33; X is 10 and Y is 34; X is 10 and Y is35; X is 10 and Y is 36; X is 10 and Y is 37; X is 10 and Y is 38; X is10 and Y is 39; X is 10 and Y is 40; X is 10 and Y is 41; X is 10 and Yis 42; X is 10 and Y is 43; X is 10 and Y is 44; X is 10 and Y is 45; Xis 10 and Y is 46; X is 10 and Y is 47; X is 10 and Y is 48; X is 10 andY is 49; X is 10 and Y is 50; X is 10 and Y is 51; X is 10 and Y is 52;X is 10 and Y is 53; X is 10 and Y is 54; X is 10 and Y is 55; X is 10and Y is 56; X is 10 and Y is 57; X is 10 and Y is 58; X is 10 and Y is59; X is 10 and Y is 60; X is 10 and Y is 61; X is 10 and Y is 62; X is10 and Y is 63; X is 10 and Y is 64; X is 10 and Y is 65; X is 10 and Yis 66; X is 10 and Y is 67; X is 10 and Y is 68; X is 10 and Y is 69; Xis 10 and Y is 70; X is 10 and Y is 71; X is 10 and Y is 72; X is 10 andY is 73; X is 10 and Y is 74; X is 10 and Y is 75; X is 10 and Y is 76;X is 10 and Y is 77; X is 10 and Y is 78; X is 10 and Y is 79; X is 10and Y is 80; X is 10 and Y is 81; X is 10 and Y is 82; X is 10 and Y is83; X is 10 and Y is 84; X is 10 and Y is 85; X is 10 and Y is 86; X is10 and Y is 87; X is 10 and Y is 88; X is 10 and Y is 89; X is 10 and Yis 90; X is 10 and Y is 91; X is 10 and Y is 92;X is 11 and Y is 1; X is 11 and Y is 2; X is 11 and Y is 3; X is 11 andY is 4; X is 11 and Y is 5; X is 11 and Y is 6; X is 11 and Y is 7; X is11 and Y is 8; X is 11 and Y is 9; X is 11 and Y is 10; X is 11 and Y is11; X is 11 and Y is 12; X is 11 and Y is 13; X is 11 and Y is 14; X is11 and Y is 15; X is 11 and Y is 16; X is 11 and Y is 17; X is 11 and Yis 18; X is 11 and Y is 19; X is 11 and Y is 20; X is 11 and Y is 21; Xis 11 and Y is 22; X is 11 and Y is 23; X is 11 and Y is 24; X is 11 andY is 25; X is 11 and Y is 26; X is 11 and Y is 27; X is 11 and Y is 28;X is 11 and Y is 29; X is 11 and Y is 30; X is 11 and Y is 31; X is 11and Y is 32; X is 11 and Y is 33; X is 11 and Y is 34; X is 11 and Y is35; X is 11 and Y is 36; X is 11 and Y is 37; X is 11 and Y is 38; X is11 and Y is 39; X is 11 and Y is 40; X is 11 and Y is 41; X is 11 and Yis 42; X is 11 and Y is 43; X is 11 and Y is 44; X is 11 and Y is 45; Xis 11 and Y is 46; X is 11 and Y is 47; X is 11 and Y is 48; X is 11 andY is 49; X is 11 and Y is 50; X is 11 and Y is 51; X is 11 and Y is 52;X is 11 and Y is 53; X is 11 and Y is 54; X is 11 and Y is 55; X is 11and Y is 56; X is 11 and Y is 57; X is 11 and Y is 58; X is 11 and Y is59; X is 11 and Y is 60; X is 11 and Y is 61; X is 11 and Y is 62; X is11 and Y is 63; X is 11 and Y is 64; X is 11 and Y is 65; X is 11 and Yis 66; X is 11 and Y is 67; X is 11 and Y is 68; X is 11 and Y is 69; Xis 11 and Y is 70; X is 11 and Y is 71; X is 11 and Y is 72; X is 11 andY is 73; X is 11 and Y is 74; X is 11 and Y is 75; X is 11 and Y is 76;X is 11 and Y is 77; X is 11 and Y is 78; X is 11 and Y is 79; X is 11and Y is 80; X is 11 and Y is 81; X is 11 and Y is 82; X is 11 and Y is83; X is 11 and Y is 84; X is 11 and Y is 85; X is 11 and Y is 86; X is11 and Y is 87; X is 11 and Y is 88; X is 11 and Y is 89; X is 11 and Yis 90; X is 11 and Y is 91; X is 11 and Y is 92;X is 12 and Y is 1; X is 12 and Y is 2; X is 12 and Y is 3; X is 12 andY is 4; X is 12 and Y is 5; X is 12 and Y is 6; X is 12 and Y is 7; X is12 and Y is 8; X is 12 and Y is 9; X is 12 and Y is 10; X is 12 and Y is11; X is 12 and Y is 12; X is 12 and Y is 13; X is 12 and Y is 14; X is12 and Y is 15; X is 12 and Y is 16; X is 12 and Y is 17; X is 12 and Yis 18; X is 12 and Y is 19; X is 12 and Y is 20; X is 12 and Y is 21; Xis 12 and Y is 22; X is 12 and Y is 23; X is 12 and Y is 24; X is 12 andY is 25; X is 12 and Y is 26; X is 12 and Y is 27; X is 12 and Y is 28;X is 12 and Y is 29; X is 12 and Y is 30; X is 12 and Y is 31; X is 12and Y is 32; X is 12 and Y is 33; X is 12 and Y is 34; X is 12 and Y is35; X is 12 and Y is 36; X is 12 and Y is 37; X is 12 and Y is 38; X is12 and Y is 39; X is 12 and Y is 40; X is 12 and Y is 41; X is 12 and Yis 42; X is 12 and Y is 43; X is 12 and Y is 44; X is 12 and Y is 45; Xis 12 and Y is 46; X is 12 and Y is 47; X is 12 and Y is 48; X is 12 andY is 49; X is 12 and Y is 50; X is 12 and Y is 51; X is 12 and Y is 52;X is 12 and Y is 53; X is 12 and Y is 54; X is 12 and Y is 55; X is 12and Y is 56; X is 12 and Y is 57; X is 12 and Y is 58; X is 12 and Y is59; X is 12 and Y is 60; X is 12 and Y is 61; X is 12 and Y is 62; X is12 and Y is 63; X is 12 and Y is 64; X is 12 and Y is 65; X is 12 and Yis 66; X is 12 and Y is 67; X is 12 and Y is 68; X is 12 and Y is 69; Xis 12 and Y is 70; X is 12 and Y is 71; X is 12 and Y is 72; X is 12 andY is 73; X is 12 and Y is 74; X is 12 and Y is 75; X is 12 and Y is 76;X is 12 and Y is 77; X is 12 and Y is 78; X is 12 and Y is 79; X is 12and Y is 80; X is 12 and Y is 81; X is 12 and Y is 82; X is 12 and Y is83; X is 12 and Y is 84; X is 12 and Y is 85; X is 12 and Y is 86; X is12 and Y is 87; X is 12 and Y is 88; X is 12 and Y is 89; X is 12 and Yis 90; X is 12 and Y is 91; or X is 12 and Y is 92.

In one embodiment, X is 2 and Y is 3. In another embodiment, X is 12 andY is 9.

In one embodiment, the first binding domain binds to OX40 (CD134) andthe second binding domain binds to CD27, wherein, preferably, thebinding agent comprises

one or more CDRs or one or more variable domains of an antibody AB134_X,wherein X is selected from the group consisting of 1 to 92, as shown inTable 8, andone or more CDRs or one or more variable domains of an antibody AB27_Y,wherein Y is selected from the group consisting of 1 to 186, as shown inTable 7.

In various embodiments, X is 1 and Y is selected from the groupconsisting of 1 to 186; X is 2 and Y is selected from the groupconsisting of 1 to 186; X is 3 and Y is selected from the groupconsisting of 1 to 186; X is 4 and Y is selected from the groupconsisting of 1 to 186; X is 5 and Y is selected from the groupconsisting of 1 to 186; X is 6 and Y is selected from the groupconsisting of 1 to 186; X is 7 and Y is selected from the groupconsisting of 1 to 186; X is 8 and Y is selected from the groupconsisting of 1 to 186; X is 9 and Y is selected from the groupconsisting of 1 to 186; X is 10 and Y is selected from the groupconsisting of 1 to 186; X is 11 and Y is selected from the groupconsisting of 1 to 186; X is 12 and Y is selected from the groupconsisting of 1 to 186; X is 13 and Y is selected from the groupconsisting of 1 to 186; X is 14 and Y is selected from the groupconsisting of 1 to 186; X is 15 and Y is selected from the groupconsisting of 1 to 186; X is 16 and Y is selected from the groupconsisting of 1 to 186; X is 17 and Y is selected from the groupconsisting of 1 to 186; X is 18 and Y is selected from the groupconsisting of 1 to 186; X is 19 and Y is selected from the groupconsisting of 1 to 186; X is 20 and Y is selected from the groupconsisting of 1 to 186; X is 21 and Y is selected from the groupconsisting of 1 to 186; X is 22 and Y is selected from the groupconsisting of 1 to 186; X is 23 and Y is selected from the groupconsisting of 1 to 186; X is 24 and Y is selected from the groupconsisting of 1 to 186; X is 25 and Y is selected from the groupconsisting of 1 to 186; X is 26 and Y is selected from the groupconsisting of 1 to 186; X is 27 and Y is selected from the groupconsisting of 1 to 186; X is 28 and Y is selected from the groupconsisting of 1 to 186; X is 29 and Y is selected from the groupconsisting of 1 to 186; X is 30 and Y is selected from the groupconsisting of 1 to 186; X is 31 and Y is selected from the groupconsisting of 1 to 186; X is 32 and Y is selected from the groupconsisting of 1 to 186; X is 33 and Y is selected from the groupconsisting of 1 to 186; X is 34 and Y is selected from the groupconsisting of 1 to 186; X is 35 and Y is selected from the groupconsisting of 1 to 186; X is 36 and Y is selected from the groupconsisting of 1 to 186; X is 37 and Y is selected from the groupconsisting of 1 to 186; X is 38 and Y is selected from the groupconsisting of 1 to 186; X is 39 and Y is selected from the groupconsisting of 1 to 186; X is 40 and Y is selected from the groupconsisting of 1 to 186; X is 41 and Y is selected from the groupconsisting of 1 to 186; X is 42 and Y is selected from the groupconsisting of 1 to 186; X is 43 and Y is selected from the groupconsisting of 1 to 186; X is 44 and Y is selected from the groupconsisting of 1 to 186; X is 45 and Y is selected from the groupconsisting of 1 to 186; X is 46 and Y is selected from the groupconsisting of 1 to 186; X is 47 and Y is selected from the groupconsisting of 1 to 186; X is 48 and Y is selected from the groupconsisting of 1 to 186; X is 49 and Y is selected from the groupconsisting of 1 to 186; X is 50 and Y is selected from the groupconsisting of 1 to 186; X is 51 and Y is selected from the groupconsisting of 1 to 186; X is 52 and Y is selected from the groupconsisting of 1 to 186; X is 53 and Y is selected from the groupconsisting of 1 to 186; X is 54 and Y is selected from the groupconsisting of 1 to 186; X is 55 and Y is selected from the groupconsisting of 1 to 186; X is 56 and Y is selected from the groupconsisting of 1 to 186; X is 57 and Y is selected from the groupconsisting of 1 to 186; X is 58 and Y is selected from the groupconsisting of 1 to 186; X is 59 and Y is selected from the groupconsisting of 1 to 186; X is 60 and Y is selected from the groupconsisting of 1 to 186; X is 61 and Y is selected from the groupconsisting of 1 to 186; X is 62 and Y is selected from the groupconsisting of 1 to 186; X is 63 and Y is selected from the groupconsisting of 1 to 186; X is 64 and Y is selected from the groupconsisting of 1 to 186; X is 65 and Y is selected from the groupconsisting of 1 to 186; X is 66 and Y is selected from the groupconsisting of 1 to 186; X is 67 and Y is selected from the groupconsisting of 1 to 186; X is 68 and Y is selected from the groupconsisting of 1 to 186; X is 69 and Y is selected from the groupconsisting of 1 to 186; X is 70 and Y is selected from the groupconsisting of 1 to 186; X is 71 and Y is selected from the groupconsisting of 1 to 186; X is 72 and Y is selected from the groupconsisting of 1 to 186; X is 73 and Y is selected from the groupconsisting of 1 to 186; X is 74 and Y is selected from the groupconsisting of 1 to 186; X is 75 and Y is selected from the groupconsisting of 1 to 186; X is 76 and Y is selected from the groupconsisting of 1 to 186; X is 77 and Y is selected from the groupconsisting of 1 to 186; X is 78 and Y is selected from the groupconsisting of 1 to 186; X is 79 and Y is selected from the groupconsisting of 1 to 186; X is 80 and Y is selected from the groupconsisting of 1 to 186; X is 81 and Y is selected from the groupconsisting of 1 to 186; X is 82 and Y is selected from the groupconsisting of 1 to 186; X is 83 and Y is selected from the groupconsisting of 1 to 186; X is 84 and Y is selected from the groupconsisting of 1 to 186; X is 85 and Y is selected from the groupconsisting of 1 to 186; X is 86 and Y is selected from the groupconsisting of 1 to 186 X is 87 and Y is selected from the groupconsisting of 1 to 186; X is 88 and Y is selected from the groupconsisting of 1 to 186; X is 89 and Y is selected from the groupconsisting of 1 to 186; X is 90 and Y is selected from the groupconsisting of 1 to 186; X is 91 and Y is selected from the groupconsisting of 1 to 186; or X is 92 and Y is selected from the groupconsisting of 1 to 186.

In various embodiments,

X is 1 and Y is 1; X is 1 and Y is 2; X is 1 and Y is 3; X is 1 and Y is4; X is 1 and Y is 5; X is 1 and Y is 6; X is 1 and Y is 7; X is 1 and Yis 8; X is 1 and Y is 9; X is 1 and Y is 10; X is 1 and Y is 11; X is 1and Y is 12; X is 1 and Y is 13; X is 1 and Y is 14; X is 1 and Y is 15;X is 1 and Y is 16; X is 1 and Y is 17; X is 1 and Y is 18; X is 1 and Yis 19; X is 1 and Y is 20; X is 1 and Y is 21; X is 1 and Y is 22; X is1 and Y is 23; X is 1 and Y is 24; X is 1 and Y is 25; X is 1 and Y is26; X is 1 and Y is 27; X is 1 and Y is 28; X is 1 and Y is 29; X is 1and Y is 30; X is 1 and Y is 31; X is 1 and Y is 32; X is 1 and Y is 33;X is 1 and Y is 34; X is 1 and Y is 35; X is 1 and Y is 36; X is 1 and Yis 37; X is 1 and Y is 38; X is 1 and Y is 39; X is 1 and Y is 40; X is1 and Y is 41; X is 1 and Y is 42; X is 1 and Y is 43; X is 1 and Y is44; X is 1 and Y is 45; X is 1 and Y is 46; X is 1 and Y is 47; X is 1and Y is 48; X is 1 and Y is 49; X is 1 and Y is 50; X is 1 and Y is 51;X is 1 and Y is 52; X is 1 and Y is 53; X is 1 and Y is 54; X is 1 and Yis 55; X is 1 and Y is 56; X is 1 and Y is 57; X is 1 and Y is 58; X is1 and Y is 59; X is 1 and Y is 60; X is 1 and Y is 61; X is 1 and Y is62; X is 1 and Y is 63; X is 1 and Y is 64; X is 1 and Y is 65; X is 1and Y is 66; X is 1 and Y is 67; X is 1 and Y is 68; X is 1 and Y is 69;X is 1 and Y is 70; X is 1 and Y is 71; X is 1 and Y is 72; X is 1 and Yis 73; X is 1 and Y is 74; X is 1 and Y is 75; X is 1 and Y is 76; X is1 and Y is 77; X is 1 and Y is 78; X is 1 and Y is 79; X is 1 and Y is80; X is 1 and Y is 81; X is 1 and Y is 82; X is 1 and Y is 83; X is 1and Y is 84; X is 1 and Y is 85; X is 1 and Y is 86; X is 1 and Y is 87;X is 1 and Y is 88; X is 1 and Y is 89; X is 1 and Y is 90; X is 1 and Yis 91; X is 1 and Y is 92; X is 1 and Y is 93; X is 1 and Y is 94; X is1 and Y is 95; X is 1 and Y is 96; X is 1 and Y is 97; X is 1 and Y is98; X is 1 and Y is 99; X is 1 and Y is 100; X is 1 and Y is 101; X is 1and Y is 102; X is 1 and Y is 103; X is 1 and Y is 104; X is 1 and Y is105; X is 1 and Y is 106; X is 1 and Y is 107; X is 1 and Y is 108; X is1 and Y is 109; X is 1 and Y is 110; X is 1 and Y is 111; X is 1 and Yis 112; X is 1 and Y is 113; X is 1 and Y is 114; X is 1 and Y is 115; Xis 1 and Y is 116; X is 1 and Y is 117; X is 1 and Y is 118; X is 1 andY is 119; X is 1 and Y is 120; X is 1 and Y is 121; X is 1 and Y is 122;X is 1 and Y is 123; X is 1 and Y is 124; X is 1 and Y is 125; X is 1and Y is 126; X is 1 and Y is 127; X is 1 and Y is 128; X is 1 and Y is129; X is 1 and Y is 130; X is 1 and Y is 131; X is 1 and Y is 132; X is1 and Y is 133; X is 1 and Y is 134; X is 1 and Y is 135; X is 1 and Yis 136; X is 1 and Y is 137; X is 1 and Y is 138; X is 1 and Y is 139; Xis 1 and Y is 140; X is 1 and Y is 141; X is 1 and Y is 142; X is 1 andY is 143; X is 1 and Y is 144; X is 1 and Y is 145; X is 1 and Y is 146;X is 1 and Y is 147; X is 1 and Y is 148; X is 1 and Y is 149; X is 1and Y is 150; X is 1 and Y is 151; X is 1 and Y is 152; X is 1 and Y is153; X is 1 and Y is 154; X is 1 and Y is 155; X is 1 and Y is 156; X is1 and Y is 157; X is 1 and Y is 158; X is 1 and Y is 159; X is 1 and Yis 160; X is 1 and Y is 161; X is 1 and Y is 162; X is 1 and Y is 163; Xis 1 and Y is 164; X is 1 and Y is 165; X is 1 and Y is 166; X is 1 andY is 167; X is 1 and Y is 168; X is 1 and Y is 169; X is 1 and Y is 170;X is 1 and Y is 171; X is 1 and Y is 172; X is 1 and Y is 173; X is 1and Y is 174; X is 1 and Y is 175; X is 1 and Y is 176; X is 1 and Y is177; X is 1 and Y is 178; X is 1 and Y is 179; X is 1 and Y is 180; X is1 and Y is 181; X is 1 and Y is 182; X is 1 and Y is 183; X is 1 and Yis 184; X is 1 and Y is 185; X is 1 and Y is 186; X is 2 and Y is 1; Xis 2 and Y is 2; X is 2 and Y is 3; X is 2 and Y is 4; X is 2 and Y is5; X is 2 and Y is 6; X is 2 and Y is 7; X is 2 and Y is 8; X is 2 and Yis 9; X is 2 and Y is 10; X is 2 and Y is 11; X is 2 and Y is 12; X is 2and Y is 13; X is 2 and Y is 14; X is 2 and Y is 15; X is 2 and Y is 16;X is 2 and Y is 17; X is 2 and Y is 18; X is 2 and Y is 19; X is 2 and Yis 20; X is 2 and Y is 21; X is 2 and Y is 22; X is 2 and Y is 23; X is2 and Y is 24; X is 2 and Y is 25; X is 2 and Y is 26; X is 2 and Y is27; X is 2 and Y is 28; X is 2 and Y is 29; X is 2 and Y is 30; X is 2and Y is 31; X is 2 and Y is 32; X is 2 and Y is 33; X is 2 and Y is 34;X is 2 and Y is 35; X is 2 and Y is 36; X is 2 and Y is 37; X is 2 and Yis 38; X is 2 and Y is 39; X is 2 and Y is 40; X is 2 and Y is 41; X is2 and Y is 42; X is 2 and Y is 43; X is 2 and Y is 44; X is 2 and Y is45; X is 2 and Y is 46; X is 2 and Y is 47; X is 2 and Y is 48; X is 2and Y is 49; X is 2 and Y is 50; X is 2 and Y is 51; X is 2 and Y is 52;X is 2 and Y is 53; X is 2 and Y is 54; X is 2 and Y is 55; X is 2 and Yis 56; X is 2 and Y is 57; X is 2 and Y is 58; X is 2 and Y is 59; X is2 and Y is 60; X is 2 and Y is 61; X is 2 and Y is 62; X is 2 and Y is63; X is 2 and Y is 64; X is 2 and Y is 65; X is 2 and Y is 66; X is 2and Y is 67; X is 2 and Y is 68; X is 2 and Y is 69; X is 2 and Y is 70;X is 2 and Y is 71; X is 2 and Y is 72; X is 2 and Y is 73; X is 2 and Yis 74; X is 2 and Y is 75; X is 2 and Y is 76; X is 2 and Y is 77; X is2 and Y is 78; X is 2 and Y is 79; X is 2 and Y is 80; X is 2 and Y is81; X is 2 and Y is 82; X is 2 and Y is 83; X is 2 and Y is 84; X is 2and Y is 85; X is 2 and Y is 86; X is 2 and Y is 87; X is 2 and Y is 88;X is 2 and Y is 89; X is 2 and Y is 90; X is 2 and Y is 91; X is 2 and Yis 92; X is 2 and Y is 93; X is 2 and Y is 94; X is 2 and Y is 95; X is2 and Y is 96; X is 2 and Y is 97; X is 2 and Y is 98; X is 2 and Y is99; X is 2 and Y is 100; X is 2 and Y is 101; X is 2 and Y is 102; X is2 and Y is 103; X is 2 and Y is 104; X is 2 and Y is 105; X is 2 and Yis 106; X is 2 and Y is 107; X is 2 and Y is 108; X is 2 and Y is 109; Xis 2 and Y is 110; X is 2 and Y is 111; X is 2 and Y is 112; X is 2 andY is 113; X is 2 and Y is 114; X is 2 and Y is 115; X is 2 and Y is 116;X is 2 and Y is 117; X is 2 and Y is 118; X is 2 and Y is 119; X is 2and Y is 120; X is 2 and Y is 121; X is 2 and Y is 122; X is 2 and Y is123; X is 2 and Y is 124; X is 2 and Y is 125; X is 2 and Y is 126; X is2 and Y is 127; X is 2 and Y is 128; X is 2 and Y is 129; X is 2 and Yis 130; X is 2 and Y is 131; X is 2 and Y is 132; X is 2 and Y is 133; Xis 2 and Y is 134; X is 2 and Y is 135; X is 2 and Y is 136; X is 2 andY is 137; X is 2 and Y is 138; X is 2 and Y is 139; X is 2 and Y is 140;X is 2 and Y is 141; X is 2 and Y is 142; X is 2 and Y is 143; X is 2and Y is 144; X is 2 and Y is 145; X is 2 and Y is 146; X is 2 and Y is147; X is 2 and Y is 148; X is 2 and Y is 149; X is 2 and Y is 150; X is2 and Y is 151; X is 2 and Y is 152; X is 2 and Y is 153; X is 2 and Yis 154; X is 2 and Y is 155; X is 2 and Y is 156; X is 2 and Y is 157; Xis 2 and Y is 158; X is 2 and Y is 159; X is 2 and Y is 160; X is 2 andY is 161; X is 2 and Y is 162; X is 2 and Y is 163; X is 2 and Y is 164;X is 2 and Y is 165; X is 2 and Y is 166; X is 2 and Y is 167; X is 2and Y is 168; X is 2 and Y is 169; X is 2 and Y is 170; X is 2 and Y is171; X is 2 and Y is 172; X is 2 and Y is 173; X is 2 and Y is 174; X is2 and Y is 175; X is 2 and Y is 176; X is 2 and Y is 177; X is 2 and Yis 178; X is 2 and Y is 179; X is 2 and Y is 180; X is 2 and Y is 181; Xis 2 and Y is 182; X is 2 and Y is 183; X is 2 and Y is 184; X is 2 andY is 185; X is 2 and Y is 186; X is 3 and Y is 1; X is 3 and Y is 2; Xis 3 and Y is 3; X is 3 and Y is 4; X is 3 and Y is 5; X is 3 and Y is6; X is 3 and Y is 7; X is 3 and Y is 8; X is 3 and Y is 9; X is 3 and Yis 10; X is 3 and Y is 11; X is 3 and Y is 12; X is 3 and Y is 13; X is3 and Y is 14; X is 3 and Y is 15; X is 3 and Y is 16; X is 3 and Y is17; X is 3 and Y is 18; X is 3 and Y is 19; X is 3 and Y is 20; X is 3and Y is 21; X is 3 and Y is 22; X is 3 and Y is 23; X is 3 and Y is 24;X is 3 and Y is 25; X is 3 and Y is 26; X is 3 and Y is 27; X is 3 and Yis 28; X is 3 and Y is 29; X is 3 and Y is 30; X is 3 and Y is 31; X is3 and Y is 32; X is 3 and Y is 33; X is 3 and Y is 34; X is 3 and Y is35; X is 3 and Y is 36; X is 3 and Y is 37; X is 3 and Y is 38; X is 3and Y is 39; X is 3 and Y is 40; X is 3 and Y is 41; X is 3 and Y is 42;X is 3 and Y is 43; X is 3 and Y is 44; X is 3 and Y is 45; X is 3 and Yis 46; X is 3 and Y is 47; X is 3 and Y is 48; X is 3 and Y is 49; X is3 and Y is 50; X is 3 and Y is 51; X is 3 and Y is 52; X is 3 and Y is53; X is 3 and Y is 54; X is 3 and Y is 55; X is 3 and Y is 56; X is 3and Y is 57; X is 3 and Y is 58; X is 3 and Y is 59; X is 3 and Y is 60;X is 3 and Y is 61; X is 3 and Y is 62; X is 3 and Y is 63; X is 3 and Yis 64; X is 3 and Y is 65; X is 3 and Y is 66; X is 3 and Y is 67; X is3 and Y is 68; X is 3 and Y is 69; X is 3 and Y is 70; X is 3 and Y is71; X is 3 and Y is 72; X is 3 and Y is 73; X is 3 and Y is 74; X is 3and Y is 75; X is 3 and Y is 76; X is 3 and Y is 77; X is 3 and Y is 78;X is 3 and Y is 79; X is 3 and Y is 80; X is 3 and Y is 81; X is 3 and Yis 82; X is 3 and Y is 83; X is 3 and Y is 84; X is 3 and Y is 85; X is3 and Y is 86; X is 3 and Y is 87; X is 3 and Y is 88; X is 3 and Y is89; X is 3 and Y is 90; X is 3 and Y is 91; X is 3 and Y is 92; X is 3and Y is 93; X is 3 and Y is 94; X is 3 and Y is 95; X is 3 and Y is 96;X is 3 and Y is 97; X is 3 and Y is 98; X is 3 and Y is 99; X is 3 and Yis 100; X is 3 and Y is 101; X is 3 and Y is 102; X is 3 and Y is 103; Xis 3 and Y is 104; X is 3 and Y is 105; X is 3 and Y is 106; X is 3 andY is 107; X is 3 and Y is 108; X is 3 and Y is 109; X is 3 and Y is 110;X is 3 and Y is 111; X is 3 and Y is 112; X is 3 and Y is 113; X is 3and Y is 114; X is 3 and Y is 115; X is 3 and Y is 116; X is 3 and Y is117; X is 3 and Y is 118; X is 3 and Y is 119; X is 3 and Y is 120; X is3 and Y is 121; X is 3 and Y is 122; X is 3 and Y is 123; X is 3 and Yis 124; X is 3 and Y is 125; X is 3 and Y is 126; X is 3 and Y is 127; Xis 3 and Y is 128; X is 3 and Y is 129; X is 3 and Y is 130; X is 3 andY is 131; X is 3 and Y is 132; X is 3 and Y is 133; X is 3 and Y is 134;X is 3 and Y is 135; X is 3 and Y is 136; X is 3 and Y is 137; X is 3and Y is 138; X is 3 and Y is 139; X is 3 and Y is 140; X is 3 and Y is141; X is 3 and Y is 142; X is 3 and Y is 143; X is 3 and Y is 144; X is3 and Y is 145; X is 3 and Y is 146; X is 3 and Y is 147; X is 3 and Yis 148; X is 3 and Y is 149; X is 3 and Y is 150; X is 3 and Y is 151; Xis 3 and Y is 152; X is 3 and Y is 153; X is 3 and Y is 154; X is 3 andY is 155; X is 3 and Y is 156; X is 3 and Y is 157; X is 3 and Y is 158;X is 3 and Y is 159; X is 3 and Y is 160; X is 3 and Y is 161; X is 3and Y is 162; X is 3 and Y is 163; X is 3 and Y is 164; X is 3 and Y is165; X is 3 and Y is 166; X is 3 and Y is 167; X is 3 and Y is 168; X is3 and Y is 169; X is 3 and Y is 170; X is 3 and Y is 171; X is 3 and Yis 172; X is 3 and Y is 173; X is 3 and Y is 174; X is 3 and Y is 175; Xis 3 and Y is 176; X is 3 and Y is 177; X is 3 and Y is 178; X is 3 andY is 179; X is 3 and Y is 180; X is 3 and Y is 181; X is 3 and Y is 182;X is 3 and Y is 183; X is 3 and Y is 184; X is 3 and Y is 185; X is 3and Y is 186; X is 4 and Y is 1; X is 4 and Y is 2; X is 4 and Y is 3; Xis 4 and Y is 4; X is 4 and Y is 5; X is 4 and Y is 6; X is 4 and Y is7; X is 4 and Y is 8; X is 4 and Y is 9; X is 4 and Y is 10; X is 4 andY is 11; X is 4 and Y is 12; X is 4 and Y is 13; X is 4 and Y is 14; Xis 4 and Y is 15; X is 4 and Y is 16; X is 4 and Y is 17; X is 4 and Yis 18; X is 4 and Y is 19; X is 4 and Y is 20; X is 4 and Y is 21; X is4 and Y is 22; X is 4 and Y is 23; X is 4 and Y is 24; X is 4 and Y is25; X is 4 and Y is 26; X is 4 and Y is 27; X is 4 and Y is 28; X is 4and Y is 29; X is 4 and Y is 30; X is 4 and Y is 31; X is 4 and Y is 32;X is 4 and Y is 33; X is 4 and Y is 34; X is 4 and Y is 35; X is 4 and Yis 36; X is 4 and Y is 37; X is 4 and Y is 38; X is 4 and Y is 39; X is4 and Y is 40; X is 4 and Y is 41; X is 4 and Y is 42; X is 4 and Y is43; X is 4 and Y is 44; X is 4 and Y is 45; X is 4 and Y is 46; X is 4and Y is 47; X is 4 and Y is 48; X is 4 and Y is 49; X is 4 and Y is 50;X is 4 and Y is 51; X is 4 and Y is 52; X is 4 and Y is 53; X is 4 and Yis 54; X is 4 and Y is 55; X is 4 and Y is 56; X is 4 and Y is 57; X is4 and Y is 58; X is 4 and Y is 59; X is 4 and Y is 60; X is 4 and Y is61; X is 4 and Y is 62; X is 4 and Y is 63; X is 4 and Y is 64; X is 4and Y is 65; X is 4 and Y is 66; X is 4 and Y is 67; X is 4 and Y is 68;X is 4 and Y is 69; X is 4 and Y is 70; X is 4 and Y is 71; X is 4 and Yis 72; X is 4 and Y is 73; X is 4 and Y is 74; X is 4 and Y is 75; X is4 and Y is 76; X is 4 and Y is 77; X is 4 and Y is 78; X is 4 and Y is79; X is 4 and Y is 80; X is 4 and Y is 81; X is 4 and Y is 82; X is 4and Y is 83; X is 4 and Y is 84; X is 4 and Y is 85; X is 4 and Y is 86;X is 4 and Y is 87; X is 4 and Y is 88; X is 4 and Y is 89; X is 4 and Yis 90; X is 4 and Y is 91; X is 4 and Y is 92; X is 4 and Y is 93; X is4 and Y is 94; X is 4 and Y is 95; X is 4 and Y is 96; X is 4 and Y is97; X is 4 and Y is 98; X is 4 and Y is 99; X is 4 and Y is 100; X is 4and Y is 101; X is 4 and Y is 102; X is 4 and Y is 103; X is 4 and Y is104; X is 4 and Y is 105; X is 4 and Y is 106; X is 4 and Y is 107; X is4 and Y is 108; X is 4 and Y is 109; X is 4 and Y is 110; X is 4 and Yis 111; X is 4 and Y is 112; X is 4 and Y is 113; X is 4 and Y is 114; Xis 4 and Y is 115; X is 4 and Y is 116; X is 4 and Y is 117; X is 4 andY is 118; X is 4 and Y is 119; X is 4 and Y is 120; X is 4 and Y is 121;X is 4 and Y is 122; X is 4 and Y is 123; X is 4 and Y is 124; X is 4and Y is 125; X is 4 and Y is 126; X is 4 and Y is 127; X is 4 and Y is128; X is 4 and Y is 129; X is 4 and Y is 130; X is 4 and Y is 131; X is4 and Y is 132; X is 4 and Y is 133; X is 4 and Y is 134; X is 4 and Yis 135; X is 4 and Y is 136; X is 4 and Y is 137; X is 4 and Y is 138; Xis 4 and Y is 139; X is 4 and Y is 140; X is 4 and Y is 141; X is 4 andY is 142; X is 4 and Y is 143; X is 4 and Y is 144; X is 4 and Y is 145;X is 4 and Y is 146; X is 4 and Y is 147; X is 4 and Y is 148; X is 4and Y is 149; X is 4 and Y is 150; X is 4 and Y is 151; X is 4 and Y is152; X is 4 and Y is 153; X is 4 and Y is 154; X is 4 and Y is 155; X is4 and Y is 156; X is 4 and Y is 157; X is 4 and Y is 158; X is 4 and Yis 159; X is 4 and Y is 160; X is 4 and Y is 161; X is 4 and Y is 162; Xis 4 and Y is 163; X is 4 and Y is 164; X is 4 and Y is 165; X is 4 andY is 166; X is 4 and Y is 167; X is 4 and Y is 168; X is 4 and Y is 169;X is 4 and Y is 170; X is 4 and Y is 171; X is 4 and Y is 172; X is 4and Y is 173; X is 4 and Y is 174; X is 4 and Y is 175; X is 4 and Y is176; X is 4 and Y is 177; X is 4 and Y is 178; X is 4 and Y is 179; X is4 and Y is 180; X is 4 and Y is 181; X is 4 and Y is 182; X is 4 and Yis 183; X is 4 and Y is 184; X is 4 and Y is 185; X is 4 and Y is 186; Xis 5 and Y is 1; X is 5 and Y is 2; X is 5 and Y is 3; X is 5 and Y is4; X is 5 and Y is 5; X is 5 and Y is 6; X is 5 and Y is 7; X is 5 and Yis 8; X is 5 and Y is 9; X is 5 and Y is 10; X is 5 and Y is 11; X is 5and Y is 12; X is 5 and Y is 13; X is 5 and Y is 14; X is 5 and Y is 15;X is 5 and Y is 16; X is 5 and Y is 17; X is 5 and Y is 18; X is 5 and Yis 19; X is 5 and Y is 20; X is 5 and Y is 21; X is 5 and Y is 22; X is5 and Y is 23; X is 5 and Y is 24; X is 5 and Y is 25; X is 5 and Y is26; X is 5 and Y is 27; X is 5 and Y is 28; X is 5 and Y is 29; X is 5and Y is 30; X is 5 and Y is 31; X is 5 and Y is 32; X is 5 and Y is 33;X is 5 and Y is 34; X is 5 and Y is 35; X is 5 and Y is 36; X is 5 and Yis 37; X is 5 and Y is 38; X is 5 and Y is 39; X is 5 and Y is 40; X is5 and Y is 41; X is 5 and Y is 42; X is 5 and Y is 43; X is 5 and Y is44; X is 5 and Y is 45; X is 5 and Y is 46; X is 5 and Y is 47; X is 5and Y is 48; X is 5 and Y is 49; X is 5 and Y is 50; X is 5 and Y is 51;X is 5 and Y is 52; X is 5 and Y is 53; X is 5 and Y is 54; X is 5 and Yis 55; X is 5 and Y is 56; X is 5 and Y is 57; X is 5 and Y is 58; X is5 and Y is 59; X is 5 and Y is 60; X is 5 and Y is 61; X is 5 and Y is62; X is 5 and Y is 63; X is 5 and Y is 64; X is 5 and Y is 65; X is 5and Y is 66; X is 5 and Y is 67; X is 5 and Y is 68; X is 5 and Y is 69;X is 5 and Y is 70; X is 5 and Y is 71; X is 5 and Y is 72; X is 5 and Yis 73; X is 5 and Y is 74; X is 5 and Y is 75; X is 5 and Y is 76; X is5 and Y is 77; X is 5 and Y is 78; X is 5 and Y is 79; X is 5 and Y is80; X is 5 and Y is 81; X is 5 and Y is 82; X is 5 and Y is 83; X is 5and Y is 84; X is 5 and Y is 85; X is 5 and Y is 86; X is 5 and Y is 87;X is 5 and Y is 88; X is 5 and Y is 89; X is 5 and Y is 90; X is 5 and Yis 91; X is 5 and Y is 92; X is 5 and Y is 93; X is 5 and Y is 94; X is5 and Y is 95; X is 5 and Y is 96; X is 5 and Y is 97; X is 5 and Y is98; X is 5 and Y is 99; X is 5 and Y is 100; X is 5 and Y is 101; X is 5and Y is 102; X is 5 and Y is 103; X is 5 and Y is 104; X is 5 and Y is105; X is 5 and Y is 106; X is 5 and Y is 107; X is 5 and Y is 108; X is5 and Y is 109; X is 5 and Y is 110; X is 5 and Y is 111; X is 5 and Yis 112; X is 5 and Y is 113; X is 5 and Y is 114; X is 5 and Y is 115; Xis 5 and Y is 116; X is 5 and Y is 117; X is 5 and Y is 118; X is 5 andY is 119; X is 5 and Y is 120; X is 5 and Y is 121; X is 5 and Y is 122;X is 5 and Y is 123; X is 5 and Y is 124; X is 5 and Y is 125; X is 5and Y is 126; X is 5 and Y is 127; X is 5 and Y is 128; X is 5 and Y is129; X is 5 and Y is 130; X is 5 and Y is 131; X is 5 and Y is 132; X is5 and Y is 133; X is 5 and Y is 134; X is 5 and Y is 135; X is 5 and Yis 136; X is 5 and Y is 137; X is 5 and Y is 138; X is 5 and Y is 139; Xis 5 and Y is 140; X is 5 and Y is 141; X is 5 and Y is 142; X is 5 andY is 143; X is 5 and Y is 144; X is 5 and Y is 145; X is 5 and Y is 146;X is 5 and Y is 147; X is 5 and Y is 148; X is 5 and Y is 149; X is 5and Y is 150; X is 5 and Y is 151; X is 5 and Y is 152; X is 5 and Y is153; X is 5 and Y is 154; X is 5 and Y is 155; X is 5 and Y is 156; X is5 and Y is 157; X is 5 and Y is 158; X is 5 and Y is 159; X is 5 and Yis 160; X is 5 and Y is 161; X is 5 and Y is 162; X is 5 and Y is 163; Xis 5 and Y is 164; X is 5 and Y is 165; X is 5 and Y is 166; X is 5 andY is 167; X is 5 and Y is 168; X is 5 and Y is 169; X is 5 and Y is 170;X is 5 and Y is 171; X is 5 and Y is 172; X is 5 and Y is 173; X is 5and Y is 174; X is 5 and Y is 175; X is 5 and Y is 176; X is 5 and Y is177; X is 5 and Y is 178; X is 5 and Y is 179; X is 5 and Y is 180; X is5 and Y is 181; X is 5 and Y is 182; X is 5 and Y is 183; X is 5 and Yis 184; X is 5 and Y is 185; X is 5 and Y is 186; X is 6 and Y is 1; Xis 6 and Y is 2; X is 6 and Y is 3; X is 6 and Y is 4; X is 6 and Y is5; X is 6 and Y is 6; X is 6 and Y is 7; X is 6 and Y is 8; X is 6 and Yis 9; X is 6 and Y is 10; X is 6 and Y is 11; X is 6 and Y is 12; X is 6and Y is 13; X is 6 and Y is 14; X is 6 and Y is 15; X is 6 and Y is 16;X is 6 and Y is 17; X is 6 and Y is 18; X is 6 and Y is 19; X is 6 and Yis 20; X is 6 and Y is 21; X is 6 and Y is 22; X is 6 and Y is 23; X is6 and Y is 24; X is 6 and Y is 25; X is 6 and Y is 26; X is 6 and Y is27; X is 6 and Y is 28; X is 6 and Y is 29; X is 6 and Y is 30; X is 6and Y is 31; X is 6 and Y is 32; X is 6 and Y is 33; X is 6 and Y is 34;X is 6 and Y is 35; X is 6 and Y is 36; X is 6 and Y is 37; X is 6 and Yis 38; X is 6 and Y is 39; X is 6 and Y is 40; X is 6 and Y is 41; X is6 and Y is 42; X is 6 and Y is 43; X is 6 and Y is 44; X is 6 and Y is45; X is 6 and Y is 46; X is 6 and Y is 47; X is 6 and Y is 48; X is 6and Y is 49; X is 6 and Y is 50; X is 6 and Y is 51; X is 6 and Y is 52;X is 6 and Y is 53; X is 6 and Y is 54; X is 6 and Y is 55; X is 6 and Yis 56; X is 6 and Y is 57; X is 6 and Y is 58; X is 6 and Y is 59; X is6 and Y is 60; X is 6 and Y is 61; X is 6 and Y is 62; X is 6 and Y is63; X is 6 and Y is 64; X is 6 and Y is 65; X is 6 and Y is 66; X is 6and Y is 67; X is 6 and Y is 68; X is 6 and Y is 69; X is 6 and Y is 70;X is 6 and Y is 71; X is 6 and Y is 72; X is 6 and Y is 73; X is 6 and Yis 74; X is 6 and Y is 75; X is 6 and Y is 76; X is 6 and Y is 77; X is6 and Y is 78; X is 6 and Y is 79; X is 6 and Y is 80; X is 6 and Y is81; X is 6 and Y is 82; X is 6 and Y is 83; X is 6 and Y is 84; X is 6and Y is 85; X is 6 and Y is 86; X is 6 and Y is 87; X is 6 and Y is 88;X is 6 and Y is 89; X is 6 and Y is 90; X is 6 and Y is 91; X is 6 and Yis 92; X is 6 and Y is 93; X is 6 and Y is 94; X is 6 and Y is 95; X is6 and Y is 96; X is 6 and Y is 97; X is 6 and Y is 98; X is 6 and Y is99; X is 6 and Y is 100; X is 6 and Y is 101; X is 6 and Y is 102; X is6 and Y is 103; X is 6 and Y is 104; X is 6 and Y is 105; X is 6 and Yis 106; X is 6 and Y is 107; X is 6 and Y is 108; X is 6 and Y is 109; Xis 6 and Y is 110; X is 6 and Y is 111; X is 6 and Y is 112; X is 6 andY is 113; X is 6 and Y is 114; X is 6 and Y is 115; X is 6 and Y is 116;X is 6 and Y is 117; X is 6 and Y is 118; X is 6 and Y is 119; X is 6and Y is 120; X is 6 and Y is 121; X is 6 and Y is 122; X is 6 and Y is123; X is 6 and Y is 124; X is 6 and Y is 125; X is 6 and Y is 126; X is6 and Y is 127; X is 6 and Y is 128; X is 6 and Y is 129; X is 6 and Yis 130; X is 6 and Y is 131; X is 6 and Y is 132; X is 6 and Y is 133; Xis 6 and Y is 134; X is 6 and Y is 135; X is 6 and Y is 136; X is 6 andY is 137; X is 6 and Y is 138; X is 6 and Y is 139; X is 6 and Y is 140;X is 6 and Y is 141; X is 6 and Y is 142; X is 6 and Y is 143; X is 6and Y is 144; X is 6 and Y is 145; X is 6 and Y is 146; X is 6 and Y is147; X is 6 and Y is 148; X is 6 and Y is 149; X is 6 and Y is 150; X is6 and Y is 151; X is 6 and Y is 152; X is 6 and Y is 153; X is 6 and Yis 154; X is 6 and Y is 155; X is 6 and Y is 156; X is 6 and Y is 157; Xis 6 and Y is 158; X is 6 and Y is 159; X is 6 and Y is 160; X is 6 andY is 161; X is 6 and Y is 162; X is 6 and Y is 163; X is 6 and Y is 164;X is 6 and Y is 165; X is 6 and Y is 166; X is 6 and Y is 167; X is 6and Y is 168; X is 6 and Y is 169; X is 6 and Y is 170; X is 6 and Y is171; X is 6 and Y is 172; X is 6 and Y is 173; X is 6 and Y is 174; X is6 and Y is 175; X is 6 and Y is 176; X is 6 and Y is 177; X is 6 and Yis 178; X is 6 and Y is 179; X is 6 and Y is 180; X is 6 and Y is 181; Xis 6 and Y is 182; X is 6 and Y is 183; X is 6 and Y is 184; X is 6 andY is 185; X is 6 and Y is 186; X is 7 and Y is 1; X is 7 and Y is 2; Xis 7 and Y is 3; X is 7 and Y is 4; X is 7 and Y is 5; X is 7 and Y is6; X is 7 and Y is 7; X is 7 and Y is 8; X is 7 and Y is 9; X is 7 and Yis 10; X is 7 and Y is 11; X is 7 and Y is 12; X is 7 and Y is 13; X is7 and Y is 14; X is 7 and Y is 15; X is 7 and Y is 16; X is 7 and Y is17; X is 7 and Y is 18; X is 7 and Y is 19; X is 7 and Y is 20; X is 7and Y is 21; X is 7 and Y is 22; X is 7 and Y is 23; X is 7 and Y is 24;X is 7 and Y is 25; X is 7 and Y is 26; X is 7 and Y is 27; X is 7 and Yis 28; X is 7 and Y is 29; X is 7 and Y is 30; X is 7 and Y is 31; X is7 and Y is 32; X is 7 and Y is 33; X is 7 and Y is 34; X is 7 and Y is35; X is 7 and Y is 36; X is 7 and Y is 37; X is 7 and Y is 38; X is 7and Y is 39; X is 7 and Y is 40; X is 7 and Y is 41; X is 7 and Y is 42;X is 7 and Y is 43; X is 7 and Y is 44; X is 7 and Y is 45; X is 7 and Yis 46; X is 7 and Y is 47; X is 7 and Y is 48; X is 7 and Y is 49; X is7 and Y is 50; X is 7 and Y is 51; X is 7 and Y is 52; X is 7 and Y is53; X is 7 and Y is 54; X is 7 and Y is 55; X is 7 and Y is 56; X is 7and Y is 57; X is 7 and Y is 58; X is 7 and Y is 59; X is 7 and Y is 60;X is 7 and Y is 61; X is 7 and Y is 62; X is 7 and Y is 63; X is 7 and Yis 64; X is 7 and Y is 65; X is 7 and Y is 66; X is 7 and Y is 67; X is7 and Y is 68; X is 7 and Y is 69; X is 7 and Y is 70; X is 7 and Y is71; X is 7 and Y is 72; X is 7 and Y is 73; X is 7 and Y is 74; X is 7and Y is 75; X is 7 and Y is 76; X is 7 and Y is 77; X is 7 and Y is 78;X is 7 and Y is 79; X is 7 and Y is 80; X is 7 and Y is 81; X is 7 and Yis 82; X is 7 and Y is 83; X is 7 and Y is 84; X is 7 and Y is 85; X is7 and Y is 86; X is 7 and Y is 87; X is 7 and Y is 88; X is 7 and Y is89; X is 7 and Y is 90; X is 7 and Y is 91; X is 7 and Y is 92; X is 7and Y is 93; X is 7 and Y is 94; X is 7 and Y is 95; X is 7 and Y is 96;X is 7 and Y is 97; X is 7 and Y is 98; X is 7 and Y is 99; X is 7 and Yis 100; X is 7 and Y is 101; X is 7 and Y is 102; X is 7 and Y is 103; Xis 7 and Y is 104; X is 7 and Y is 105; X is 7 and Y is 106; X is 7 andY is 107; X is 7 and Y is 108; X is 7 and Y is 109; X is 7 and Y is 110;X is 7 and Y is 111; X is 7 and Y is 112; X is 7 and Y is 113; X is 7and Y is 114; X is 7 and Y is 115; X is 7 and Y is 116; X is 7 and Y is117; X is 7 and Y is 118; X is 7 and Y is 119; X is 7 and Y is 120; X is7 and Y is 121; X is 7 and Y is 122; X is 7 and Y is 123; X is 7 and Yis 124; X is 7 and Y is 125; X is 7 and Y is 126; X is 7 and Y is 127; Xis 7 and Y is 128; X is 7 and Y is 129; X is 7 and Y is 130; X is 7 andY is 131; X is 7 and Y is 132; X is 7 and Y is 133; X is 7 and Y is 134;X is 7 and Y is 135; X is 7 and Y is 136; X is 7 and Y is 137; X is 7and Y is 138; X is 7 and Y is 139; X is 7 and Y is 140; X is 7 and Y is141; X is 7 and Y is 142; X is 7 and Y is 143; X is 7 and Y is 144; X is7 and Y is 145; X is 7 and Y is 146; X is 7 and Y is 147; X is 7 and Yis 148; X is 7 and Y is 149; X is 7 and Y is 150; X is 7 and Y is 151; Xis 7 and Y is 152; X is 7 and Y is 153; X is 7 and Y is 154; X is 7 andY is 155; X is 7 and Y is 156; X is 7 and Y is 157; X is 7 and Y is 158;X is 7 and Y is 159; X is 7 and Y is 160; X is 7 and Y is 161; X is 7and Y is 162; X is 7 and Y is 163; X is 7 and Y is 164; X is 7 and Y is165; X is 7 and Y is 166; X is 7 and Y is 167; X is 7 and Y is 168; X is7 and Y is 169; X is 7 and Y is 170; X is 7 and Y is 171; X is 7 and Yis 172; X is 7 and Y is 173; X is 7 and Y is 174; X is 7 and Y is 175; Xis 7 and Y is 176; X is 7 and Y is 177; X is 7 and Y is 178; X is 7 andY is 179; X is 7 and Y is 180; X is 7 and Y is 181; X is 7 and Y is 182;X is 7 and Y is 183; X is 7 and Y is 184; X is 7 and Y is 185; X is 7and Y is 186; X is 8 and Y is 1; X is 8 and Y is 2; X is 8 and Y is 3; Xis 8 and Y is 4; X is 8 and Y is 5; X is 8 and Y is 6; X is 8 and Y is7; X is 8 and Y is 8; X is 8 and Y is 9; X is 8 and Y is 10; X is 8 andY is 11; X is 8 and Y is 12; X is 8 and Y is 13; X is 8 and Y is 14; Xis 8 and Y is 15; X is 8 and Y is 16; X is 8 and Y is 17; X is 8 and Yis 18; X is 8 and Y is 19; X is 8 and Y is 20; X is 8 and Y is 21; X is8 and Y is 22; X is 8 and Y is 23; X is 8 and Y is 24; X is 8 and Y is25; X is 8 and Y is 26; X is 8 and Y is 27; X is 8 and Y is 28; X is 8and Y is 29; X is 8 and Y is 30; X is 8 and Y is 31; X is 8 and Y is 32;X is 8 and Y is 33; X is 8 and Y is 34; X is 8 and Y is 35; X is 8 and Yis 36; X is 8 and Y is 37; X is 8 and Y is 38; X is 8 and Y is 39; X is8 and Y is 40; X is 8 and Y is 41; X is 8 and Y is 42; X is 8 and Y is43; X is 8 and Y is 44; X is 8 and Y is 45; X is 8 and Y is 46; X is 8and Y is 47; X is 8 and Y is 48; X is 8 and Y is 49; X is 8 and Y is 50;X is 8 and Y is 51; X is 8 and Y is 52; X is 8 and Y is 53; X is 8 and Yis 54; X is 8 and Y is 55; X is 8 and Y is 56; X is 8 and Y is 57; X is8 and Y is 58; X is 8 and Y is 59; X is 8 and Y is 60; X is 8 and Y is61; X is 8 and Y is 62; X is 8 and Y is 63; X is 8 and Y is 64; X is 8and Y is 65; X is 8 and Y is 66; X is 8 and Y is 67; X is 8 and Y is 68;X is 8 and Y is 69; X is 8 and Y is 70; X is 8 and Y is 71; X is 8 and Yis 72; X is 8 and Y is 73; X is 8 and Y is 74; X is 8 and Y is 75; X is8 and Y is 76; X is 8 and Y is 77; X is 8 and Y is 78; X is 8 and Y is79; X is 8 and Y is 80; X is 8 and Y is 81; X is 8 and Y is 82; X is 8and Y is 83; X is 8 and Y is 84; X is 8 and Y is 85; X is 8 and Y is 86;X is 8 and Y is 87; X is 8 and Y is 88; X is 8 and Y is 89; X is 8 and Yis 90; X is 8 and Y is 91; X is 8 and Y is 92; X is 8 and Y is 93; X is8 and Y is 94; X is 8 and Y is 95; X is 8 and Y is 96; X is 8 and Y is97; X is 8 and Y is 98; X is 8 and Y is 99; X is 8 and Y is 100; X is 8and Y is 101; X is 8 and Y is 102; X is 8 and Y is 103; X is 8 and Y is104; X is 8 and Y is 105; X is 8 and Y is 106; X is 8 and Y is 107; X is8 and Y is 108; X is 8 and Y is 109; X is 8 and Y is 110; X is 8 and Yis 111; X is 8 and Y is 112; X is 8 and Y is 113; X is 8 and Y is 114; Xis 8 and Y is 115; X is 8 and Y is 116; X is 8 and Y is 117; X is 8 andY is 118; X is 8 and Y is 119; X is 8 and Y is 120; X is 8 and Y is 121;X is 8 and Y is 122; X is 8 and Y is 123; X is 8 and Y is 124; X is 8and Y is 125; X is 8 and Y is 126; X is 8 and Y is 127; X is 8 and Y is128; X is 8 and Y is 129; X is 8 and Y is 130; X is 8 and Y is 131; X is8 and Y is 132; X is 8 and Y is 133; X is 8 and Y is 134; X is 8 and Yis 135; X is 8 and Y is 136; X is 8 and Y is 137; X is 8 and Y is 138; Xis 8 and Y is 139; X is 8 and Y is 140; X is 8 and Y is 141; X is 8 andY is 142; X is 8 and Y is 143; X is 8 and Y is 144; X is 8 and Y is 145;X is 8 and Y is 146; X is 8 and Y is 147; X is 8 and Y is 148; X is 8and Y is 149; X is 8 and Y is 150; X is 8 and Y is 151; X is 8 and Y is152; X is 8 and Y is 153; X is 8 and Y is 154; X is 8 and Y is 155; X is8 and Y is 156; X is 8 and Y is 157; X is 8 and Y is 158; X is 8 and Yis 159; X is 8 and Y is 160; X is 8 and Y is 161; X is 8 and Y is 162; Xis 8 and Y is 163; X is 8 and Y is 164; X is 8 and Y is 165; X is 8 andY is 166; X is 8 and Y is 167; X is 8 and Y is 168; X is 8 and Y is 169;X is 8 and Y is 170; X is 8 and Y is 171; X is 8 and Y is 172; X is 8and Y is 173; X is 8 and Y is 174; X is 8 and Y is 175; X is 8 and Y is176; X is 8 and Y is 177; X is 8 and Y is 178; X is 8 and Y is 179; X is8 and Y is 180; X is 8 and Y is 181; X is 8 and Y is 182; X is 8 and Yis 183; X is 8 and Y is 184; X is 8 and Y is 185; X is 8 and Y is 186; Xis 9 and Y is 1; X is 9 and Y is 2; X is 9 and Y is 3; X is 9 and Y is4; X is 9 and Y is 5; X is 9 and Y is 6; X is 9 and Y is 7; X is 9 and Yis 8; X is 9 and Y is 9; X is 9 and Y is 10; X is 9 and Y is 11; X is 9and Y is 12; X is 9 and Y is 13; X is 9 and Y is 14; X is 9 and Y is 15;X is 9 and Y is 16; X is 9 and Y is 17; X is 9 and Y is 18; X is 9 and Yis 19; X is 9 and Y is 20; X is 9 and Y is 21; X is 9 and Y is 22; X is9 and Y is 23; X is 9 and Y is 24; X is 9 and Y is 25; X is 9 and Y is26; X is 9 and Y is 27; X is 9 and Y is 28; X is 9 and Y is 29; X is 9and Y is 30; X is 9 and Y is 31; X is 9 and Y is 32; X is 9 and Y is 33;X is 9 and Y is 34; X is 9 and Y is 35; X is 9 and Y is 36; X is 9 and Yis 37; X is 9 and Y is 38; X is 9 and Y is 39; X is 9 and Y is 40; X is9 and Y is 41; X is 9 and Y is 42; X is 9 and Y is 43; X is 9 and Y is44; X is 9 and Y is 45; X is 9 and Y is 46; X is 9 and Y is 47; X is 9and Y is 48; X is 9 and Y is 49; X is 9 and Y is 50; X is 9 and Y is 51;X is 9 and Y is 52; X is 9 and Y is 53; X is 9 and Y is 54; X is 9 and Yis 55; X is 9 and Y is 56; X is 9 and Y is 57; X is 9 and Y is 58; X is9 and Y is 59; X is 9 and Y is 60; X is 9 and Y is 61; X is 9 and Y is62; X is 9 and Y is 63; X is 9 and Y is 64; X is 9 and Y is 65; X is 9and Y is 66; X is 9 and Y is 67; X is 9 and Y is 68; X is 9 and Y is 69;X is 9 and Y is 70; X is 9 and Y is 71; X is 9 and Y is 72; X is 9 and Yis 73; X is 9 and Y is 74; X is 9 and Y is 75; X is 9 and Y is 76; X is9 and Y is 77; X is 9 and Y is 78; X is 9 and Y is 79; X is 9 and Y is80; X is 9 and Y is 81; X is 9 and Y is 82; X is 9 and Y is 83; X is 9and Y is 84; X is 9 and Y is 85; X is 9 and Y is 86; X is 9 and Y is 87;X is 9 and Y is 88; X is 9 and Y is 89; X is 9 and Y is 90; X is 9 and Yis 91; X is 9 and Y is 92; X is 9 and Y is 93; X is 9 and Y is 94; X is9 and Y is 95; X is 9 and Y is 96; X is 9 and Y is 97; X is 9 and Y is98; X is 9 and Y is 99; X is 9 and Y is 100; X is 9 and Y is 101; X is 9and Y is 102; X is 9 and Y is 103; X is 9 and Y is 104; X is 9 and Y is105; X is 9 and Y is 106; X is 9 and Y is 107; X is 9 and Y is 108; X is9 and Y is 109; X is 9 and Y is 110; X is 9 and Y is 111; X is 9 and Yis 112; X is 9 and Y is 113; X is 9 and Y is 114; X is 9 and Y is 115; Xis 9 and Y is 116; X is 9 and Y is 117; X is 9 and Y is 118; X is 9 andY is 119; X is 9 and Y is 120; X is 9 and Y is 121; X is 9 and Y is 122;X is 9 and Y is 123; X is 9 and Y is 124; X is 9 and Y is 125; X is 9and Y is 126; X is 9 and Y is 127; X is 9 and Y is 128; X is 9 and Y is129; X is 9 and Y is 130; X is 9 and Y is 131; X is 9 and Y is 132; X is9 and Y is 133; X is 9 and Y is 134; X is 9 and Y is 135; X is 9 and Yis 136; X is 9 and Y is 137; X is 9 and Y is 138; X is 9 and Y is 139; Xis 9 and Y is 140; X is 9 and Y is 141; X is 9 and Y is 142; X is 9 andY is 143; X is 9 and Y is 144; X is 9 and Y is 145; X is 9 and Y is 146;X is 9 and Y is 147; X is 9 and Y is 148; X is 9 and Y is 149; X is 9and Y is 150; X is 9 and Y is 151; X is 9 and Y is 152; X is 9 and Y is153; X is 9 and Y is 154; X is 9 and Y is 155; X is 9 and Y is 156; X is9 and Y is 157; X is 9 and Y is 158; X is 9 and Y is 159; X is 9 and Yis 160; X is 9 and Y is 161; X is 9 and Y is 162; X is 9 and Y is 163; Xis 9 and Y is 164; X is 9 and Y is 165; X is 9 and Y is 166; X is 9 andY is 167; X is 9 and Y is 168; X is 9 and Y is 169; X is 9 and Y is 170;X is 9 and Y is 171; X is 9 and Y is 172; X is 9 and Y is 173; X is 9and Y is 174; X is 9 and Y is 175; X is 9 and Y is 176; X is 9 and Y is177; X is 9 and Y is 178; X is 9 and Y is 179; X is 9 and Y is 180; X is9 and Y is 181; X is 9 and Y is 182; X is 9 and Y is 183; X is 9 and Yis 184; X is 9 and Y is 185; X is 9 and Y is 186; X is 10 and Y is 1; Xis 10 and Y is 2; X is 10 and Y is 3; X is 10 and Y is 4; X is 10 and Yis 5; X is 10 and Y is 6; X is 10 and Y is 7; X is 10 and Y is 8; X is10 and Y is 9; X is 10 and Y is 10; X is 10 and Y is 11; X is 10 and Yis 12; X is 10 and Y is 13; X is 10 and Y is 14; X is 10 and Y is 15; Xis 10 and Y is 16; X is 10 and Y is 17; X is 10 and Y is 18; X is 10 andY is 19; X is 10 and Y is 20; X is 10 and Y is 21; X is 10 and Y is 22;X is 10 and Y is 23; X is 10 and Y is 24; X is 10 and Y is 25; X is 10and Y is 26; X is 10 and Y is 27; X is 10 and Y is 28; X is 10 and Y is29; X is 10 and Y is 30; X is 10 and Y is 31; X is 10 and Y is 32; X is10 and Y is 33; X is 10 and Y is 34; X is 10 and Y is 35; X is 10 and Yis 36; X is 10 and Y is 37; X is 10 and Y is 38; X is 10 and Y is 39; Xis 10 and Y is 40; X is 10 and Y is 41; X is 10 and Y is 42; X is 10 andY is 43; X is 10 and Y is 44; X is 10 and Y is 45; X is 10 and Y is 46;X is 10 and Y is 47; X is 10 and Y is 48; X is 10 and Y is 49; X is 10and Y is 50; X is 10 and Y is 51; X is 10 and Y is 52; X is 10 and Y is53; X is 10 and Y is 54; X is 10 and Y is 55; X is 10 and Y is 56; X is10 and Y is 57; X is 10 and Y is 58; X is 10 and Y is 59; X is 10 and Yis 60; X is 10 and Y is 61; X is 10 and Y is 62; X is 10 and Y is 63; Xis 10 and Y is 64; X is 10 and Y is 65; X is 10 and Y is 66; X is 10 andY is 67; X is 10 and Y is 68; X is 10 and Y is 69; X is 10 and Y is 70;X is 10 and Y is 71; X is 10 and Y is 72; X is 10 and Y is 73; X is 10and Y is 74; X is 10 and Y is 75; X is 10 and Y is 76; X is 10 and Y is77; X is 10 and Y is 78; X is 10 and Y is 79; X is 10 and Y is 80; X is10 and Y is 81; X is 10 and Y is 82; X is 10 and Y is 83; X is 10 and Yis 84; X is 10 and Y is 85; X is 10 and Y is 86; X is 10 and Y is 87; Xis 10 and Y is 88; X is 10 and Y is 89; X is 10 and Y is 90; X is 10 andY is 91; X is 10 and Y is 92; X is 10 and Y is 93; X is 10 and Y is 94;X is 10 and Y is 95; X is 10 and Y is 96; X is 10 and Y is 97; X is 10and Y is 98; X is 10 and Y is 99; X is 10 and Y is 100; X is 10 and Y is101; X is 10 and Y is 102; X is 10 and Y is 103; X is 10 and Y is 104; Xis 10 and Y is 105; X is 10 and Y is 106; X is 10 and Y is 107; X is 10and Y is 108; X is 10 and Y is 109; X is 10 and Y is 110; X is 10 and Yis 111; X is 10 and Y is 112; X is 10 and Y is 113; X is 10 and Y is114; X is 10 and Y is 115; X is 10 and Y is 116; X is 10 and Y is 117; Xis 10 and Y is 118; X is 10 and Y is 119; X is 10 and Y is 120; X is 10and Y is 121; X is 10 and Y is 122; X is 10 and Y is 123; X is 10 and Yis 124; X is 10 and Y is 125; X is 10 and Y is 126; X is 10 and Y is127; X is 10 and Y is 128; X is 10 and Y is 129; X is 10 and Y is 130; Xis 10 and Y is 131; X is 10 and Y is 132; X is 10 and Y is 133; X is 10and Y is 134; X is 10 and Y is 135; X is 10 and Y is 136; X is 10 and Yis 137; X is 10 and Y is 138; X is 10 and Y is 139; X is 10 and Y is140; X is 10 and Y is 141; X is 10 and Y is 142; X is 10 and Y is 143; Xis 10 and Y is 144; X is 10 and Y is 145; X is 10 and Y is 146; X is 10and Y is 147; X is 10 and Y is 148; X is 10 and Y is 149; X is 10 and Yis 150; X is 10 and Y is 151; X is 10 and Y is 152; X is 10 and Y is153; X is 10 and Y is 154; X is 10 and Y is 155; X is 10 and Y is 156; Xis 10 and Y is 157; X is 10 and Y is 158; X is 10 and Y is 159; X is 10and Y is 160; X is 10 and Y is 161; X is 10 and Y is 162; X is 10 and Yis 163; X is 10 and Y is 164; X is 10 and Y is 165; X is 10 and Y is166; X is 10 and Y is 167; X is 10 and Y is 168; X is 10 and Y is 169; Xis 10 and Y is 170; X is 10 and Y is 171; X is 10 and Y is 172; X is 10and Y is 173; X is 10 and Y is 174; X is 10 and Y is 175; X is 10 and Yis 176; X is 10 and Y is 177; X is 10 and Y is 178; X is 10 and Y is179; X is 10 and Y is 180; X is 10 and Y is 181; X is 10 and Y is 182; Xis 10 and Y is 183; X is 10 and Y is 184; X is 10 and Y is 185; X is 10and Y is 186;X is 11 and Y is 1; X is 11 and Y is 2; X is 11 and Y is 3; X is 11 andY is 4; X is 11 and Y is 5; X is 11 and Y is 6; X is 11 and Y is 7; X is11 and Y is 8; X is 11 and Y is 9; X is 11 and Y is 10; X is 11 and Y is11; X is 11 and Y is 12; X is 11 and Y is 13; X is 11 and Y is 14; X is11 and Y is 15; X is 11 and Y is 16; X is 11 and Y is 17; X is 11 and Yis 18; X is 11 and Y is 19; X is 11 and Y is 20; X is 11 and Y is 21; Xis 11 and Y is 22; X is 11 and Y is 23; X is 11 and Y is 24; X is 11 andY is 25; X is 11 and Y is 26; X is 11 and Y is 27; X is 11 and Y is 28;X is 11 and Y is 29; X is 11 and Y is 30; X is 11 and Y is 31; X is 11and Y is 32; X is 11 and Y is 33; X is 11 and Y is 34; X is 11 and Y is35; X is 11 and Y is 36; X is 11 and Y is 37; X is 11 and Y is 38; X is11 and Y is 39; X is 11 and Y is 40; X is 11 and Y is 41; X is 11 and Yis 42; X is 11 and Y is 43; X is 11 and Y is 44; X is 11 and Y is 45; Xis 11 and Y is 46; X is 11 and Y is 47; X is 11 and Y is 48; X is 11 andY is 49; X is 11 and Y is 50; X is 11 and Y is 51; X is 11 and Y is 52;X is 11 and Y is 53; X is 11 and Y is 54; X is 11 and Y is 55; X is 11and Y is 56; X is 11 and Y is 57; X is 11 and Y is 58; X is 11 and Y is59; X is 11 and Y is 60; X is 11 and Y is 61; X is 11 and Y is 62; X is11 and Y is 63; X is 11 and Y is 64; X is 11 and Y is 65; X is 11 and Yis 66; X is 11 and Y is 67; X is 11 and Y is 68; X is 11 and Y is 69; Xis 11 and Y is 70; X is 11 and Y is 71; X is 11 and Y is 72; X is 11 andY is 73; X is 11 and Y is 74; X is 11 and Y is 75; X is 11 and Y is 76;X is 11 and Y is 77; X is 11 and Y is 78; X is 11 and Y is 79; X is 11and Y is 80; X is 11 and Y is 81; X is 11 and Y is 82; X is 11 and Y is83; X is 11 and Y is 84; X is 11 and Y is 85; X is 11 and Y is 86; X is11 and Y is 87; X is 11 and Y is 88; X is 11 and Y is 89; X is 11 and Yis 90; X is 11 and Y is 91; X is 11 and Y is 92; X is 11 and Y is 93; Xis 11 and Y is 94; X is 11 and Y is 95; X is 11 and Y is 96; X is 11 andY is 97; X is 11 and Y is 98; X is 11 and Y is 99; X is 11 and Y is 100;X is 11 and Y is 101; X is 11 and Y is 102; X is 11 and Y is 103; X is11 and Y is 104; X is 11 and Y is 105; X is 11 and Y is 106; X is 11 andY is 107; X is 11 and Y is 108; X is 11 and Y is 109; X is 11 and Y is110; X is 11 and Y is 111; X is 11 and Y is 112; X is 11 and Y is 113; Xis 11 and Y is 114; X is 11 and Y is 115; X is 11 and Y is 116; X is 11and Y is 117; X is 11 and Y is 118; X is 11 and Y is 119; X is 11 and Yis 120; X is 11 and Y is 121; X is 11 and Y is 122; X is 11 and Y is123; X is 11 and Y is 124; X is 11 and Y is 125; X is 11 and Y is 126; Xis 11 and Y is 127; X is 11 and Y is 128; X is 11 and Y is 129; X is 11and Y is 130; X is 11 and Y is 131; X is 11 and Y is 132; X is 11 and Yis 133; X is 11 and Y is 134; X is 11 and Y is 135; X is 11 and Y is136; X is 11 and Y is 137; X is 11 and Y is 138; X is 11 and Y is 139; Xis 11 and Y is 140; X is 11 and Y is 141; X is 11 and Y is 142; X is 11and Y is 143; X is 11 and Y is 144; X is 11 and Y is 145; X is 11 and Yis 146; X is 11 and Y is 147; X is 11 and Y is 148; X is 11 and Y is149; X is 11 and Y is 150; X is 11 and Y is 151; X is 11 and Y is 152; Xis 11 and Y is 153; X is 11 and Y is 154; X is 11 and Y is 155; X is 11and Y is 156; X is 11 and Y is 157; X is 11 and Y is 158; X is 11 and Yis 159; X is 11 and Y is 160; X is 11 and Y is 161; X is 11 and Y is162; X is 11 and Y is 163; X is 11 and Y is 164; X is 11 and Y is 165; Xis 11 and Y is 166; X is 11 and Y is 167; X is 11 and Y is 168; X is 11and Y is 169; X is 11 and Y is 170; X is 11 and Y is 171; X is 11 and Yis 172; X is 11 and Y is 173; X is 11 and Y is 174; X is 11 and Y is175; X is 11 and Y is 176; X is 11 and Y is 177; X is 11 and Y is 178; Xis 11 and Y is 179; X is 11 and Y is 180; X is 11 and Y is 181; X is 11and Y is 182; X is 11 and Y is 183; X is 11 and Y is 184; X is 11 and Yis 185; X is 11 and Y is 186;X is 12 and Y is 1; X is 12 and Y is 2; X is 12 and Y is 3; X is 12 andY is 4; X is 12 and Y is 5; X is 12 and Y is 6; X is 12 and Y is 7; X is12 and Y is 8; X is 12 and Y is 9; X is 12 and Y is 10; X is 12 and Y is11; X is 12 and Y is 12; X is 12 and Y is 13; X is 12 and Y is 14; X is12 and Y is 15; X is 12 and Y is 16; X is 12 and Y is 17; X is 12 and Yis 18; X is 12 and Y is 19; X is 12 and Y is 20; X is 12 and Y is 21; Xis 12 and Y is 22; X is 12 and Y is 23; X is 12 and Y is 24; X is 12 andY is 25; X is 12 and Y is 26; X is 12 and Y is 27; X is 12 and Y is 28;X is 12 and Y is 29; X is 12 and Y is 30; X is 12 and Y is 31; X is 12and Y is 32; X is 12 and Y is 33; X is 12 and Y is 34; X is 12 and Y is35; X is 12 and Y is 36; X is 12 and Y is 37; X is 12 and Y is 38; X is12 and Y is 39; X is 12 and Y is 40; X is 12 and Y is 41; X is 12 and Yis 42; X is 12 and Y is 43; X is 12 and Y is 44; X is 12 and Y is 45; Xis 12 and Y is 46; X is 12 and Y is 47; X is 12 and Y is 48; X is 12 andY is 49; X is 12 and Y is 50; X is 12 and Y is 51; X is 12 and Y is 52;X is 12 and Y is 53; X is 12 and Y is 54; X is 12 and Y is 55; X is 12and Y is 56; X is 12 and Y is 57; X is 12 and Y is 58; X is 12 and Y is59; X is 12 and Y is 60; X is 12 and Y is 61; X is 12 and Y is 62; X is12 and Y is 63; X is 12 and Y is 64; X is 12 and Y is 65; X is 12 and Yis 66; X is 12 and Y is 67; X is 12 and Y is 68; X is 12 and Y is 69; Xis 12 and Y is 70; X is 12 and Y is 71; X is 12 and Y is 72; X is 12 andY is 73; X is 12 and Y is 74; X is 12 and Y is 75; X is 12 and Y is 76;X is 12 and Y is 77; X is 12 and Y is 78; X is 12 and Y is 79; X is 12and Y is 80; X is 12 and Y is 81; X is 12 and Y is 82; X is 12 and Y is83; X is 12 and Y is 84; X is 12 and Y is 85; X is 12 and Y is 86; X is12 and Y is 87; X is 12 and Y is 88; X is 12 and Y is 89; X is 12 and Yis 90; X is 12 and Y is 91; X is 12 and Y is 92; X is 12 and Y is 93; Xis 12 and Y is 94; X is 12 and Y is 95; X is 12 and Y is 96; X is 12 andY is 97; X is 12 and Y is 98; X is 12 and Y is 99; X is 12 and Y is 100;X is 12 and Y is 101; X is 12 and Y is 102; X is 12 and Y is 103; X is12 and Y is 104; X is 12 and Y is 105; X is 12 and Y is 106; X is 12 andY is 107; X is 12 and Y is 108; X is 12 and Y is 109; X is 12 and Y is110; X is 12 and Y is 111; X is 12 and Y is 112; X is 12 and Y is 113; Xis 12 and Y is 114; X is 12 and Y is 115; X is 12 and Y is 116; X is 12and Y is 117; X is 12 and Y is 118; X is 12 and Y is 119; X is 12 and Yis 120; X is 12 and Y is 121; X is 12 and Y is 122; X is 12 and Y is123; X is 12 and Y is 124; X is 12 and Y is 125; X is 12 and Y is 126; Xis 12 and Y is 127; X is 12 and Y is 128; X is 12 and Y is 129; X is 12and Y is 130; X is 12 and Y is 131; X is 12 and Y is 132; X is 12 and Yis 133; X is 12 and Y is 134; X is 12 and Y is 135; X is 12 and Y is136; X is 12 and Y is 137; X is 12 and Y is 138; X is 12 and Y is 139; Xis 12 and Y is 140; X is 12 and Y is 141; X is 12 and Y is 142; X is 12and Y is 143; X is 12 and Y is 144; X is 12 and Y is 145; X is 12 and Yis 146; X is 12 and Y is 147; X is 12 and Y is 148; X is 12 and Y is149; X is 12 and Y is 150; X is 12 and Y is 151; X is 12 and Y is 152; Xis 12 and Y is 153; X is 12 and Y is 154; X is 12 and Y is 155; X is 12and Y is 156; X is 12 and Y is 157; X is 12 and Y is 158; X is 12 and Yis 159; X is 12 and Y is 160; X is 12 and Y is 161; X is 12 and Y is162; X is 12 and Y is 163; X is 12 and Y is 164; X is 12 and Y is 165; Xis 12 and Y is 166; X is 12 and Y is 167; X is 12 and Y is 168; X is 12and Y is 169; X is 12 and Y is 170; X is 12 and Y is 171; X is 12 and Yis 172; X is 12 and Y is 173; X is 12 and Y is 174; X is 12 and Y is175; X is 12 and Y is 176; X is 12 and Y is 177; X is 12 and Y is 178; Xis 12 and Y is 179; X is 12 and Y is 180; X is 12 and Y is 181; X is 12and Y is 182; X is 12 and Y is 183; X is 12 and Y is 184; X is 12 and Yis 185; X is 12 and Y is 186;X is 13 and Y is 1; X is 13 and Y is 2; X is 13 and Y is 3; X is 13 andY is 4; X is 13 and Y is 5; X is 13 and Y is 6; X is 13 and Y is 7; X is13 and Y is 8; X is 13 and Y is 9; X is 13 and Y is 10; X is 13 and Y is11; X is 13 and Y is 12; X is 13 and Y is 13; X is 13 and Y is 14; X is13 and Y is 15; X is 13 and Y is 16; X is 13 and Y is 17; X is 13 and Yis 18; X is 13 and Y is 19; X is 13 and Y is 20; X is 13 and Y is 21; Xis 13 and Y is 22; X is 13 and Y is 23; X is 13 and Y is 24; X is 13 andY is 25; X is 13 and Y is 26; X is 13 and Y is 27; X is 13 and Y is 28;X is 13 and Y is 29; X is 13 and Y is 30; X is 13 and Y is 31; X is 13and Y is 32; X is 13 and Y is 33; X is 13 and Y is 34; X is 13 and Y is35; X is 13 and Y is 36; X is 13 and Y is 37; X is 13 and Y is 38; X is13 and Y is 39; X is 13 and Y is 40; X is 13 and Y is 41; X is 13 and Yis 42; X is 13 and Y is 43; X is 13 and Y is 44; X is 13 and Y is 45; Xis 13 and Y is 46; X is 13 and Y is 47; X is 13 and Y is 48; X is 13 andY is 49; X is 13 and Y is 50; X is 13 and Y is 51; X is 13 and Y is 52;X is 13 and Y is 53; X is 13 and Y is 54; X is 13 and Y is 55; X is 13and Y is 56; X is 13 and Y is 57; X is 13 and Y is 58; X is 13 and Y is59; X is 13 and Y is 60; X is 13 and Y is 61; X is 13 and Y is 62; X is13 and Y is 63; X is 13 and Y is 64; X is 13 and Y is 65; X is 13 and Yis 66; X is 13 and Y is 67; X is 13 and Y is 68; X is 13 and Y is 69; Xis 13 and Y is 70; X is 13 and Y is 71; X is 13 and Y is 72; X is 13 andY is 73; X is 13 and Y is 74; X is 13 and Y is 75; X is 13 and Y is 76;X is 13 and Y is 77; X is 13 and Y is 78; X is 13 and Y is 79; X is 13and Y is 80; X is 13 and Y is 81; X is 13 and Y is 82; X is 13 and Y is83; X is 13 and Y is 84; X is 13 and Y is 85; X is 13 and Y is 86; X is13 and Y is 87; X is 13 and Y is 88; X is 13 and Y is 89; X is 13 and Yis 90; X is 13 and Y is 91; X is 13 and Y is 92; X is 13 and Y is 93; Xis 13 and Y is 94; X is 13 and Y is 95; X is 13 and Y is 96; X is 13 andY is 97; X is 13 and Y is 98; X is 13 and Y is 99; X is 13 and Y is 100;X is 13 and Y is 101; X is 13 and Y is 102; X is 13 and Y is 103; X is13 and Y is 104; X is 13 and Y is 105; X is 13 and Y is 106; X is 13 andY is 107; X is 13 and Y is 108; X is 13 and Y is 109; X is 13 and Y is110;X is 13 and Y is 111; X is 13 and Y is 112; X is 13 and Y is 113; X is13 and Y is 114; X is 13 and Y is 115; X is 13 and Y is 116; X is 13 andY is 117; X is 13 and Y is 118; X is 13 and Y is 119; X is 13 and Y is120; X is 13 and Y is 121; X is 13 and Y is 122; X is 13 and Y is 123; Xis 13 and Y is 124; X is 13 and Y is 125; X is 13 and Y is 126; X is 13and Y is 127; X is 13 and Y is 128; X is 13 and Y is 129; X is 13 and Yis 130; X is 13 and Y is 131; X is 13 and Y is 132; X is 13 and Y is133; X is 13 and Y is 134; X is 13 and Y is 135; X is 13 and Y is 136; Xis 13 and Y is 137; X is 13 and Y is 138; X is 13 and Y is 139; X is 13and Y is 140; X is 13 and Y is 141; X is 13 and Y is 142; X is 13 and Yis 143; X is 13 and Y is 144; X is 13 and Y is 145; X is 13 and Y is146; X is 13 and Y is 147; X is 13 and Y is 148; X is 13 and Y is 149; Xis 13 and Y is 150; X is 13 and Y is 151; X is 13 and Y is 152; X is 13and Y is 153; X is 13 and Y is 154; X is 13 and Y is 155; X is 13 and Yis 156; X is 13 and Y is 157; X is 13 and Y is 158; X is 13 and Y is159; X is 13 and Y is 160; X is 13 and Y is 161; X is 13 and Y is 162; Xis 13 and Y is 163; X is 13 and Y is 164; X is 13 and Y is 165; X is 13and Y is 166; X is 13 and Y is 167; X is 13 and Y is 168; X is 13 and Yis 169; X is 13 and Y is 170; X is 13 and Y is 171; X is 13 and Y is172; X is 13 and Y is 173; X is 13 and Y is 174; X is 13 and Y is 175; Xis 13 and Y is 176; X is 13 and Y is 177; X is 13 and Y is 178; X is 13and Y is 179; X is 13 and Y is 180; X is 13 and Y is 181; X is 13 and Yis 182; X is 13 and Y is 183; X is 13 and Y is 184; X is 13 and Y is185; X is 13 and Y is 186;X is 14 and Y is 1; X is 14 and Y is 2; X is 14 and Y is 3; X is 14 andY is 4; X is 14 and Y is 5; X is 14 and Y is 6; X is 14 and Y is 7; X is14 and Y is 8; X is 14 and Y is 9; X is 14 and Y is 10; X is 14 and Y is11; X is 14 and Y is 12; X is 14 and Y is 13; X is 14 and Y is 14; X is14 and Y is 15; X is 14 and Y is 16; X is 14 and Y is 17; X is 14 and Yis 18; X is 14 and Y is 19; X is 14 and Y is 20; X is 14 and Y is 21; Xis 14 and Y is 22; X is 14 and Y is 23; X is 14 and Y is 24; X is 14 andY is 25; X is 14 and Y is 26; X is 14 and Y is 27; X is 14 and Y is 28;X is 14 and Y is 29; X is 14 and Y is 30; X is 14 and Y is 31; X is 14and Y is 32; X is 14 and Y is 33; X is 14 and Y is 34; X is 14 and Y is35; X is 14 and Y is 36; X is 14 and Y is 37; X is 14 and Y is 38; X is14 and Y is 39; X is 14 and Y is 40; X is 14 and Y is 41; X is 14 and Yis 42; X is 14 and Y is 43; X is 14 and Y is 44; X is 14 and Y is 45; Xis 14 and Y is 46; X is 14 and Y is 47; X is 14 and Y is 48; X is 14 andY is 49; X is 14 and Y is 50; X is 14 and Y is 51; X is 14 and Y is 52;X is 14 and Y is 53; X is 14 and Y is 54; X is 14 and Y is 55; X is 14and Y is 56; X is 14 and Y is 57; X is 14 and Y is 58; X is 14 and Y is59; X is 14 and Y is 60; X is 14 and Y is 61; X is 14 and Y is 62; X is14 and Y is 63; X is 14 and Y is 64; X is 14 and Y is 65; X is 14 and Yis 66; X is 14 and Y is 67; X is 14 and Y is 68; X is 14 and Y is 69; Xis 14 and Y is 70; X is 14 and Y is 71; X is 14 and Y is 72; X is 14 andY is 73; X is 14 and Y is 74; X is 14 and Y is 75; X is 14 and Y is 76;X is 14 and Y is 77; X is 14 and Y is 78; X is 14 and Y is 79; X is 14and Y is 80; X is 14 and Y is 81; X is 14 and Y is 82; X is 14 and Y is83; X is 14 and Y is 84; X is 14 and Y is 85; X is 14 and Y is 86; X is14 and Y is 87; X is 14 and Y is 88; X is 14 and Y is 89; X is 14 and Yis 90; X is 14 and Y is 91; X is 14 and Y is 92; X is 14 and Y is 93; Xis 14 and Y is 94; X is 14 and Y is 95; X is 14 and Y is 96; X is 14 andY is 97; X is 14 and Y is 98; X is 14 and Y is 99; X is 14 and Y is 100;X is 14 and Y is 101; X is 14 and Y is 102; X is 14 and Y is 103; X is14 and Y is 104; X is 14 and Y is 105; X is 14 and Y is 106; X is 14 andY is 107; X is 14 and Y is 108; X is 14 and Y is 109; X is 14 and Y is110; X is 14 and Y is 111; X is 14 and Y is 112; X is 14 and Y is 113; Xis 14 and Y is 114; X is 14 and Y is 115; X is 14 and Y is 116; X is 14and Y is 117; X is 14 and Y is 118; X is 14 and Y is 119; X is 14 and Yis 120; X is 14 and Y is 121; X is 14 and Y is 122; X is 14 and Y is123; X is 14 and Y is 124; X is 14 and Y is 125; X is 14 and Y is 126; Xis 14 and Y is 127; X is 14 and Y is 128; X is 14 and Y is 129; X is 14and Y is 130; X is 14 and Y is 131; X is 14 and Y is 132; X is 14 and Yis 133; X is 14 and Y is 134; X is 14 and Y is 135; X is 14 and Y is136; X is 14 and Y is 137; X is 14 and Y is 138; X is 14 and Y is 139; Xis 14 and Y is 140; X is 14 and Y is 141; X is 14 and Y is 142; X is 14and Y is 143; X is 14 and Y is 144; X is 14 and Y is 145; X is 14 and Yis 146; X is 14 and Y is 147; X is 14 and Y is 148; X is 14 and Y is149; X is 14 and Y is 150; X is 14 and Y is 151; X is 14 and Y is 152; Xis 14 and Y is 153; X is 14 and Y is 154; X is 14 and Y is 155; X is 14and Y is 156; X is 14 and Y is 157; X is 14 and Y is 158; X is 14 and Yis 159; X is 14 and Y is 160; X is 14 and Y is 161; X is 14 and Y is162; X is 14 and Y is 163; X is 14 and Y is 164; X is 14 and Y is 165; Xis 14 and Y is 166; X is 14 and Y is 167; X is 14 and Y is 168; X is 14and Y is 169; X is 14 and Y is 170; X is 14 and Y is 171; X is 14 and Yis 172; X is 14 and Y is 173; X is 14 and Y is 174; X is 14 and Y is175; X is 14 and Y is 176; X is 14 and Y is 177; X is 14 and Y is 178; Xis 14 and Y is 179; X is 14 and Y is 180; X is 14 and Y is 181; X is 14and Y is 182; X is 14 and Y is 183; X is 14 and Y is 184; X is 14 and Yis 185; X is 14 and Y is 186;X is 15 and Y is 1; X is 15 and Y is 2; X is 15 and Y is 3; X is 15 andY is 4; X is 15 and Y is 5; X is 15 and Y is 6; X is 15 and Y is 7; X is15 and Y is 8; X is 15 and Y is 9; X is 15 and Y is 10; X is 15 and Y is11; X is 15 and Y is 12; X is 15 and Y is 13; X is 15 and Y is 14; X is15 and Y is 15; X is 15 and Y is 16; X is 15 and Y is 17; X is 15 and Yis 18; X is 15 and Y is 19; X is 15 and Y is 20; X is 15 and Y is 21; Xis 15 and Y is 22; X is 15 and Y is 23; X is 15 and Y is 24; X is 15 andY is 25; X is 15 and Y is 26; X is 15 and Y is 27; X is 15 and Y is 28;X is 15 and Y is 29; X is 15 and Y is 30; X is 15 and Y is 31; X is 15and Y is 32; X is 15 and Y is 33; X is 15 and Y is 34; X is 15 and Y is35; X is 15 and Y is 36; X is 15 and Y is 37; X is 15 and Y is 38; X is15 and Y is 39; X is 15 and Y is 40; X is 15 and Y is 41; X is 15 and Yis 42; X is 15 and Y is 43; X is 15 and Y is 44; X is 15 and Y is 45; Xis 15 and Y is 46; X is 15 and Y is 47; X is 15 and Y is 48; X is 15 andY is 49; X is 15 and Y is 50; X is 15 and Y is 51; X is 15 and Y is 52;X is 15 and Y is 53; X is 15 and Y is 54; X is 15 and Y is 55; X is 15and Y is 56; X is 15 and Y is 57; X is 15 and Y is 58; X is 15 and Y is59; X is 15 and Y is 60; X is 15 and Y is 61; X is 15 and Y is 62; X is15 and Y is 63; X is 15 and Y is 64; X is 15 and Y is 65; X is 15 and Yis 66; X is 15 and Y is 67; X is 15 and Y is 68; X is 15 and Y is 69; Xis 15 and Y is 70; X is 15 and Y is 71; X is 15 and Y is 72; X is 15 andY is 73; X is 15 and Y is 74; X is 15 and Y is 75; X is 15 and Y is 76;X is 15 and Y is 77; X is 15 and Y is 78; X is 15 and Y is 79; X is 15and Y is 80; X is 15 and Y is 81; X is 15 and Y is 82; X is 15 and Y is83; X is 15 and Y is 84; X is 15 and Y is 85; X is 15 and Y is 86; X is15 and Y is 87; X is 15 and Y is 88; X is 15 and Y is 89; X is 15 and Yis 90; X is 15 and Y is 91; X is 15 and Y is 92; X is 15 and Y is 93; Xis 15 and Y is 94; X is 15 and Y is 95; X is 15 and Y is 96; X is 15 andY is 97; X is 15 and Y is 98; X is 15 and Y is 99; X is 15 and Y is 100;X is 15 and Y is 101; X is 15 and Y is 102; X is 15 and Y is 103; X is15 and Y is 104; X is 15 and Y is 105; X is 15 and Y is 106; X is 15 andY is 107; X is 15 and Y is 108; X is 15 and Y is 109; X is 15 and Y is110; X is 15 and Y is 111; X is 15 and Y is 112; X is 15 and Y is 113; Xis 15 and Y is 114; X is 15 and Y is 115; X is 15 and Y is 116; X is 15and Y is 117; X is 15 and Y is 118; X is 15 and Y is 119; X is 15 and Yis 120; X is 15 and Y is 121; X is 15 and Y is 122; X is 15 and Y is123; X is 15 and Y is 124; X is 15 and Y is 125; X is 15 and Y is 126; Xis 15 and Y is 127; X is 15 and Y is 128; X is 15 and Y is 129; X is 15and Y is 130; X is 15 and Y is 131; X is 15 and Y is 132; X is 15 and Yis 133; X is 15 and Y is 134; X is 15 and Y is 135; X is 15 and Y is136; X is 15 and Y is 137; X is 15 and Y is 138; X is 15 and Y is 139; Xis 15 and Y is 140; X is 15 and Y is 141; X is 15 and Y is 142; X is 15and Y is 143; X is 15 and Y is 144; X is 15 and Y is 145; X is 15 and Yis 146; X is 15 and Y is 147; X is 15 and Y is 148; X is 15 and Y is149; X is 15 and Y is 150; X is 15 and Y is 151; X is 15 and Y is 152; Xis 15 and Y is 153; X is 15 and Y is 154; X is 15 and Y is 155; X is 15and Y is 156; X is 15 and Y is 157; X is 15 and Y is 158; X is 15 and Yis 159; X is 15 and Y is 160; X is 15 and Y is 161; X is 15 and Y is162; X is 15 and Y is 163; X is 15 and Y is 164; X is 15 and Y is 165; Xis 15 and Y is 166; X is 15 and Y is 167; X is 15 and Y is 168; X is 15and Y is 169; X is 15 and Y is 170; X is 15 and Y is 171; X is 15 and Yis 172; X is 15 and Y is 173; X is 15 and Y is 174; X is 15 and Y is175; X is 15 and Y is 176; X is 15 and Y is 177; X is 15 and Y is 178; Xis 15 and Y is 179; X is 15 and Y is 180; X is 15 and Y is 181; X is 15and Y is 182; X is 15 and Y is 183; X is 15 and Y is 184; X is 15 and Yis 185; X is 15 and Y is 186;X is 16 and Y is 1; X is 16 and Y is 2; X is 16 and Y is 3; X is 16 andY is 4; X is 16 and Y is 5; X is 16 and Y is 6; X is 16 and Y is 7; X is16 and Y is 8; X is 16 and Y is 9; X is 16 and Y is 10; X is 16 and Y is11; X is 16 and Y is 12; X is 16 and Y is 13; X is 16 and Y is 14; X is16 and Y is 15; X is 16 and Y is 16; X is 16 and Y is 17; X is 16 and Yis 18; X is 16 and Y is 19; X is 16 and Y is 20; X is 16 and Y is 21; Xis 16 and Y is 22; X is 16 and Y is 23; X is 16 and Y is 24; X is 16 andY is 25; X is 16 and Y is 26; X is 16 and Y is 27; X is 16 and Y is 28;X is 16 and Y is 29; X is 16 and Y is 30; X is 16 and Y is 31; X is 16and Y is 32; X is 16 and Y is 33; X is 16 and Y is 34; X is 16 and Y is35; X is 16 and Y is 36; X is 16 and Y is 37; X is 16 and Y is 38; X is16 and Y is 39; X is 16 and Y is 40; X is 16 and Y is 41; X is 16 and Yis 42; X is 16 and Y is 43; X is 16 and Y is 44; X is 16 and Y is 45; Xis 16 and Y is 46; X is 16 and Y is 47; X is 16 and Y is 48; X is 16 andY is 49; X is 16 and Y is 50; X is 16 and Y is 51; X is 16 and Y is 52;X is 16 and Y is 53; X is 16 and Y is 54; X is 16 and Y is 55; X is 16and Y is 56; X is 16 and Y is 57; X is 16 and Y is 58; X is 16 and Y is59; X is 16 and Y is 60; X is 16 and Y is 61; X is 16 and Y is 62; X is16 and Y is 63; X is 16 and Y is 64; X is 16 and Y is 65; X is 16 and Yis 66; X is 16 and Y is 67; X is 16 and Y is 68; X is 16 and Y is 69; Xis 16 and Y is 70; X is 16 and Y is 71; X is 16 and Y is 72; X is 16 andY is 73; X is 16 and Y is 74; X is 16 and Y is 75; X is 16 and Y is 76;X is 16 and Y is 77; X is 16 and Y is 78; X is 16 and Y is 79; X is 16and Y is 80; X is 16 and Y is 81; X is 16 and Y is 82; X is 16 and Y is83; X is 16 and Y is 84; X is 16 and Y is 85; X is 16 and Y is 86; X is16 and Y is 87; X is 16 and Y is 88; X is 16 and Y is 89; X is 16 and Yis 90; X is 16 and Y is 91; X is 16 and Y is 92; X is 16 and Y is 93; Xis 16 and Y is 94; X is 16 and Y is 95; X is 16 and Y is 96; X is 16 andY is 97; X is 16 and Y is 98; X is 16 and Y is 99; X is 16 and Y is 100;X is 16 and Y is 101; X is 16 and Y is 102; X is 16 and Y is 103; X is16 and Y is 104; X is 16 and Y is 105; X is 16 and Y is 106; X is 16 andY is 107; X is 16 and Y is 108; X is 16 and Y is 109; X is 16 and Y is110; X is 16 and Y is 111; X is 16 and Y is 112; X is 16 and Y is 113; Xis 16 and Y is 114; X is 16 and Y is 115; X is 16 and Y is 116; X is 16and Y is 117; X is 16 and Y is 118; X is 16 and Y is 119; X is 16 and Yis 120; X is 16 and Y is 121; X is 16 and Y is 122; X is 16 and Y is123; X is 16 and Y is 124; X is 16 and Y is 125; X is 16 and Y is 126; Xis 16 and Y is 127; X is 16 and Y is 128; X is 16 and Y is 129; X is 16and Y is 130; X is 16 and Y is 131; X is 16 and Y is 132; X is 16 and Yis 133; X is 16 and Y is 134; X is 16 and Y is 135; X is 16 and Y is136; X is 16 and Y is 137; X is 16 and Y is 138; X is 16 and Y is 139; Xis 16 and Y is 140; X is 16 and Y is 141; X is 16 and Y is 142; X is 16and Y is 143; X is 16 and Y is 144; X is 16 and Y is 145; X is 16 and Yis 146; X is 16 and Y is 147; X is 16 and Y is 148; X is 16 and Y is149; X is 16 and Y is 150; X is 16 and Y is 151; X is 16 and Y is 152; Xis 16 and Y is 153; X is 16 and Y is 154; X is 16 and Y is 155; X is 16and Y is 156; X is 16 and Y is 157; X is 16 and Y is 158; X is 16 and Yis 159; X is 16 and Y is 160; X is 16 and Y is 161; X is 16 and Y is162; X is 16 and Y is 163; X is 16 and Y is 164; X is 16 and Y is 165; Xis 16 and Y is 166; X is 16 and Y is 167; X is 16 and Y is 168; X is 16and Y is 169; X is 16 and Y is 170; X is 16 and Y is 171; X is 16 and Yis 172; X is 16 and Y is 173; X is 16 and Y is 174; X is 16 and Y is175; X is 16 and Y is 176; X is 16 and Y is 177; X is 16 and Y is 178; Xis 16 and Y is 179; X is 16 and Y is 180; X is 16 and Y is 181; X is 16and Y is 182; X is 16 and Y is 183; X is 16 and Y is 184; X is 16 and Yis 185; X is 16 and Y is 186;X is 17 and Y is 1; X is 17 and Y is 2; X is 17 and Y is 3; X is 17 andY is 4; X is 17 and Y is 5; X is 17 and Y is 6; X is 17 and Y is 7; X is17 and Y is 8; X is 17 and Y is 9; X is 17 and Y is 10; X is 17 and Y is11; X is 17 and Y is 12; X is 17 and Y is 13; X is 17 and Y is 14; X is17 and Y is 15; X is 17 and Y is 16; X is 17 and Y is 17; X is 17 and Yis 18; X is 17 and Y is 19; X is 17 and Y is 20; X is 17 and Y is 21; Xis 17 and Y is 22; X is 17 and Y is 23; X is 17 and Y is 24; X is 17 andY is 25; X is 17 and Y is 26; X is 17 and Y is 27; X is 17 and Y is 28;X is 17 and Y is 29; X is 17 and Y is 30; X is 17 and Y is 31; X is 17and Y is 32; X is 17 and Y is 33; X is 17 and Y is 34; X is 17 and Y is35; X is 17 and Y is 36; X is 17 and Y is 37; X is 17 and Y is 38; X is17 and Y is 39; X is 17 and Y is 40; X is 17 and Y is 41; X is 17 and Yis 42; X is 17 and Y is 43; X is 17 and Y is 44; X is 17 and Y is 45; Xis 17 and Y is 46; X is 17 and Y is 47; X is 17 and Y is 48; X is 17 andY is 49; X is 17 and Y is 50; X is 17 and Y is 51; X is 17 and Y is 52;X is 17 and Y is 53; X is 17 and Y is 54; X is 17 and Y is 55; X is 17and Y is 56; X is 17 and Y is 57; X is 17 and Y is 58; X is 17 and Y is59; X is 17 and Y is 60; X is 17 and Y is 61; X is 17 and Y is 62; X is17 and Y is 63; X is 17 and Y is 64; X is 17 and Y is 65; X is 17 and Yis 66; X is 17 and Y is 67; X is 17 and Y is 68; X is 17 and Y is 69; Xis 17 and Y is 70; X is 17 and Y is 71; X is 17 and Y is 72; X is 17 andY is 73; X is 17 and Y is 74; X is 17 and Y is 75; X is 17 and Y is 76;X is 17 and Y is 77; X is 17 and Y is 78; X is 17 and Y is 79; X is 17and Y is 80; X is 17 and Y is 81; X is 17 and Y is 82; X is 17 and Y is83; X is 17 and Y is 84; X is 17 and Y is 85; X is 17 and Y is 86; X is17 and Y is 87; X is 17 and Y is 88; X is 17 and Y is 89; X is 17 and Yis 90; X is 17 and Y is 91; X is 17 and Y is 92; X is 17 and Y is 93; Xis 17 and Y is 94; X is 17 and Y is 95; X is 17 and Y is 96; X is 17 andY is 97; X is 17 and Y is 98; X is 17 and Y is 99; X is 17 and Y is 100;X is 17 and Y is 101; X is 17 and Y is 102; X is 17 and Y is 103; X is17 and Y is 104; X is 17 and Y is 105; X is 17 and Y is 106; X is 17 andY is 107; X is 17 and Y is 108; X is 17 and Y is 109; X is 17 and Y is110; X is 17 and Y is 111; X is 17 and Y is 112; X is 17 and Y is 113; Xis 17 and Y is 114; X is 17 and Y is 115; X is 17 and Y is 116; X is 17and Y is 117; X is 17 and Y is 118; X is 17 and Y is 119; X is 17 and Yis 120; X is 17 and Y is 121; X is 17 and Y is 122; X is 17 and Y is123; X is 17 and Y is 124; X is 17 and Y is 125; X is 17 and Y is 126; Xis 17 and Y is 127; X is 17 and Y is 128; X is 17 and Y is 129; X is 17and Y is 130; X is 17 and Y is 131; X is 17 and Y is 132; X is 17 and Yis 133; X is 17 and Y is 134; X is 17 and Y is 135; X is 17 and Y is136; X is 17 and Y is 137; X is 17 and Y is 138; X is 17 and Y is 139; Xis 17 and Y is 140; X is 17 and Y is 141; X is 17 and Y is 142; X is 17and Y is 143; X is 17 and Y is 144; X is 17 and Y is 145; X is 17 and Yis 146; X is 17 and Y is 147; X is 17 and Y is 148; X is 17 and Y is149; X is 17 and Y is 150; X is 17 and Y is 151; X is 17 and Y is 152; Xis 17 and Y is 153; X is 17 and Y is 154; X is 17 and Y is 155; X is 17and Y is 156; X is 17 and Y is 157; X is 17 and Y is 158; X is 17 and Yis 159; X is 17 and Y is 160; X is 17 and Y is 161; X is 17 and Y is162; X is 17 and Y is 163; X is 17 and Y is 164; X is 17 and Y is 165; Xis 17 and Y is 166; X is 17 and Y is 167; X is 17 and Y is 168; X is 17and Y is 169; X is 17 and Y is 170; X is 17 and Y is 171; X is 17 and Yis 172; X is 17 and Y is 173; X is 17 and Y is 174; X is 17 and Y is175; X is 17 and Y is 176; X is 17 and Y is 177; X is 17 and Y is 178; Xis 17 and Y is 179; X is 17 and Y is 180; X is 17 and Y is 181; X is 17and Y is 182; X is 17 and Y is 183; X is 17 and Y is 184; X is 17 and Yis 185; X is 17 and Y is 186;X is 18 and Y is 1; X is 18 and Y is 2; X is 18 and Y is 3; X is 18 andY is 4; X is 18 and Y is 5; X is 18 and Y is 6; X is 18 and Y is 7; X is18 and Y is 8; X is 18 and Y is 9; X is 18 and Y is 10; X is 18 and Y is11; X is 18 and Y is 12; X is 18 and Y is 13; X is 18 and Y is 14; X is18 and Y is 15; X is 18 and Y is 16; X is 18 and Y is 17; X is 18 and Yis 18; X is 18 and Y is 19; X is 18 and Y is 20; X is 18 and Y is 21; Xis 18 and Y is 22; X is 18 and Y is 23; X is 18 and Y is 24; X is 18 andY is 25; X is 18 and Y is 26; X is 18 and Y is 27; X is 18 and Y is 28;X is 18 and Y is 29; X is 18 and Y is 30; X is 18 and Y is 31; X is 18and Y is 32; X is 18 and Y is 33; X is 18 and Y is 34; X is 18 and Y is35; X is 18 and Y is 36; X is 18 and Y is 37; X is 18 and Y is 38; X is18 and Y is 39; X is 18 and Y is 40; X is 18 and Y is 41; X is 18 and Yis 42; X is 18 and Y is 43; X is 18 and Y is 44; X is 18 and Y is 45; Xis 18 and Y is 46; X is 18 and Y is 47; X is 18 and Y is 48; X is 18 andY is 49; X is 18 and Y is 50; X is 18 and Y is 51; X is 18 and Y is 52;X is 18 and Y is 53; X is 18 and Y is 54; X is 18 and Y is 55; X is 18and Y is 56; X is 18 and Y is 57; X is 18 and Y is 58; X is 18 and Y is59; X is 18 and Y is 60; X is 18 and Y is 61; X is 18 and Y is 62; X is18 and Y is 63; X is 18 and Y is 64; X is 18 and Y is 65; X is 18 and Yis 66; X is 18 and Y is 67; X is 18 and Y is 68; X is 18 and Y is 69; Xis 18 and Y is 70; X is 18 and Y is 71; X is 18 and Y is 72; X is 18 andY is 73; X is 18 and Y is 74; X is 18 and Y is 75; X is 18 and Y is 76;X is 18 and Y is 77; X is 18 and Y is 78; X is 18 and Y is 79; X is 18and Y is 80; X is 18 and Y is 81; X is 18 and Y is 82; X is 18 and Y is83; X is 18 and Y is 84; X is 18 and Y is 85; X is 18 and Y is 86; X is18 and Y is 87; X is 18 and Y is 88; X is 18 and Y is 89; X is 18 and Yis 90; X is 18 and Y is 91; X is 18 and Y is 92; X is 18 and Y is 93; Xis 18 and Y is 94; X is 18 and Y is 95; X is 18 and Y is 96; X is 18 andY is 97; X is 18 and Y is 98; X is 18 and Y is 99; X is 18 and Y is 100;X is 18 and Y is 101; X is 18 and Y is 102; X is 18 and Y is 103; X is18 and Y is 104; X is 18 and Y is 105; X is 18 and Y is 106; X is 18 andY is 107; X is 18 and Y is 108; X is 18 and Y is 109; X is 18 and Y is110; X is 18 and Y is 111; X is 18 and Y is 112; X is 18 and Y is 113; Xis 18 and Y is 114; X is 18 and Y is 115; X is 18 and Y is 116; X is 18and Y is 117; X is 18 and Y is 118; X is 18 and Y is 119; X is 18 and Yis 120; X is 18 and Y is 121; X is 18 and Y is 122; X is 18 and Y is123; X is 18 and Y is 124; X is 18 and Y is 125; X is 18 and Y is 126; Xis 18 and Y is 127; X is 18 and Y is 128; X is 18 and Y is 129; X is 18and Y is 130; X is 18 and Y is 131; X is 18 and Y is 132; X is 18 and Yis 133; X is 18 and Y is 134; X is 18 and Y is 135; X is 18 and Y is136; X is 18 and Y is 137; X is 18 and Y is 138; X is 18 and Y is 139; Xis 18 and Y is 140; X is 18 and Y is 141; X is 18 and Y is 142; X is 18and Y is 143; X is 18 and Y is 144; X is 18 and Y is 145; X is 18 and Yis 146; X is 18 and Y is 147; X is 18 and Y is 148; X is 18 and Y is149; X is 18 and Y is 150; X is 18 and Y is 151; X is 18 and Y is 152; Xis 18 and Y is 153; X is 18 and Y is 154; X is 18 and Y is 155; X is 18and Y is 156; X is 18 and Y is 157; X is 18 and Y is 158; X is 18 and Yis 159; X is 18 and Y is 160; X is 18 and Y is 161; X is 18 and Y is162; X is 18 and Y is 163; X is 18 and Y is 164; X is 18 and Y is 165; Xis 18 and Y is 166; X is 18 and Y is 167; X is 18 and Y is 168; X is 18and Y is 169; X is 18 and Y is 170; X is 18 and Y is 171; X is 18 and Yis 172; X is 18 and Y is 173; X is 18 and Y is 174; X is 18 and Y is175; X is 18 and Y is 176; X is 18 and Y is 177; X is 18 and Y is 178; Xis 18 and Y is 179; X is 18 and Y is 180; X is 18 and Y is 181; X is 18and Y is 182; X is 18 and Y is 183; X is 18 and Y is 184; X is 18 and Yis 185; X is 18 and Y is 186;X is 19 and Y is 1; X is 19 and Y is 2; X is 19 and Y is 3; X is 19 andY is 4; X is 19 and Y is 5; X is 19 and Y is 6; X is 19 and Y is 7; X is19 and Y is 8; X is 19 and Y is 9; X is 19 and Y is 10; X is 19 and Y is11; X is 19 and Y is 12; X is 19 and Y is 13; X is 19 and Y is 14; X is19 and Y is 15; X is 19 and Y is 16; X is 19 and Y is 17; X is 19 and Yis 18; X is 19 and Y is 19; X is 19 and Y is 20; X is 19 and Y is 21; Xis 19 and Y is 22; X is 19 and Y is 23; X is 19 and Y is 24; X is 19 andY is 25; X is 19 and Y is 26; X is 19 and Y is 27; X is 19 and Y is 28;X is 19 and Y is 29; X is 19 and Y is 30; X is 19 and Y is 31; X is 19and Y is 32; X is 19 and Y is 33; X is 19 and Y is 34; X is 19 and Y is35; X is 19 and Y is 36; X is 19 and Y is 37; X is 19 and Y is 38; X is19 and Y is 39; X is 19 and Y is 40; X is 19 and Y is 41; X is 19 and Yis 42; X is 19 and Y is 43; X is 19 and Y is 44; X is 19 and Y is 45; Xis 19 and Y is 46; X is 19 and Y is 47; X is 19 and Y is 48; X is 19 andY is 49; X is 19 and Y is 50; X is 19 and Y is 51; X is 19 and Y is 52;X is 19 and Y is 53; X is 19 and Y is 54; X is 19 and Y is 55; X is 19and Y is 56; X is 19 and Y is 57; X is 19 and Y is 58; X is 19 and Y is59; X is 19 and Y is 60; X is 19 and Y is 61; X is 19 and Y is 62; X is19 and Y is 63; X is 19 and Y is 64; X is 19 and Y is 65; X is 19 and Yis 66; X is 19 and Y is 67; X is 19 and Y is 68; X is 19 and Y is 69; Xis 19 and Y is 70; X is 19 and Y is 71; X is 19 and Y is 72; X is 19 andY is 73; X is 19 and Y is 74; X is 19 and Y is 75; X is 19 and Y is 76;X is 19 and Y is 77; X is 19 and Y is 78; X is 19 and Y is 79; X is 19and Y is 80; X is 19 and Y is 81; X is 19 and Y is 82; X is 19 and Y is83; X is 19 and Y is 84; X is 19 and Y is 85; X is 19 and Y is 86; X is19 and Y is 87; X is 19 and Y is 88; X is 19 and Y is 89; X is 19 and Yis 90; X is 19 and Y is 91; X is 19 and Y is 92; X is 19 and Y is 93; Xis 19 and Y is 94; X is 19 and Y is 95; X is 19 and Y is 96; X is 19 andY is 97; X is 19 and Y is 98; X is 19 and Y is 99; X is 19 and Y is 100;X is 19 and Y is 101; X is 19 and Y is 102; X is 19 and Y is 103; X is19 and Y is 104; X is 19 and Y is 105; X is 19 and Y is 106; X is 19 andY is 107; X is 19 and Y is 108; X is 19 and Y is 109; X is 19 and Y is110; X is 19 and Y is 111; X is 19 and Y is 112; X is 19 and Y is 113; Xis 19 and Y is 114; X is 19 and Y is 115; X is 19 and Y is 116; X is 19and Y is 117; X is 19 and Y is 118; X is 19 and Y is 119; X is 19 and Yis 120; X is 19 and Y is 121; X is 19 and Y is 122; X is 19 and Y is123; X is 19 and Y is 124; X is 19 and Y is 125; X is 19 and Y is 126; Xis 19 and Y is 127; X is 19 and Y is 128; X is 19 and Y is 129; X is 19and Y is 130; X is 19 and Y is 131; X is 19 and Y is 132; X is 19 and Yis 133; X is 19 and Y is 134; X is 19 and Y is 135; X is 19 and Y is136; X is 19 and Y is 137; X is 19 and Y is 138; X is 19 and Y is 139; Xis 19 and Y is 140; X is 19 and Y is 141; X is 19 and Y is 142; X is 19and Y is 143; X is 19 and Y is 144; X is 19 and Y is 145; X is 19 and Yis 146; X is 19 and Y is 147; X is 19 and Y is 148; X is 19 and Y is149; X is 19 and Y is 150; X is 19 and Y is 151; X is 19 and Y is 152; Xis 19 and Y is 153; X is 19 and Y is 154; X is 19 and Y is 155; X is 19and Y is 156; X is 19 and Y is 157; X is 19 and Y is 158; X is 19 and Yis 159; X is 19 and Y is 160; X is 19 and Y is 161; X is 19 and Y is162; X is 19 and Y is 163; X is 19 and Y is 164; X is 19 and Y is 165; Xis 19 and Y is 166; X is 19 and Y is 167; X is 19 and Y is 168; X is 19and Y is 169; X is 19 and Y is 170; X is 19 and Y is 171; X is 19 and Yis 172; X is 19 and Y is 173; X is 19 and Y is 174; X is 19 and Y is175; X is 19 and Y is 176; X is 19 and Y is 177; X is 19 and Y is 178; Xis 19 and Y is 179; X is 19 and Y is 180; X is 19 and Y is 181; X is 19and Y is 182; X is 19 and Y is 183; X is 19 and Y is 184; X is 19 and Yis 185; X is 19 and Y is 186;X is 20 and Y is 1; X is 20 and Y is 2; X is 20 and Y is 3; X is 20 andY is 4; X is 20 and Y is 5; X is 20 and Y is 6; X is 20 and Y is 7; X is20 and Y is 8; X is 20 and Y is 9; X is 20 and Y is 10; X is 20 and Y is11; X is 20 and Y is 12; X is 20 and Y is 13; X is 20 and Y is 14; X is20 and Y is 15; X is 20 and Y is 16; X is 20 and Y is 17; X is 20 and Yis 18; X is 20 and Y is 19; X is 20 and Y is 20; X is 20 and Y is 21; Xis 20 and Y is 22; X is 20 and Y is 23; X is 20 and Y is 24; X is 20 andY is 25; X is 20 and Y is 26; X is 20 and Y is 27; X is 20 and Y is 28;X is 20 and Y is 29; X is 20 and Y is 30; X is 20 and Y is 31; X is 20and Y is 32; X is 20 and Y is 33; X is 20 and Y is 34; X is 20 and Y is35; X is 20 and Y is 36; X is 20 and Y is 37; X is 20 and Y is 38; X is20 and Y is 39; X is 20 and Y is 40; X is 20 and Y is 41; X is 20 and Yis 42; X is 20 and Y is 43; X is 20 and Y is 44; X is 20 and Y is 45; Xis 20 and Y is 46; X is 20 and Y is 47; X is 20 and Y is 48; X is 20 andY is 49; X is 20 and Y is 50; X is 20 and Y is 51; X is 20 and Y is 52;X is 20 and Y is 53; X is 20 and Y is 54; X is 20 and Y is 55; X is 20and Y is 56; X is 20 and Y is 57; X is 20 and Y is 58; X is 20 and Y is59; X is 20 and Y is 60; X is 20 and Y is 61; X is 20 and Y is 62; X is20 and Y is 63; X is 20 and Y is 64; X is 20 and Y is 65; X is 20 and Yis 66; X is 20 and Y is 67; X is 20 and Y is 68; X is 20 and Y is 69; Xis 20 and Y is 70; X is 20 and Y is 71; X is 20 and Y is 72; X is 20 andY is 73; X is 20 and Y is 74; X is 20 and Y is 75; X is 20 and Y is 76;X is 20 and Y is 77; X is 20 and Y is 78; X is 20 and Y is 79; X is 20and Y is 80; X is 20 and Y is 81; X is 20 and Y is 82; X is 20 and Y is83; X is 20 and Y is 84; X is 20 and Y is 85; X is 20 and Y is 86; X is20 and Y is 87; X is 20 and Y is 88; X is 20 and Y is 89; X is 20 and Yis 90; X is 20 and Y is 91; X is 20 and Y is 92; X is 20 and Y is 93; Xis 20 and Y is 94; X is 20 and Y is 95; X is 20 and Y is 96; X is 20 andY is 97; X is 20 and Y is 98; X is 20 and Y is 99; X is 20 and Y is 100;X is 20 and Y is 101; X is 20 and Y is 102; X is 20 and Y is 103; X is20 and Y is 104; X is 20 and Y is 105; X is 20 and Y is 106; X is 20 andY is 107; X is 20 and Y is 108; X is 20 and Y is 109; X is 20 and Y is110; X is 20 and Y is 111; X is 20 and Y is 112; X is 20 and Y is 113; Xis 20 and Y is 114; X is 20 and Y is 115; X is 20 and Y is 116; X is 20and Y is 117; X is 20 and Y is 118; X is 20 and Y is 119; X is 20 and Yis 120; X is 20 and Y is 121; X is 20 and Y is 122; X is 20 and Y is123; X is 20 and Y is 124; X is 20 and Y is 125; X is 20 and Y is 126; Xis 20 and Y is 127; X is 20 and Y is 128; X is 20 and Y is 129; X is 20and Y is 130; X is 20 and Y is 131; X is 20 and Y is 132; X is 20 and Yis 133; X is 20 and Y is 134; X is 20 and Y is 135; X is 20 and Y is136; X is 20 and Y is 137; X is 20 and Y is 138; X is 20 and Y is 139; Xis 20 and Y is 140; X is 20 and Y is 141; X is 20 and Y is 142; X is 20and Y is 143; X is 20 and Y is 144; X is 20 and Y is 145; X is 20 and Yis 146; X is 20 and Y is 147; X is 20 and Y is 148; X is 20 and Y is149; X is 20 and Y is 150; X is 20 and Y is 151; X is 20 and Y is 152; Xis 20 and Y is 153; X is 20 and Y is 154; X is 20 and Y is 155; X is 20and Y is 156; X is 20 and Y is 157; X is 20 and Y is 158; X is 20 and Yis 159; X is 20 and Y is 160; X is 20 and Y is 161; X is 20 and Y is162; X is 20 and Y is 163; X is 20 and Y is 164; X is 20 and Y is 165; Xis 20 and Y is 166; X is 20 and Y is 167; X is 20 and Y is 168; X is 20and Y is 169; X is 20 and Y is 170; X is 20 and Y is 171; X is 20 and Yis 172; X is 20 and Y is 173; X is 20 and Y is 174; X is 20 and Y is175; X is 20 and Y is 176; X is 20 and Y is 177; X is 20 and Y is 178; Xis 20 and Y is 179; X is 20 and Y is 180; X is 20 and Y is 181; X is 20and Y is 182; X is 20 and Y is 183; X is 20 and Y is 184; X is 20 and Yis 185; X is 20 and Y is 186;X is 21 and Y is 1; X is 21 and Y is 2; X is 21 and Y is 3; X is 21 andY is 4; X is 21 and Y is 5; X is 21 and Y is 6; X is 21 and Y is 7; X is21 and Y is 8; X is 21 and Y is 9; X is 21 and Y is 10; X is 21 and Y is11; X is 21 and Y is 12; X is 21 and Y is 13; X is 21 and Y is 14; X is21 and Y is 15; X is 21 and Y is 16; X is 21 and Y is 17; X is 21 and Yis 18; X is 21 and Y is 19; X is 21 and Y is 20; X is 21 and Y is 21; Xis 21 and Y is 22; X is 21 and Y is 23; X is 21 and Y is 24; X is 21 andY is 25; X is 21 and Y is 26; X is 21 and Y is 27; X is 21 and Y is 28;X is 21 and Y is 29; X is 21 and Y is 30; X is 21 and Y is 31; X is 21and Y is 32; X is 21 and Y is 33; X is 21 and Y is 34; X is 21 and Y is35; X is 21 and Y is 36; X is 21 and Y is 37; X is 21 and Y is 38; X is21 and Y is 39; X is 21 and Y is 40; X is 21 and Y is 41; X is 21 and Yis 42; X is 21 and Y is 43; X is 21 and Y is 44; X is 21 and Y is 45; Xis 21 and Y is 46; X is 21 and Y is 47; X is 21 and Y is 48; X is 21 andY is 49; X is 21 and Y is 50; X is 21 and Y is 51; X is 21 and Y is 52;X is 21 and Y is 53; X is 21 and Y is 54; X is 21 and Y is 55; X is 21and Y is 56; X is 21 and Y is 57; X is 21 and Y is 58; X is 21 and Y is59; X is 21 and Y is 60; X is 21 and Y is 61; X is 21 and Y is 62; X is21 and Y is 63; X is 21 and Y is 64; X is 21 and Y is 65; X is 21 and Yis 66; X is 21 and Y is 67; X is 21 and Y is 68; X is 21 and Y is 69; Xis 21 and Y is 70; X is 21 and Y is 71; X is 21 and Y is 72; X is 21 andY is 73; X is 21 and Y is 74; X is 21 and Y is 75; X is 21 and Y is 76;X is 21 and Y is 77; X is 21 and Y is 78; X is 21 and Y is 79; X is 21and Y is 80; X is 21 and Y is 81; X is 21 and Y is 82; X is 21 and Y is83; X is 21 and Y is 84; X is 21 and Y is 85; X is 21 and Y is 86; X is21 and Y is 87; X is 21 and Y is 88; X is 21 and Y is 89; X is 21 and Yis 90; X is 21 and Y is 91; X is 21 and Y is 92; X is 21 and Y is 93; Xis 21 and Y is 94; X is 21 and Y is 95; X is 21 and Y is 96; X is 21 andY is 97; X is 21 and Y is 98; X is 21 and Y is 99; X is 21 and Y is 100;X is 21 and Y is 101; X is 21 and Y is 102; X is 21 and Y is 103; X is21 and Y is 104; X is 21 and Y is 105; X is 21 and Y is 106; X is 21 andY is 107; X is 21 and Y is 108; X is 21 and Y is 109; X is 21 and Y is110; X is 21 and Y is 111; X is 21 and Y is 112; X is 21 and Y is 113; Xis 21 and Y is 114; X is 21 and Y is 115; X is 21 and Y is 116; X is 21and Y is 117; X is 21 and Y is 118; X is 21 and Y is 119; X is 21 and Yis 120; X is 21 and Y is 121; X is 21 and Y is 122; X is 21 and Y is123; X is 21 and Y is 124; X is 21 and Y is 125; X is 21 and Y is 126; Xis 21 and Y is 127; X is 21 and Y is 128; X is 21 and Y is 129; X is 21and Y is 130; X is 21 and Y is 131; X is 21 and Y is 132; X is 21 and Yis 133; X is 21 and Y is 134; X is 21 and Y is 135; X is 21 and Y is136; X is 21 and Y is 137; X is 21 and Y is 138; X is 21 and Y is 139; Xis 21 and Y is 140; X is 21 and Y is 141; X is 21 and Y is 142; X is 21and Y is 143; X is 21 and Y is 144; X is 21 and Y is 145; X is 21 and Yis 146; X is 21 and Y is 147; X is 21 and Y is 148; X is 21 and Y is149; X is 21 and Y is 150; X is 21 and Y is 151; X is 21 and Y is 152; Xis 21 and Y is 153; X is 21 and Y is 154; X is 21 and Y is 155; X is 21and Y is 156; X is 21 and Y is 157; X is 21 and Y is 158; X is 21 and Yis 159; X is 21 and Y is 160; X is 21 and Y is 161; X is 21 and Y is162; X is 21 and Y is 163; X is 21 and Y is 164; X is 21 and Y is 165; Xis 21 and Y is 166; X is 21 and Y is 167; X is 21 and Y is 168; X is 21and Y is 169; X is 21 and Y is 170; X is 21 and Y is 171; X is 21 and Yis 172; X is 21 and Y is 173; X is 21 and Y is 174; X is 21 and Y is175; X is 21 and Y is 176; X is 21 and Y is 177; X is 21 and Y is 178; Xis 21 and Y is 179; X is 21 and Y is 180; X is 21 and Y is 181; X is 21and Y is 182; X is 21 and Y is 183; X is 21 and Y is 184; X is 21 and Yis 185; X is 21 and Y is 186;X is 22 and Y is 1; X is 22 and Y is 2; X is 22 and Y is 3; X is 22 andY is 4; X is 22 and Y is 5; X is 22 and Y is 6; X is 22 and Y is 7; X is22 and Y is 8; X is 22 and Y is 9; X is 22 and Y is 10; X is 22 and Y is11; X is 22 and Y is 12; X is 22 and Y is 13; X is 22 and Y is 14; X is22 and Y is 15; X is 22 and Y is 16; X is 22 and Y is 17; X is 22 and Yis 18; X is 22 and Y is 19; X is 22 and Y is 20; X is 22 and Y is 21; Xis 22 and Y is 22; X is 22 and Y is 23; X is 22 and Y is 24; X is 22 andY is 25; X is 22 and Y is 26; X is 22 and Y is 27; X is 22 and Y is 28;X is 22 and Y is 29; X is 22 and Y is 30; X is 22 and Y is 31; X is 22and Y is 32; X is 22 and Y is 33; X is 22 and Y is 34; X is 22 and Y is35; X is 22 and Y is 36; X is 22 and Y is 37; X is 22 and Y is 38; X is22 and Y is 39; X is 22 and Y is 40; X is 22 and Y is 41; X is 22 and Yis 42; X is 22 and Y is 43; X is 22 and Y is 44; X is 22 and Y is 45; Xis 22 and Y is 46; X is 22 and Y is 47; X is 22 and Y is 48; X is 22 andY is 49; X is 22 and Y is 50; X is 22 and Y is 51; X is 22 and Y is 52;X is 22 and Y is 53; X is 22 and Y is 54; X is 22 and Y is 55; X is 22and Y is 56; X is 22 and Y is 57; X is 22 and Y is 58; X is 22 and Y is59; X is 22 and Y is 60; X is 22 and Y is 61; X is 22 and Y is 62; X is22 and Y is 63; X is 22 and Y is 64; X is 22 and Y is 65; X is 22 and Yis 66; X is 22 and Y is 67; X is 22 and Y is 68; X is 22 and Y is 69; Xis 22 and Y is 70; X is 22 and Y is 71; X is 22 and Y is 72; X is 22 andY is 73; X is 22 and Y is 74; X is 22 and Y is 75; X is 22 and Y is 76;X is 22 and Y is 77; X is 22 and Y is 78; X is 22 and Y is 79; X is 22and Y is 80; X is 22 and Y is 81; X is 22 and Y is 82; X is 22 and Y is83; X is 22 and Y is 84; X is 22 and Y is 85; X is 22 and Y is 86; X is22 and Y is 87; X is 22 and Y is 88; X is 22 and Y is 89; X is 22 and Yis 90; X is 22 and Y is 91; X is 22 and Y is 92; X is 22 and Y is 93; Xis 22 and Y is 94; X is 22 and Y is 95; X is 22 and Y is 96; X is 22 andY is 97; X is 22 and Y is 98; X is 22 and Y is 99; X is 22 and Y is 100;X is 22 and Y is 101; X is 22 and Y is 102; X is 22 and Y is 103; X is22 and Y is 104; X is 22 and Y is 105; X is 22 and Y is 106; X is 22 andY is 107; X is 22 and Y is 108; X is 22 and Y is 109; X is 22 and Y is110; X is 22 and Y is 111; X is 22 and Y is 112; X is 22 and Y is 113; Xis 22 and Y is 114; X is 22 and Y is 115; X is 22 and Y is 116; X is 22and Y is 117; X is 22 and Y is 118; X is 22 and Y is 119; X is 22 and Yis 120; X is 22 and Y is 121; X is 22 and Y is 122; X is 22 and Y is123; X is 22 and Y is 124; X is 22 and Y is 125; X is 22 and Y is 126; Xis 22 and Y is 127; X is 22 and Y is 128; X is 22 and Y is 129; X is 22and Y is 130; X is 22 and Y is 131; X is 22 and Y is 132; X is 22 and Yis 133; X is 22 and Y is 134; X is 22 and Y is 135; X is 22 and Y is136; X is 22 and Y is 137; X is 22 and Y is 138; X is 22 and Y is 139; Xis 22 and Y is 140; X is 22 and Y is 141; X is 22 and Y is 142; X is 22and Y is 143; X is 22 and Y is 144; X is 22 and Y is 145; X is 22 and Yis 146; X is 22 and Y is 147; X is 22 and Y is 148; X is 22 and Y is149; X is 22 and Y is 150; X is 22 and Y is 151; X is 22 and Y is 152; Xis 22 and Y is 153; X is 22 and Y is 154; X is 22 and Y is 155; X is 22and Y is 156; X is 22 and Y is 157; X is 22 and Y is 158; X is 22 and Yis 159; X is 22 and Y is 160; X is 22 and Y is 161; X is 22 and Y is162; X is 22 and Y is 163; X is 22 and Y is 164; X is 22 and Y is 165; Xis 22 and Y is 166; X is 22 and Y is 167; X is 22 and Y is 168; X is 22and Y is 169; X is 22 and Y is 170; X is 22 and Y is 171; X is 22 and Yis 172; X is 22 and Y is 173; X is 22 and Y is 174; X is 22 and Y is175; X is 22 and Y is 176; X is 22 and Y is 177; X is 22 and Y is 178; Xis 22 and Y is 179; X is 22 and Y is 180; X is 22 and Y is 181; X is 22and Y is 182; X is 22 and Y is 183; X is 22 and Y is 184; X is 22 and Yis 185; X is 22 and Y is 186;X is 23 and Y is 1; X is 23 and Y is 2; X is 23 and Y is 3; X is 23 andY is 4; X is 23 and Y is 5; X is 23 and Y is 6; X is 23 and Y is 7; X is23 and Y is 8; X is 23 and Y is 9; X is 23 and Y is 10; X is 23 and Y is11; X is 23 and Y is 12; X is 23 and Y is 13; X is 23 and Y is 14; X is23 and Y is 15; X is 23 and Y is 16; X is 23 and Y is 17; X is 23 and Yis 18; X is 23 and Y is 19; X is 23 and Y is 20; X is 23 and Y is 21; Xis 23 and Y is 22; X is 23 and Y is 23; X is 23 and Y is 24; X is 23 andY is 25; X is 23 and Y is 26; X is 23 and Y is 27; X is 23 and Y is 28;X is 23 and Y is 29; X is 23 and Y is 30; X is 23 and Y is 31; X is 23and Y is 32; X is 23 and Y is 33; X is 23 and Y is 34; X is 23 and Y is35; X is 23 and Y is 36; X is 23 and Y is 37; X is 23 and Y is 38; X is23 and Y is 39; X is 23 and Y is 40; X is 23 and Y is 41; X is 23 and Yis 42; X is 23 and Y is 43; X is 23 and Y is 44; X is 23 and Y is 45; Xis 23 and Y is 46; X is 23 and Y is 47; X is 23 and Y is 48; X is 23 andY is 49; X is 23 and Y is 50; X is 23 and Y is 51; X is 23 and Y is 52;X is 23 and Y is 53; X is 23 and Y is 54; X is 23 and Y is 55; X is 23and Y is 56; X is 23 and Y is 57; X is 23 and Y is 58; X is 23 and Y is59; X is 23 and Y is 60; X is 23 and Y is 61; X is 23 and Y is 62; X is23 and Y is 63; X is 23 and Y is 64; X is 23 and Y is 65; X is 23 and Yis 66; X is 23 and Y is 67; X is 23 and Y is 68; X is 23 and Y is 69; Xis 23 and Y is 70; X is 23 and Y is 71; X is 23 and Y is 72; X is 23 andY is 73; X is 23 and Y is 74; X is 23 and Y is 75; X is 23 and Y is 76;X is 23 and Y is 77; X is 23 and Y is 78; X is 23 and Y is 79; X is 23and Y is 80; X is 23 and Y is 81; X is 23 and Y is 82; X is 23 and Y is83; X is 23 and Y is 84; X is 23 and Y is 85; X is 23 and Y is 86; X is23 and Y is 87; X is 23 and Y is 88; X is 23 and Y is 89; X is 23 and Yis 90; X is 23 and Y is 91; X is 23 and Y is 92; X is 23 and Y is 93; Xis 23 and Y is 94; X is 23 and Y is 95; X is 23 and Y is 96; X is 23 andY is 97; X is 23 and Y is 98; X is 23 and Y is 99; X is 23 and Y is 100;X is 23 and Y is 101; X is 23 and Y is 102; X is 23 and Y is 103; X is23 and Y is 104; X is 23 and Y is 105; X is 23 and Y is 106; X is 23 andY is 107; X is 23 and Y is 108; X is 23 and Y is 109; X is 23 and Y is110; X is 23 and Y is 111; X is 23 and Y is 112; X is 23 and Y is 113; Xis 23 and Y is 114; X is 23 and Y is 115; X is 23 and Y is 116; X is 23and Y is 117; X is 23 and Y is 118; X is 23 and Y is 119; X is 23 and Yis 120; X is 23 and Y is 121; X is 23 and Y is 122; X is 23 and Y is123; X is 23 and Y is 124; X is 23 and Y is 125; X is 23 and Y is 126; Xis 23 and Y is 127; X is 23 and Y is 128; X is 23 and Y is 129; X is 23and Y is 130; X is 23 and Y is 131; X is 23 and Y is 132; X is 23 and Yis 133; X is 23 and Y is 134; X is 23 and Y is 135; X is 23 and Y is136; X is 23 and Y is 137; X is 23 and Y is 138; X is 23 and Y is 139; Xis 23 and Y is 140; X is 23 and Y is 141; X is 23 and Y is 142; X is 23and Y is 143; X is 23 and Y is 144; X is 23 and Y is 145; X is 23 and Yis 146; X is 23 and Y is 147; X is 23 and Y is 148; X is 23 and Y is149; X is 23 and Y is 150; X is 23 and Y is 151; X is 23 and Y is 152; Xis 23 and Y is 153; X is 23 and Y is 154; X is 23 and Y is 155; X is 23and Y is 156; X is 23 and Y is 157; X is 23 and Y is 158; X is 23 and Yis 159; X is 23 and Y is 160; X is 23 and Y is 161; X is 23 and Y is162; X is 23 and Y is 163; X is 23 and Y is 164; X is 23 and Y is 165; Xis 23 and Y is 166; X is 23 and Y is 167; X is 23 and Y is 168; X is 23and Y is 169; X is 23 and Y is 170; X is 23 and Y is 171; X is 23 and Yis 172; X is 23 and Y is 173; X is 23 and Y is 174; X is 23 and Y is175; X is 23 and Y is 176; X is 23 and Y is 177; X is 23 and Y is 178; Xis 23 and Y is 179; X is 23 and Y is 180; X is 23 and Y is 181; X is 23and Y is 182; X is 23 and Y is 183; X is 23 and Y is 184; X is 23 and Yis 185; X is 23 and Y is 186;X is 24 and Y is 1; X is 24 and Y is 2; X is 24 and Y is 3; X is 24 andY is 4; X is 24 and Y is 5; X is 24 and Y is 6; X is 24 and Y is 7; X is24 and Y is 8; X is 24 and Y is 9; X is 24 and Y is 10; X is 24 and Y is11; X is 24 and Y is 12; X is 24 and Y is 13; X is 24 and Y is 14; X is24 and Y is 15; X is 24 and Y is 16; X is 24 and Y is 17; X is 24 and Yis 18; X is 24 and Y is 19; X is 24 and Y is 20; X is 24 and Y is 21; Xis 24 and Y is 22; X is 24 and Y is 23; X is 24 and Y is 24; X is 24 andY is 25; X is 24 and Y is 26; X is 24 and Y is 27; X is 24 and Y is 28;X is 24 and Y is 29; X is 24 and Y is 30; X is 24 and Y is 31; X is 24and Y is 32; X is 24 and Y is 33; X is 24 and Y is 34; X is 24 and Y is35; X is 24 and Y is 36; X is 24 and Y is 37; X is 24 and Y is 38; X is24 and Y is 39; X is 24 and Y is 40; X is 24 and Y is 41; X is 24 and Yis 42; X is 24 and Y is 43; X is 24 and Y is 44; X is 24 and Y is 45; Xis 24 and Y is 46; X is 24 and Y is 47; X is 24 and Y is 48; X is 24 andY is 49; X is 24 and Y is 50; X is 24 and Y is 51; X is 24 and Y is 52;X is 24 and Y is 53; X is 24 and Y is 54; X is 24 and Y is 55; X is 24and Y is 56; X is 24 and Y is 57; X is 24 and Y is 58; X is 24 and Y is59; X is 24 and Y is 60; X is 24 and Y is 61; X is 24 and Y is 62; X is24 and Y is 63; X is 24 and Y is 64; X is 24 and Y is 65; X is 24 and Yis 66; X is 24 and Y is 67; X is 24 and Y is 68; X is 24 and Y is 69; Xis 24 and Y is 70; X is 24 and Y is 71; X is 24 and Y is 72; X is 24 andY is 73; X is 24 and Y is 74; X is 24 and Y is 75; X is 24 and Y is 76;X is 24 and Y is 77; X is 24 and Y is 78; X is 24 and Y is 79; X is 24and Y is 80; X is 24 and Y is 81; X is 24 and Y is 82; X is 24 and Y is83; X is 24 and Y is 84; X is 24 and Y is 85; X is 24 and Y is 86; X is24 and Y is 87; X is 24 and Y is 88; X is 24 and Y is 89; X is 24 and Yis 90; X is 24 and Y is 91; X is 24 and Y is 92; X is 24 and Y is 93; Xis 24 and Y is 94; X is 24 and Y is 95; X is 24 and Y is 96; X is 24 andY is 97; X is 24 and Y is 98; X is 24 and Y is 99; X is 24 and Y is 100;X is 24 and Y is 101; X is 24 and Y is 102; X is 24 and Y is 103; X is24 and Y is 104; X is 24 and Y is 105; X is 24 and Y is 106; X is 24 andY is 107; X is 24 and Y is 108; X is 24 and Y is 109; X is 24 and Y is110; X is 24 and Y is 111; X is 24 and Y is 112; X is 24 and Y is 113; Xis 24 and Y is 114; X is 24 and Y is 115; X is 24 and Y is 116; X is 24and Y is 117; X is 24 and Y is 118; X is 24 and Y is 119; X is 24 and Yis 120; X is 24 and Y is 121; X is 24 and Y is 122; X is 24 and Y is123; X is 24 and Y is 124; X is 24 and Y is 125; X is 24 and Y is 126; Xis 24 and Y is 127; X is 24 and Y is 128; X is 24 and Y is 129; X is 24and Y is 130; X is 24 and Y is 131; X is 24 and Y is 132; X is 24 and Yis 133; X is 24 and Y is 134; X is 24 and Y is 135; X is 24 and Y is136; X is 24 and Y is 137; X is 24 and Y is 138; X is 24 and Y is 139; Xis 24 and Y is 140; X is 24 and Y is 141; X is 24 and Y is 142; X is 24and Y is 143; X is 24 and Y is 144; X is 24 and Y is 145; X is 24 and Yis 146; X is 24 and Y is 147; X is 24 and Y is 148; X is 24 and Y is149; X is 24 and Y is 150; X is 24 and Y is 151; X is 24 and Y is 152; Xis 24 and Y is 153; X is 24 and Y is 154; X is 24 and Y is 155; X is 24and Y is 156; X is 24 and Y is 157; X is 24 and Y is 158; X is 24 and Yis 159; X is 24 and Y is 160; X is 24 and Y is 161; X is 24 and Y is162; X is 24 and Y is 163; X is 24 and Y is 164; X is 24 and Y is 165; Xis 24 and Y is 166; X is 24 and Y is 167; X is 24 and Y is 168; X is 24and Y is 169; X is 24 and Y is 170; X is 24 and Y is 171; X is 24 and Yis 172; X is 24 and Y is 173; X is 24 and Y is 174; X is 24 and Y is175; X is 24 and Y is 176; X is 24 and Y is 177; X is 24 and Y is 178; Xis 24 and Y is 179; X is 24 and Y is 180; X is 24 and Y is 181; X is 24and Y is 182; X is 24 and Y is 183; X is 24 and Y is 184; X is 24 and Yis 185; X is 24 and Y is 186;X is 25 and Y is 1; X is 25 and Y is 2; X is 25 and Y is 3; X is 25 andY is 4; X is 25 and Y is 5; X is 25 and Y is 6; X is 25 and Y is 7; X is25 and Y is 8; X is 25 and Y is 9; X is 25 and Y is 10; X is 25 and Y is11; X is 25 and Y is 12; X is 25 and Y is 13; X is 25 and Y is 14; X is25 and Y is 15; X is 25 and Y is 16; X is 25 and Y is 17; X is 25 and Yis 18; X is 25 and Y is 19; X is 25 and Y is 20; X is 25 and Y is 21; Xis 25 and Y is 22; X is 25 and Y is 23; X is 25 and Y is 24; X is 25 andY is 25; X is 25 and Y is 26; X is 25 and Y is 27; X is 25 and Y is 28;X is 25 and Y is 29; X is 25 and Y is 30; X is 25 and Y is 31; X is 25and Y is 32; X is 25 and Y is 33; X is 25 and Y is 34; X is 25 and Y is35; X is 25 and Y is 36; X is 25 and Y is 37; X is 25 and Y is 38; X is25 and Y is 39; X is 25 and Y is 40; X is 25 and Y is 41; X is 25 and Yis 42; X is 25 and Y is 43; X is 25 and Y is 44; X is 25 and Y is 45; Xis 25 and Y is 46; X is 25 and Y is 47; X is 25 and Y is 48; X is 25 andY is 49; X is 25 and Y is 50; X is 25 and Y is 51; X is 25 and Y is 52;X is 25 and Y is 53; X is 25 and Y is 54; X is 25 and Y is 55; X is 25and Y is 56; X is 25 and Y is 57; X is 25 and Y is 58; X is 25 and Y is59; X is 25 and Y is 60; X is 25 and Y is 61; X is 25 and Y is 62; X is25 and Y is 63; X is 25 and Y is 64; X is 25 and Y is 65; X is 25 and Yis 66; X is 25 and Y is 67; X is 25 and Y is 68; X is 25 and Y is 69; Xis 25 and Y is 70; X is 25 and Y is 71; X is 25 and Y is 72; X is 25 andY is 73; X is 25 and Y is 74; X is 25 and Y is 75; X is 25 and Y is 76;X is 25 and Y is 77; X is 25 and Y is 78; X is 25 and Y is 79; X is 25and Y is 80; X is 25 and Y is 81; X is 25 and Y is 82; X is 25 and Y is83; X is 25 and Y is 84; X is 25 and Y is 85; X is 25 and Y is 86; X is25 and Y is 87; X is 25 and Y is 88; X is 25 and Y is 89; X is 25 and Yis 90; X is 25 and Y is 91; X is 25 and Y is 92; X is 25 and Y is 93; Xis 25 and Y is 94; X is 25 and Y is 95; X is 25 and Y is 96; X is 25 andY is 97; X is 25 and Y is 98; X is 25 and Y is 99; X is 25 and Y is 100;X is 25 and Y is 101; X is 25 and Y is 102; X is 25 and Y is 103; X is25 and Y is 104; X is 25 and Y is 105; X is 25 and Y is 106; X is 25 andY is 107; X is 25 and Y is 108; X is 25 and Y is 109; X is 25 and Y is110; X is 25 and Y is 111; X is 25 and Y is 112; X is 25 and Y is 113; Xis 25 and Y is 114; X is 25 and Y is 115; X is 25 and Y is 116; X is 25and Y is 117; X is 25 and Y is 118; X is 25 and Y is 119; X is 25 and Yis 120; X is 25 and Y is 121; X is 25 and Y is 122; X is 25 and Y is123; X is 25 and Y is 124; X is 25 and Y is 125; X is 25 and Y is 126; Xis 25 and Y is 127; X is 25 and Y is 128; X is 25 and Y is 129; X is 25and Y is 130; X is 25 and Y is 131; X is 25 and Y is 132; X is 25 and Yis 133; X is 25 and Y is 134; X is 25 and Y is 135; X is 25 and Y is136; X is 25 and Y is 137; X is 25 and Y is 138; X is 25 and Y is 139; Xis 25 and Y is 140; X is 25 and Y is 141; X is 25 and Y is 142; X is 25and Y is 143; X is 25 and Y is 144; X is 25 and Y is 145; X is 25 and Yis 146; X is 25 and Y is 147; X is 25 and Y is 148; X is 25 and Y is149; X is 25 and Y is 150; X is 25 and Y is 151; X is 25 and Y is 152; Xis 25 and Y is 153; X is 25 and Y is 154; X is 25 and Y is 155; X is 25and Y is 156; X is 25 and Y is 157; X is 25 and Y is 158; X is 25 and Yis 159; X is 25 and Y is 160; X is 25 and Y is 161; X is 25 and Y is162; X is 25 and Y is 163; X is 25 and Y is 164; X is 25 and Y is 165; Xis 25 and Y is 166; X is 25 and Y is 167; X is 25 and Y is 168; X is 25and Y is 169; X is 25 and Y is 170; X is 25 and Y is 171; X is 25 and Yis 172; X is 25 and Y is 173; X is 25 and Y is 174; X is 25 and Y is175; X is 25 and Y is 176; X is 25 and Y is 177; X is 25 and Y is 178; Xis 25 and Y is 179; X is 25 and Y is 180; X is 25 and Y is 181; X is 25and Y is 182; X is 25 and Y is 183; X is 25 and Y is 184; X is 25 and Yis 185; X is 25 and Y is 186;X is 26 and Y is 1; X is 26 and Y is 2; X is 26 and Y is 3; X is 26 andY is 4; X is 26 and Y is 5; X is 26 and Y is 6; X is 26 and Y is 7; X is26 and Y is 8; X is 26 and Y is 9; X is 26 and Y is 10; X is 26 and Y is11; X is 26 and Y is 12; X is 26 and Y is 13; X is 26 and Y is 14; X is26 and Y is 15; X is 26 and Y is 16; X is 26 and Y is 17; X is 26 and Yis 18; X is 26 and Y is 19; X is 26 and Y is 20; X is 26 and Y is 21; Xis 26 and Y is 22; X is 26 and Y is 23; X is 26 and Y is 24; X is 26 andY is 25; X is 26 and Y is 26; X is 26 and Y is 27; X is 26 and Y is 28;X is 26 and Y is 29; X is 26 and Y is 30; X is 26 and Y is 31; X is 26and Y is 32; X is 26 and Y is 33; X is 26 and Y is 34; X is 26 and Y is35; X is 26 and Y is 36; X is 26 and Y is 37; X is 26 and Y is 38; X is26 and Y is 39; X is 26 and Y is 40; X is 26 and Y is 41; X is 26 and Yis 42; X is 26 and Y is 43; X is 26 and Y is 44; X is 26 and Y is 45; Xis 26 and Y is 46; X is 26 and Y is 47; X is 26 and Y is 48; X is 26 andY is 49; X is 26 and Y is 50; X is 26 and Y is 51; X is 26 and Y is 52;X is 26 and Y is 53; X is 26 and Y is 54; X is 26 and Y is 55; X is 26and Y is 56; X is 26 and Y is 57; X is 26 and Y is 58; X is 26 and Y is59; X is 26 and Y is 60; X is 26 and Y is 61; X is 26 and Y is 62; X is26 and Y is 63; X is 26 and Y is 64; X is 26 and Y is 65; X is 26 and Yis 66; X is 26 and Y is 67; X is 26 and Y is 68; X is 26 and Y is 69; Xis 26 and Y is 70; X is 26 and Y is 71; X is 26 and Y is 72; X is 26 andY is 73; X is 26 and Y is 74; X is 26 and Y is 75; X is 26 and Y is 76;X is 26 and Y is 77; X is 26 and Y is 78; X is 26 and Y is 79; X is 26and Y is 80; X is 26 and Y is 81; X is 26 and Y is 82; X is 26 and Y is83; X is 26 and Y is 84; X is 26 and Y is 85; X is 26 and Y is 86; X is26 and Y is 87; X is 26 and Y is 88; X is 26 and Y is 89; X is 26 and Yis 90; X is 26 and Y is 91; X is 26 and Y is 92; X is 26 and Y is 93; Xis 26 and Y is 94; X is 26 and Y is 95; X is 26 and Y is 96; X is 26 andY is 97; X is 26 and Y is 98; X is 26 and Y is 99; X is 26 and Y is 100;X is 26 and Y is 101; X is 26 and Y is 102; X is 26 and Y is 103; X is26 and Y is 104; X is 26 and Y is 105; X is 26 and Y is 106; X is 26 andY is 107; X is 26 and Y is 108; X is 26 and Y is 109; X is 26 and Y is110; X is 26 and Y is 111; X is 26 and Y is 112; X is 26 and Y is 113; Xis 26 and Y is 114; X is 26 and Y is 115; X is 26 and Y is 116; X is 26and Y is 117; X is 26 and Y is 118; X is 26 and Y is 119; X is 26 and Yis 120; X is 26 and Y is 121; X is 26 and Y is 122; X is 26 and Y is123; X is 26 and Y is 124; X is 26 and Y is 125; X is 26 and Y is 126; Xis 26 and Y is 127; X is 26 and Y is 128; X is 26 and Y is 129; X is 26and Y is 130; X is 26 and Y is 131; X is 26 and Y is 132; X is 26 and Yis 133; X is 26 and Y is 134; X is 26 and Y is 135; X is 26 and Y is136; X is 26 and Y is 137; X is 26 and Y is 138; X is 26 and Y is 139; Xis 26 and Y is 140; X is 26 and Y is 141; X is 26 and Y is 142; X is 26and Y is 143; X is 26 and Y is 144; X is 26 and Y is 145; X is 26 and Yis 146; X is 26 and Y is 147; X is 26 and Y is 148; X is 26 and Y is149; X is 26 and Y is 150; X is 26 and Y is 151; X is 26 and Y is 152; Xis 26 and Y is 153; X is 26 and Y is 154; X is 26 and Y is 155; X is 26and Y is 156; X is 26 and Y is 157; X is 26 and Y is 158; X is 26 and Yis 159; X is 26 and Y is 160; X is 26 and Y is 161; X is 26 and Y is162; X is 26 and Y is 163; X is 26 and Y is 164; X is 26 and Y is 165; Xis 26 and Y is 166; X is 26 and Y is 167; X is 26 and Y is 168; X is 26and Y is 169; X is 26 and Y is 170; X is 26 and Y is 171; X is 26 and Yis 172; X is 26 and Y is 173; X is 26 and Y is 174; X is 26 and Y is175; X is 26 and Y is 176; X is 26 and Y is 177; X is 26 and Y is 178; Xis 26 and Y is 179; X is 26 and Y is 180; X is 26 and Y is 181; X is 26and Y is 182; X is 26 and Y is 183; X is 26 and Y is 184; X is 26 and Yis 185; X is 26 and Y is 186;X is 27 and Y is 1; X is 27 and Y is 2; X is 27 and Y is 3; X is 27 andY is 4; X is 27 and Y is 5; X is 27 and Y is 6; X is 27 and Y is 7; X is27 and Y is 8; X is 27 and Y is 9; X is 27 and Y is 10; X is 27 and Y is11; X is 27 and Y is 12; X is 27 and Y is 13; X is 27 and Y is 14; X is27 and Y is 15; X is 27 and Y is 16; X is 27 and Y is 17; X is 27 and Yis 18; X is 27 and Y is 19; X is 27 and Y is 20; X is 27 and Y is 21; Xis 27 and Y is 22; X is 27 and Y is 23; X is 27 and Y is 24; X is 27 andY is 25; X is 27 and Y is 26; X is 27 and Y is 27; X is 27 and Y is 28;X is 27 and Y is 29; X is 27 and Y is 30; X is 27 and Y is 31; X is 27and Y is 32; X is 27 and Y is 33; X is 27 and Y is 34; X is 27 and Y is35; X is 27 and Y is 36; X is 27 and Y is 37; X is 27 and Y is 38; X is27 and Y is 39; X is 27 and Y is 40; X is 27 and Y is 41; X is 27 and Yis 42; X is 27 and Y is 43; X is 27 and Y is 44; X is 27 and Y is 45; Xis 27 and Y is 46; X is 27 and Y is 47; X is 27 and Y is 48; X is 27 andY is 49; X is 27 and Y is 50; X is 27 and Y is 51; X is 27 and Y is 52;X is 27 and Y is 53; X is 27 and Y is 54; X is 27 and Y is 55; X is 27and Y is 56; X is 27 and Y is 57; X is 27 and Y is 58; X is 27 and Y is59; X is 27 and Y is 60; X is 27 and Y is 61; X is 27 and Y is 62; X is27 and Y is 63; X is 27 and Y is 64; X is 27 and Y is 65; X is 27 and Yis 66; X is 27 and Y is 67; X is 27 and Y is 68; X is 27 and Y is 69; Xis 27 and Y is 70; X is 27 and Y is 71; X is 27 and Y is 72; X is 27 andY is 73; X is 27 and Y is 74; X is 27 and Y is 75; X is 27 and Y is 76;X is 27 and Y is 77; X is 27 and Y is 78; X is 27 and Y is 79; X is 27and Y is 80; X is 27 and Y is 81; X is 27 and Y is 82; X is 27 and Y is83; X is 27 and Y is 84; X is 27 and Y is 85; X is 27 and Y is 86; X is27 and Y is 87; X is 27 and Y is 88; X is 27 and Y is 89; X is 27 and Yis 90; X is 27 and Y is 91; X is 27 and Y is 92; X is 27 and Y is 93; Xis 27 and Y is 94; X is 27 and Y is 95; X is 27 and Y is 96; X is 27 andY is 97; X is 27 and Y is 98; X is 27 and Y is 99; X is 27 and Y is 100;X is 27 and Y is 101; X is 27 and Y is 102; X is 27 and Y is 103; X is27 and Y is 104; X is 27 and Y is 105; X is 27 and Y is 106; X is 27 andY is 107; X is 27 and Y is 108; X is 27 and Y is 109; X is 27 and Y is110; X is 27 and Y is 111; X is 27 and Y is 112; X is 27 and Y is 113; Xis 27 and Y is 114; X is 27 and Y is 115; X is 27 and Y is 116; X is 27and Y is 117; X is 27 and Y is 118; X is 27 and Y is 119; X is 27 and Yis 120; X is 27 and Y is 121; X is 27 and Y is 122; X is 27 and Y is123; X is 27 and Y is 124; X is 27 and Y is 125; X is 27 and Y is 126; Xis 27 and Y is 127; X is 27 and Y is 128; X is 27 and Y is 129; X is 27and Y is 130; X is 27 and Y is 131; X is 27 and Y is 132; X is 27 and Yis 133; X is 27 and Y is 134; X is 27 and Y is 135; X is 27 and Y is136; X is 27 and Y is 137; X is 27 and Y is 138; X is 27 and Y is 139; Xis 27 and Y is 140; X is 27 and Y is 141; X is 27 and Y is 142; X is 27and Y is 143; X is 27 and Y is 144; X is 27 and Y is 145; X is 27 and Yis 146; X is 27 and Y is 147; X is 27 and Y is 148; X is 27 and Y is149; X is 27 and Y is 150; X is 27 and Y is 151; X is 27 and Y is 152; Xis 27 and Y is 153; X is 27 and Y is 154; X is 27 and Y is 155; X is 27and Y is 156; X is 27 and Y is 157; X is 27 and Y is 158; X is 27 and Yis 159; X is 27 and Y is 160; X is 27 and Y is 161; X is 27 and Y is162; X is 27 and Y is 163; X is 27 and Y is 164; X is 27 and Y is 165; Xis 27 and Y is 166; X is 27 and Y is 167; X is 27 and Y is 168; X is 27and Y is 169; X is 27 and Y is 170; X is 27 and Y is 171; X is 27 and Yis 172; X is 27 and Y is 173; X is 27 and Y is 174; X is 27 and Y is175; X is 27 and Y is 176; X is 27 and Y is 177; X is 27 and Y is 178; Xis 27 and Y is 179; X is 27 and Y is 180; X is 27 and Y is 181; X is 27and Y is 182; X is 27 and Y is 183; X is 27 and Y is 184; X is 27 and Yis 185; X is 27 and Y is 186;X is 28 and Y is 1; X is 28 and Y is 2; X is 28 and Y is 3; X is 28 andY is 4; X is 28 and Y is 5; X is 28 and Y is 6; X is 28 and Y is 7; X is28 and Y is 8; X is 28 and Y is 9; X is 28 and Y is 10; X is 28 and Y is11; X is 28 and Y is 12; X is 28 and Y is 13; X is 28 and Y is 14; X is28 and Y is 15; X is 28 and Y is 16; X is 28 and Y is 17; X is 28 and Yis 18; X is 28 and Y is 19; X is 28 and Y is 20; X is 28 and Y is 21; Xis 28 and Y is 22; X is 28 and Y is 23; X is 28 and Y is 24; X is 28 andY is 25; X is 28 and Y is 26; X is 28 and Y is 27; X is 28 and Y is 28;X is 28 and Y is 29; X is 28 and Y is 30; X is 28 and Y is 31; X is 28and Y is 32; X is 28 and Y is 33; X is 28 and Y is 34; X is 28 and Y is35; X is 28 and Y is 36; X is 28 and Y is 37; X is 28 and Y is 38; X is28 and Y is 39; X is 28 and Y is 40; X is 28 and Y is 41; X is 28 and Yis 42; X is 28 and Y is 43; X is 28 and Y is 44; X is 28 and Y is 45; Xis 28 and Y is 46; X is 28 and Y is 47; X is 28 and Y is 48; X is 28 andY is 49; X is 28 and Y is 50; X is 28 and Y is 51; X is 28 and Y is 52;X is 28 and Y is 53; X is 28 and Y is 54; X is 28 and Y is 55; X is 28and Y is 56; X is 28 and Y is 57; X is 28 and Y is 58; X is 28 and Y is59; X is 28 and Y is 60; X is 28 and Y is 61; X is 28 and Y is 62; X is28 and Y is 63; X is 28 and Y is 64; X is 28 and Y is 65; X is 28 and Yis 66; X is 28 and Y is 67; X is 28 and Y is 68; X is 28 and Y is 69; Xis 28 and Y is 70; X is 28 and Y is 71; X is 28 and Y is 72; X is 28 andY is 73; X is 28 and Y is 74; X is 28 and Y is 75; X is 28 and Y is 76;X is 28 and Y is 77; X is 28 and Y is 78; X is 28 and Y is 79; X is 28and Y is 80; X is 28 and Y is 81; X is 28 and Y is 82; X is 28 and Y is83; X is 28 and Y is 84; X is 28 and Y is 85; X is 28 and Y is 86; X is28 and Y is 87; X is 28 and Y is 88; X is 28 and Y is 89; X is 28 and Yis 90; X is 28 and Y is 91; X is 28 and Y is 92; X is 28 and Y is 93; Xis 28 and Y is 94; X is 28 and Y is 95; X is 28 and Y is 96; X is 28 andY is 97; X is 28 and Y is 98; X is 28 and Y is 99; X is 28 and Y is 100;X is 28 and Y is 101; X is 28 and Y is 102; X is 28 and Y is 103; X is28 and Y is 104; X is 28 and Y is 105; X is 28 and Y is 106; X is 28 andY is 107; X is 28 and Y is 108; X is 28 and Y is 109; X is 28 and Y is110; X is 28 and Y is 111; X is 28 and Y is 112; X is 28 and Y is 113; Xis 28 and Y is 114; X is 28 and Y is 115; X is 28 and Y is 116; X is 28and Y is 117; X is 28 and Y is 118; X is 28 and Y is 119; X is 28 and Yis 120; X is 28 and Y is 121; X is 28 and Y is 122; X is 28 and Y is123; X is 28 and Y is 124; X is 28 and Y is 125; X is 28 and Y is 126; Xis 28 and Y is 127; X is 28 and Y is 128; X is 28 and Y is 129; X is 28and Y is 130; X is 28 and Y is 131; X is 28 and Y is 132; X is 28 and Yis 133; X is 28 and Y is 134; X is 28 and Y is 135; X is 28 and Y is136; X is 28 and Y is 137; X is 28 and Y is 138; X is 28 and Y is 139; Xis 28 and Y is 140; X is 28 and Y is 141; X is 28 and Y is 142; X is 28and Y is 143; X is 28 and Y is 144; X is 28 and Y is 145; X is 28 and Yis 146; X is 28 and Y is 147; X is 28 and Y is 148; X is 28 and Y is149; X is 28 and Y is 150; X is 28 and Y is 151; X is 28 and Y is 152; Xis 28 and Y is 153; X is 28 and Y is 154; X is 28 and Y is 155; X is 28and Y is 156; X is 28 and Y is 157; X is 28 and Y is 158; X is 28 and Yis 159; X is 28 and Y is 160; X is 28 and Y is 161; X is 28 and Y is162; X is 28 and Y is 163; X is 28 and Y is 164; X is 28 and Y is 165; Xis 28 and Y is 166; X is 28 and Y is 167; X is 28 and Y is 168; X is 28and Y is 169; X is 28 and Y is 170; X is 28 and Y is 171; X is 28 and Yis 172; X is 28 and Y is 173; X is 28 and Y is 174; X is 28 and Y is175; X is 28 and Y is 176; X is 28 and Y is 177; X is 28 and Y is 178; Xis 28 and Y is 179; X is 28 and Y is 180; X is 28 and Y is 181; X is 28and Y is 182; X is 28 and Y is 183; X is 28 and Y is 184; X is 28 and Yis 185; X is 28 and Y is 186;X is 29 and Y is 1; X is 29 and Y is 2; X is 29 and Y is 3; X is 29 andY is 4; X is 29 and Y is 5; X is 29 and Y is 6; X is 29 and Y is 7; X is29 and Y is 8; X is 29 and Y is 9; X is 29 and Y is 10; X is 29 and Y is11; X is 29 and Y is 12; X is 29 and Y is 13; X is 29 and Y is 14; X is29 and Y is 15; X is 29 and Y is 16; X is 29 and Y is 17; X is 29 and Yis 18; X is 29 and Y is 19; X is 29 and Y is 20; X is 29 and Y is 21; Xis 29 and Y is 22; X is 29 and Y is 23; X is 29 and Y is 24; X is 29 andY is 25; X is 29 and Y is 26; X is 29 and Y is 27; X is 29 and Y is 28;X is 29 and Y is 29; X is 29 and Y is 30; X is 29 and Y is 31; X is 29and Y is 32; X is 29 and Y is 33; X is 29 and Y is 34; X is 29 and Y is35; X is 29 and Y is 36; X is 29 and Y is 37; X is 29 and Y is 38; X is29 and Y is 39; X is 29 and Y is 40; X is 29 and Y is 41; X is 29 and Yis 42; X is 29 and Y is 43; X is 29 and Y is 44; X is 29 and Y is 45; Xis 29 and Y is 46; X is 29 and Y is 47; X is 29 and Y is 48; X is 29 andY is 49; X is 29 and Y is 50; X is 29 and Y is 51; X is 29 and Y is 52;X is 29 and Y is 53; X is 29 and Y is 54; X is 29 and Y is 55; X is 29and Y is 56; X is 29 and Y is 57; X is 29 and Y is 58; X is 29 and Y is59; X is 29 and Y is 60; X is 29 and Y is 61; X is 29 and Y is 62; X is29 and Y is 63; X is 29 and Y is 64; X is 29 and Y is 65; X is 29 and Yis 66; X is 29 and Y is 67; X is 29 and Y is 68; X is 29 and Y is 69; Xis 29 and Y is 70; X is 29 and Y is 71; X is 29 and Y is 72; X is 29 andY is 73; X is 29 and Y is 74; X is 29 and Y is 75; X is 29 and Y is 76;X is 29 and Y is 77; X is 29 and Y is 78; X is 29 and Y is 79; X is 29and Y is 80; X is 29 and Y is 81; X is 29 and Y is 82; X is 29 and Y is83; X is 29 and Y is 84; X is 29 and Y is 85; X is 29 and Y is 86; X is29 and Y is 87; X is 29 and Y is 88; X is 29 and Y is 89; X is 29 and Yis 90; X is 29 and Y is 91; X is 29 and Y is 92; X is 29 and Y is 93; Xis 29 and Y is 94; X is 29 and Y is 95; X is 29 and Y is 96; X is 29 andY is 97; X is 29 and Y is 98; X is 29 and Y is 99; X is 29 and Y is 100;X is 29 and Y is 101; X is 29 and Y is 102; X is 29 and Y is 103; X is29 and Y is 104; X is 29 and Y is 105; X is 29 and Y is 106; X is 29 andY is 107; X is 29 and Y is 108; X is 29 and Y is 109; X is 29 and Y is110; X is 29 and Y is 111; X is 29 and Y is 112; X is 29 and Y is 113; Xis 29 and Y is 114; X is 29 and Y is 115; X is 29 and Y is 116; X is 29and Y is 117; X is 29 and Y is 118; X is 29 and Y is 119; X is 29 and Yis 120; X is 29 and Y is 121; X is 29 and Y is 122; X is 29 and Y is123; X is 29 and Y is 124; X is 29 and Y is 125; X is 29 and Y is 126; Xis 29 and Y is 127; X is 29 and Y is 128; X is 29 and Y is 129; X is 29and Y is 130; X is 29 and Y is 131; X is 29 and Y is 132; X is 29 and Yis 133; X is 29 and Y is 134; X is 29 and Y is 135; X is 29 and Y is136; X is 29 and Y is 137; X is 29 and Y is 138; X is 29 and Y is 139; Xis 29 and Y is 140; X is 29 and Y is 141; X is 29 and Y is 142; X is 29and Y is 143; X is 29 and Y is 144; X is 29 and Y is 145; X is 29 and Yis 146; X is 29 and Y is 147; X is 29 and Y is 148; X is 29 and Y is149; X is 29 and Y is 150; X is 29 and Y is 151; X is 29 and Y is 152; Xis 29 and Y is 153; X is 29 and Y is 154; X is 29 and Y is 155; X is 29and Y is 156; X is 29 and Y is 157; X is 29 and Y is 158; X is 29 and Yis 159; X is 29 and Y is 160; X is 29 and Y is 161; X is 29 and Y is162; X is 29 and Y is 163; X is 29 and Y is 164; X is 29 and Y is 165; Xis 29 and Y is 166; X is 29 and Y is 167; X is 29 and Y is 168; X is 29and Y is 169; X is 29 and Y is 170; X is 29 and Y is 171; X is 29 and Yis 172; X is 29 and Y is 173; X is 29 and Y is 174; X is 29 and Y is175; X is 29 and Y is 176; X is 29 and Y is 177; X is 29 and Y is 178; Xis 29 and Y is 179; X is 29 and Y is 180; X is 29 and Y is 181; X is 29and Y is 182; X is 29 and Y is 183; X is 29 and Y is 184; X is 29 and Yis 185; X is 29 and Y is 186;X is 30 and Y is 1; X is 30 and Y is 2; X is 30 and Y is 3; X is 30 andY is 4; X is 30 and Y is 5; X is 30 and Y is 6; X is 30 and Y is 7; X is30 and Y is 8; X is 30 and Y is 9; X is 30 and Y is 10; X is 30 and Y is11; X is 30 and Y is 12; X is 30 and Y is 13; X is 30 and Y is 14; X is30 and Y is 15; X is 30 and Y is 16; X is 30 and Y is 17; X is 30 and Yis 18; X is 30 and Y is 19; X is 30 and Y is 20; X is 30 and Y is 21; Xis 30 and Y is 22; X is 30 and Y is 23; X is 30 and Y is 24; X is 30 andY is 25; X is 30 and Y is 26; X is 30 and Y is 27; X is 30 and Y is 28;X is 30 and Y is 29; X is 30 and Y is 30; X is 30 and Y is 31; X is 30and Y is 32; X is 30 and Y is 33; X is 30 and Y is 34; X is 30 and Y is35; X is 30 and Y is 36; X is 30 and Y is 37; X is 30 and Y is 38; X is30 and Y is 39; X is 30 and Y is 40; X is 30 and Y is 41; X is 30 and Yis 42; X is 30 and Y is 43; X is 30 and Y is 44; X is 30 and Y is 45; Xis 30 and Y is 46; X is 30 and Y is 47; X is 30 and Y is 48; X is 30 andY is 49; X is 30 and Y is 50; X is 30 and Y is 51; X is 30 and Y is 52;X is 30 and Y is 53; X is 30 and Y is 54; X is 30 and Y is 55; X is 30and Y is 56; X is 30 and Y is 57; X is 30 and Y is 58; X is 30 and Y is59; X is 30 and Y is 60; X is 30 and Y is 61; X is 30 and Y is 62; X is30 and Y is 63; X is 30 and Y is 64; X is 30 and Y is 65; X is 30 and Yis 66; X is 30 and Y is 67; X is 30 and Y is 68; X is 30 and Y is 69; Xis 30 and Y is 70; X is 30 and Y is 71; X is 30 and Y is 72; X is 30 andY is 73; X is 30 and Y is 74; X is 30 and Y is 75; X is 30 and Y is 76;X is 30 and Y is 77; X is 30 and Y is 78; X is 30 and Y is 79; X is 30and Y is 80; X is 30 and Y is 81; X is 30 and Y is 82; X is 30 and Y is83; X is 30 and Y is 84; X is 30 and Y is 85; X is 30 and Y is 86; X is30 and Y is 87; X is 30 and Y is 88; X is 30 and Y is 89; X is 30 and Yis 90; X is 30 and Y is 91; X is 30 and Y is 92; X is 30 and Y is 93; Xis 30 and Y is 94; X is 30 and Y is 95; X is 30 and Y is 96; X is 30 andY is 97; X is 30 and Y is 98; X is 30 and Y is 99; X is 30 and Y is 100;X is 30 and Y is 101; X is 30 and Y is 102; X is 30 and Y is 103; X is30 and Y is 104; X is 30 and Y is 105; X is 30 and Y is 106; X is 30 andY is 107; X is 30 and Y is 108; X is 30 and Y is 109; X is 30 and Y is110; X is 30 and Y is 111; X is 30 and Y is 112; X is 30 and Y is 113; Xis 30 and Y is 114; X is 30 and Y is 115; X is 30 and Y is 116; X is 30and Y is 117; X is 30 and Y is 118; X is 30 and Y is 119; X is 30 and Yis 120; X is 30 and Y is 121; X is 30 and Y is 122; X is 30 and Y is123; X is 30 and Y is 124; X is 30 and Y is 125; X is 30 and Y is 126; Xis 30 and Y is 127; X is 30 and Y is 128; X is 30 and Y is 129; X is 30and Y is 130; X is 30 and Y is 131; X is 30 and Y is 132; X is 30 and Yis 133; X is 30 and Y is 134; X is 30 and Y is 135; X is 30 and Y is136; X is 30 and Y is 137; X is 30 and Y is 138; X is 30 and Y is 139; Xis 30 and Y is 140; X is 30 and Y is 141; X is 30 and Y is 142; X is 30and Y is 143; X is 30 and Y is 144; X is 30 and Y is 145; X is 30 and Yis 146; X is 30 and Y is 147; X is 30 and Y is 148; X is 30 and Y is149; X is 30 and Y is 150; X is 30 and Y is 151; X is 30 and Y is 152; Xis 30 and Y is 153; X is 30 and Y is 154; X is 30 and Y is 155; X is 30and Y is 156; X is 30 and Y is 157; X is 30 and Y is 158; X is 30 and Yis 159; X is 30 and Y is 160; X is 30 and Y is 161; X is 30 and Y is162; X is 30 and Y is 163; X is 30 and Y is 164; X is 30 and Y is 165; Xis 30 and Y is 166; X is 30 and Y is 167; X is 30 and Y is 168; X is 30and Y is 169; X is 30 and Y is 170; X is 30 and Y is 171; X is 30 and Yis 172; X is 30 and Y is 173; X is 30 and Y is 174; X is 30 and Y is175; X is 30 and Y is 176; X is 30 and Y is 177; X is 30 and Y is 178; Xis 30 and Y is 179; X is 30 and Y is 180; X is 30 and Y is 181; X is 30and Y is 182; X is 30 and Y is 183; X is 30 and Y is 184; X is 30 and Yis 185; X is 30 and Y is 186;X is 31 and Y is 1; X is 31 and Y is 2; X is 31 and Y is 3; X is 31 andY is 4; X is 31 and Y is 5; X is 31 and Y is 6; X is 31 and Y is 7; X is31 and Y is 8; X is 31 and Y is 9; X is 31 and Y is 10; X is 31 and Y is11; X is 31 and Y is 12; X is 31 and Y is 13; X is 31 and Y is 14; X is31 and Y is 15; X is 31 and Y is 16; X is 31 and Y is 17; X is 31 and Yis 18; X is 31 and Y is 19; X is 31 and Y is 20; X is 31 and Y is 21; Xis 31 and Y is 22; X is 31 and Y is 23; X is 31 and Y is 24; X is 31 andY is 25; X is 31 and Y is 26; X is 31 and Y is 27; X is 31 and Y is 28;X is 31 and Y is 29; X is 31 and Y is 30; X is 31 and Y is 31; X is 31and Y is 32; X is 31 and Y is 33; X is 31 and Y is 34; X is 31 and Y is35; X is 31 and Y is 36; X is 31 and Y is 37; X is 31 and Y is 38; X is31 and Y is 39; X is 31 and Y is 40; X is 31 and Y is 41; X is 31 and Yis 42; X is 31 and Y is 43; X is 31 and Y is 44; X is 31 and Y is 45; Xis 31 and Y is 46; X is 31 and Y is 47; X is 31 and Y is 48; X is 31 andY is 49; X is 31 and Y is 50; X is 31 and Y is 51; X is 31 and Y is 52;X is 31 and Y is 53; X is 31 and Y is 54; X is 31 and Y is 55; X is 31and Y is 56; X is 31 and Y is 57; X is 31 and Y is 58; X is 31 and Y is59; X is 31 and Y is 60; X is 31 and Y is 61; X is 31 and Y is 62; X is31 and Y is 63; X is 31 and Y is 64; X is 31 and Y is 65; X is 31 and Yis 66; X is 31 and Y is 67; X is 31 and Y is 68; X is 31 and Y is 69; Xis 31 and Y is 70; X is 31 and Y is 71; X is 31 and Y is 72; X is 31 andY is 73; X is 31 and Y is 74; X is 31 and Y is 75; X is 31 and Y is 76;X is 31 and Y is 77; X is 31 and Y is 78; X is 31 and Y is 79; X is 31and Y is 80; X is 31 and Y is 81; X is 31 and Y is 82; X is 31 and Y is83; X is 31 and Y is 84; X is 31 and Y is 85; X is 31 and Y is 86; X is31 and Y is 87; X is 31 and Y is 88; X is 31 and Y is 89; X is 31 and Yis 90; X is 31 and Y is 91; X is 31 and Y is 92; X is 31 and Y is 93; Xis 31 and Y is 94; X is 31 and Y is 95; X is 31 and Y is 96; X is 31 andY is 97; X is 31 and Y is 98; X is 31 and Y is 99; X is 31 and Y is 100;X is 31 and Y is 101; X is 31 and Y is 102; X is 31 and Y is 103; X is31 and Y is 104; X is 31 and Y is 105; X is 31 and Y is 106; X is 31 andY is 107; X is 31 and Y is 108; X is 31 and Y is 109; X is 31 and Y is110; X is 31 and Y is 111; X is 31 and Y is 112; X is 31 and Y is 113; Xis 31 and Y is 114; X is 31 and Y is 115; X is 31 and Y is 116; X is 31and Y is 117; X is 31 and Y is 118; X is 31 and Y is 119; X is 31 and Yis 120; X is 31 and Y is 121; X is 31 and Y is 122; X is 31 and Y is123; X is 31 and Y is 124; X is 31 and Y is 125; X is 31 and Y is 126; Xis 31 and Y is 127; X is 31 and Y is 128; X is 31 and Y is 129; X is 31and Y is 130; X is 31 and Y is 131; X is 31 and Y is 132; X is 31 and Yis 133; X is 31 and Y is 134; X is 31 and Y is 135; X is 31 and Y is136; X is 31 and Y is 137; X is 31 and Y is 138; X is 31 and Y is 139; Xis 31 and Y is 140; X is 31 and Y is 141; X is 31 and Y is 142; X is 31and Y is 143; X is 31 and Y is 144; X is 31 and Y is 145; X is 31 and Yis 146; X is 31 and Y is 147; X is 31 and Y is 148; X is 31 and Y is149; X is 31 and Y is 150; X is 31 and Y is 151; X is 31 and Y is 152; Xis 31 and Y is 153; X is 31 and Y is 154; X is 31 and Y is 155; X is 31and Y is 156; X is 31 and Y is 157; X is 31 and Y is 158; X is 31 and Yis 159; X is 31 and Y is 160; X is 31 and Y is 161; X is 31 and Y is162; X is 31 and Y is 163; X is 31 and Y is 164; X is 31 and Y is 165; Xis 31 and Y is 166; X is 31 and Y is 167; X is 31 and Y is 168; X is 31and Y is 169; X is 31 and Y is 170; X is 31 and Y is 171; X is 31 and Yis 172; X is 31 and Y is 173; X is 31 and Y is 174; X is 31 and Y is175; X is 31 and Y is 176; X is 31 and Y is 177; X is 31 and Y is 178; Xis 31 and Y is 179; X is 31 and Y is 180; X is 31 and Y is 181; X is 31and Y is 182; X is 31 and Y is 183; X is 31 and Y is 184; X is 31 and Yis 185; X is 31 and Y is 186;X is 32 and Y is 1; X is 32 and Y is 2; X is 32 and Y is 3; X is 32 andY is 4; X is 32 and Y is 5; X is 32 and Y is 6; X is 32 and Y is 7; X is32 and Y is 8; X is 32 and Y is 9; X is 32 and Y is 10; X is 32 and Y is11; X is 32 and Y is 12; X is 32 and Y is 13; X is 32 and Y is 14; X is32 and Y is 15; X is 32 and Y is 16; X is 32 and Y is 17; X is 32 and Yis 18; X is 32 and Y is 19; X is 32 and Y is 20; X is 32 and Y is 21; Xis 32 and Y is 22; X is 32 and Y is 23; X is 32 and Y is 24; X is 32 andY is 25; X is 32 and Y is 26; X is 32 and Y is 27; X is 32 and Y is 28;X is 32 and Y is 29; X is 32 and Y is 30; X is 32 and Y is 31; X is 32and Y is 32; X is 32 and Y is 33; X is 32 and Y is 34; X is 32 and Y is35; X is 32 and Y is 36; X is 32 and Y is 37; X is 32 and Y is 38; X is32 and Y is 39; X is 32 and Y is 40; X is 32 and Y is 41; X is 32 and Yis 42; X is 32 and Y is 43; X is 32 and Y is 44; X is 32 and Y is 45; Xis 32 and Y is 46; X is 32 and Y is 47; X is 32 and Y is 48; X is 32 andY is 49; X is 32 and Y is 50; X is 32 and Y is 51; X is 32 and Y is 52;X is 32 and Y is 53; X is 32 and Y is 54; X is 32 and Y is 55; X is 32and Y is 56; X is 32 and Y is 57; X is 32 and Y is 58; X is 32 and Y is59; X is 32 and Y is 60; X is 32 and Y is 61; X is 32 and Y is 62; X is32 and Y is 63; X is 32 and Y is 64; X is 32 and Y is 65; X is 32 and Yis 66; X is 32 and Y is 67; X is 32 and Y is 68; X is 32 and Y is 69; Xis 32 and Y is 70; X is 32 and Y is 71; X is 32 and Y is 72; X is 32 andY is 73; X is 32 and Y is 74; X is 32 and Y is 75; X is 32 and Y is 76;X is 32 and Y is 77; X is 32 and Y is 78; X is 32 and Y is 79; X is 32and Y is 80; X is 32 and Y is 81; X is 32 and Y is 82; X is 32 and Y is83; X is 32 and Y is 84; X is 32 and Y is 85; X is 32 and Y is 86; X is32 and Y is 87; X is 32 and Y is 88; X is 32 and Y is 89; X is 32 and Yis 90; X is 32 and Y is 91; X is 32 and Y is 92; X is 32 and Y is 93; Xis 32 and Y is 94; X is 32 and Y is 95; X is 32 and Y is 96; X is 32 andY is 97; X is 32 and Y is 98; X is 32 and Y is 99; X is 32 and Y is 100;X is 32 and Y is 101; X is 32 and Y is 102; X is 32 and Y is 103; X is32 and Y is 104; X is 32 and Y is 105; X is 32 and Y is 106; X is 32 andY is 107; X is 32 and Y is 108; X is 32 and Y is 109; X is 32 and Y is110; X is 32 and Y is 111; X is 32 and Y is 112; X is 32 and Y is 113; Xis 32 and Y is 114; X is 32 and Y is 115; X is 32 and Y is 116; X is 32and Y is 117; X is 32 and Y is 118; X is 32 and Y is 119; X is 32 and Yis 120; X is 32 and Y is 121; X is 32 and Y is 122; X is 32 and Y is123; X is 32 and Y is 124; X is 32 and Y is 125; X is 32 and Y is 126; Xis 32 and Y is 127; X is 32 and Y is 128; X is 32 and Y is 129; X is 32and Y is 130; X is 32 and Y is 131; X is 32 and Y is 132; X is 32 and Yis 133; X is 32 and Y is 134; X is 32 and Y is 135; X is 32 and Y is136; X is 32 and Y is 137; X is 32 and Y is 138; X is 32 and Y is 139; Xis 32 and Y is 140; X is 32 and Y is 141; X is 32 and Y is 142; X is 32and Y is 143; X is 32 and Y is 144; X is 32 and Y is 145; X is 32 and Yis 146; X is 32 and Y is 147; X is 32 and Y is 148; X is 32 and Y is149; X is 32 and Y is 150; X is 32 and Y is 151; X is 32 and Y is 152; Xis 32 and Y is 153; X is 32 and Y is 154; X is 32 and Y is 155; X is 32and Y is 156; X is 32 and Y is 157; X is 32 and Y is 158; X is 32 and Yis 159; X is 32 and Y is 160; X is 32 and Y is 161; X is 32 and Y is162; X is 32 and Y is 163; X is 32 and Y is 164; X is 32 and Y is 165; Xis 32 and Y is 166; X is 32 and Y is 167; X is 32 and Y is 168; X is 32and Y is 169; X is 32 and Y is 170; X is 32 and Y is 171; X is 32 and Yis 172; X is 32 and Y is 173; X is 32 and Y is 174; X is 32 and Y is175; X is 32 and Y is 176; X is 32 and Y is 177; X is 32 and Y is 178; Xis 32 and Y is 179; X is 32 and Y is 180; X is 32 and Y is 181; X is 32and Y is 182; X is 32 and Y is 183; X is 32 and Y is 184; X is 32 and Yis 185; X is 32 and Y is 186;X is 33 and Y is 1; X is 33 and Y is 2; X is 33 and Y is 3; X is 33 andY is 4; X is 33 and Y is 5; X is 33 and Y is 6; X is 33 and Y is 7; X is33 and Y is 8; X is 33 and Y is 9; X is 33 and Y is 10; X is 33 and Y is11; X is 33 and Y is 12; X is 33 and Y is 13; X is 33 and Y is 14; X is33 and Y is 15; X is 33 and Y is 16; X is 33 and Y is 17; X is 33 and Yis 18; X is 33 and Y is 19; X is 33 and Y is 20; X is 33 and Y is 21; Xis 33 and Y is 22; X is 33 and Y is 23; X is 33 and Y is 24; X is 33 andY is 25; X is 33 and Y is 26; X is 33 and Y is 27; X is 33 and Y is 28;X is 33 and Y is 29; X is 33 and Y is 30; X is 33 and Y is 31; X is 33and Y is 32; X is 33 and Y is 33; X is 33 and Y is 34; X is 33 and Y is35; X is 33 and Y is 36; X is 33 and Y is 37; X is 33 and Y is 38; X is33 and Y is 39; X is 33 and Y is 40; X is 33 and Y is 41; X is 33 and Yis 42; X is 33 and Y is 43; X is 33 and Y is 44; X is 33 and Y is 45; Xis 33 and Y is 46; X is 33 and Y is 47; X is 33 and Y is 48; X is 33 andY is 49; X is 33 and Y is 50; X is 33 and Y is 51; X is 33 and Y is 52;X is 33 and Y is 53; X is 33 and Y is 54; X is 33 and Y is 55; X is 33and Y is 56; X is 33 and Y is 57; X is 33 and Y is 58; X is 33 and Y is59; X is 33 and Y is 60; X is 33 and Y is 61; X is 33 and Y is 62; X is33 and Y is 63; X is 33 and Y is 64; X is 33 and Y is 65; X is 33 and Yis 66; X is 33 and Y is 67; X is 33 and Y is 68; X is 33 and Y is 69; Xis 33 and Y is 70; X is 33 and Y is 71; X is 33 and Y is 72; X is 33 andY is 73; X is 33 and Y is 74; X is 33 and Y is 75; X is 33 and Y is 76;X is 33 and Y is 77; X is 33 and Y is 78; X is 33 and Y is 79; X is 33and Y is 80; X is 33 and Y is 81; X is 33 and Y is 82; X is 33 and Y is83; X is 33 and Y is 84; X is 33 and Y is 85; X is 33 and Y is 86; X is33 and Y is 87; X is 33 and Y is 88; X is 33 and Y is 89; X is 33 and Yis 90; X is 33 and Y is 91; X is 33 and Y is 92; X is 33 and Y is 93; Xis 33 and Y is 94; X is 33 and Y is 95; X is 33 and Y is 96; X is 33 andY is 97; X is 33 and Y is 98; X is 33 and Y is 99; X is 33 and Y is 100;X is 33 and Y is 101; X is 33 and Y is 102; X is 33 and Y is 103; X is33 and Y is 104; X is 33 and Y is 105; X is 33 and Y is 106; X is 33 andY is 107; X is 33 and Y is 108; X is 33 and Y is 109; X is 33 and Y is110; X is 33 and Y is 111; X is 33 and Y is 112; X is 33 and Y is 113; Xis 33 and Y is 114; X is 33 and Y is 115; X is 33 and Y is 116; X is 33and Y is 117; X is 33 and Y is 118; X is 33 and Y is 119; X is 33 and Yis 120; X is 33 and Y is 121; X is 33 and Y is 122; X is 33 and Y is123; X is 33 and Y is 124; X is 33 and Y is 125; X is 33 and Y is 126; Xis 33 and Y is 127; X is 33 and Y is 128; X is 33 and Y is 129; X is 33and Y is 130; X is 33 and Y is 131; X is 33 and Y is 132; X is 33 and Yis 133; X is 33 and Y is 134; X is 33 and Y is 135; X is 33 and Y is136; X is 33 and Y is 137; X is 33 and Y is 138; X is 33 and Y is 139; Xis 33 and Y is 140; X is 33 and Y is 141; X is 33 and Y is 142; X is 33and Y is 143; X is 33 and Y is 144; X is 33 and Y is 145; X is 33 and Yis 146; X is 33 and Y is 147; X is 33 and Y is 148; X is 33 and Y is149; X is 33 and Y is 150; X is 33 and Y is 151; X is 33 and Y is 152; Xis 33 and Y is 153; X is 33 and Y is 154; X is 33 and Y is 155; X is 33and Y is 156; X is 33 and Y is 157; X is 33 and Y is 158; X is 33 and Yis 159; X is 33 and Y is 160; X is 33 and Y is 161; X is 33 and Y is162; X is 33 and Y is 163; X is 33 and Y is 164; X is 33 and Y is 165; Xis 33 and Y is 166; X is 33 and Y is 167; X is 33 and Y is 168; X is 33and Y is 169; X is 33 and Y is 170; X is 33 and Y is 171; X is 33 and Yis 172; X is 33 and Y is 173; X is 33 and Y is 174; X is 33 and Y is175; X is 33 and Y is 176; X is 33 and Y is 177; X is 33 and Y is 178; Xis 33 and Y is 179; X is 33 and Y is 180; X is 33 and Y is 181; X is 33and Y is 182; X is 33 and Y is 183; X is 33 and Y is 184; X is 33 and Yis 185; X is 33 and Y is 186;X is 34 and Y is 1; X is 34 and Y is 2; X is 34 and Y is 3; X is 34 andY is 4; X is 34 and Y is 5; X is 34 and Y is 6; X is 34 and Y is 7; X is34 and Y is 8; X is 34 and Y is 9; X is 34 and Y is 10; X is 34 and Y is11; X is 34 and Y is 12; X is 34 and Y is 13; X is 34 and Y is 14; X is34 and Y is 15; X is 34 and Y is 16; X is 34 and Y is 17; X is 34 and Yis 18; X is 34 and Y is 19; X is 34 and Y is 20; X is 34 and Y is 21; Xis 34 and Y is 22; X is 34 and Y is 23; X is 34 and Y is 24; X is 34 andY is 25; X is 34 and Y is 26; X is 34 and Y is 27; X is 34 and Y is 28;X is 34 and Y is 29; X is 34 and Y is 30; X is 34 and Y is 31; X is 34and Y is 32; X is 34 and Y is 33; X is 34 and Y is 34; X is 34 and Y is35; X is 34 and Y is 36; X is 34 and Y is 37; X is 34 and Y is 38; X is34 and Y is 39; X is 34 and Y is 40; X is 34 and Y is 41; X is 34 and Yis 42; X is 34 and Y is 43; X is 34 and Y is 44; X is 34 and Y is 45; Xis 34 and Y is 46; X is 34 and Y is 47; X is 34 and Y is 48; X is 34 andY is 49; X is 34 and Y is 50; X is 34 and Y is 51; X is 34 and Y is 52;X is 34 and Y is 53; X is 34 and Y is 54; X is 34 and Y is 55; X is 34and Y is 56; X is 34 and Y is 57; X is 34 and Y is 58; X is 34 and Y is59; X is 34 and Y is 60; X is 34 and Y is 61; X is 34 and Y is 62; X is34 and Y is 63; X is 34 and Y is 64; X is 34 and Y is 65; X is 34 and Yis 66; X is 34 and Y is 67; X is 34 and Y is 68; X is 34 and Y is 69; Xis 34 and Y is 70; X is 34 and Y is 71; X is 34 and Y is 72; X is 34 andY is 73; X is 34 and Y is 74; X is 34 and Y is 75; X is 34 and Y is 76;X is 34 and Y is 77; X is 34 and Y is 78; X is 34 and Y is 79; X is 34and Y is 80; X is 34 and Y is 81; X is 34 and Y is 82; X is 34 and Y is83; X is 34 and Y is 84; X is 34 and Y is 85; X is 34 and Y is 86; X is34 and Y is 87; X is 34 and Y is 88; X is 34 and Y is 89; X is 34 and Yis 90; X is 34 and Y is 91; X is 34 and Y is 92; X is 34 and Y is 93; Xis 34 and Y is 94; X is 34 and Y is 95; X is 34 and Y is 96; X is 34 andY is 97; X is 34 and Y is 98; X is 34 and Y is 99; X is 34 and Y is 100;X is 34 and Y is 101; X is 34 and Y is 102; X is 34 and Y is 103; X is34 and Y is 104; X is 34 and Y is 105; X is 34 and Y is 106; X is 34 andY is 107; X is 34 and Y is 108; X is 34 and Y is 109; X is 34 and Y is110; X is 34 and Y is 111; X is 34 and Y is 112; X is 34 and Y is 113; Xis 34 and Y is 114; X is 34 and Y is 115; X is 34 and Y is 116; X is 34and Y is 117; X is 34 and Y is 118; X is 34 and Y is 119; X is 34 and Yis 120; X is 34 and Y is 121; X is 34 and Y is 122; X is 34 and Y is123; X is 34 and Y is 124; X is 34 and Y is 125; X is 34 and Y is 126; Xis 34 and Y is 127; X is 34 and Y is 128; X is 34 and Y is 129; X is 34and Y is 130; X is 34 and Y is 131; X is 34 and Y is 132; X is 34 and Yis 133; X is 34 and Y is 134; X is 34 and Y is 135; X is 34 and Y is136; X is 34 and Y is 137; X is 34 and Y is 138; X is 34 and Y is 139; Xis 34 and Y is 140; X is 34 and Y is 141; X is 34 and Y is 142; X is 34and Y is 143; X is 34 and Y is 144; X is 34 and Y is 145; X is 34 and Yis 146; X is 34 and Y is 147; X is 34 and Y is 148; X is 34 and Y is149; X is 34 and Y is 150; X is 34 and Y is 151; X is 34 and Y is 152; Xis 34 and Y is 153; X is 34 and Y is 154; X is 34 and Y is 155; X is 34and Y is 156; X is 34 and Y is 157; X is 34 and Y is 158; X is 34 and Yis 159; X is 34 and Y is 160; X is 34 and Y is 161; X is 34 and Y is162; X is 34 and Y is 163; X is 34 and Y is 164; X is 34 and Y is 165; Xis 34 and Y is 166; X is 34 and Y is 167; X is 34 and Y is 168; X is 34and Y is 169; X is 34 and Y is 170; X is 34 and Y is 171; X is 34 and Yis 172; X is 34 and Y is 173; X is 34 and Y is 174; X is 34 and Y is175; X is 34 and Y is 176; X is 34 and Y is 177; X is 34 and Y is 178; Xis 34 and Y is 179; X is 34 and Y is 180; X is 34 and Y is 181; X is 34and Y is 182; X is 34 and Y is 183; X is 34 and Y is 184; X is 34 and Yis 185; X is 34 and Y is 186;X is 35 and Y is 1; X is 35 and Y is 2; X is 35 and Y is 3; X is 35 andY is 4; X is 35 and Y is 5; X is 35 and Y is 6; X is 35 and Y is 7; X is35 and Y is 8; X is 35 and Y is 9; X is 35 and Y is 10; X is 35 and Y is11; X is 35 and Y is 12; X is 35 and Y is 13; X is 35 and Y is 14; X is35 and Y is 15; X is 35 and Y is 16; X is 35 and Y is 17; X is 35 and Yis 18; X is 35 and Y is 19; X is 35 and Y is 20; X is 35 and Y is 21; Xis 35 and Y is 22; X is 35 and Y is 23; X is 35 and Y is 24; X is 35 andY is 25; X is 35 and Y is 26; X is 35 and Y is 27; X is 35 and Y is 28;X is 35 and Y is 29; X is 35 and Y is 30; X is 35 and Y is 31; X is 35and Y is 32; X is 35 and Y is 33; X is 35 and Y is 34; X is 35 and Y is35; X is 35 and Y is 36; X is 35 and Y is 37; X is 35 and Y is 38; X is35 and Y is 39; X is 35 and Y is 40; X is 35 and Y is 41; X is 35 and Yis 42; X is 35 and Y is 43; X is 35 and Y is 44; X is 35 and Y is 45; Xis 35 and Y is 46; X is 35 and Y is 47; X is 35 and Y is 48; X is 35 andY is 49; X is 35 and Y is 50; X is 35 and Y is 51; X is 35 and Y is 52;X is 35 and Y is 53; X is 35 and Y is 54; X is 35 and Y is 55; X is 35and Y is 56; X is 35 and Y is 57; X is 35 and Y is 58; X is 35 and Y is59; X is 35 and Y is 60; X is 35 and Y is 61; X is 35 and Y is 62; X is35 and Y is 63; X is 35 and Y is 64; X is 35 and Y is 65; X is 35 and Yis 66; X is 35 and Y is 67; X is 35 and Y is 68; X is 35 and Y is 69; Xis 35 and Y is 70; X is 35 and Y is 71; X is 35 and Y is 72; X is 35 andY is 73; X is 35 and Y is 74; X is 35 and Y is 75; X is 35 and Y is 76;X is 35 and Y is 77; X is 35 and Y is 78; X is 35 and Y is 79; X is 35and Y is 80; X is 35 and Y is 81; X is 35 and Y is 82; X is 35 and Y is83; X is 35 and Y is 84; X is 35 and Y is 85; X is 35 and Y is 86; X is35 and Y is 87; X is 35 and Y is 88; X is 35 and Y is 89; X is 35 and Yis 90; X is 35 and Y is 91; X is 35 and Y is 92; X is 35 and Y is 93; Xis 35 and Y is 94; X is 35 and Y is 95; X is 35 and Y is 96; X is 35 andY is 97; X is 35 and Y is 98; X is 35 and Y is 99; X is 35 and Y is 100;X is 35 and Y is 101; X is 35 and Y is 102; X is 35 and Y is 103; X is35 and Y is 104; X is 35 and Y is 105; X is 35 and Y is 106; X is 35 andY is 107; X is 35 and Y is 108; X is 35 and Y is 109; X is 35 and Y is110; X is 35 and Y is 111; X is 35 and Y is 112; X is 35 and Y is 113; Xis 35 and Y is 114; X is 35 and Y is 115; X is 35 and Y is 116; X is 35and Y is 117; X is 35 and Y is 118; X is 35 and Y is 119; X is 35 and Yis 120; X is 35 and Y is 121; X is 35 and Y is 122; X is 35 and Y is123; X is 35 and Y is 124; X is 35 and Y is 125; X is 35 and Y is 126; Xis 35 and Y is 127; X is 35 and Y is 128; X is 35 and Y is 129; X is 35and Y is 130; X is 35 and Y is 131; X is 35 and Y is 132; X is 35 and Yis 133; X is 35 and Y is 134; X is 35 and Y is 135; X is 35 and Y is136; X is 35 and Y is 137; X is 35 and Y is 138; X is 35 and Y is 139; Xis 35 and Y is 140; X is 35 and Y is 141; X is 35 and Y is 142; X is 35and Y is 143; X is 35 and Y is 144; X is 35 and Y is 145; X is 35 and Yis 146; X is 35 and Y is 147; X is 35 and Y is 148; X is 35 and Y is149; X is 35 and Y is 150; X is 35 and Y is 151; X is 35 and Y is 152; Xis 35 and Y is 153; X is 35 and Y is 154; X is 35 and Y is 155; X is 35and Y is 156; X is 35 and Y is 157; X is 35 and Y is 158; X is 35 and Yis 159; X is 35 and Y is 160; X is 35 and Y is 161; X is 35 and Y is162; X is 35 and Y is 163; X is 35 and Y is 164; X is 35 and Y is 165; Xis 35 and Y is 166; X is 35 and Y is 167; X is 35 and Y is 168; X is 35and Y is 169; X is 35 and Y is 170; X is 35 and Y is 171; X is 35 and Yis 172; X is 35 and Y is 173; X is 35 and Y is 174; X is 35 and Y is175; X is 35 and Y is 176; X is 35 and Y is 177; X is 35 and Y is 178; Xis 35 and Y is 179; X is 35 and Y is 180; X is 35 and Y is 181; X is 35and Y is 182; X is 35 and Y is 183; X is 35 and Y is 184; X is 35 and Yis 185; X is 35 and Y is 186;X is 36 and Y is 1; X is 36 and Y is 2; X is 36 and Y is 3; X is 36 andY is 4; X is 36 and Y is 5; X is 36 and Y is 6; X is 36 and Y is 7; X is36 and Y is 8; X is 36 and Y is 9; X is 36 and Y is 10; X is 36 and Y is11; X is 36 and Y is 12; X is 36 and Y is 13; X is 36 and Y is 14; X is36 and Y is 15; X is 36 and Y is 16; X is 36 and Y is 17; X is 36 and Yis 18; X is 36 and Y is 19; X is 36 and Y is 20; X is 36 and Y is 21; Xis 36 and Y is 22; X is 36 and Y is 23; X is 36 and Y is 24; X is 36 andY is 25; X is 36 and Y is 26; X is 36 and Y is 27; X is 36 and Y is 28;X is 36 and Y is 29; X is 36 and Y is 30; X is 36 and Y is 31; X is 36and Y is 32; X is 36 and Y is 33; X is 36 and Y is 34; X is 36 and Y is35; X is 36 and Y is 36; X is 36 and Y is 37; X is 36 and Y is 38; X is36 and Y is 39; X is 36 and Y is 40; X is 36 and Y is 41; X is 36 and Yis 42; X is 36 and Y is 43; X is 36 and Y is 44; X is 36 and Y is 45; Xis 36 and Y is 46; X is 36 and Y is 47; X is 36 and Y is 48; X is 36 andY is 49; X is 36 and Y is 50; X is 36 and Y is 51; X is 36 and Y is 52;X is 36 and Y is 53; X is 36 and Y is 54; X is 36 and Y is 55; X is 36and Y is 56; X is 36 and Y is 57; X is 36 and Y is 58; X is 36 and Y is59; X is 36 and Y is 60; X is 36 and Y is 61; X is 36 and Y is 62; X is36 and Y is 63; X is 36 and Y is 64; X is 36 and Y is 65; X is 36 and Yis 66; X is 36 and Y is 67; X is 36 and Y is 68; X is 36 and Y is 69; Xis 36 and Y is 70; X is 36 and Y is 71; X is 36 and Y is 72; X is 36 andY is 73; X is 36 and Y is 74; X is 36 and Y is 75; X is 36 and Y is 76;X is 36 and Y is 77; X is 36 and Y is 78; X is 36 and Y is 79; X is 36and Y is 80; X is 36 and Y is 81; X is 36 and Y is 82; X is 36 and Y is83; X is 36 and Y is 84; X is 36 and Y is 85; X is 36 and Y is 86; X is36 and Y is 87; X is 36 and Y is 88; X is 36 and Y is 89; X is 36 and Yis 90; X is 36 and Y is 91; X is 36 and Y is 92; X is 36 and Y is 93; Xis 36 and Y is 94; X is 36 and Y is 95; X is 36 and Y is 96; X is 36 andY is 97; X is 36 and Y is 98; X is 36 and Y is 99; X is 36 and Y is 100;X is 36 and Y is 101; X is 36 and Y is 102; X is 36 and Y is 103; X is36 and Y is 104; X is 36 and Y is 105; X is 36 and Y is 106; X is 36 andY is 107; X is 36 and Y is 108; X is 36 and Y is 109; X is 36 and Y is110; X is 36 and Y is 111; X is 36 and Y is 112; X is 36 and Y is 113; Xis 36 and Y is 114; X is 36 and Y is 115; X is 36 and Y is 116; X is 36and Y is 117; X is 36 and Y is 118; X is 36 and Y is 119; X is 36 and Yis 120; X is 36 and Y is 121; X is 36 and Y is 122; X is 36 and Y is123; X is 36 and Y is 124; X is 36 and Y is 125; X is 36 and Y is 126; Xis 36 and Y is 127; X is 36 and Y is 128; X is 36 and Y is 129; X is 36and Y is 130; X is 36 and Y is 131; X is 36 and Y is 132; X is 36 and Yis 133; X is 36 and Y is 134; X is 36 and Y is 135; X is 36 and Y is136; X is 36 and Y is 137; X is 36 and Y is 138; X is 36 and Y is 139; Xis 36 and Y is 140; X is 36 and Y is 141; X is 36 and Y is 142; X is 36and Y is 143; X is 36 and Y is 144; X is 36 and Y is 145; X is 36 and Yis 146; X is 36 and Y is 147; X is 36 and Y is 148; X is 36 and Y is149; X is 36 and Y is 150; X is 36 and Y is 151; X is 36 and Y is 152; Xis 36 and Y is 153; X is 36 and Y is 154; X is 36 and Y is 155; X is 36and Y is 156; X is 36 and Y is 157; X is 36 and Y is 158; X is 36 and Yis 159; X is 36 and Y is 160; X is 36 and Y is 161; X is 36 and Y is162; X is 36 and Y is 163; X is 36 and Y is 164; X is 36 and Y is 165; Xis 36 and Y is 166; X is 36 and Y is 167; X is 36 and Y is 168; X is 36and Y is 169; X is 36 and Y is 170; X is 36 and Y is 171; X is 36 and Yis 172; X is 36 and Y is 173; X is 36 and Y is 174; X is 36 and Y is175; X is 36 and Y is 176; X is 36 and Y is 177; X is 36 and Y is 178; Xis 36 and Y is 179; X is 36 and Y is 180; X is 36 and Y is 181; X is 36and Y is 182; X is 36 and Y is 183; X is 36 and Y is 184; X is 36 and Yis 185; X is 36 and Y is 186;X is 37 and Y is 1; X is 37 and Y is 2; X is 37 and Y is 3; X is 37 andY is 4; X is 37 and Y is 5; X is 37 and Y is 6; X is 37 and Y is 7; X is37 and Y is 8; X is 37 and Y is 9; X is 37 and Y is 10; X is 37 and Y is11; X is 37 and Y is 12; X is 37 and Y is 13; X is 37 and Y is 14; X is37 and Y is 15; X is 37 and Y is 16; X is 37 and Y is 17; X is 37 and Yis 18; X is 37 and Y is 19; X is 37 and Y is 20; X is 37 and Y is 21; Xis 37 and Y is 22; X is 37 and Y is 23; X is 37 and Y is 24; X is 37 andY is 25; X is 37 and Y is 26; X is 37 and Y is 27; X is 37 and Y is 28;X is 37 and Y is 29; X is 37 and Y is 30; X is 37 and Y is 31; X is 37and Y is 32; X is 37 and Y is 33; X is 37 and Y is 34; X is 37 and Y is35; X is 37 and Y is 36; X is 37 and Y is 37; X is 37 and Y is 38; X is37 and Y is 39; X is 37 and Y is 40; X is 37 and Y is 41; X is 37 and Yis 42; X is 37 and Y is 43; X is 37 and Y is 44; X is 37 and Y is 45; Xis 37 and Y is 46; X is 37 and Y is 47; X is 37 and Y is 48; X is 37 andY is 49; X is 37 and Y is 50; X is 37 and Y is 51; X is 37 and Y is 52;X is 37 and Y is 53; X is 37 and Y is 54; X is 37 and Y is 55; X is 37and Y is 56; X is 37 and Y is 57; X is 37 and Y is 58; X is 37 and Y is59; X is 37 and Y is 60; X is 37 and Y is 61; X is 37 and Y is 62; X is37 and Y is 63; X is 37 and Y is 64; X is 37 and Y is 65; X is 37 and Yis 66; X is 37 and Y is 67; X is 37 and Y is 68; X is 37 and Y is 69; Xis 37 and Y is 70; X is 37 and Y is 71; X is 37 and Y is 72; X is 37 andY is 73; X is 37 and Y is 74; X is 37 and Y is 75; X is 37 and Y is 76;X is 37 and Y is 77; X is 37 and Y is 78; X is 37 and Y is 79; X is 37and Y is 80; X is 37 and Y is 81; X is 37 and Y is 82; X is 37 and Y is83; X is 37 and Y is 84; X is 37 and Y is 85; X is 37 and Y is 86; X is37 and Y is 87; X is 37 and Y is 88; X is 37 and Y is 89; X is 37 and Yis 90; X is 37 and Y is 91; X is 37 and Y is 92; X is 37 and Y is 93; Xis 37 and Y is 94; X is 37 and Y is 95; X is 37 and Y is 96; X is 37 andY is 97; X is 37 and Y is 98; X is 37 and Y is 99; X is 37 and Y is 100;X is 37 and Y is 101; X is 37 and Y is 102; X is 37 and Y is 103; X is37 and Y is 104; X is 37 and Y is 105; X is 37 and Y is 106; X is 37 andY is 107; X is 37 and Y is 108; X is 37 and Y is 109; X is 37 and Y is110; X is 37 and Y is 111; X is 37 and Y is 112; X is 37 and Y is 113; Xis 37 and Y is 114; X is 37 and Y is 115; X is 37 and Y is 116; X is 37and Y is 117; X is 37 and Y is 118; X is 37 and Y is 119; X is 37 and Yis 120; X is 37 and Y is 121; X is 37 and Y is 122; X is 37 and Y is123; X is 37 and Y is 124; X is 37 and Y is 125; X is 37 and Y is 126; Xis 37 and Y is 127; X is 37 and Y is 128; X is 37 and Y is 129; X is 37and Y is 130; X is 37 and Y is 131; X is 37 and Y is 132; X is 37 and Yis 133; X is 37 and Y is 134; X is 37 and Y is 135; X is 37 and Y is136; X is 37 and Y is 137; X is 37 and Y is 138; X is 37 and Y is 139; Xis 37 and Y is 140; X is 37 and Y is 141; X is 37 and Y is 142; X is 37and Y is 143; X is 37 and Y is 144; X is 37 and Y is 145; X is 37 and Yis 146; X is 37 and Y is 147; X is 37 and Y is 148; X is 37 and Y is149; X is 37 and Y is 150; X is 37 and Y is 151; X is 37 and Y is 152; Xis 37 and Y is 153; X is 37 and Y is 154; X is 37 and Y is 155; X is 37and Y is 156; X is 37 and Y is 157; X is 37 and Y is 158; X is 37 and Yis 159; X is 37 and Y is 160; X is 37 and Y is 161; X is 37 and Y is162; X is 37 and Y is 163; X is 37 and Y is 164; X is 37 and Y is 165; Xis 37 and Y is 166; X is 37 and Y is 167; X is 37 and Y is 168; X is 37and Y is 169; X is 37 and Y is 170; X is 37 and Y is 171; X is 37 and Yis 172; X is 37 and Y is 173; X is 37 and Y is 174; X is 37 and Y is175; X is 37 and Y is 176; X is 37 and Y is 177; X is 37 and Y is 178; Xis 37 and Y is 179; X is 37 and Y is 180; X is 37 and Y is 181; X is 37and Y is 182; X is 37 and Y is 183; X is 37 and Y is 184; X is 37 and Yis 185; X is 37 and Y is 186;X is 38 and Y is 1; X is 38 and Y is 2; X is 38 and Y is 3; X is 38 andY is 4; X is 38 and Y is 5; X is 38 and Y is 6; X is 38 and Y is 7; X is38 and Y is 8; X is 38 and Y is 9; X is 38 and Y is 10; X is 38 and Y is11; X is 38 and Y is 12; X is 38 and Y is 13; X is 38 and Y is 14; X is38 and Y is 15; X is 38 and Y is 16; X is 38 and Y is 17; X is 38 and Yis 18; X is 38 and Y is 19; X is 38 and Y is 20; X is 38 and Y is 21; Xis 38 and Y is 22; X is 38 and Y is 23; X is 38 and Y is 24; X is 38 andY is 25; X is 38 and Y is 26; X is 38 and Y is 27; X is 38 and Y is 28;X is 38 and Y is 29; X is 38 and Y is 30; X is 38 and Y is 31; X is 38and Y is 32; X is 38 and Y is 33; X is 38 and Y is 34; X is 38 and Y is35; X is 38 and Y is 36; X is 38 and Y is 37; X is 38 and Y is 38; X is38 and Y is 39; X is 38 and Y is 40; X is 38 and Y is 41; X is 38 and Yis 42; X is 38 and Y is 43; X is 38 and Y is 44; X is 38 and Y is 45; Xis 38 and Y is 46; X is 38 and Y is 47; X is 38 and Y is 48; X is 38 andY is 49; X is 38 and Y is 50; X is 38 and Y is 51; X is 38 and Y is 52;X is 38 and Y is 53; X is 38 and Y is 54; X is 38 and Y is 55; X is 38and Y is 56; X is 38 and Y is 57; X is 38 and Y is 58; X is 38 and Y is59; X is 38 and Y is 60; X is 38 and Y is 61; X is 38 and Y is 62; X is38 and Y is 63; X is 38 and Y is 64; X is 38 and Y is 65; X is 38 and Yis 66; X is 38 and Y is 67; X is 38 and Y is 68; X is 38 and Y is 69; Xis 38 and Y is 70; X is 38 and Y is 71; X is 38 and Y is 72; X is 38 andY is 73; X is 38 and Y is 74; X is 38 and Y is 75; X is 38 and Y is 76;X is 38 and Y is 77; X is 38 and Y is 78; X is 38 and Y is 79; X is 38and Y is 80; X is 38 and Y is 81; X is 38 and Y is 82; X is 38 and Y is83; X is 38 and Y is 84; X is 38 and Y is 85; X is 38 and Y is 86; X is38 and Y is 87; X is 38 and Y is 88; X is 38 and Y is 89; X is 38 and Yis 90; X is 38 and Y is 91; X is 38 and Y is 92; X is 38 and Y is 93; Xis 38 and Y is 94; X is 38 and Y is 95; X is 38 and Y is 96; X is 38 andY is 97; X is 38 and Y is 98; X is 38 and Y is 99; X is 38 and Y is 100;X is 38 and Y is 101; X is 38 and Y is 102; X is 38 and Y is 103; X is38 and Y is 104; X is 38 and Y is 105; X is 38 and Y is 106; X is 38 andY is 107; X is 38 and Y is 108; X is 38 and Y is 109; X is 38 and Y is110; X is 38 and Y is 111; X is 38 and Y is 112; X is 38 and Y is 113; Xis 38 and Y is 114; X is 38 and Y is 115; X is 38 and Y is 116; X is 38and Y is 117; X is 38 and Y is 118; X is 38 and Y is 119; X is 38 and Yis 120; X is 38 and Y is 121; X is 38 and Y is 122; X is 38 and Y is123; X is 38 and Y is 124; X is 38 and Y is 125; X is 38 and Y is 126; Xis 38 and Y is 127; X is 38 and Y is 128; X is 38 and Y is 129; X is 38and Y is 130; X is 38 and Y is 131; X is 38 and Y is 132; X is 38 and Yis 133; X is 38 and Y is 134; X is 38 and Y is 135; X is 38 and Y is136; X is 38 and Y is 137; X is 38 and Y is 138; X is 38 and Y is 139; Xis 38 and Y is 140; X is 38 and Y is 141; X is 38 and Y is 142; X is 38and Y is 143; X is 38 and Y is 144; X is 38 and Y is 145; X is 38 and Yis 146; X is 38 and Y is 147; X is 38 and Y is 148; X is 38 and Y is149; X is 38 and Y is 150; X is 38 and Y is 151; X is 38 and Y is 152; Xis 38 and Y is 153; X is 38 and Y is 154; X is 38 and Y is 155; X is 38and Y is 156; X is 38 and Y is 157; X is 38 and Y is 158; X is 38 and Yis 159; X is 38 and Y is 160; X is 38 and Y is 161; X is 38 and Y is162; X is 38 and Y is 163; X is 38 and Y is 164; X is 38 and Y is 165; Xis 38 and Y is 166; X is 38 and Y is 167; X is 38 and Y is 168; X is 38and Y is 169; X is 38 and Y is 170; X is 38 and Y is 171; X is 38 and Yis 172; X is 38 and Y is 173; X is 38 and Y is 174; X is 38 and Y is175; X is 38 and Y is 176; X is 38 and Y is 177; X is 38 and Y is 178; Xis 38 and Y is 179; X is 38 and Y is 180; X is 38 and Y is 181; X is 38and Y is 182; X is 38 and Y is 183; X is 38 and Y is 184; X is 38 and Yis 185; X is 38 and Y is 186;X is 39 and Y is 1; X is 39 and Y is 2; X is 39 and Y is 3; X is 39 andY is 4; X is 39 and Y is 5; X is 39 and Y is 6; X is 39 and Y is 7; X is39 and Y is 8; X is 39 and Y is 9; X is 39 and Y is 10; X is 39 and Y is11; X is 39 and Y is 12; X is 39 and Y is 13; X is 39 and Y is 14; X is39 and Y is 15; X is 39 and Y is 16; X is 39 and Y is 17; X is 39 and Yis 18; X is 39 and Y is 19; X is 39 and Y is 20; X is 39 and Y is 21; Xis 39 and Y is 22; X is 39 and Y is 23; X is 39 and Y is 24; X is 39 andY is 25; X is 39 and Y is 26; X is 39 and Y is 27; X is 39 and Y is 28;X is 39 and Y is 29; X is 39 and Y is 30; X is 39 and Y is 31; X is 39and Y is 32; X is 39 and Y is 33; X is 39 and Y is 34; X is 39 and Y is35; X is 39 and Y is 36; X is 39 and Y is 37; X is 39 and Y is 38; X is39 and Y is 39; X is 39 and Y is 40; X is 39 and Y is 41; X is 39 and Yis 42; X is 39 and Y is 43; X is 39 and Y is 44; X is 39 and Y is 45; Xis 39 and Y is 46; X is 39 and Y is 47; X is 39 and Y is 48; X is 39 andY is 49; X is 39 and Y is 50; X is 39 and Y is 51; X is 39 and Y is 52;X is 39 and Y is 53; X is 39 and Y is 54; X is 39 and Y is 55; X is 39and Y is 56; X is 39 and Y is 57; X is 39 and Y is 58; X is 39 and Y is59; X is 39 and Y is 60; X is 39 and Y is 61; X is 39 and Y is 62; X is39 and Y is 63; X is 39 and Y is 64; X is 39 and Y is 65; X is 39 and Yis 66; X is 39 and Y is 67; X is 39 and Y is 68; X is 39 and Y is 69; Xis 39 and Y is 70; X is 39 and Y is 71; X is 39 and Y is 72; X is 39 andY is 73; X is 39 and Y is 74; X is 39 and Y is 75; X is 39 and Y is 76;X is 39 and Y is 77; X is 39 and Y is 78; X is 39 and Y is 79; X is 39and Y is 80; X is 39 and Y is 81; X is 39 and Y is 82; X is 39 and Y is83; X is 39 and Y is 84; X is 39 and Y is 85; X is 39 and Y is 86; X is39 and Y is 87; X is 39 and Y is 88; X is 39 and Y is 89; X is 39 and Yis 90; X is 39 and Y is 91; X is 39 and Y is 92; X is 39 and Y is 93; Xis 39 and Y is 94; X is 39 and Y is 95; X is 39 and Y is 96; X is 39 andY is 97; X is 39 and Y is 98; X is 39 and Y is 99; X is 39 and Y is 100;X is 39 and Y is 101; X is 39 and Y is 102; X is 39 and Y is 103; X is39 and Y is 104; X is 39 and Y is 105; X is 39 and Y is 106; X is 39 andY is 107; X is 39 and Y is 108; X is 39 and Y is 109; X is 39 and Y is110; X is 39 and Y is 111; X is 39 and Y is 112; X is 39 and Y is 113; Xis 39 and Y is 114; X is 39 and Y is 115; X is 39 and Y is 116; X is 39and Y is 117; X is 39 and Y is 118; X is 39 and Y is 119; X is 39 and Yis 120; X is 39 and Y is 121; X is 39 and Y is 122; X is 39 and Y is123; X is 39 and Y is 124; X is 39 and Y is 125; X is 39 and Y is 126; Xis 39 and Y is 127; X is 39 and Y is 128; X is 39 and Y is 129; X is 39and Y is 130; X is 39 and Y is 131; X is 39 and Y is 132; X is 39 and Yis 133; X is 39 and Y is 134; X is 39 and Y is 135; X is 39 and Y is136; X is 39 and Y is 137; X is 39 and Y is 138; X is 39 and Y is 139; Xis 39 and Y is 140; X is 39 and Y is 141; X is 39 and Y is 142; X is 39and Y is 143; X is 39 and Y is 144; X is 39 and Y is 145; X is 39 and Yis 146; X is 39 and Y is 147; X is 39 and Y is 148; X is 39 and Y is149; X is 39 and Y is 150; X is 39 and Y is 151; X is 39 and Y is 152; Xis 39 and Y is 153; X is 39 and Y is 154; X is 39 and Y is 155; X is 39and Y is 156; X is 39 and Y is 157; X is 39 and Y is 158; X is 39 and Yis 159; X is 39 and Y is 160; X is 39 and Y is 161; X is 39 and Y is162; X is 39 and Y is 163; X is 39 and Y is 164; X is 39 and Y is 165; Xis 39 and Y is 166; X is 39 and Y is 167; X is 39 and Y is 168; X is 39and Y is 169; X is 39 and Y is 170; X is 39 and Y is 171; X is 39 and Yis 172; X is 39 and Y is 173; X is 39 and Y is 174; X is 39 and Y is175; X is 39 and Y is 176; X is 39 and Y is 177; X is 39 and Y is 178; Xis 39 and Y is 179; X is 39 and Y is 180; X is 39 and Y is 181; X is 39and Y is 182; X is 39 and Y is 183; X is 39 and Y is 184; X is 39 and Yis 185; X is 39 and Y is 186;X is 40 and Y is 1; X is 40 and Y is 2; X is 40 and Y is 3; X is 40 andY is 4; X is 40 and Y is 5; X is 40 and Y is 6; X is 40 and Y is 7; X is40 and Y is 8; X is 40 and Y is 9; X is 40 and Y is 10; X is 40 and Y is11; X is 40 and Y is 12; X is 40 and Y is 13; X is 40 and Y is 14; X is40 and Y is 15; X is 40 and Y is 16; X is 40 and Y is 17; X is 40 and Yis 18; X is 40 and Y is 19; X is 40 and Y is 20; X is 40 and Y is 21; Xis 40 and Y is 22; X is 40 and Y is 23; X is 40 and Y is 24; X is 40 andY is 25; X is 40 and Y is 26; X is 40 and Y is 27; X is 40 and Y is 28;X is 40 and Y is 29; X is 40 and Y is 30; X is 40 and Y is 31; X is 40and Y is 32; X is 40 and Y is 33; X is 40 and Y is 34; X is 40 and Y is35; X is 40 and Y is 36; X is 40 and Y is 37; X is 40 and Y is 38; X is40 and Y is 39; X is 40 and Y is 40; X is 40 and Y is 41; X is 40 and Yis 42; X is 40 and Y is 43; X is 40 and Y is 44; X is 40 and Y is 45; Xis 40 and Y is 46; X is 40 and Y is 47; X is 40 and Y is 48; X is 40 andY is 49; X is 40 and Y is 50; X is 40 and Y is 51; X is 40 and Y is 52;X is 40 and Y is 53; X is 40 and Y is 54; X is 40 and Y is 55; X is 40and Y is 56; X is 40 and Y is 57; X is 40 and Y is 58; X is 40 and Y is59; X is 40 and Y is 60; X is 40 and Y is 61; X is 40 and Y is 62; X is40 and Y is 63; X is 40 and Y is 64; X is 40 and Y is 65; X is 40 and Yis 66; X is 40 and Y is 67; X is 40 and Y is 68; X is 40 and Y is 69; Xis 40 and Y is 70; X is 40 and Y is 71; X is 40 and Y is 72; X is 40 andY is 73; X is 40 and Y is 74; X is 40 and Y is 75; X is 40 and Y is 76;X is 40 and Y is 77; X is 40 and Y is 78; X is 40 and Y is 79; X is 40and Y is 80; X is 40 and Y is 81; X is 40 and Y is 82; X is 40 and Y is83; X is 40 and Y is 84; X is 40 and Y is 85; X is 40 and Y is 86; X is40 and Y is 87; X is 40 and Y is 88; X is 40 and Y is 89; X is 40 and Yis 90; X is 40 and Y is 91; X is 40 and Y is 92; X is 40 and Y is 93; Xis 40 and Y is 94; X is 40 and Y is 95; X is 40 and Y is 96; X is 40 andY is 97; X is 40 and Y is 98; X is 40 and Y is 99; X is 40 and Y is 100;X is 40 and Y is 101; X is 40 and Y is 102; X is 40 and Y is 103; X is40 and Y is 104; X is 40 and Y is 105; X is 40 and Y is 106; X is 40 andY is 107; X is 40 and Y is 108; X is 40 and Y is 109; X is 40 and Y is110; X is 40 and Y is 111; X is 40 and Y is 112; X is 40 and Y is 113; Xis 40 and Y is 114; X is 40 and Y is 115; X is 40 and Y is 116; X is 40and Y is 117; X is 40 and Y is 118; X is 40 and Y is 119; X is 40 and Yis 120; X is 40 and Y is 121; X is 40 and Y is 122; X is 40 and Y is123; X is 40 and Y is 124; X is 40 and Y is 125; X is 40 and Y is 126; Xis 40 and Y is 127; X is 40 and Y is 128; X is 40 and Y is 129; X is 40and Y is 130; X is 40 and Y is 131; X is 40 and Y is 132; X is 40 and Yis 133; X is 40 and Y is 134; X is 40 and Y is 135; X is 40 and Y is136; X is 40 and Y is 137; X is 40 and Y is 138; X is 40 and Y is 139; Xis 40 and Y is 140; X is 40 and Y is 141; X is 40 and Y is 142; X is 40and Y is 143; X is 40 and Y is 144; X is 40 and Y is 145; X is 40 and Yis 146; X is 40 and Y is 147; X is 40 and Y is 148; X is 40 and Y is149; X is 40 and Y is 150; X is 40 and Y is 151; X is 40 and Y is 152; Xis 40 and Y is 153; X is 40 and Y is 154; X is 40 and Y is 155; X is 40and Y is 156; X is 40 and Y is 157; X is 40 and Y is 158; X is 40 and Yis 159; X is 40 and Y is 160; X is 40 and Y is 161; X is 40 and Y is162; X is 40 and Y is 163; X is 40 and Y is 164; X is 40 and Y is 165; Xis 40 and Y is 166; X is 40 and Y is 167; X is 40 and Y is 168; X is 40and Y is 169; X is 40 and Y is 170; X is 40 and Y is 171; X is 40 and Yis 172; X is 40 and Y is 173; X is 40 and Y is 174; X is 40 and Y is175; X is 40 and Y is 176; X is 40 and Y is 177; X is 40 and Y is 178; Xis 40 and Y is 179; X is 40 and Y is 180; X is 40 and Y is 181; X is 40and Y is 182; X is 40 and Y is 183; X is 40 and Y is 184; X is 40 and Yis 185; X is 40 and Y is 186;X is 41 and Y is 1; X is 41 and Y is 2; X is 41 and Y is 3; X is 41 andY is 4; X is 41 and Y is 5; X is 41 and Y is 6; X is 41 and Y is 7; X is41 and Y is 8; X is 41 and Y is 9; X is 41 and Y is 10; X is 41 and Y is11; X is 41 and Y is 12; X is 41 and Y is 13; X is 41 and Y is 14; X is41 and Y is 15; X is 41 and Y is 16; X is 41 and Y is 17; X is 41 and Yis 18; X is 41 and Y is 19; X is 41 and Y is 20; X is 41 and Y is 21; Xis 41 and Y is 22; X is 41 and Y is 23; X is 41 and Y is 24; X is 41 andY is 25; X is 41 and Y is 26; X is 41 and Y is 27; X is 41 and Y is 28;X is 41 and Y is 29; X is 41 and Y is 30; X is 41 and Y is 31; X is 41and Y is 32; X is 41 and Y is 33; X is 41 and Y is 34; X is 41 and Y is35; X is 41 and Y is 36; X is 41 and Y is 37; X is 41 and Y is 38; X is41 and Y is 39; X is 41 and Y is 40; X is 41 and Y is 41; X is 41 and Yis 42; X is 41 and Y is 43; X is 41 and Y is 44; X is 41 and Y is 45; Xis 41 and Y is 46; X is 41 and Y is 47; X is 41 and Y is 48; X is 41 andY is 49; X is 41 and Y is 50; X is 41 and Y is 51; X is 41 and Y is 52;X is 41 and Y is 53; X is 41 and Y is 54; X is 41 and Y is 55; X is 41and Y is 56; X is 41 and Y is 57; X is 41 and Y is 58; X is 41 and Y is59; X is 41 and Y is 60; X is 41 and Y is 61; X is 41 and Y is 62; X is41 and Y is 63; X is 41 and Y is 64; X is 41 and Y is 65; X is 41 and Yis 66; X is 41 and Y is 67; X is 41 and Y is 68; X is 41 and Y is 69; Xis 41 and Y is 70; X is 41 and Y is 71; X is 41 and Y is 72; X is 41 andY is 73; X is 41 and Y is 74; X is 41 and Y is 75; X is 41 and Y is 76;X is 41 and Y is 77; X is 41 and Y is 78; X is 41 and Y is 79; X is 41and Y is 80; X is 41 and Y is 81; X is 41 and Y is 82; X is 41 and Y is83; X is 41 and Y is 84; X is 41 and Y is 85; X is 41 and Y is 86; X is41 and Y is 87; X is 41 and Y is 88; X is 41 and Y is 89; X is 41 and Yis 90; X is 41 and Y is 91; X is 41 and Y is 92; X is 41 and Y is 93; Xis 41 and Y is 94; X is 41 and Y is 95; X is 41 and Y is 96; X is 41 andY is 97; X is 41 and Y is 98; X is 41 and Y is 99; X is 41 and Y is 100;X is 41 and Y is 101; X is 41 and Y is 102; X is 41 and Y is 103; X is41 and Y is 104; X is 41 and Y is 105; X is 41 and Y is 106; X is 41 andY is 107; X is 41 and Y is 108; X is 41 and Y is 109; X is 41 and Y is110; X is 41 and Y is 111; X is 41 and Y is 112; X is 41 and Y is 113; Xis 41 and Y is 114; X is 41 and Y is 115; X is 41 and Y is 116; X is 41and Y is 117; X is 41 and Y is 118; X is 41 and Y is 119; X is 41 and Yis 120; X is 41 and Y is 121; X is 41 and Y is 122; X is 41 and Y is123; X is 41 and Y is 124; X is 41 and Y is 125; X is 41 and Y is 126; Xis 41 and Y is 127; X is 41 and Y is 128; X is 41 and Y is 129; X is 41and Y is 130; X is 41 and Y is 131; X is 41 and Y is 132; X is 41 and Yis 133; X is 41 and Y is 134; X is 41 and Y is 135; X is 41 and Y is136; X is 41 and Y is 137; X is 41 and Y is 138; X is 41 and Y is 139; Xis 41 and Y is 140; X is 41 and Y is 141; X is 41 and Y is 142; X is 41and Y is 143; X is 41 and Y is 144; X is 41 and Y is 145; X is 41 and Yis 146; X is 41 and Y is 147; X is 41 and Y is 148; X is 41 and Y is149; X is 41 and Y is 150; X is 41 and Y is 151; X is 41 and Y is 152; Xis 41 and Y is 153; X is 41 and Y is 154; X is 41 and Y is 155; X is 41and Y is 156; X is 41 and Y is 157; X is 41 and Y is 158; X is 41 and Yis 159; X is 41 and Y is 160; X is 41 and Y is 161; X is 41 and Y is162; X is 41 and Y is 163; X is 41 and Y is 164; X is 41 and Y is 165; Xis 41 and Y is 166; X is 41 and Y is 167; X is 41 and Y is 168; X is 41and Y is 169; X is 41 and Y is 170; X is 41 and Y is 171; X is 41 and Yis 172; X is 41 and Y is 173; X is 41 and Y is 174; X is 41 and Y is175; X is 41 and Y is 176; X is 41 and Y is 177; X is 41 and Y is 178; Xis 41 and Y is 179; X is 41 and Y is 180; X is 41 and Y is 181; X is 41and Y is 182; X is 41 and Y is 183; X is 41 and Y is 184; X is 41 and Yis 185; X is 41 and Y is 186;X is 42 and Y is 1; X is 42 and Y is 2; X is 42 and Y is 3; X is 42 andY is 4; X is 42 and Y is 5; X is 42 and Y is 6; X is 42 and Y is 7; X is42 and Y is 8; X is 42 and Y is 9; X is 42 and Y is 10; X is 42 and Y is11; X is 42 and Y is 12; X is 42 and Y is 13; X is 42 and Y is 14; X is42 and Y is 15; X is 42 and Y is 16; X is 42 and Y is 17; X is 42 and Yis 18; X is 42 and Y is 19; X is 42 and Y is 20; X is 42 and Y is 21; Xis 42 and Y is 22; X is 42 and Y is 23; X is 42 and Y is 24; X is 42 andY is 25; X is 42 and Y is 26; X is 42 and Y is 27; X is 42 and Y is 28;X is 42 and Y is 29; X is 42 and Y is 30; X is 42 and Y is 31; X is 42and Y is 32; X is 42 and Y is 33; X is 42 and Y is 34; X is 42 and Y is35; X is 42 and Y is 36; X is 42 and Y is 37; X is 42 and Y is 38; X is42 and Y is 39; X is 42 and Y is 40; X is 42 and Y is 41; X is 42 and Yis 42; X is 42 and Y is 43; X is 42 and Y is 44; X is 42 and Y is 45; Xis 42 and Y is 46; X is 42 and Y is 47; X is 42 and Y is 48; X is 42 andY is 49; X is 42 and Y is 50; X is 42 and Y is 51; X is 42 and Y is 52;X is 42 and Y is 53; X is 42 and Y is 54; X is 42 and Y is 55; X is 42and Y is 56; X is 42 and Y is 57; X is 42 and Y is 58; X is 42 and Y is59; X is 42 and Y is 60; X is 42 and Y is 61; X is 42 and Y is 62; X is42 and Y is 63; X is 42 and Y is 64; X is 42 and Y is 65; X is 42 and Yis 66; X is 42 and Y is 67; X is 42 and Y is 68; X is 42 and Y is 69; Xis 42 and Y is 70; X is 42 and Y is 71; X is 42 and Y is 72; X is 42 andY is 73; X is 42 and Y is 74; X is 42 and Y is 75; X is 42 and Y is 76;X is 42 and Y is 77; X is 42 and Y is 78; X is 42 and Y is 79; X is 42and Y is 80; X is 42 and Y is 81; X is 42 and Y is 82; X is 42 and Y is83; X is 42 and Y is 84; X is 42 and Y is 85; X is 42 and Y is 86; X is42 and Y is 87; X is 42 and Y is 88; X is 42 and Y is 89; X is 42 and Yis 90; X is 42 and Y is 91; X is 42 and Y is 92; X is 42 and Y is 93; Xis 42 and Y is 94; X is 42 and Y is 95; X is 42 and Y is 96; X is 42 andY is 97; X is 42 and Y is 98; X is 42 and Y is 99; X is 42 and Y is 100;X is 42 and Y is 101; X is 42 and Y is 102; X is 42 and Y is 103; X is42 and Y is 104; X is 42 and Y is 105; X is 42 and Y is 106; X is 42 andY is 107; X is 42 and Y is 108; X is 42 and Y is 109; X is 42 and Y is110; X is 42 and Y is 111; X is 42 and Y is 112; X is 42 and Y is 113; Xis 42 and Y is 114; X is 42 and Y is 115; X is 42 and Y is 116; X is 42and Y is 117; X is 42 and Y is 118; X is 42 and Y is 119; X is 42 and Yis 120; X is 42 and Y is 121; X is 42 and Y is 122; X is 42 and Y is123; X is 42 and Y is 124; X is 42 and Y is 125; X is 42 and Y is 126; Xis 42 and Y is 127; X is 42 and Y is 128; X is 42 and Y is 129; X is 42and Y is 130; X is 42 and Y is 131; X is 42 and Y is 132; X is 42 and Yis 133; X is 42 and Y is 134; X is 42 and Y is 135; X is 42 and Y is136; X is 42 and Y is 137; X is 42 and Y is 138; X is 42 and Y is 139; Xis 42 and Y is 140; X is 42 and Y is 141; X is 42 and Y is 142; X is 42and Y is 143; X is 42 and Y is 144; X is 42 and Y is 145; X is 42 and Yis 146; X is 42 and Y is 147; X is 42 and Y is 148; X is 42 and Y is149; X is 42 and Y is 150; X is 42 and Y is 151; X is 42 and Y is 152; Xis 42 and Y is 153; X is 42 and Y is 154; X is 42 and Y is 155; X is 42and Y is 156; X is 42 and Y is 157; X is 42 and Y is 158; X is 42 and Yis 159; X is 42 and Y is 160; X is 42 and Y is 161; X is 42 and Y is162; X is 42 and Y is 163; X is 42 and Y is 164; X is 42 and Y is 165; Xis 42 and Y is 166; X is 42 and Y is 167; X is 42 and Y is 168; X is 42and Y is 169; X is 42 and Y is 170; X is 42 and Y is 171; X is 42 and Yis 172; X is 42 and Y is 173; X is 42 and Y is 174; X is 42 and Y is175; X is 42 and Y is 176; X is 42 and Y is 177; X is 42 and Y is 178; Xis 42 and Y is 179; X is 42 and Y is 180; X is 42 and Y is 181; X is 42and Y is 182; X is 42 and Y is 183; X is 42 and Y is 184; X is 42 and Yis 185; X is 42 and Y is 186;X is 43 and Y is 1; X is 43 and Y is 2; X is 43 and Y is 3; X is 43 andY is 4; X is 43 and Y is 5; X is 43 and Y is 6; X is 43 and Y is 7; X is43 and Y is 8; X is 43 and Y is 9; X is 43 and Y is 10; X is 43 and Y is11; X is 43 and Y is 12; X is 43 and Y is 13; X is 43 and Y is 14; X is43 and Y is 15; X is 43 and Y is 16; X is 43 and Y is 17; X is 43 and Yis 18; X is 43 and Y is 19; X is 43 and Y is 20; X is 43 and Y is 21; Xis 43 and Y is 22; X is 43 and Y is 23; X is 43 and Y is 24; X is 43 andY is 25; X is 43 and Y is 26; X is 43 and Y is 27; X is 43 and Y is 28;X is 43 and Y is 29; X is 43 and Y is 30; X is 43 and Y is 31; X is 43and Y is 32; X is 43 and Y is 33; X is 43 and Y is 34; X is 43 and Y is35; X is 43 and Y is 36; X is 43 and Y is 37; X is 43 and Y is 38; X is43 and Y is 39; X is 43 and Y is 40; X is 43 and Y is 41; X is 43 and Yis 42; X is 43 and Y is 43; X is 43 and Y is 44; X is 43 and Y is 45; Xis 43 and Y is 46; X is 43 and Y is 47; X is 43 and Y is 48; X is 43 andY is 49; X is 43 and Y is 50; X is 43 and Y is 51; X is 43 and Y is 52;X is 43 and Y is 53; X is 43 and Y is 54; X is 43 and Y is 55; X is 43and Y is 56; X is 43 and Y is 57; X is 43 and Y is 58; X is 43 and Y is59; X is 43 and Y is 60; X is 43 and Y is 61; X is 43 and Y is 62; X is43 and Y is 63; X is 43 and Y is 64; X is 43 and Y is 65; X is 43 and Yis 66; X is 43 and Y is 67; X is 43 and Y is 68; X is 43 and Y is 69; Xis 43 and Y is 70; X is 43 and Y is 71; X is 43 and Y is 72; X is 43 andY is 73; X is 43 and Y is 74; X is 43 and Y is 75; X is 43 and Y is 76;X is 43 and Y is 77; X is 43 and Y is 78; X is 43 and Y is 79; X is 43and Y is 80; X is 43 and Y is 81; X is 43 and Y is 82; X is 43 and Y is83; X is 43 and Y is 84; X is 43 and Y is 85; X is 43 and Y is 86; X is43 and Y is 87; X is 43 and Y is 88; X is 43 and Y is 89; X is 43 and Yis 90; X is 43 and Y is 91; X is 43 and Y is 92; X is 43 and Y is 93; Xis 43 and Y is 94; X is 43 and Y is 95; X is 43 and Y is 96; X is 43 andY is 97; X is 43 and Y is 98; X is 43 and Y is 99; X is 43 and Y is 100;X is 43 and Y is 101; X is 43 and Y is 102; X is 43 and Y is 103; X is43 and Y is 104; X is 43 and Y is 105; X is 43 and Y is 106; X is 43 andY is 107; X is 43 and Y is 108; X is 43 and Y is 109; X is 43 and Y is110; X is 43 and Y is 111; X is 43 and Y is 112; X is 43 and Y is 113; Xis 43 and Y is 114; X is 43 and Y is 115; X is 43 and Y is 116; X is 43and Y is 117; X is 43 and Y is 118; X is 43 and Y is 119; X is 43 and Yis 120; X is 43 and Y is 121; X is 43 and Y is 122; X is 43 and Y is123; X is 43 and Y is 124; X is 43 and Y is 125; X is 43 and Y is 126; Xis 43 and Y is 127; X is 43 and Y is 128; X is 43 and Y is 129; X is 43and Y is 130; X is 43 and Y is 131; X is 43 and Y is 132; X is 43 and Yis 133; X is 43 and Y is 134; X is 43 and Y is 135; X is 43 and Y is136; X is 43 and Y is 137; X is 43 and Y is 138; X is 43 and Y is 139; Xis 43 and Y is 140; X is 43 and Y is 141; X is 43 and Y is 142; X is 43and Y is 143; X is 43 and Y is 144; X is 43 and Y is 145; X is 43 and Yis 146; X is 43 and Y is 147; X is 43 and Y is 148; X is 43 and Y is149; X is 43 and Y is 150; X is 43 and Y is 151; X is 43 and Y is 152; Xis 43 and Y is 153; X is 43 and Y is 154; X is 43 and Y is 155; X is 43and Y is 156; X is 43 and Y is 157; X is 43 and Y is 158; X is 43 and Yis 159; X is 43 and Y is 160; X is 43 and Y is 161; X is 43 and Y is162; X is 43 and Y is 163; X is 43 and Y is 164; X is 43 and Y is 165; Xis 43 and Y is 166; X is 43 and Y is 167; X is 43 and Y is 168; X is 43and Y is 169; X is 43 and Y is 170; X is 43 and Y is 171; X is 43 and Yis 172; X is 43 and Y is 173; X is 43 and Y is 174; X is 43 and Y is175; X is 43 and Y is 176; X is 43 and Y is 177; X is 43 and Y is 178; Xis 43 and Y is 179; X is 43 and Y is 180; X is 43 and Y is 181; X is 43and Y is 182; X is 43 and Y is 183; X is 43 and Y is 184; X is 43 and Yis 185; X is 43 and Y is 186;X is 44 and Y is 1; X is 44 and Y is 2; X is 44 and Y is 3; X is 44 andY is 4; X is 44 and Y is 5; X is 44 and Y is 6; X is 44 and Y is 7; X is44 and Y is 8; X is 44 and Y is 9; X is 44 and Y is 10; X is 44 and Y is11; X is 44 and Y is 12; X is 44 and Y is 13; X is 44 and Y is 14; X is44 and Y is 15; X is 44 and Y is 16; X is 44 and Y is 17; X is 44 and Yis 18; X is 44 and Y is 19; X is 44 and Y is 20; X is 44 and Y is 21; Xis 44 and Y is 22; X is 44 and Y is 23; X is 44 and Y is 24; X is 44 andY is 25; X is 44 and Y is 26; X is 44 and Y is 27; X is 44 and Y is 28;X is 44 and Y is 29; X is 44 and Y is 30; X is 44 and Y is 31; X is 44and Y is 32; X is 44 and Y is 33; X is 44 and Y is 34; X is 44 and Y is35; X is 44 and Y is 36; X is 44 and Y is 37; X is 44 and Y is 38; X is44 and Y is 39; X is 44 and Y is 40; X is 44 and Y is 41; X is 44 and Yis 42; X is 44 and Y is 43; X is 44 and Y is 44; X is 44 and Y is 45; Xis 44 and Y is 46; X is 44 and Y is 47; X is 44 and Y is 48; X is 44 andY is 49; X is 44 and Y is 50; X is 44 and Y is 51; X is 44 and Y is 52;X is 44 and Y is 53; X is 44 and Y is 54; X is 44 and Y is 55; X is 44and Y is 56; X is 44 and Y is 57; X is 44 and Y is 58; X is 44 and Y is59; X is 44 and Y is 60; X is 44 and Y is 61; X is 44 and Y is 62; X is44 and Y is 63; X is 44 and Y is 64; X is 44 and Y is 65; X is 44 and Yis 66; X is 44 and Y is 67; X is 44 and Y is 68; X is 44 and Y is 69; Xis 44 and Y is 70; X is 44 and Y is 71; X is 44 and Y is 72; X is 44 andY is 73; X is 44 and Y is 74; X is 44 and Y is 75; X is 44 and Y is 76;X is 44 and Y is 77; X is 44 and Y is 78; X is 44 and Y is 79; X is 44and Y is 80; X is 44 and Y is 81; X is 44 and Y is 82; X is 44 and Y is83; X is 44 and Y is 84; X is 44 and Y is 85; X is 44 and Y is 86; X is44 and Y is 87; X is 44 and Y is 88; X is 44 and Y is 89; X is 44 and Yis 90; X is 44 and Y is 91; X is 44 and Y is 92; X is 44 and Y is 93; Xis 44 and Y is 94; X is 44 and Y is 95; X is 44 and Y is 96; X is 44 andY is 97; X is 44 and Y is 98; X is 44 and Y is 99; X is 44 and Y is 100;X is 44 and Y is 101; X is 44 and Y is 102; X is 44 and Y is 103; X is44 and Y is 104; X is 44 and Y is 105; X is 44 and Y is 106; X is 44 andY is 107; X is 44 and Y is 108; X is 44 and Y is 109; X is 44 and Y is110; X is 44 and Y is 111; X is 44 and Y is 112; X is 44 and Y is 113; Xis 44 and Y is 114; X is 44 and Y is 115; X is 44 and Y is 116; X is 44and Y is 117; X is 44 and Y is 118; X is 44 and Y is 119; X is 44 and Yis 120; X is 44 and Y is 121; X is 44 and Y is 122; X is 44 and Y is123; X is 44 and Y is 124; X is 44 and Y is 125; X is 44 and Y is 126; Xis 44 and Y is 127; X is 44 and Y is 128; X is 44 and Y is 129; X is 44and Y is 130; X is 44 and Y is 131; X is 44 and Y is 132; X is 44 and Yis 133; X is 44 and Y is 134; X is 44 and Y is 135; X is 44 and Y is136; X is 44 and Y is 137; X is 44 and Y is 138; X is 44 and Y is 139; Xis 44 and Y is 140; X is 44 and Y is 141; X is 44 and Y is 142; X is 44and Y is 143; X is 44 and Y is 144; X is 44 and Y is 145; X is 44 and Yis 146; X is 44 and Y is 147; X is 44 and Y is 148; X is 44 and Y is149; X is 44 and Y is 150; X is 44 and Y is 151; X is 44 and Y is 152; Xis 44 and Y is 153; X is 44 and Y is 154; X is 44 and Y is 155; X is 44and Y is 156; X is 44 and Y is 157; X is 44 and Y is 158; X is 44 and Yis 159; X is 44 and Y is 160; X is 44 and Y is 161; X is 44 and Y is162; X is 44 and Y is 163; X is 44 and Y is 164; X is 44 and Y is 165; Xis 44 and Y is 166; X is 44 and Y is 167; X is 44 and Y is 168; X is 44and Y is 169; X is 44 and Y is 170; X is 44 and Y is 171; X is 44 and Yis 172; X is 44 and Y is 173; X is 44 and Y is 174; X is 44 and Y is175; X is 44 and Y is 176; X is 44 and Y is 177; X is 44 and Y is 178; Xis 44 and Y is 179; X is 44 and Y is 180; X is 44 and Y is 181; X is 44and Y is 182; X is 44 and Y is 183; X is 44 and Y is 184; X is 44 and Yis 185; X is 44 and Y is 186;X is 45 and Y is 1; X is 45 and Y is 2; X is 45 and Y is 3; X is 45 andY is 4; X is 45 and Y is 5; X is 45 and Y is 6; X is 45 and Y is 7; X is45 and Y is 8; X is 45 and Y is 9; X is 45 and Y is 10; X is 45 and Y is11; X is 45 and Y is 12; X is 45 and Y is 13; X is 45 and Y is 14; X is45 and Y is 15; X is 45 and Y is 16; X is 45 and Y is 17; X is 45 and Yis 18; X is 45 and Y is 19; X is 45 and Y is 20; X is 45 and Y is 21; Xis 45 and Y is 22; X is 45 and Y is 23; X is 45 and Y is 24; X is 45 andY is 25; X is 45 and Y is 26; X is 45 and Y is 27; X is 45 and Y is 28;X is 45 and Y is 29; X is 45 and Y is 30; X is 45 and Y is 31; X is 45and Y is 32; X is 45 and Y is 33; X is 45 and Y is 34; X is 45 and Y is35; X is 45 and Y is 36; X is 45 and Y is 37; X is 45 and Y is 38; X is45 and Y is 39; X is 45 and Y is 40; X is 45 and Y is 41; X is 45 and Yis 42; X is 45 and Y is 43; X is 45 and Y is 44; X is 45 and Y is 45; Xis 45 and Y is 46; X is 45 and Y is 47; X is 45 and Y is 48; X is 45 andY is 49; X is 45 and Y is 50; X is 45 and Y is 51; X is 45 and Y is 52;X is 45 and Y is 53; X is 45 and Y is 54; X is 45 and Y is 55; X is 45and Y is 56; X is 45 and Y is 57; X is 45 and Y is 58; X is 45 and Y is59; X is 45 and Y is 60; X is 45 and Y is 61; X is 45 and Y is 62; X is45 and Y is 63; X is 45 and Y is 64; X is 45 and Y is 65; X is 45 and Yis 66; X is 45 and Y is 67; X is 45 and Y is 68; X is 45 and Y is 69; Xis 45 and Y is 70; X is 45 and Y is 71; X is 45 and Y is 72; X is 45 andY is 73; X is 45 and Y is 74; X is 45 and Y is 75; X is 45 and Y is 76;X is 45 and Y is 77; X is 45 and Y is 78; X is 45 and Y is 79; X is 45and Y is 80; X is 45 and Y is 81; X is 45 and Y is 82; X is 45 and Y is83; X is 45 and Y is 84; X is 45 and Y is 85; X is 45 and Y is 86; X is45 and Y is 87; X is 45 and Y is 88; X is 45 and Y is 89; X is 45 and Yis 90; X is 45 and Y is 91; X is 45 and Y is 92; X is 45 and Y is 93; Xis 45 and Y is 94; X is 45 and Y is 95; X is 45 and Y is 96; X is 45 andY is 97; X is 45 and Y is 98; X is 45 and Y is 99; X is 45 and Y is 100;X is 45 and Y is 101; X is 45 and Y is 102; X is 45 and Y is 103; X is45 and Y is 104; X is 45 and Y is 105; X is 45 and Y is 106; X is 45 andY is 107; X is 45 and Y is 108; X is 45 and Y is 109; X is 45 and Y is110; X is 45 and Y is 111; X is 45 and Y is 112; X is 45 and Y is 113; Xis 45 and Y is 114; X is 45 and Y is 115; X is 45 and Y is 116; X is 45and Y is 117; X is 45 and Y is 118; X is 45 and Y is 119; X is 45 and Yis 120; X is 45 and Y is 121; X is 45 and Y is 122; X is 45 and Y is123; X is 45 and Y is 124; X is 45 and Y is 125; X is 45 and Y is 126; Xis 45 and Y is 127; X is 45 and Y is 128; X is 45 and Y is 129; X is 45and Y is 130; X is 45 and Y is 131; X is 45 and Y is 132; X is 45 and Yis 133; X is 45 and Y is 134; X is 45 and Y is 135; X is 45 and Y is136; X is 45 and Y is 137; X is 45 and Y is 138; X is 45 and Y is 139; Xis 45 and Y is 140; X is 45 and Y is 141; X is 45 and Y is 142; X is 45and Y is 143; X is 45 and Y is 144; X is 45 and Y is 145; X is 45 and Yis 146; X is 45 and Y is 147; X is 45 and Y is 148; X is 45 and Y is149; X is 45 and Y is 150; X is 45 and Y is 151; X is 45 and Y is 152; Xis 45 and Y is 153; X is 45 and Y is 154; X is 45 and Y is 155; X is 45and Y is 156; X is 45 and Y is 157; X is 45 and Y is 158; X is 45 and Yis 159; X is 45 and Y is 160; X is 45 and Y is 161; X is 45 and Y is162; X is 45 and Y is 163; X is 45 and Y is 164; X is 45 and Y is 165; Xis 45 and Y is 166; X is 45 and Y is 167; X is 45 and Y is 168; X is 45and Y is 169; X is 45 and Y is 170; X is 45 and Y is 171; X is 45 and Yis 172; X is 45 and Y is 173; X is 45 and Y is 174; X is 45 and Y is175; X is 45 and Y is 176; X is 45 and Y is 177; X is 45 and Y is 178; Xis 45 and Y is 179; X is 45 and Y is 180; X is 45 and Y is 181; X is 45and Y is 182; X is 45 and Y is 183; X is 45 and Y is 184; X is 45 and Yis 185; X is 45 and Y is 186;X is 46 and Y is 1; X is 46 and Y is 2; X is 46 and Y is 3; X is 46 andY is 4; X is 46 and Y is 5; X is 46 and Y is 6; X is 46 and Y is 7; X is46 and Y is 8; X is 46 and Y is 9; X is 46 and Y is 10; X is 46 and Y is11; X is 46 and Y is 12; X is 46 and Y is 13; X is 46 and Y is 14; X is46 and Y is 15; X is 46 and Y is 16; X is 46 and Y is 17; X is 46 and Yis 18; X is 46 and Y is 19; X is 46 and Y is 20; X is 46 and Y is 21; Xis 46 and Y is 22; X is 46 and Y is 23; X is 46 and Y is 24; X is 46 andY is 25; X is 46 and Y is 26; X is 46 and Y is 27; X is 46 and Y is 28;X is 46 and Y is 29; X is 46 and Y is 30; X is 46 and Y is 31; X is 46and Y is 32; X is 46 and Y is 33; X is 46 and Y is 34; X is 46 and Y is35; X is 46 and Y is 36; X is 46 and Y is 37; X is 46 and Y is 38; X is46 and Y is 39; X is 46 and Y is 40; X is 46 and Y is 41; X is 46 and Yis 42; X is 46 and Y is 43; X is 46 and Y is 44; X is 46 and Y is 45; Xis 46 and Y is 46; X is 46 and Y is 47; X is 46 and Y is 48; X is 46 andY is 49; X is 46 and Y is 50; X is 46 and Y is 51; X is 46 and Y is 52;X is 46 and Y is 53; X is 46 and Y is 54; X is 46 and Y is 55; X is 46and Y is 56; X is 46 and Y is 57; X is 46 and Y is 58; X is 46 and Y is59; X is 46 and Y is 60; X is 46 and Y is 61; X is 46 and Y is 62; X is46 and Y is 63; X is 46 and Y is 64; X is 46 and Y is 65; X is 46 and Yis 66; X is 46 and Y is 67; X is 46 and Y is 68; X is 46 and Y is 69; Xis 46 and Y is 70; X is 46 and Y is 71; X is 46 and Y is 72; X is 46 andY is 73; X is 46 and Y is 74; X is 46 and Y is 75; X is 46 and Y is 76;X is 46 and Y is 77; X is 46 and Y is 78; X is 46 and Y is 79; X is 46and Y is 80; X is 46 and Y is 81; X is 46 and Y is 82; X is 46 and Y is83; X is 46 and Y is 84; X is 46 and Y is 85; X is 46 and Y is 86; X is46 and Y is 87; X is 46 and Y is 88; X is 46 and Y is 89; X is 46 and Yis 90; X is 46 and Y is 91; X is 46 and Y is 92; X is 46 and Y is 93; Xis 46 and Y is 94; X is 46 and Y is 95; X is 46 and Y is 96; X is 46 andY is 97; X is 46 and Y is 98; X is 46 and Y is 99; X is 46 and Y is 100;X is 46 and Y is 101; X is 46 and Y is 102; X is 46 and Y is 103; X is46 and Y is 104; X is 46 and Y is 105; X is 46 and Y is 106; X is 46 andY is 107; X is 46 and Y is 108; X is 46 and Y is 109; X is 46 and Y is110; X is 46 and Y is 111; X is 46 and Y is 112; X is 46 and Y is 113; Xis 46 and Y is 114; X is 46 and Y is 115; X is 46 and Y is 116; X is 46and Y is 117; X is 46 and Y is 118; X is 46 and Y is 119; X is 46 and Yis 120; X is 46 and Y is 121; X is 46 and Y is 122; X is 46 and Y is123; X is 46 and Y is 124; X is 46 and Y is 125; X is 46 and Y is 126; Xis 46 and Y is 127; X is 46 and Y is 128; X is 46 and Y is 129; X is 46and Y is 130; X is 46 and Y is 131; X is 46 and Y is 132; X is 46 and Yis 133; X is 46 and Y is 134; X is 46 and Y is 135; X is 46 and Y is136; X is 46 and Y is 137; X is 46 and Y is 138; X is 46 and Y is 139; Xis 46 and Y is 140; X is 46 and Y is 141; X is 46 and Y is 142; X is 46and Y is 143; X is 46 and Y is 144; X is 46 and Y is 145; X is 46 and Yis 146; X is 46 and Y is 147; X is 46 and Y is 148; X is 46 and Y is149; X is 46 and Y is 150; X is 46 and Y is 151; X is 46 and Y is 152; Xis 46 and Y is 153; X is 46 and Y is 154; X is 46 and Y is 155; X is 46and Y is 156; X is 46 and Y is 157; X is 46 and Y is 158; X is 46 and Yis 159; X is 46 and Y is 160; X is 46 and Y is 161; X is 46 and Y is162; X is 46 and Y is 163; X is 46 and Y is 164; X is 46 and Y is 165; Xis 46 and Y is 166; X is 46 and Y is 167; X is 46 and Y is 168; X is 46and Y is 169; X is 46 and Y is 170; X is 46 and Y is 171; X is 46 and Yis 172; X is 46 and Y is 173; X is 46 and Y is 174; X is 46 and Y is175; X is 46 and Y is 176; X is 46 and Y is 177; X is 46 and Y is 178; Xis 46 and Y is 179; X is 46 and Y is 180; X is 46 and Y is 181; X is 46and Y is 182; X is 46 and Y is 183; X is 46 and Y is 184; X is 46 and Yis 185; X is 46 and Y is 186;X is 47 and Y is 1; X is 47 and Y is 2; X is 47 and Y is 3; X is 47 andY is 4; X is 47 and Y is 5; X is 47 and Y is 6; X is 47 and Y is 7; X is47 and Y is 8; X is 47 and Y is 9; X is 47 and Y is 10; X is 47 and Y is11; X is 47 and Y is 12; X is 47 and Y is 13; X is 47 and Y is 14; X is47 and Y is 15; X is 47 and Y is 16; X is 47 and Y is 17; X is 47 and Yis 18; X is 47 and Y is 19; X is 47 and Y is 20; X is 47 and Y is 21; Xis 47 and Y is 22; X is 47 and Y is 23; X is 47 and Y is 24; X is 47 andY is 25; X is 47 and Y is 26; X is 47 and Y is 27; X is 47 and Y is 28;X is 47 and Y is 29; X is 47 and Y is 30; X is 47 and Y is 31; X is 47and Y is 32; X is 47 and Y is 33; X is 47 and Y is 34; X is 47 and Y is35; X is 47 and Y is 36; X is 47 and Y is 37; X is 47 and Y is 38; X is47 and Y is 39; X is 47 and Y is 40; X is 47 and Y is 41; X is 47 and Yis 42; X is 47 and Y is 43; X is 47 and Y is 44; X is 47 and Y is 45; Xis 47 and Y is 46; X is 47 and Y is 47; X is 47 and Y is 48; X is 47 andY is 49; X is 47 and Y is 50; X is 47 and Y is 51; X is 47 and Y is 52;X is 47 and Y is 53; X is 47 and Y is 54; X is 47 and Y is 55; X is 47and Y is 56; X is 47 and Y is 57; X is 47 and Y is 58; X is 47 and Y is59; X is 47 and Y is 60; X is 47 and Y is 61; X is 47 and Y is 62; X is47 and Y is 63; X is 47 and Y is 64; X is 47 and Y is 65; X is 47 and Yis 66; X is 47 and Y is 67; X is 47 and Y is 68; X is 47 and Y is 69; Xis 47 and Y is 70; X is 47 and Y is 71; X is 47 and Y is 72; X is 47 andY is 73; X is 47 and Y is 74; X is 47 and Y is 75; X is 47 and Y is 76;X is 47 and Y is 77; X is 47 and Y is 78; X is 47 and Y is 79; X is 47and Y is 80; X is 47 and Y is 81; X is 47 and Y is 82; X is 47 and Y is83; X is 47 and Y is 84; X is 47 and Y is 85; X is 47 and Y is 86; X is47 and Y is 87; X is 47 and Y is 88; X is 47 and Y is 89; X is 47 and Yis 90; X is 47 and Y is 91; X is 47 and Y is 92; X is 47 and Y is 93; Xis 47 and Y is 94; X is 47 and Y is 95; X is 47 and Y is 96; X is 47 andY is 97; X is 47 and Y is 98; X is 47 and Y is 99; X is 47 and Y is 100;X is 47 and Y is 101; X is 47 and Y is 102; X is 47 and Y is 103; X is47 and Y is 104; X is 47 and Y is 105; X is 47 and Y is 106; X is 47 andY is 107; X is 47 and Y is 108; X is 47 and Y is 109; X is 47 and Y is110; X is 47 and Y is 111; X is 47 and Y is 112; X is 47 and Y is 113; Xis 47 and Y is 114; X is 47 and Y is 115; X is 47 and Y is 116; X is 47and Y is 117; X is 47 and Y is 118; X is 47 and Y is 119; X is 47 and Yis 120; X is 47 and Y is 121; X is 47 and Y is 122; X is 47 and Y is123; X is 47 and Y is 124; X is 47 and Y is 125; X is 47 and Y is 126; Xis 47 and Y is 127; X is 47 and Y is 128; X is 47 and Y is 129; X is 47and Y is 130; X is 47 and Y is 131; X is 47 and Y is 132; X is 47 and Yis 133; X is 47 and Y is 134; X is 47 and Y is 135; X is 47 and Y is136; X is 47 and Y is 137; X is 47 and Y is 138; X is 47 and Y is 139; Xis 47 and Y is 140; X is 47 and Y is 141; X is 47 and Y is 142; X is 47and Y is 143; X is 47 and Y is 144; X is 47 and Y is 145; X is 47 and Yis 146; X is 47 and Y is 147; X is 47 and Y is 148; X is 47 and Y is149; X is 47 and Y is 150; X is 47 and Y is 151; X is 47 and Y is 152; Xis 47 and Y is 153; X is 47 and Y is 154; X is 47 and Y is 155; X is 47and Y is 156; X is 47 and Y is 157; X is 47 and Y is 158; X is 47 and Yis 159; X is 47 and Y is 160; X is 47 and Y is 161; X is 47 and Y is162; X is 47 and Y is 163; X is 47 and Y is 164; X is 47 and Y is 165; Xis 47 and Y is 166; X is 47 and Y is 167; X is 47 and Y is 168; X is 47and Y is 169; X is 47 and Y is 170; X is 47 and Y is 171; X is 47 and Yis 172; X is 47 and Y is 173; X is 47 and Y is 174; X is 47 and Y is175; X is 47 and Y is 176; X is 47 and Y is 177; X is 47 and Y is 178; Xis 47 and Y is 179; X is 47 and Y is 180; X is 47 and Y is 181; X is 47and Y is 182; X is 47 and Y is 183; X is 47 and Y is 184; X is 47 and Yis 185; X is 47 and Y is 186;X is 48 and Y is 1; X is 48 and Y is 2; X is 48 and Y is 3; X is 48 andY is 4; X is 48 and Y is 5; X is 48 and Y is 6; X is 48 and Y is 7; X is48 and Y is 8; X is 48 and Y is 9; X is 48 and Y is 10; X is 48 and Y is11; X is 48 and Y is 12; X is 48 and Y is 13; X is 48 and Y is 14; X is48 and Y is 15; X is 48 and Y is 16; X is 48 and Y is 17; X is 48 and Yis 18; X is 48 and Y is 19; X is 48 and Y is 20; X is 48 and Y is 21; Xis 48 and Y is 22; X is 48 and Y is 23; X is 48 and Y is 24; X is 48 andY is 25; X is 48 and Y is 26; X is 48 and Y is 27; X is 48 and Y is 28;X is 48 and Y is 29; X is 48 and Y is 30; X is 48 and Y is 31; X is 48and Y is 32; X is 48 and Y is 33; X is 48 and Y is 34; X is 48 and Y is35; X is 48 and Y is 36; X is 48 and Y is 37; X is 48 and Y is 38; X is48 and Y is 39; X is 48 and Y is 40; X is 48 and Y is 41; X is 48 and Yis 42; X is 48 and Y is 43; X is 48 and Y is 44; X is 48 and Y is 45; Xis 48 and Y is 46; X is 48 and Y is 47; X is 48 and Y is 48; X is 48 andY is 49; X is 48 and Y is 50; X is 48 and Y is 51; X is 48 and Y is 52;X is 48 and Y is 53; X is 48 and Y is 54; X is 48 and Y is 55; X is 48and Y is 56; X is 48 and Y is 57; X is 48 and Y is 58; X is 48 and Y is59; X is 48 and Y is 60; X is 48 and Y is 61; X is 48 and Y is 62; X is48 and Y is 63; X is 48 and Y is 64; X is 48 and Y is 65; X is 48 and Yis 66; X is 48 and Y is 67; X is 48 and Y is 68; X is 48 and Y is 69; Xis 48 and Y is 70; X is 48 and Y is 71; X is 48 and Y is 72; X is 48 andY is 73; X is 48 and Y is 74; X is 48 and Y is 75; X is 48 and Y is 76;X is 48 and Y is 77; X is 48 and Y is 78; X is 48 and Y is 79; X is 48and Y is 80; X is 48 and Y is 81; X is 48 and Y is 82; X is 48 and Y is83; X is 48 and Y is 84; X is 48 and Y is 85; X is 48 and Y is 86; X is48 and Y is 87; X is 48 and Y is 88; X is 48 and Y is 89; X is 48 and Yis 90; X is 48 and Y is 91; X is 48 and Y is 92; X is 48 and Y is 93; Xis 48 and Y is 94; X is 48 and Y is 95; X is 48 and Y is 96; X is 48 andY is 97; X is 48 and Y is 98; X is 48 and Y is 99; X is 48 and Y is 100;X is 48 and Y is 101; X is 48 and Y is 102; X is 48 and Y is 103; X is48 and Y is 104; X is 48 and Y is 105; X is 48 and Y is 106; X is 48 andY is 107; X is 48 and Y is 108; X is 48 and Y is 109; X is 48 and Y is110; X is 48 and Y is 111; X is 48 and Y is 112; X is 48 and Y is 113; Xis 48 and Y is 114; X is 48 and Y is 115; X is 48 and Y is 116; X is 48and Y is 117; X is 48 and Y is 118; X is 48 and Y is 119; X is 48 and Yis 120; X is 48 and Y is 121; X is 48 and Y is 122; X is 48 and Y is123; X is 48 and Y is 124; X is 48 and Y is 125; X is 48 and Y is 126; Xis 48 and Y is 127; X is 48 and Y is 128; X is 48 and Y is 129; X is 48and Y is 130; X is 48 and Y is 131; X is 48 and Y is 132; X is 48 and Yis 133; X is 48 and Y is 134; X is 48 and Y is 135; X is 48 and Y is136; X is 48 and Y is 137; X is 48 and Y is 138; X is 48 and Y is 139; Xis 48 and Y is 140; X is 48 and Y is 141; X is 48 and Y is 142; X is 48and Y is 143; X is 48 and Y is 144; X is 48 and Y is 145; X is 48 and Yis 146; X is 48 and Y is 147; X is 48 and Y is 148; X is 48 and Y is149; X is 48 and Y is 150; X is 48 and Y is 151; X is 48 and Y is 152; Xis 48 and Y is 153; X is 48 and Y is 154; X is 48 and Y is 155; X is 48and Y is 156; X is 48 and Y is 157; X is 48 and Y is 158; X is 48 and Yis 159; X is 48 and Y is 160; X is 48 and Y is 161; X is 48 and Y is162; X is 48 and Y is 163; X is 48 and Y is 164; X is 48 and Y is 165; Xis 48 and Y is 166; X is 48 and Y is 167; X is 48 and Y is 168; X is 48and Y is 169; X is 48 and Y is 170; X is 48 and Y is 171; X is 48 and Yis 172; X is 48 and Y is 173; X is 48 and Y is 174; X is 48 and Y is175; X is 48 and Y is 176; X is 48 and Y is 177; X is 48 and Y is 178; Xis 48 and Y is 179; X is 48 and Y is 180; X is 48 and Y is 181; X is 48and Y is 182; X is 48 and Y is 183; X is 48 and Y is 184; X is 48 and Yis 185; X is 48 and Y is 186;X is 49 and Y is 1; X is 49 and Y is 2; X is 49 and Y is 3; X is 49 andY is 4; X is 49 and Y is 5; X is 49 and Y is 6; X is 49 and Y is 7; X is49 and Y is 8; X is 49 and Y is 9; X is 49 and Y is 10; X is 49 and Y is11; X is 49 and Y is 12; X is 49 and Y is 13; X is 49 and Y is 14; X is49 and Y is 15; X is 49 and Y is 16; X is 49 and Y is 17; X is 49 and Yis 18; X is 49 and Y is 19; X is 49 and Y is 20; X is 49 and Y is 21; Xis 49 and Y is 22; X is 49 and Y is 23; X is 49 and Y is 24; X is 49 andY is 25; X is 49 and Y is 26; X is 49 and Y is 27; X is 49 and Y is 28;X is 49 and Y is 29; X is 49 and Y is 30; X is 49 and Y is 31; X is 49and Y is 32; X is 49 and Y is 33; X is 49 and Y is 34; X is 49 and Y is35; X is 49 and Y is 36; X is 49 and Y is 37; X is 49 and Y is 38; X is49 and Y is 39; X is 49 and Y is 40; X is 49 and Y is 41; X is 49 and Yis 42; X is 49 and Y is 43; X is 49 and Y is 44; X is 49 and Y is 45; Xis 49 and Y is 46; X is 49 and Y is 47; X is 49 and Y is 48; X is 49 andY is 49; X is 49 and Y is 50; X is 49 and Y is 51; X is 49 and Y is 52;X is 49 and Y is 53; X is 49 and Y is 54; X is 49 and Y is 55; X is 49and Y is 56; X is 49 and Y is 57; X is 49 and Y is 58; X is 49 and Y is59; X is 49 and Y is 60; X is 49 and Y is 61; X is 49 and Y is 62; X is49 and Y is 63; X is 49 and Y is 64; X is 49 and Y is 65; X is 49 and Yis 66; X is 49 and Y is 67; X is 49 and Y is 68; X is 49 and Y is 69; Xis 49 and Y is 70; X is 49 and Y is 71; X is 49 and Y is 72; X is 49 andY is 73; X is 49 and Y is 74; X is 49 and Y is 75; X is 49 and Y is 76;X is 49 and Y is 77; X is 49 and Y is 78; X is 49 and Y is 79; X is 49and Y is 80; X is 49 and Y is 81; X is 49 and Y is 82; X is 49 and Y is83; X is 49 and Y is 84; X is 49 and Y is 85; X is 49 and Y is 86; X is49 and Y is 87; X is 49 and Y is 88; X is 49 and Y is 89; X is 49 and Yis 90; X is 49 and Y is 91; X is 49 and Y is 92; X is 49 and Y is 93; Xis 49 and Y is 94; X is 49 and Y is 95; X is 49 and Y is 96; X is 49 andY is 97; X is 49 and Y is 98; X is 49 and Y is 99; X is 49 and Y is 100;X is 49 and Y is 101; X is 49 and Y is 102; X is 49 and Y is 103; X is49 and Y is 104; X is 49 and Y is 105; X is 49 and Y is 106; X is 49 andY is 107; X is 49 and Y is 108; X is 49 and Y is 109; X is 49 and Y is110; X is 49 and Y is 111; X is 49 and Y is 112; X is 49 and Y is 113; Xis 49 and Y is 114; X is 49 and Y is 115; X is 49 and Y is 116; X is 49and Y is 117; X is 49 and Y is 118; X is 49 and Y is 119; X is 49 and Yis 120; X is 49 and Y is 121; X is 49 and Y is 122; X is 49 and Y is123; X is 49 and Y is 124; X is 49 and Y is 125; X is 49 and Y is 126; Xis 49 and Y is 127; X is 49 and Y is 128; X is 49 and Y is 129; X is 49and Y is 130; X is 49 and Y is 131; X is 49 and Y is 132; X is 49 and Yis 133; X is 49 and Y is 134; X is 49 and Y is 135; X is 49 and Y is136; X is 49 and Y is 137; X is 49 and Y is 138; X is 49 and Y is 139; Xis 49 and Y is 140; X is 49 and Y is 141; X is 49 and Y is 142; X is 49and Y is 143; X is 49 and Y is 144; X is 49 and Y is 145; X is 49 and Yis 146; X is 49 and Y is 147; X is 49 and Y is 148; X is 49 and Y is149; X is 49 and Y is 150; X is 49 and Y is 151; X is 49 and Y is 152; Xis 49 and Y is 153; X is 49 and Y is 154; X is 49 and Y is 155; X is 49and Y is 156; X is 49 and Y is 157; X is 49 and Y is 158; X is 49 and Yis 159; X is 49 and Y is 160; X is 49 and Y is 161; X is 49 and Y is162; X is 49 and Y is 163; X is 49 and Y is 164; X is 49 and Y is 165; Xis 49 and Y is 166; X is 49 and Y is 167; X is 49 and Y is 168; X is 49and Y is 169; X is 49 and Y is 170; X is 49 and Y is 171; X is 49 and Yis 172; X is 49 and Y is 173; X is 49 and Y is 174; X is 49 and Y is175; X is 49 and Y is 176; X is 49 and Y is 177; X is 49 and Y is 178; Xis 49 and Y is 179; X is 49 and Y is 180; X is 49 and Y is 181; X is 49and Y is 182; X is 49 and Y is 183; X is 49 and Y is 184; X is 49 and Yis 185; X is 49 and Y is 186;X is 50 and Y is 1; X is 50 and Y is 2; X is 50 and Y is 3; X is 50 andY is 4; X is 50 and Y is 5; X is 50 and Y is 6; X is 50 and Y is 7; X is50 and Y is 8; X is 50 and Y is 9; X is 50 and Y is 10; X is 50 and Y is11; X is 50 and Y is 12; X is 50 and Y is 13; X is 50 and Y is 14; X is50 and Y is 15; X is 50 and Y is 16; X is 50 and Y is 17; X is 50 and Yis 18; X is 50 and Y is 19; X is 50 and Y is 20; X is 50 and Y is 21; Xis 50 and Y is 22; X is 50 and Y is 23; X is 50 and Y is 24; X is 50 andY is 25; X is 50 and Y is 26; X is 50 and Y is 27; X is 50 and Y is 28;X is 50 and Y is 29; X is 50 and Y is 30; X is 50 and Y is 31; X is 50and Y is 32; X is 50 and Y is 33; X is 50 and Y is 34; X is 50 and Y is35; X is 50 and Y is 36; X is 50 and Y is 37; X is 50 and Y is 38; X is50 and Y is 39; X is 50 and Y is 40; X is 50 and Y is 41; X is 50 and Yis 42; X is 50 and Y is 43; X is 50 and Y is 44; X is 50 and Y is 45; Xis 50 and Y is 46; X is 50 and Y is 47; X is 50 and Y is 48; X is 50 andY is 49; X is 50 and Y is 50; X is 50 and Y is 51; X is 50 and Y is 52;X is 50 and Y is 53; X is 50 and Y is 54; X is 50 and Y is 55; X is 50and Y is 56; X is 50 and Y is 57; X is 50 and Y is 58; X is 50 and Y is59; X is 50 and Y is 60; X is 50 and Y is 61; X is 50 and Y is 62; X is50 and Y is 63; X is 50 and Y is 64; X is 50 and Y is 65; X is 50 and Yis 66; X is 50 and Y is 67; X is 50 and Y is 68; X is 50 and Y is 69; Xis 50 and Y is 70; X is 50 and Y is 71; X is 50 and Y is 72; X is 50 andY is 73; X is 50 and Y is 74; X is 50 and Y is 75; X is 50 and Y is 76;X is 50 and Y is 77; X is 50 and Y is 78; X is 50 and Y is 79; X is 50and Y is 80; X is 50 and Y is 81; X is 50 and Y is 82; X is 50 and Y is83; X is 50 and Y is 84; X is 50 and Y is 85; X is 50 and Y is 86; X is50 and Y is 87; X is 50 and Y is 88; X is 50 and Y is 89; X is 50 and Yis 90; X is 50 and Y is 91; X is 50 and Y is 92; X is 50 and Y is 93; Xis 50 and Y is 94; X is 50 and Y is 95; X is 50 and Y is 96; X is 50 andY is 97; X is 50 and Y is 98; X is 50 and Y is 99; X is 50 and Y is 100;X is 50 and Y is 101; X is 50 and Y is 102; X is 50 and Y is 103; X is50 and Y is 104; X is 50 and Y is 105; X is 50 and Y is 106; X is 50 andY is 107; X is 50 and Y is 108; X is 50 and Y is 109; X is 50 and Y is110; X is 50 and Y is 111; X is 50 and Y is 112; X is 50 and Y is 113; Xis 50 and Y is 114; X is 50 and Y is 115; X is 50 and Y is 116; X is 50and Y is 117; X is 50 and Y is 118; X is 50 and Y is 119; X is 50 and Yis 120; X is 50 and Y is 121; X is 50 and Y is 122; X is 50 and Y is123; X is 50 and Y is 124; X is 50 and Y is 125; X is 50 and Y is 126; Xis 50 and Y is 127; X is 50 and Y is 128; X is 50 and Y is 129; X is 50and Y is 130; X is 50 and Y is 131; X is 50 and Y is 132; X is 50 and Yis 133; X is 50 and Y is 134; X is 50 and Y is 135; X is 50 and Y is136; X is 50 and Y is 137; X is 50 and Y is 138; X is 50 and Y is 139; Xis 50 and Y is 140; X is 50 and Y is 141; X is 50 and Y is 142; X is 50and Y is 143; X is 50 and Y is 144; X is 50 and Y is 145; X is 50 and Yis 146; X is 50 and Y is 147; X is 50 and Y is 148; X is 50 and Y is149; X is 50 and Y is 150; X is 50 and Y is 151; X is 50 and Y is 152; Xis 50 and Y is 153; X is 50 and Y is 154; X is 50 and Y is 155; X is 50and Y is 156; X is 50 and Y is 157; X is 50 and Y is 158; X is 50 and Yis 159; X is 50 and Y is 160; X is 50 and Y is 161; X is 50 and Y is162; X is 50 and Y is 163; X is 50 and Y is 164; X is 50 and Y is 165; Xis 50 and Y is 166; X is 50 and Y is 167; X is 50 and Y is 168; X is 50and Y is 169; X is 50 and Y is 170; X is 50 and Y is 171; X is 50 and Yis 172; X is 50 and Y is 173; X is 50 and Y is 174; X is 50 and Y is175; X is 50 and Y is 176; X is 50 and Y is 177; X is 50 and Y is 178; Xis 50 and Y is 179; X is 50 and Y is 180; X is 50 and Y is 181; X is 50and Y is 182; X is 50 and Y is 183; X is 50 and Y is 184; X is 50 and Yis 185; X is 50 and Y is 186;X is 51 and Y is 1; X is 51 and Y is 2; X is 51 and Y is 3; X is 51 andY is 4; X is 51 and Y is 5; X is 51 and Y is 6; X is 51 and Y is 7; X is51 and Y is 8; X is 51 and Y is 9; X is 51 and Y is 10; X is 51 and Y is11; X is 51 and Y is 12; X is 51 and Y is 13; X is 51 and Y is 14; X is51 and Y is 15; X is 51 and Y is 16; X is 51 and Y is 17; X is 51 and Yis 18; X is 51 and Y is 19; X is 51 and Y is 20; X is 51 and Y is 21; Xis 51 and Y is 22; X is 51 and Y is 23; X is 51 and Y is 24; X is 51 andY is 25; X is 51 and Y is 26; X is 51 and Y is 27; X is 51 and Y is 28;X is 51 and Y is 29; X is 51 and Y is 30; X is 51 and Y is 31; X is 51and Y is 32; X is 51 and Y is 33; X is 51 and Y is 34; X is 51 and Y is35; X is 51 and Y is 36; X is 51 and Y is 37; X is 51 and Y is 38; X is51 and Y is 39; X is 51 and Y is 40; X is 51 and Y is 41; X is 51 and Yis 42; X is 51 and Y is 43; X is 51 and Y is 44; X is 51 and Y is 45; Xis 51 and Y is 46; X is 51 and Y is 47; X is 51 and Y is 48; X is 51 andY is 49; X is 51 and Y is 50; X is 51 and Y is 51; X is 51 and Y is 52;X is 51 and Y is 53; X is 51 and Y is 54; X is 51 and Y is 55; X is 51and Y is 56; X is 51 and Y is 57; X is 51 and Y is 58; X is 51 and Y is59; X is 51 and Y is 60; X is 51 and Y is 61; X is 51 and Y is 62; X is51 and Y is 63; X is 51 and Y is 64; X is 51 and Y is 65; X is 51 and Yis 66; X is 51 and Y is 67; X is 51 and Y is 68; X is 51 and Y is 69; Xis 51 and Y is 70; X is 51 and Y is 71; X is 51 and Y is 72; X is 51 andY is 73; X is 51 and Y is 74; X is 51 and Y is 75; X is 51 and Y is 76;X is 51 and Y is 77; X is 51 and Y is 78; X is 51 and Y is 79; X is 51and Y is 80; X is 51 and Y is 81; X is 51 and Y is 82; X is 51 and Y is83; X is 51 and Y is 84; X is 51 and Y is 85; X is 51 and Y is 86; X is51 and Y is 87; X is 51 and Y is 88; X is 51 and Y is 89; X is 51 and Yis 90; X is 51 and Y is 91; X is 51 and Y is 92; X is 51 and Y is 93; Xis 51 and Y is 94; X is 51 and Y is 95; X is 51 and Y is 96; X is 51 andY is 97; X is 51 and Y is 98; X is 51 and Y is 99; X is 51 and Y is 100;X is 51 and Y is 101; X is 51 and Y is 102; X is 51 and Y is 103; X is51 and Y is 104; X is 51 and Y is 105; X is 51 and Y is 106; X is 51 andY is 107; X is 51 and Y is 108; X is 51 and Y is 109; X is 51 and Y is110; X is 51 and Y is 111; X is 51 and Y is 112; X is 51 and Y is 113; Xis 51 and Y is 114; X is 51 and Y is 115; X is 51 and Y is 116; X is 51and Y is 117; X is 51 and Y is 118; X is 51 and Y is 119; X is 51 and Yis 120; X is 51 and Y is 121; X is 51 and Y is 122; X is 51 and Y is123; X is 51 and Y is 124; X is 51 and Y is 125; X is 51 and Y is 126; Xis 51 and Y is 127; X is 51 and Y is 128; X is 51 and Y is 129; X is 51and Y is 130; X is 51 and Y is 131; X is 51 and Y is 132; X is 51 and Yis 133; X is 51 and Y is 134; X is 51 and Y is 135; X is 51 and Y is136; X is 51 and Y is 137; X is 51 and Y is 138; X is 51 and Y is 139; Xis 51 and Y is 140; X is 51 and Y is 141; X is 51 and Y is 142; X is 51and Y is 143; X is 51 and Y is 144; X is 51 and Y is 145; X is 51 and Yis 146; X is 51 and Y is 147; X is 51 and Y is 148; X is 51 and Y is149; X is 51 and Y is 150; X is 51 and Y is 151; X is 51 and Y is 152; Xis 51 and Y is 153; X is 51 and Y is 154; X is 51 and Y is 155; X is 51and Y is 156; X is 51 and Y is 157; X is 51 and Y is 158; X is 51 and Yis 159; X is 51 and Y is 160; X is 51 and Y is 161; X is 51 and Y is162; X is 51 and Y is 163; X is 51 and Y is 164; X is 51 and Y is 165; Xis 51 and Y is 166; X is 51 and Y is 167; X is 51 and Y is 168; X is 51and Y is 169; X is 51 and Y is 170; X is 51 and Y is 171; X is 51 and Yis 172; X is 51 and Y is 173; X is 51 and Y is 174; X is 51 and Y is175; X is 51 and Y is 176; X is 51 and Y is 177; X is 51 and Y is 178; Xis 51 and Y is 179; X is 51 and Y is 180; X is 51 and Y is 181; X is 51and Y is 182; X is 51 and Y is 183; X is 51 and Y is 184; X is 51 and Yis 185; X is 51 and Y is 186;X is 52 and Y is 1; X is 52 and Y is 2; X is 52 and Y is 3; X is 52 andY is 4; X is 52 and Y is 5; X is 52 and Y is 6; X is 52 and Y is 7; X is52 and Y is 8; X is 52 and Y is 9; X is 52 and Y is 10; X is 52 and Y is11; X is 52 and Y is 12; X is 52 and Y is 13; X is 52 and Y is 14; X is52 and Y is 15; X is 52 and Y is 16; X is 52 and Y is 17; X is 52 and Yis 18; X is 52 and Y is 19; X is 52 and Y is 20; X is 52 and Y is 21; Xis 52 and Y is 22; X is 52 and Y is 23; X is 52 and Y is 24; X is 52 andY is 25; X is 52 and Y is 26; X is 52 and Y is 27; X is 52 and Y is 28;X is 52 and Y is 29; X is 52 and Y is 30; X is 52 and Y is 31; X is 52and Y is 32; X is 52 and Y is 33; X is 52 and Y is 34; X is 52 and Y is35; X is 52 and Y is 36; X is 52 and Y is 37; X is 52 and Y is 38; X is52 and Y is 39; X is 52 and Y is 40; X is 52 and Y is 41; X is 52 and Yis 42; X is 52 and Y is 43; X is 52 and Y is 44; X is 52 and Y is 45; Xis 52 and Y is 46; X is 52 and Y is 47; X is 52 and Y is 48; X is 52 andY is 49; X is 52 and Y is 50; X is 52 and Y is 51; X is 52 and Y is 52;X is 52 and Y is 53; X is 52 and Y is 54; X is 52 and Y is 55; X is 52and Y is 56; X is 52 and Y is 57; X is 52 and Y is 58; X is 52 and Y is59; X is 52 and Y is 60; X is 52 and Y is 61; X is 52 and Y is 62; X is52 and Y is 63; X is 52 and Y is 64; X is 52 and Y is 65; X is 52 and Yis 66; X is 52 and Y is 67; X is 52 and Y is 68; X is 52 and Y is 69; Xis 52 and Y is 70; X is 52 and Y is 71; X is 52 and Y is 72; X is 52 andY is 73; X is 52 and Y is 74; X is 52 and Y is 75; X is 52 and Y is 76;X is 52 and Y is 77; X is 52 and Y is 78; X is 52 and Y is 79; X is 52and Y is 80; X is 52 and Y is 81; X is 52 and Y is 82; X is 52 and Y is83; X is 52 and Y is 84; X is 52 and Y is 85; X is 52 and Y is 86; X is52 and Y is 87; X is 52 and Y is 88; X is 52 and Y is 89; X is 52 and Yis 90; X is 52 and Y is 91; X is 52 and Y is 92; X is 52 and Y is 93; Xis 52 and Y is 94; X is 52 and Y is 95; X is 52 and Y is 96; X is 52 andY is 97; X is 52 and Y is 98; X is 52 and Y is 99; X is 52 and Y is 100;X is 52 and Y is 101; X is 52 and Y is 102; X is 52 and Y is 103; X is52 and Y is 104; X is 52 and Y is 105; X is 52 and Y is 106; X is 52 andY is 107; X is 52 and Y is 108; X is 52 and Y is 109; X is 52 and Y is110; X is 52 and Y is 111; X is 52 and Y is 112; X is 52 and Y is 113; Xis 52 and Y is 114; X is 52 and Y is 115; X is 52 and Y is 116; X is 52and Y is 117; X is 52 and Y is 118; X is 52 and Y is 119; X is 52 and Yis 120; X is 52 and Y is 121; X is 52 and Y is 122; X is 52 and Y is123; X is 52 and Y is 124; X is 52 and Y is 125; X is 52 and Y is 126; Xis 52 and Y is 127; X is 52 and Y is 128; X is 52 and Y is 129; X is 52and Y is 130; X is 52 and Y is 131; X is 52 and Y is 132; X is 52 and Yis 133; X is 52 and Y is 134; X is 52 and Y is 135; X is 52 and Y is136; X is 52 and Y is 137; X is 52 and Y is 138; X is 52 and Y is 139; Xis 52 and Y is 140; X is 52 and Y is 141; X is 52 and Y is 142; X is 52and Y is 143; X is 52 and Y is 144; X is 52 and Y is 145; X is 52 and Yis 146; X is 52 and Y is 147; X is 52 and Y is 148; X is 52 and Y is149; X is 52 and Y is 150; X is 52 and Y is 151; X is 52 and Y is 152; Xis 52 and Y is 153; X is 52 and Y is 154; X is 52 and Y is 155; X is 52and Y is 156; X is 52 and Y is 157; X is 52 and Y is 158; X is 52 and Yis 159; X is 52 and Y is 160; X is 52 and Y is 161; X is 52 and Y is162; X is 52 and Y is 163; X is 52 and Y is 164; X is 52 and Y is 165; Xis 52 and Y is 166; X is 52 and Y is 167; X is 52 and Y is 168; X is 52and Y is 169; X is 52 and Y is 170; X is 52 and Y is 171; X is 52 and Yis 172; X is 52 and Y is 173; X is 52 and Y is 174; X is 52 and Y is175; X is 52 and Y is 176; X is 52 and Y is 177; X is 52 and Y is 178; Xis 52 and Y is 179; X is 52 and Y is 180; X is 52 and Y is 181; X is 52and Y is 182; X is 52 and Y is 183; X is 52 and Y is 184; X is 52 and Yis 185; X is 52 and Y is 186;X is 53 and Y is 1; X is 53 and Y is 2; X is 53 and Y is 3; X is 53 andY is 4; X is 53 and Y is 5; X is 53 and Y is 6; X is 53 and Y is 7; X is53 and Y is 8; X is 53 and Y is 9; X is 53 and Y is 10; X is 53 and Y is11; X is 53 and Y is 12; X is 53 and Y is 13; X is 53 and Y is 14; X is53 and Y is 15; X is 53 and Y is 16; X is 53 and Y is 17; X is 53 and Yis 18; X is 53 and Y is 19; X is 53 and Y is 20; X is 53 and Y is 21; Xis 53 and Y is 22; X is 53 and Y is 23; X is 53 and Y is 24; X is 53 andY is 25; X is 53 and Y is 26; X is 53 and Y is 27; X is 53 and Y is 28;X is 53 and Y is 29; X is 53 and Y is 30; X is 53 and Y is 31; X is 53and Y is 32; X is 53 and Y is 33; X is 53 and Y is 34; X is 53 and Y is35; X is 53 and Y is 36; X is 53 and Y is 37; X is 53 and Y is 38; X is53 and Y is 39; X is 53 and Y is 40; X is 53 and Y is 41; X is 53 and Yis 42; X is 53 and Y is 43; X is 53 and Y is 44; X is 53 and Y is 45; Xis 53 and Y is 46; X is 53 and Y is 47; X is 53 and Y is 48; X is 53 andY is 49; X is 53 and Y is 50; X is 53 and Y is 51; X is 53 and Y is 52;X is 53 and Y is 53; X is 53 and Y is 54; X is 53 and Y is 55; X is 53and Y is 56; X is 53 and Y is 57; X is 53 and Y is 58; X is 53 and Y is59; X is 53 and Y is 60; X is 53 and Y is 61; X is 53 and Y is 62; X is53 and Y is 63; X is 53 and Y is 64; X is 53 and Y is 65; X is 53 and Yis 66; X is 53 and Y is 67; X is 53 and Y is 68; X is 53 and Y is 69; Xis 53 and Y is 70; X is 53 and Y is 71; X is 53 and Y is 72; X is 53 andY is 73; X is 53 and Y is 74; X is 53 and Y is 75; X is 53 and Y is 76;X is 53 and Y is 77; X is 53 and Y is 78; X is 53 and Y is 79; X is 53and Y is 80; X is 53 and Y is 81; X is 53 and Y is 82; X is 53 and Y is83; X is 53 and Y is 84; X is 53 and Y is 85; X is 53 and Y is 86; X is53 and Y is 87; X is 53 and Y is 88; X is 53 and Y is 89; X is 53 and Yis 90; X is 53 and Y is 91; X is 53 and Y is 92; X is 53 and Y is 93; Xis 53 and Y is 94; X is 53 and Y is 95; X is 53 and Y is 96; X is 53 andY is 97; X is 53 and Y is 98; X is 53 and Y is 99; X is 53 and Y is 100;X is 53 and Y is 101; X is 53 and Y is 102; X is 53 and Y is 103; X is53 and Y is 104; X is 53 and Y is 105; X is 53 and Y is 106; X is 53 andY is 107; X is 53 and Y is 108; X is 53 and Y is 109; X is 53 and Y is110; X is 53 and Y is 111; X is 53 and Y is 112; X is 53 and Y is 113; Xis 53 and Y is 114; X is 53 and Y is 115; X is 53 and Y is 116; X is 53and Y is 117; X is 53 and Y is 118; X is 53 and Y is 119; X is 53 and Yis 120; X is 53 and Y is 121; X is 53 and Y is 122; X is 53 and Y is123; X is 53 and Y is 124; X is 53 and Y is 125; X is 53 and Y is 126; Xis 53 and Y is 127; X is 53 and Y is 128; X is 53 and Y is 129; X is 53and Y is 130; X is 53 and Y is 131; X is 53 and Y is 132; X is 53 and Yis 133; X is 53 and Y is 134; X is 53 and Y is 135; X is 53 and Y is136; X is 53 and Y is 137; X is 53 and Y is 138; X is 53 and Y is 139; Xis 53 and Y is 140; X is 53 and Y is 141; X is 53 and Y is 142; X is 53and Y is 143; X is 53 and Y is 144; X is 53 and Y is 145; X is 53 and Yis 146; X is 53 and Y is 147; X is 53 and Y is 148; X is 53 and Y is149; X is 53 and Y is 150; X is 53 and Y is 151; X is 53 and Y is 152; Xis 53 and Y is 153; X is 53 and Y is 154; X is 53 and Y is 155; X is 53and Y is 156; X is 53 and Y is 157; X is 53 and Y is 158; X is 53 and Yis 159; X is 53 and Y is 160; X is 53 and Y is 161; X is 53 and Y is162; X is 53 and Y is 163; X is 53 and Y is 164; X is 53 and Y is 165; Xis 53 and Y is 166; X is 53 and Y is 167; X is 53 and Y is 168; X is 53and Y is 169; X is 53 and Y is 170; X is 53 and Y is 171; X is 53 and Yis 172; X is 53 and Y is 173; X is 53 and Y is 174; X is 53 and Y is175; X is 53 and Y is 176; X is 53 and Y is 177; X is 53 and Y is 178; Xis 53 and Y is 179; X is 53 and Y is 180; X is 53 and Y is 181; X is 53and Y is 182; X is 53 and Y is 183; X is 53 and Y is 184; X is 53 and Yis 185; X is 53 and Y is 186;X is 54 and Y is 1; X is 54 and Y is 2; X is 54 and Y is 3; X is 54 andY is 4; X is 54 and Y is 5; X is 54 and Y is 6; X is 54 and Y is 7; X is54 and Y is 8; X is 54 and Y is 9; X is 54 and Y is 10; X is 54 and Y is11; X is 54 and Y is 12; X is 54 and Y is 13; X is 54 and Y is 14; X is54 and Y is 15; X is 54 and Y is 16; X is 54 and Y is 17; X is 54 and Yis 18; X is 54 and Y is 19; X is 54 and Y is 20; X is 54 and Y is 21; Xis 54 and Y is 22; X is 54 and Y is 23; X is 54 and Y is 24; X is 54 andY is 25; X is 54 and Y is 26; X is 54 and Y is 27; X is 54 and Y is 28;X is 54 and Y is 29; X is 54 and Y is 30; X is 54 and Y is 31; X is 54and Y is 32; X is 54 and Y is 33; X is 54 and Y is 34; X is 54 and Y is35; X is 54 and Y is 36; X is 54 and Y is 37; X is 54 and Y is 38; X is54 and Y is 39; X is 54 and Y is 40; X is 54 and Y is 41; X is 54 and Yis 42; X is 54 and Y is 43; X is 54 and Y is 44; X is 54 and Y is 45; Xis 54 and Y is 46; X is 54 and Y is 47; X is 54 and Y is 48; X is 54 andY is 49; X is 54 and Y is 50; X is 54 and Y is 51; X is 54 and Y is 52;X is 54 and Y is 53; X is 54 and Y is 54; X is 54 and Y is 55; X is 54and Y is 56; X is 54 and Y is 57; X is 54 and Y is 58; X is 54 and Y is59; X is 54 and Y is 60; X is 54 and Y is 61; X is 54 and Y is 62; X is54 and Y is 63; X is 54 and Y is 64; X is 54 and Y is 65; X is 54 and Yis 66; X is 54 and Y is 67; X is 54 and Y is 68; X is 54 and Y is 69; Xis 54 and Y is 70; X is 54 and Y is 71; X is 54 and Y is 72; X is 54 andY is 73; X is 54 and Y is 74; X is 54 and Y is 75; X is 54 and Y is 76;X is 54 and Y is 77; X is 54 and Y is 78; X is 54 and Y is 79; X is 54and Y is 80; X is 54 and Y is 81; X is 54 and Y is 82; X is 54 and Y is83; X is 54 and Y is 84; X is 54 and Y is 85; X is 54 and Y is 86; X is54 and Y is 87; X is 54 and Y is 88; X is 54 and Y is 89; X is 54 and Yis 90; X is 54 and Y is 91; X is 54 and Y is 92; X is 54 and Y is 93; Xis 54 and Y is 94; X is 54 and Y is 95; X is 54 and Y is 96; X is 54 andY is 97; X is 54 and Y is 98; X is 54 and Y is 99; X is 54 and Y is 100;X is 54 and Y is 101; X is 54 and Y is 102; X is 54 and Y is 103; X is54 and Y is 104; X is 54 and Y is 105; X is 54 and Y is 106; X is 54 andY is 107; X is 54 and Y is 108; X is 54 and Y is 109; X is 54 and Y is110; X is 54 and Y is 111; X is 54 and Y is 112; X is 54 and Y is 113; Xis 54 and Y is 114; X is 54 and Y is 115; X is 54 and Y is 116; X is 54and Y is 117; X is 54 and Y is 118; X is 54 and Y is 119; X is 54 and Yis 120; X is 54 and Y is 121; X is 54 and Y is 122; X is 54 and Y is123; X is 54 and Y is 124; X is 54 and Y is 125; X is 54 and Y is 126; Xis 54 and Y is 127; X is 54 and Y is 128; X is 54 and Y is 129; X is 54and Y is 130; X is 54 and Y is 131; X is 54 and Y is 132; X is 54 and Yis 133; X is 54 and Y is 134; X is 54 and Y is 135; X is 54 and Y is136; X is 54 and Y is 137; X is 54 and Y is 138; X is 54 and Y is 139; Xis 54 and Y is 140; X is 54 and Y is 141; X is 54 and Y is 142; X is 54and Y is 143; X is 54 and Y is 144; X is 54 and Y is 145; X is 54 and Yis 146; X is 54 and Y is 147; X is 54 and Y is 148; X is 54 and Y is149; X is 54 and Y is 150; X is 54 and Y is 151; X is 54 and Y is 152; Xis 54 and Y is 153; X is 54 and Y is 154; X is 54 and Y is 155; X is 54and Y is 156; X is 54 and Y is 157; X is 54 and Y is 158; X is 54 and Yis 159; X is 54 and Y is 160; X is 54 and Y is 161; X is 54 and Y is162; X is 54 and Y is 163; X is 54 and Y is 164; X is 54 and Y is 165; Xis 54 and Y is 166; X is 54 and Y is 167; X is 54 and Y is 168; X is 54and Y is 169; X is 54 and Y is 170; X is 54 and Y is 171; X is 54 and Yis 172; X is 54 and Y is 173; X is 54 and Y is 174; X is 54 and Y is175; X is 54 and Y is 176; X is 54 and Y is 177; X is 54 and Y is 178; Xis 54 and Y is 179; X is 54 and Y is 180; X is 54 and Y is 181; X is 54and Y is 182; X is 54 and Y is 183; X is 54 and Y is 184; X is 54 and Yis 185; X is 54 and Y is 186;X is 55 and Y is 1; X is 55 and Y is 2; X is 55 and Y is 3; X is 55 andY is 4; X is 55 and Y is 5; X is 55 and Y is 6; X is 55 and Y is 7; X is55 and Y is 8; X is 55 and Y is 9; X is 55 and Y is 10; X is 55 and Y is11; X is 55 and Y is 12; X is 55 and Y is 13; X is 55 and Y is 14; X is55 and Y is 15; X is 55 and Y is 16; X is 55 and Y is 17; X is 55 and Yis 18; X is 55 and Y is 19; X is 55 and Y is 20; X is 55 and Y is 21; Xis 55 and Y is 22; X is 55 and Y is 23; X is 55 and Y is 24; X is 55 andY is 25; X is 55 and Y is 26; X is 55 and Y is 27; X is 55 and Y is 28;X is 55 and Y is 29; X is 55 and Y is 30; X is 55 and Y is 31; X is 55and Y is 32; X is 55 and Y is 33; X is 55 and Y is 34; X is 55 and Y is35; X is 55 and Y is 36; X is 55 and Y is 37; X is 55 and Y is 38; X is55 and Y is 39; X is 55 and Y is 40; X is 55 and Y is 41; X is 55 and Yis 42; X is 55 and Y is 43; X is 55 and Y is 44; X is 55 and Y is 45; Xis 55 and Y is 46; X is 55 and Y is 47; X is 55 and Y is 48; X is 55 andY is 49; X is 55 and Y is 50; X is 55 and Y is 51; X is 55 and Y is 52;X is 55 and Y is 53; X is 55 and Y is 54; X is 55 and Y is 55; X is 55and Y is 56; X is 55 and Y is 57; X is 55 and Y is 58; X is 55 and Y is59; X is 55 and Y is 60; X is 55 and Y is 61; X is 55 and Y is 62; X is55 and Y is 63; X is 55 and Y is 64; X is 55 and Y is 65; X is 55 and Yis 66; X is 55 and Y is 67; X is 55 and Y is 68; X is 55 and Y is 69; Xis 55 and Y is 70; X is 55 and Y is 71; X is 55 and Y is 72; X is 55 andY is 73; X is 55 and Y is 74; X is 55 and Y is 75; X is 55 and Y is 76;X is 55 and Y is 77; X is 55 and Y is 78; X is 55 and Y is 79; X is 55and Y is 80; X is 55 and Y is 81; X is 55 and Y is 82; X is 55 and Y is83; X is 55 and Y is 84; X is 55 and Y is 85; X is 55 and Y is 86; X is55 and Y is 87; X is 55 and Y is 88; X is 55 and Y is 89; X is 55 and Yis 90; X is 55 and Y is 91; X is 55 and Y is 92; X is 55 and Y is 93; Xis 55 and Y is 94; X is 55 and Y is 95; X is 55 and Y is 96; X is 55 andY is 97; X is 55 and Y is 98; X is 55 and Y is 99; X is 55 and Y is 100;X is 55 and Y is 101; X is 55 and Y is 102; X is 55 and Y is 103; X is55 and Y is 104; X is 55 and Y is 105; X is 55 and Y is 106; X is 55 andY is 107; X is 55 and Y is 108; X is 55 and Y is 109; X is 55 and Y is110; X is 55 and Y is 111; X is 55 and Y is 112; X is 55 and Y is 113; Xis 55 and Y is 114; X is 55 and Y is 115; X is 55 and Y is 116; X is 55and Y is 117; X is 55 and Y is 118; X is 55 and Y is 119; X is 55 and Yis 120; X is 55 and Y is 121; X is 55 and Y is 122; X is 55 and Y is123; X is 55 and Y is 124; X is 55 and Y is 125; X is 55 and Y is 126; Xis 55 and Y is 127; X is 55 and Y is 128; X is 55 and Y is 129; X is 55and Y is 130; X is 55 and Y is 131; X is 55 and Y is 132; X is 55 and Yis 133; X is 55 and Y is 134; X is 55 and Y is 135; X is 55 and Y is136; X is 55 and Y is 137; X is 55 and Y is 138; X is 55 and Y is 139; Xis 55 and Y is 140; X is 55 and Y is 141; X is 55 and Y is 142; X is 55and Y is 143; X is 55 and Y is 144; X is 55 and Y is 145; X is 55 and Yis 146; X is 55 and Y is 147; X is 55 and Y is 148; X is 55 and Y is149; X is 55 and Y is 150; X is 55 and Y is 151; X is 55 and Y is 152; Xis 55 and Y is 153; X is 55 and Y is 154; X is 55 and Y is 155; X is 55and Y is 156; X is 55 and Y is 157; X is 55 and Y is 158; X is 55 and Yis 159; X is 55 and Y is 160; X is 55 and Y is 161; X is 55 and Y is162; X is 55 and Y is 163; X is 55 and Y is 164; X is 55 and Y is 165; Xis 55 and Y is 166; X is 55 and Y is 167; X is 55 and Y is 168; X is 55and Y is 169; X is 55 and Y is 170; X is 55 and Y is 171; X is 55 and Yis 172; X is 55 and Y is 173; X is 55 and Y is 174; X is 55 and Y is175; X is 55 and Y is 176; X is 55 and Y is 177; X is 55 and Y is 178; Xis 55 and Y is 179; X is 55 and Y is 180; X is 55 and Y is 181; X is 55and Y is 182; X is 55 and Y is 183; X is 55 and Y is 184; X is 55 and Yis 185; X is 55 and Y is 186;X is 56 and Y is 1; X is 56 and Y is 2; X is 56 and Y is 3; X is 56 andY is 4; X is 56 and Y is 5; X is 56 and Y is 6; X is 56 and Y is 7; X is56 and Y is 8; X is 56 and Y is 9; X is 56 and Y is 10; X is 56 and Y is11; X is 56 and Y is 12; X is 56 and Y is 13; X is 56 and Y is 14; X is56 and Y is 15; X is 56 and Y is 16; X is 56 and Y is 17; X is 56 and Yis 18; X is 56 and Y is 19; X is 56 and Y is 20; X is 56 and Y is 21; Xis 56 and Y is 22; X is 56 and Y is 23; X is 56 and Y is 24; X is 56 andY is 25; X is 56 and Y is 26; X is 56 and Y is 27; X is 56 and Y is 28;X is 56 and Y is 29; X is 56 and Y is 30; X is 56 and Y is 31; X is 56and Y is 32; X is 56 and Y is 33; X is 56 and Y is 34; X is 56 and Y is35; X is 56 and Y is 36; X is 56 and Y is 37; X is 56 and Y is 38; X is56 and Y is 39; X is 56 and Y is 40; X is 56 and Y is 41; X is 56 and Yis 42; X is 56 and Y is 43; X is 56 and Y is 44; X is 56 and Y is 45; Xis 56 and Y is 46; X is 56 and Y is 47; X is 56 and Y is 48; X is 56 andY is 49; X is 56 and Y is 50; X is 56 and Y is 51; X is 56 and Y is 52;X is 56 and Y is 53; X is 56 and Y is 54; X is 56 and Y is 55; X is 56and Y is 56; X is 56 and Y is 57; X is 56 and Y is 58; X is 56 and Y is59; X is 56 and Y is 60; X is 56 and Y is 61; X is 56 and Y is 62; X is56 and Y is 63; X is 56 and Y is 64; X is 56 and Y is 65; X is 56 and Yis 66; X is 56 and Y is 67; X is 56 and Y is 68; X is 56 and Y is 69; Xis 56 and Y is 70; X is 56 and Y is 71; X is 56 and Y is 72; X is 56 andY is 73; X is 56 and Y is 74; X is 56 and Y is 75; X is 56 and Y is 76;X is 56 and Y is 77; X is 56 and Y is 78; X is 56 and Y is 79; X is 56and Y is 80; X is 56 and Y is 81; X is 56 and Y is 82; X is 56 and Y is83; X is 56 and Y is 84; X is 56 and Y is 85; X is 56 and Y is 86; X is56 and Y is 87; X is 56 and Y is 88; X is 56 and Y is 89; X is 56 and Yis 90; X is 56 and Y is 91; X is 56 and Y is 92; X is 56 and Y is 93; Xis 56 and Y is 94; X is 56 and Y is 95; X is 56 and Y is 96; X is 56 andY is 97; X is 56 and Y is 98; X is 56 and Y is 99; X is 56 and Y is 100;X is 56 and Y is 101; X is 56 and Y is 102; X is 56 and Y is 103; X is56 and Y is 104; X is 56 and Y is 105; X is 56 and Y is 106; X is 56 andY is 107; X is 56 and Y is 108; X is 56 and Y is 109; X is 56 and Y is110; X is 56 and Y is 111; X is 56 and Y is 112; X is 56 and Y is 113; Xis 56 and Y is 114; X is 56 and Y is 115; X is 56 and Y is 116; X is 56and Y is 117; X is 56 and Y is 118; X is 56 and Y is 119; X is 56 and Yis 120; X is 56 and Y is 121; X is 56 and Y is 122; X is 56 and Y is123; X is 56 and Y is 124; X is 56 and Y is 125; X is 56 and Y is 126; Xis 56 and Y is 127; X is 56 and Y is 128; X is 56 and Y is 129; X is 56and Y is 130; X is 56 and Y is 131; X is 56 and Y is 132; X is 56 and Yis 133; X is 56 and Y is 134; X is 56 and Y is 135; X is 56 and Y is136; X is 56 and Y is 137; X is 56 and Y is 138; X is 56 and Y is 139; Xis 56 and Y is 140; X is 56 and Y is 141; X is 56 and Y is 142; X is 56and Y is 143; X is 56 and Y is 144; X is 56 and Y is 145; X is 56 and Yis 146; X is 56 and Y is 147; X is 56 and Y is 148; X is 56 and Y is149; X is 56 and Y is 150; X is 56 and Y is 151; X is 56 and Y is 152; Xis 56 and Y is 153; X is 56 and Y is 154; X is 56 and Y is 155; X is 56and Y is 156; X is 56 and Y is 157; X is 56 and Y is 158; X is 56 and Yis 159; X is 56 and Y is 160; X is 56 and Y is 161; X is 56 and Y is162; X is 56 and Y is 163; X is 56 and Y is 164; X is 56 and Y is 165; Xis 56 and Y is 166; X is 56 and Y is 167; X is 56 and Y is 168; X is 56and Y is 169; X is 56 and Y is 170; X is 56 and Y is 171; X is 56 and Yis 172; X is 56 and Y is 173; X is 56 and Y is 174; X is 56 and Y is175; X is 56 and Y is 176; X is 56 and Y is 177; X is 56 and Y is 178; Xis 56 and Y is 179; X is 56 and Y is 180; X is 56 and Y is 181; X is 56and Y is 182; X is 56 and Y is 183; X is 56 and Y is 184; X is 56 and Yis 185; X is 56 and Y is 186;X is 57 and Y is 1; X is 57 and Y is 2; X is 57 and Y is 3; X is 57 andY is 4; X is 57 and Y is 5; X is 57 and Y is 6; X is 57 and Y is 7; X is57 and Y is 8; X is 57 and Y is 9; X is 57 and Y is 10; X is 57 and Y is11; X is 57 and Y is 12; X is 57 and Y is 13; X is 57 and Y is 14; X is57 and Y is 15; X is 57 and Y is 16; X is 57 and Y is 17; X is 57 and Yis 18; X is 57 and Y is 19; X is 57 and Y is 20; X is 57 and Y is 21; Xis 57 and Y is 22; X is 57 and Y is 23; X is 57 and Y is 24; X is 57 andY is 25; X is 57 and Y is 26; X is 57 and Y is 27; X is 57 and Y is 28;X is 57 and Y is 29; X is 57 and Y is 30; X is 57 and Y is 31; X is 57and Y is 32; X is 57 and Y is 33; X is 57 and Y is 34; X is 57 and Y is35; X is 57 and Y is 36; X is 57 and Y is 37; X is 57 and Y is 38; X is57 and Y is 39; X is 57 and Y is 40; X is 57 and Y is 41; X is 57 and Yis 42; X is 57 and Y is 43; X is 57 and Y is 44; X is 57 and Y is 45; Xis 57 and Y is 46; X is 57 and Y is 47; X is 57 and Y is 48; X is 57 andY is 49; X is 57 and Y is 50; X is 57 and Y is 51; X is 57 and Y is 52;X is 57 and Y is 53; X is 57 and Y is 54; X is 57 and Y is 55; X is 57and Y is 56; X is 57 and Y is 57; X is 57 and Y is 58; X is 57 and Y is59; X is 57 and Y is 60; X is 57 and Y is 61; X is 57 and Y is 62; X is57 and Y is 63; X is 57 and Y is 64; X is 57 and Y is 65; X is 57 and Yis 66; X is 57 and Y is 67; X is 57 and Y is 68; X is 57 and Y is 69; Xis 57 and Y is 70; X is 57 and Y is 71; X is 57 and Y is 72; X is 57 andY is 73; X is 57 and Y is 74; X is 57 and Y is 75; X is 57 and Y is 76;X is 57 and Y is 77; X is 57 and Y is 78; X is 57 and Y is 79; X is 57and Y is 80; X is 57 and Y is 81; X is 57 and Y is 82; X is 57 and Y is83; X is 57 and Y is 84; X is 57 and Y is 85; X is 57 and Y is 86; X is57 and Y is 87; X is 57 and Y is 88; X is 57 and Y is 89; X is 57 and Yis 90; X is 57 and Y is 91; X is 57 and Y is 92; X is 57 and Y is 93; Xis 57 and Y is 94; X is 57 and Y is 95; X is 57 and Y is 96; X is 57 andY is 97; X is 57 and Y is 98; X is 57 and Y is 99; X is 57 and Y is 100;X is 57 and Y is 101; X is 57 and Y is 102; X is 57 and Y is 103; X is57 and Y is 104; X is 57 and Y is 105; X is 57 and Y is 106; X is 57 andY is 107; X is 57 and Y is 108; X is 57 and Y is 109; X is 57 and Y is110; X is 57 and Y is 111; X is 57 and Y is 112; X is 57 and Y is 113; Xis 57 and Y is 114; X is 57 and Y is 115; X is 57 and Y is 116; X is 57and Y is 117; X is 57 and Y is 118; X is 57 and Y is 119; X is 57 and Yis 120; X is 57 and Y is 121; X is 57 and Y is 122; X is 57 and Y is123; X is 57 and Y is 124; X is 57 and Y is 125; X is 57 and Y is 126; Xis 57 and Y is 127; X is 57 and Y is 128; X is 57 and Y is 129; X is 57and Y is 130; X is 57 and Y is 131; X is 57 and Y is 132; X is 57 and Yis 133; X is 57 and Y is 134; X is 57 and Y is 135; X is 57 and Y is136; X is 57 and Y is 137; X is 57 and Y is 138; X is 57 and Y is 139; Xis 57 and Y is 140; X is 57 and Y is 141; X is 57 and Y is 142; X is 57and Y is 143; X is 57 and Y is 144; X is 57 and Y is 145; X is 57 and Yis 146; X is 57 and Y is 147; X is 57 and Y is 148; X is 57 and Y is149; X is 57 and Y is 150; X is 57 and Y is 151; X is 57 and Y is 152; Xis 57 and Y is 153; X is 57 and Y is 154; X is 57 and Y is 155; X is 57and Y is 156; X is 57 and Y is 157; X is 57 and Y is 158; X is 57 and Yis 159; X is 57 and Y is 160; X is 57 and Y is 161; X is 57 and Y is162; X is 57 and Y is 163; X is 57 and Y is 164; X is 57 and Y is 165; Xis 57 and Y is 166; X is 57 and Y is 167; X is 57 and Y is 168; X is 57and Y is 169; X is 57 and Y is 170; X is 57 and Y is 171; X is 57 and Yis 172; X is 57 and Y is 173; X is 57 and Y is 174; X is 57 and Y is175; X is 57 and Y is 176; X is 57 and Y is 177; X is 57 and Y is 178; Xis 57 and Y is 179; X is 57 and Y is 180; X is 57 and Y is 181; X is 57and Y is 182; X is 57 and Y is 183; X is 57 and Y is 184; X is 57 and Yis 185; X is 57 and Y is 186;X is 58 and Y is 1; X is 58 and Y is 2; X is 58 and Y is 3; X is 58 andY is 4; X is 58 and Y is 5; X is 58 and Y is 6; X is 58 and Y is 7; X is58 and Y is 8; X is 58 and Y is 9; X is 58 and Y is 10; X is 58 and Y is11; X is 58 and Y is 12; X is 58 and Y is 13; X is 58 and Y is 14; X is58 and Y is 15; X is 58 and Y is 16; X is 58 and Y is 17; X is 58 and Yis 18; X is 58 and Y is 19; X is 58 and Y is 20; X is 58 and Y is 21; Xis 58 and Y is 22; X is 58 and Y is 23; X is 58 and Y is 24; X is 58 andY is 25; X is 58 and Y is 26; X is 58 and Y is 27; X is 58 and Y is 28;X is 58 and Y is 29; X is 58 and Y is 30; X is 58 and Y is 31; X is 58and Y is 32; X is 58 and Y is 33; X is 58 and Y is 34; X is 58 and Y is35; X is 58 and Y is 36; X is 58 and Y is 37; X is 58 and Y is 38; X is58 and Y is 39; X is 58 and Y is 40; X is 58 and Y is 41; X is 58 and Yis 42; X is 58 and Y is 43; X is 58 and Y is 44; X is 58 and Y is 45; Xis 58 and Y is 46; X is 58 and Y is 47; X is 58 and Y is 48; X is 58 andY is 49; X is 58 and Y is 50; X is 58 and Y is 51; X is 58 and Y is 52;X is 58 and Y is 53; X is 58 and Y is 54; X is 58 and Y is 55; X is 58and Y is 56; X is 58 and Y is 57; X is 58 and Y is 58; X is 58 and Y is59; X is 58 and Y is 60; X is 58 and Y is 61; X is 58 and Y is 62; X is58 and Y is 63; X is 58 and Y is 64; X is 58 and Y is 65; X is 58 and Yis 66; X is 58 and Y is 67; X is 58 and Y is 68; X is 58 and Y is 69; Xis 58 and Y is 70; X is 58 and Y is 71; X is 58 and Y is 72; X is 58 andY is 73; X is 58 and Y is 74; X is 58 and Y is 75; X is 58 and Y is 76;X is 58 and Y is 77; X is 58 and Y is 78; X is 58 and Y is 79; X is 58and Y is 80; X is 58 and Y is 81; X is 58 and Y is 82; X is 58 and Y is83; X is 58 and Y is 84; X is 58 and Y is 85; X is 58 and Y is 86; X is58 and Y is 87; X is 58 and Y is 88; X is 58 and Y is 89; X is 58 and Yis 90; X is 58 and Y is 91; X is 58 and Y is 92; X is 58 and Y is 93; Xis 58 and Y is 94; X is 58 and Y is 95; X is 58 and Y is 96; X is 58 andY is 97; X is 58 and Y is 98; X is 58 and Y is 99; X is 58 and Y is 100;X is 58 and Y is 101; X is 58 and Y is 102; X is 58 and Y is 103; X is58 and Y is 104; X is 58 and Y is 105; X is 58 and Y is 106; X is 58 andY is 107; X is 58 and Y is 108; X is 58 and Y is 109; X is 58 and Y is110; X is 58 and Y is 111; X is 58 and Y is 112; X is 58 and Y is 113; Xis 58 and Y is 114; X is 58 and Y is 115; X is 58 and Y is 116; X is 58and Y is 117; X is 58 and Y is 118; X is 58 and Y is 119; X is 58 and Yis 120; X is 58 and Y is 121; X is 58 and Y is 122; X is 58 and Y is123; X is 58 and Y is 124; X is 58 and Y is 125; X is 58 and Y is 126; Xis 58 and Y is 127; X is 58 and Y is 128; X is 58 and Y is 129; X is 58and Y is 130; X is 58 and Y is 131; X is 58 and Y is 132; X is 58 and Yis 133; X is 58 and Y is 134; X is 58 and Y is 135; X is 58 and Y is136; X is 58 and Y is 137; X is 58 and Y is 138; X is 58 and Y is 139; Xis 58 and Y is 140; X is 58 and Y is 141; X is 58 and Y is 142; X is 58and Y is 143; X is 58 and Y is 144; X is 58 and Y is 145; X is 58 and Yis 146; X is 58 and Y is 147; X is 58 and Y is 148; X is 58 and Y is149; X is 58 and Y is 150; X is 58 and Y is 151; X is 58 and Y is 152; Xis 58 and Y is 153; X is 58 and Y is 154; X is 58 and Y is 155; X is 58and Y is 156; X is 58 and Y is 157; X is 58 and Y is 158; X is 58 and Yis 159; X is 58 and Y is 160; X is 58 and Y is 161; X is 58 and Y is162; X is 58 and Y is 163; X is 58 and Y is 164; X is 58 and Y is 165; Xis 58 and Y is 166; X is 58 and Y is 167; X is 58 and Y is 168; X is 58and Y is 169; X is 58 and Y is 170; X is 58 and Y is 171; X is 58 and Yis 172; X is 58 and Y is 173; X is 58 and Y is 174; X is 58 and Y is175; X is 58 and Y is 176; X is 58 and Y is 177; X is 58 and Y is 178; Xis 58 and Y is 179; X is 58 and Y is 180; X is 58 and Y is 181; X is 58and Y is 182; X is 58 and Y is 183; X is 58 and Y is 184; X is 58 and Yis 185; X is 58 and Y is 186;X is 59 and Y is 1; X is 59 and Y is 2; X is 59 and Y is 3; X is 59 andY is 4; X is 59 and Y is 5; X is 59 and Y is 6; X is 59 and Y is 7; X is59 and Y is 8; X is 59 and Y is 9; X is 59 and Y is 10; X is 59 and Y is11; X is 59 and Y is 12; X is 59 and Y is 13; X is 59 and Y is 14; X is59 and Y is 15; X is 59 and Y is 16; X is 59 and Y is 17; X is 59 and Yis 18; X is 59 and Y is 19; X is 59 and Y is 20; X is 59 and Y is 21; Xis 59 and Y is 22; X is 59 and Y is 23; X is 59 and Y is 24; X is 59 andY is 25; X is 59 and Y is 26; X is 59 and Y is 27; X is 59 and Y is 28;X is 59 and Y is 29; X is 59 and Y is 30; X is 59 and Y is 31; X is 59and Y is 32; X is 59 and Y is 33; X is 59 and Y is 34; X is 59 and Y is35; X is 59 and Y is 36; X is 59 and Y is 37; X is 59 and Y is 38; X is59 and Y is 39; X is 59 and Y is 40; X is 59 and Y is 41; X is 59 and Yis 42; X is 59 and Y is 43; X is 59 and Y is 44; X is 59 and Y is 45; Xis 59 and Y is 46; X is 59 and Y is 47; X is 59 and Y is 48; X is 59 andY is 49; X is 59 and Y is 50; X is 59 and Y is 51; X is 59 and Y is 52;X is 59 and Y is 53; X is 59 and Y is 54; X is 59 and Y is 55; X is 59and Y is 56; X is 59 and Y is 57; X is 59 and Y is 58; X is 59 and Y is59; X is 59 and Y is 60; X is 59 and Y is 61; X is 59 and Y is 62; X is59 and Y is 63; X is 59 and Y is 64; X is 59 and Y is 65; X is 59 and Yis 66; X is 59 and Y is 67; X is 59 and Y is 68; X is 59 and Y is 69; Xis 59 and Y is 70; X is 59 and Y is 71; X is 59 and Y is 72; X is 59 andY is 73; X is 59 and Y is 74; X is 59 and Y is 75; X is 59 and Y is 76;X is 59 and Y is 77; X is 59 and Y is 78; X is 59 and Y is 79; X is 59and Y is 80; X is 59 and Y is 81; X is 59 and Y is 82; X is 59 and Y is83; X is 59 and Y is 84; X is 59 and Y is 85; X is 59 and Y is 86; X is59 and Y is 87; X is 59 and Y is 88; X is 59 and Y is 89; X is 59 and Yis 90; X is 59 and Y is 91; X is 59 and Y is 92; X is 59 and Y is 93; Xis 59 and Y is 94; X is 59 and Y is 95; X is 59 and Y is 96; X is 59 andY is 97; X is 59 and Y is 98; X is 59 and Y is 99; X is 59 and Y is 100;X is 59 and Y is 101; X is 59 and Y is 102; X is 59 and Y is 103; X is59 and Y is 104; X is 59 and Y is 105; X is 59 and Y is 106; X is 59 andY is 107; X is 59 and Y is 108; X is 59 and Y is 109; X is 59 and Y is110; X is 59 and Y is 111; X is 59 and Y is 112; X is 59 and Y is 113; Xis 59 and Y is 114; X is 59 and Y is 115; X is 59 and Y is 116; X is 59and Y is 117; X is 59 and Y is 118; X is 59 and Y is 119; X is 59 and Yis 120; X is 59 and Y is 121; X is 59 and Y is 122; X is 59 and Y is123; X is 59 and Y is 124; X is 59 and Y is 125; X is 59 and Y is 126; Xis 59 and Y is 127; X is 59 and Y is 128; X is 59 and Y is 129; X is 59and Y is 130; X is 59 and Y is 131; X is 59 and Y is 132; X is 59 and Yis 133; X is 59 and Y is 134; X is 59 and Y is 135; X is 59 and Y is136; X is 59 and Y is 137; X is 59 and Y is 138; X is 59 and Y is 139; Xis 59 and Y is 140; X is 59 and Y is 141; X is 59 and Y is 142; X is 59and Y is 143; X is 59 and Y is 144; X is 59 and Y is 145; X is 59 and Yis 146; X is 59 and Y is 147; X is 59 and Y is 148; X is 59 and Y is149; X is 59 and Y is 150; X is 59 and Y is 151; X is 59 and Y is 152; Xis 59 and Y is 153; X is 59 and Y is 154; X is 59 and Y is 155; X is 59and Y is 156; X is 59 and Y is 157; X is 59 and Y is 158; X is 59 and Yis 159; X is 59 and Y is 160; X is 59 and Y is 161; X is 59 and Y is162; X is 59 and Y is 163; X is 59 and Y is 164; X is 59 and Y is 165; Xis 59 and Y is 166; X is 59 and Y is 167; X is 59 and Y is 168; X is 59and Y is 169; X is 59 and Y is 170; X is 59 and Y is 171; X is 59 and Yis 172; X is 59 and Y is 173; X is 59 and Y is 174; X is 59 and Y is175; X is 59 and Y is 176; X is 59 and Y is 177; X is 59 and Y is 178; Xis 59 and Y is 179; X is 59 and Y is 180; X is 59 and Y is 181; X is 59and Y is 182; X is 59 and Y is 183; X is 59 and Y is 184; X is 59 and Yis 185; X is 59 and Y is 186;X is 60 and Y is 1; X is 60 and Y is 2; X is 60 and Y is 3; X is 60 andY is 4; X is 60 and Y is 5; X is 60 and Y is 6; X is 60 and Y is 7; X is60 and Y is 8; X is 60 and Y is 9; X is 60 and Y is 10; X is 60 and Y is11; X is 60 and Y is 12; X is 60 and Y is 13; X is 60 and Y is 14; X is60 and Y is 15; X is 60 and Y is 16; X is 60 and Y is 17; X is 60 and Yis 18; X is 60 and Y is 19; X is 60 and Y is 20; X is 60 and Y is 21; Xis 60 and Y is 22; X is 60 and Y is 23; X is 60 and Y is 24; X is 60 andY is 25; X is 60 and Y is 26; X is 60 and Y is 27; X is 60 and Y is 28;X is 60 and Y is 29; X is 60 and Y is 30; X is 60 and Y is 31; X is 60and Y is 32; X is 60 and Y is 33; X is 60 and Y is 34; X is 60 and Y is35; X is 60 and Y is 36; X is 60 and Y is 37; X is 60 and Y is 38; X is60 and Y is 39; X is 60 and Y is 40; X is 60 and Y is 41; X is 60 and Yis 42; X is 60 and Y is 43; X is 60 and Y is 44; X is 60 and Y is 45; Xis 60 and Y is 46; X is 60 and Y is 47; X is 60 and Y is 48; X is 60 andY is 49; X is 60 and Y is 50; X is 60 and Y is 51; X is 60 and Y is 52;X is 60 and Y is 53; X is 60 and Y is 54; X is 60 and Y is 55; X is 60and Y is 56; X is 60 and Y is 57; X is 60 and Y is 58; X is 60 and Y is59; X is 60 and Y is 60; X is 60 and Y is 61; X is 60 and Y is 62; X is60 and Y is 63; X is 60 and Y is 64; X is 60 and Y is 65; X is 60 and Yis 66; X is 60 and Y is 67; X is 60 and Y is 68; X is 60 and Y is 69; Xis 60 and Y is 70; X is 60 and Y is 71; X is 60 and Y is 72; X is 60 andY is 73; X is 60 and Y is 74; X is 60 and Y is 75; X is 60 and Y is 76;X is 60 and Y is 77; X is 60 and Y is 78; X is 60 and Y is 79; X is 60and Y is 80; X is 60 and Y is 81; X is 60 and Y is 82; X is 60 and Y is83; X is 60 and Y is 84; X is 60 and Y is 85; X is 60 and Y is 86; X is60 and Y is 87; X is 60 and Y is 88; X is 60 and Y is 89; X is 60 and Yis 90; X is 60 and Y is 91; X is 60 and Y is 92; X is 60 and Y is 93; Xis 60 and Y is 94; X is 60 and Y is 95; X is 60 and Y is 96; X is 60 andY is 97; X is 60 and Y is 98; X is 60 and Y is 99; X is 60 and Y is 100;X is 60 and Y is 101; X is 60 and Y is 102; X is 60 and Y is 103; X is60 and Y is 104; X is 60 and Y is 105; X is 60 and Y is 106; X is 60 andY is 107; X is 60 and Y is 108; X is 60 and Y is 109; X is 60 and Y is110; X is 60 and Y is 111; X is 60 and Y is 112; X is 60 and Y is 113; Xis 60 and Y is 114; X is 60 and Y is 115; X is 60 and Y is 116; X is 60and Y is 117; X is 60 and Y is 118; X is 60 and Y is 119; X is 60 and Yis 120; X is 60 and Y is 121; X is 60 and Y is 122; X is 60 and Y is123; X is 60 and Y is 124; X is 60 and Y is 125; X is 60 and Y is 126; Xis 60 and Y is 127; X is 60 and Y is 128; X is 60 and Y is 129; X is 60and Y is 130; X is 60 and Y is 131; X is 60 and Y is 132; X is 60 and Yis 133; X is 60 and Y is 134; X is 60 and Y is 135; X is 60 and Y is136; X is 60 and Y is 137; X is 60 and Y is 138; X is 60 and Y is 139; Xis 60 and Y is 140; X is 60 and Y is 141; X is 60 and Y is 142; X is 60and Y is 143; X is 60 and Y is 144; X is 60 and Y is 145; X is 60 and Yis 146; X is 60 and Y is 147; X is 60 and Y is 148; X is 60 and Y is149; X is 60 and Y is 150; X is 60 and Y is 151; X is 60 and Y is 152; Xis 60 and Y is 153; X is 60 and Y is 154; X is 60 and Y is 155; X is 60and Y is 156; X is 60 and Y is 157; X is 60 and Y is 158; X is 60 and Yis 159; X is 60 and Y is 160; X is 60 and Y is 161; X is 60 and Y is162; X is 60 and Y is 163; X is 60 and Y is 164; X is 60 and Y is 165; Xis 60 and Y is 166; X is 60 and Y is 167; X is 60 and Y is 168; X is 60and Y is 169; X is 60 and Y is 170; X is 60 and Y is 171; X is 60 and Yis 172; X is 60 and Y is 173; X is 60 and Y is 174; X is 60 and Y is175; X is 60 and Y is 176; X is 60 and Y is 177; X is 60 and Y is 178; Xis 60 and Y is 179; X is 60 and Y is 180; X is 60 and Y is 181; X is 60and Y is 182; X is 60 and Y is 183; X is 60 and Y is 184; X is 60 and Yis 185; X is 60 and Y is 186;X is 61 and Y is 1; X is 61 and Y is 2; X is 61 and Y is 3; X is 61 andY is 4; X is 61 and Y is 5; X is 61 and Y is 6; X is 61 and Y is 7; X is61 and Y is 8; X is 61 and Y is 9; X is 61 and Y is 10; X is 61 and Y is11; X is 61 and Y is 12; X is 61 and Y is 13; X is 61 and Y is 14; X is61 and Y is 15; X is 61 and Y is 16; X is 61 and Y is 17; X is 61 and Yis 18; X is 61 and Y is 19; X is 61 and Y is 20; X is 61 and Y is 21; Xis 61 and Y is 22; X is 61 and Y is 23; X is 61 and Y is 24; X is 61 andY is 25; X is 61 and Y is 26; X is 61 and Y is 27; X is 61 and Y is 28;X is 61 and Y is 29; X is 61 and Y is 30; X is 61 and Y is 31; X is 61and Y is 32; X is 61 and Y is 33; X is 61 and Y is 34; X is 61 and Y is35; X is 61 and Y is 36; X is 61 and Y is 37; X is 61 and Y is 38; X is61 and Y is 39; X is 61 and Y is 40; X is 61 and Y is 41; X is 61 and Yis 42; X is 61 and Y is 43; X is 61 and Y is 44; X is 61 and Y is 45; Xis 61 and Y is 46; X is 61 and Y is 47; X is 61 and Y is 48; X is 61 andY is 49; X is 61 and Y is 50; X is 61 and Y is 51; X is 61 and Y is 52;X is 61 and Y is 53; X is 61 and Y is 54; X is 61 and Y is 55; X is 61and Y is 56; X is 61 and Y is 57; X is 61 and Y is 58; X is 61 and Y is59; X is 61 and Y is 60; X is 61 and Y is 61; X is 61 and Y is 62; X is61 and Y is 63; X is 61 and Y is 64; X is 61 and Y is 65; X is 61 and Yis 66; X is 61 and Y is 67; X is 61 and Y is 68; X is 61 and Y is 69; Xis 61 and Y is 70; X is 61 and Y is 71; X is 61 and Y is 72; X is 61 andY is 73; X is 61 and Y is 74; X is 61 and Y is 75; X is 61 and Y is 76;X is 61 and Y is 77; X is 61 and Y is 78; X is 61 and Y is 79; X is 61and Y is 80; X is 61 and Y is 81; X is 61 and Y is 82; X is 61 and Y is83; X is 61 and Y is 84; X is 61 and Y is 85; X is 61 and Y is 86; X is61 and Y is 87; X is 61 and Y is 88; X is 61 and Y is 89; X is 61 and Yis 90; X is 61 and Y is 91; X is 61 and Y is 92; X is 61 and Y is 93; Xis 61 and Y is 94; X is 61 and Y is 95; X is 61 and Y is 96; X is 61 andY is 97; X is 61 and Y is 98; X is 61 and Y is 99; X is 61 and Y is 100;X is 61 and Y is 101; X is 61 and Y is 102; X is 61 and Y is 103; X is61 and Y is 104; X is 61 and Y is 105; X is 61 and Y is 106; X is 61 andY is 107; X is 61 and Y is 108; X is 61 and Y is 109; X is 61 and Y is110; X is 61 and Y is 111; X is 61 and Y is 112; X is 61 and Y is 113; Xis 61 and Y is 114; X is 61 and Y is 115; X is 61 and Y is 116; X is 61and Y is 117; X is 61 and Y is 118; X is 61 and Y is 119; X is 61 and Yis 120; X is 61 and Y is 121; X is 61 and Y is 122; X is 61 and Y is123; X is 61 and Y is 124; X is 61 and Y is 125; X is 61 and Y is 126; Xis 61 and Y is 127; X is 61 and Y is 128; X is 61 and Y is 129; X is 61and Y is 130; X is 61 and Y is 131; X is 61 and Y is 132; X is 61 and Yis 133; X is 61 and Y is 134; X is 61 and Y is 135; X is 61 and Y is136; X is 61 and Y is 137; X is 61 and Y is 138; X is 61 and Y is 139; Xis 61 and Y is 140; X is 61 and Y is 141; X is 61 and Y is 142; X is 61and Y is 143; X is 61 and Y is 144; X is 61 and Y is 145; X is 61 and Yis 146; X is 61 and Y is 147; X is 61 and Y is 148; X is 61 and Y is149; X is 61 and Y is 150; X is 61 and Y is 151; X is 61 and Y is 152; Xis 61 and Y is 153; X is 61 and Y is 154; X is 61 and Y is 155; X is 61and Y is 156; X is 61 and Y is 157; X is 61 and Y is 158; X is 61 and Yis 159; X is 61 and Y is 160; X is 61 and Y is 161; X is 61 and Y is162; X is 61 and Y is 163; X is 61 and Y is 164; X is 61 and Y is 165; Xis 61 and Y is 166; X is 61 and Y is 167; X is 61 and Y is 168; X is 61and Y is 169; X is 61 and Y is 170; X is 61 and Y is 171; X is 61 and Yis 172; X is 61 and Y is 173; X is 61 and Y is 174; X is 61 and Y is175; X is 61 and Y is 176; X is 61 and Y is 177; X is 61 and Y is 178; Xis 61 and Y is 179; X is 61 and Y is 180; X is 61 and Y is 181; X is 61and Y is 182; X is 61 and Y is 183; X is 61 and Y is 184; X is 61 and Yis 185; X is 61 and Y is 186;X is 62 and Y is 1; X is 62 and Y is 2; X is 62 and Y is 3; X is 62 andY is 4; X is 62 and Y is 5; X is 62 and Y is 6; X is 62 and Y is 7; X is62 and Y is 8; X is 62 and Y is 9; X is 62 and Y is 10; X is 62 and Y is11; X is 62 and Y is 12; X is 62 and Y is 13; X is 62 and Y is 14; X is62 and Y is 15; X is 62 and Y is 16; X is 62 and Y is 17; X is 62 and Yis 18; X is 62 and Y is 19; X is 62 and Y is 20; X is 62 and Y is 21; Xis 62 and Y is 22; X is 62 and Y is 23; X is 62 and Y is 24; X is 62 andY is 25; X is 62 and Y is 26; X is 62 and Y is 27; X is 62 and Y is 28;X is 62 and Y is 29; X is 62 and Y is 30; X is 62 and Y is 31; X is 62and Y is 32; X is 62 and Y is 33; X is 62 and Y is 34; X is 62 and Y is35; X is 62 and Y is 36; X is 62 and Y is 37; X is 62 and Y is 38; X is62 and Y is 39; X is 62 and Y is 40; X is 62 and Y is 41; X is 62 and Yis 42; X is 62 and Y is 43; X is 62 and Y is 44; X is 62 and Y is 45; Xis 62 and Y is 46; X is 62 and Y is 47; X is 62 and Y is 48; X is 62 andY is 49; X is 62 and Y is 50; X is 62 and Y is 51; X is 62 and Y is 52;X is 62 and Y is 53; X is 62 and Y is 54; X is 62 and Y is 55; X is 62and Y is 56; X is 62 and Y is 57; X is 62 and Y is 58; X is 62 and Y is59; X is 62 and Y is 60; X is 62 and Y is 61; X is 62 and Y is 62; X is62 and Y is 63; X is 62 and Y is 64; X is 62 and Y is 65; X is 62 and Yis 66; X is 62 and Y is 67; X is 62 and Y is 68; X is 62 and Y is 69; Xis 62 and Y is 70; X is 62 and Y is 71; X is 62 and Y is 72; X is 62 andY is 73; X is 62 and Y is 74; X is 62 and Y is 75; X is 62 and Y is 76;X is 62 and Y is 77; X is 62 and Y is 78; X is 62 and Y is 79; X is 62and Y is 80; X is 62 and Y is 81; X is 62 and Y is 82; X is 62 and Y is83; X is 62 and Y is 84; X is 62 and Y is 85; X is 62 and Y is 86; X is62 and Y is 87; X is 62 and Y is 88; X is 62 and Y is 89; X is 62 and Yis 90; X is 62 and Y is 91; X is 62 and Y is 92; X is 62 and Y is 93; Xis 62 and Y is 94; X is 62 and Y is 95; X is 62 and Y is 96; X is 62 andY is 97; X is 62 and Y is 98; X is 62 and Y is 99; X is 62 and Y is 100;X is 62 and Y is 101; X is 62 and Y is 102; X is 62 and Y is 103; X is62 and Y is 104; X is 62 and Y is 105; X is 62 and Y is 106; X is 62 andY is 107; X is 62 and Y is 108; X is 62 and Y is 109; X is 62 and Y is110; X is 62 and Y is 111; X is 62 and Y is 112; X is 62 and Y is 113; Xis 62 and Y is 114; X is 62 and Y is 115; X is 62 and Y is 116; X is 62and Y is 117; X is 62 and Y is 118; X is 62 and Y is 119; X is 62 and Yis 120; X is 62 and Y is 121; X is 62 and Y is 122; X is 62 and Y is123; X is 62 and Y is 124; X is 62 and Y is 125; X is 62 and Y is 126; Xis 62 and Y is 127; X is 62 and Y is 128; X is 62 and Y is 129; X is 62and Y is 130; X is 62 and Y is 131; X is 62 and Y is 132; X is 62 and Yis 133; X is 62 and Y is 134; X is 62 and Y is 135; X is 62 and Y is136; X is 62 and Y is 137; X is 62 and Y is 138; X is 62 and Y is 139; Xis 62 and Y is 140; X is 62 and Y is 141; X is 62 and Y is 142; X is 62and Y is 143; X is 62 and Y is 144; X is 62 and Y is 145; X is 62 and Yis 146; X is 62 and Y is 147; X is 62 and Y is 148; X is 62 and Y is149; X is 62 and Y is 150; X is 62 and Y is 151; X is 62 and Y is 152; Xis 62 and Y is 153; X is 62 and Y is 154; X is 62 and Y is 155; X is 62and Y is 156; X is 62 and Y is 157; X is 62 and Y is 158; X is 62 and Yis 159; X is 62 and Y is 160; X is 62 and Y is 161; X is 62 and Y is162; X is 62 and Y is 163; X is 62 and Y is 164; X is 62 and Y is 165; Xis 62 and Y is 166; X is 62 and Y is 167; X is 62 and Y is 168; X is 62and Y is 169; X is 62 and Y is 170; X is 62 and Y is 171; X is 62 and Yis 172; X is 62 and Y is 173; X is 62 and Y is 174; X is 62 and Y is175; X is 62 and Y is 176; X is 62 and Y is 177; X is 62 and Y is 178; Xis 62 and Y is 179; X is 62 and Y is 180; X is 62 and Y is 181; X is 62and Y is 182; X is 62 and Y is 183; X is 62 and Y is 184; X is 62 and Yis 185; X is 62 and Y is 186;X is 63 and Y is 1; X is 63 and Y is 2; X is 63 and Y is 3; X is 63 andY is 4; X is 63 and Y is 5; X is 63 and Y is 6; X is 63 and Y is 7; X is63 and Y is 8; X is 63 and Y is 9; X is 63 and Y is 10; X is 63 and Y is11; X is 63 and Y is 12; X is 63 and Y is 13; X is 63 and Y is 14; X is63 and Y is 15; X is 63 and Y is 16; X is 63 and Y is 17; X is 63 and Yis 18; X is 63 and Y is 19; X is 63 and Y is 20; X is 63 and Y is 21; Xis 63 and Y is 22; X is 63 and Y is 23; X is 63 and Y is 24; X is 63 andY is 25; X is 63 and Y is 26; X is 63 and Y is 27; X is 63 and Y is 28;X is 63 and Y is 29; X is 63 and Y is 30; X is 63 and Y is 31; X is 63and Y is 32; X is 63 and Y is 33; X is 63 and Y is 34; X is 63 and Y is35; X is 63 and Y is 36; X is 63 and Y is 37; X is 63 and Y is 38; X is63 and Y is 39; X is 63 and Y is 40; X is 63 and Y is 41; X is 63 and Yis 42; X is 63 and Y is 43; X is 63 and Y is 44; X is 63 and Y is 45; Xis 63 and Y is 46; X is 63 and Y is 47; X is 63 and Y is 48; X is 63 andY is 49; X is 63 and Y is 50; X is 63 and Y is 51; X is 63 and Y is 52;X is 63 and Y is 53; X is 63 and Y is 54; X is 63 and Y is 55; X is 63and Y is 56; X is 63 and Y is 57; X is 63 and Y is 58; X is 63 and Y is59; X is 63 and Y is 60; X is 63 and Y is 61; X is 63 and Y is 62; X is63 and Y is 63; X is 63 and Y is 64; X is 63 and Y is 65; X is 63 and Yis 66; X is 63 and Y is 67; X is 63 and Y is 68; X is 63 and Y is 69; Xis 63 and Y is 70; X is 63 and Y is 71; X is 63 and Y is 72; X is 63 andY is 73; X is 63 and Y is 74; X is 63 and Y is 75; X is 63 and Y is 76;X is 63 and Y is 77; X is 63 and Y is 78; X is 63 and Y is 79; X is 63and Y is 80; X is 63 and Y is 81; X is 63 and Y is 82; X is 63 and Y is83; X is 63 and Y is 84; X is 63 and Y is 85; X is 63 and Y is 86; X is63 and Y is 87; X is 63 and Y is 88; X is 63 and Y is 89; X is 63 and Yis 90; X is 63 and Y is 91; X is 63 and Y is 92; X is 63 and Y is 93; Xis 63 and Y is 94; X is 63 and Y is 95; X is 63 and Y is 96; X is 63 andY is 97; X is 63 and Y is 98; X is 63 and Y is 99; X is 63 and Y is 100;X is 63 and Y is 101; X is 63 and Y is 102; X is 63 and Y is 103; X is63 and Y is 104; X is 63 and Y is 105; X is 63 and Y is 106; X is 63 andY is 107; X is 63 and Y is 108; X is 63 and Y is 109; X is 63 and Y is110; X is 63 and Y is 111; X is 63 and Y is 112; X is 63 and Y is 113; Xis 63 and Y is 114; X is 63 and Y is 115; X is 63 and Y is 116; X is 63and Y is 117; X is 63 and Y is 118; X is 63 and Y is 119; X is 63 and Yis 120; X is 63 and Y is 121; X is 63 and Y is 122; X is 63 and Y is123; X is 63 and Y is 124; X is 63 and Y is 125; X is 63 and Y is 126; Xis 63 and Y is 127; X is 63 and Y is 128; X is 63 and Y is 129; X is 63and Y is 130; X is 63 and Y is 131; X is 63 and Y is 132; X is 63 and Yis 133; X is 63 and Y is 134; X is 63 and Y is 135; X is 63 and Y is136; X is 63 and Y is 137; X is 63 and Y is 138; X is 63 and Y is 139; Xis 63 and Y is 140; X is 63 and Y is 141; X is 63 and Y is 142; X is 63and Y is 143; X is 63 and Y is 144; X is 63 and Y is 145; X is 63 and Yis 146; X is 63 and Y is 147; X is 63 and Y is 148; X is 63 and Y is149; X is 63 and Y is 150; X is 63 and Y is 151; X is 63 and Y is 152; Xis 63 and Y is 153; X is 63 and Y is 154; X is 63 and Y is 155; X is 63and Y is 156; X is 63 and Y is 157; X is 63 and Y is 158; X is 63 and Yis 159; X is 63 and Y is 160; X is 63 and Y is 161; X is 63 and Y is162; X is 63 and Y is 163; X is 63 and Y is 164; X is 63 and Y is 165; Xis 63 and Y is 166; X is 63 and Y is 167; X is 63 and Y is 168; X is 63and Y is 169; X is 63 and Y is 170; X is 63 and Y is 171; X is 63 and Yis 172; X is 63 and Y is 173; X is 63 and Y is 174; X is 63 and Y is175; X is 63 and Y is 176; X is 63 and Y is 177; X is 63 and Y is 178; Xis 63 and Y is 179; X is 63 and Y is 180; X is 63 and Y is 181; X is 63and Y is 182; X is 63 and Y is 183; X is 63 and Y is 184; X is 63 and Yis 185; X is 63 and Y is 186;X is 64 and Y is 1; X is 64 and Y is 2; X is 64 and Y is 3; X is 64 andY is 4; X is 64 and Y is 5; X is 64 and Y is 6; X is 64 and Y is 7; X is64 and Y is 8; X is 64 and Y is 9; X is 64 and Y is 10; X is 64 and Y is11; X is 64 and Y is 12; X is 64 and Y is 13; X is 64 and Y is 14; X is64 and Y is 15; X is 64 and Y is 16; X is 64 and Y is 17; X is 64 and Yis 18; X is 64 and Y is 19; X is 64 and Y is 20; X is 64 and Y is 21; Xis 64 and Y is 22; X is 64 and Y is 23; X is 64 and Y is 24; X is 64 andY is 25; X is 64 and Y is 26; X is 64 and Y is 27; X is 64 and Y is 28;X is 64 and Y is 29; X is 64 and Y is 30; X is 64 and Y is 31; X is 64and Y is 32; X is 64 and Y is 33; X is 64 and Y is 34; X is 64 and Y is35; X is 64 and Y is 36; X is 64 and Y is 37; X is 64 and Y is 38; X is64 and Y is 39; X is 64 and Y is 40; X is 64 and Y is 41; X is 64 and Yis 42; X is 64 and Y is 43; X is 64 and Y is 44; X is 64 and Y is 45; Xis 64 and Y is 46; X is 64 and Y is 47; X is 64 and Y is 48; X is 64 andY is 49; X is 64 and Y is 50; X is 64 and Y is 51; X is 64 and Y is 52;X is 64 and Y is 53; X is 64 and Y is 54; X is 64 and Y is 55; X is 64and Y is 56; X is 64 and Y is 57; X is 64 and Y is 58; X is 64 and Y is59; X is 64 and Y is 60; X is 64 and Y is 61; X is 64 and Y is 62; X is64 and Y is 63; X is 64 and Y is 64; X is 64 and Y is 65; X is 64 and Yis 66; X is 64 and Y is 67; X is 64 and Y is 68; X is 64 and Y is 69; Xis 64 and Y is 70; X is 64 and Y is 71; X is 64 and Y is 72; X is 64 andY is 73; X is 64 and Y is 74; X is 64 and Y is 75; X is 64 and Y is 76;X is 64 and Y is 77; X is 64 and Y is 78; X is 64 and Y is 79; X is 64and Y is 80; X is 64 and Y is 81; X is 64 and Y is 82; X is 64 and Y is83; X is 64 and Y is 84; X is 64 and Y is 85; X is 64 and Y is 86; X is64 and Y is 87; X is 64 and Y is 88; X is 64 and Y is 89; X is 64 and Yis 90; X is 64 and Y is 91; X is 64 and Y is 92; X is 64 and Y is 93; Xis 64 and Y is 94; X is 64 and Y is 95; X is 64 and Y is 96; X is 64 andY is 97; X is 64 and Y is 98; X is 64 and Y is 99; X is 64 and Y is 100;X is 64 and Y is 101; X is 64 and Y is 102; X is 64 and Y is 103; X is64 and Y is 104; X is 64 and Y is 105; X is 64 and Y is 106; X is 64 andY is 107; X is 64 and Y is 108; X is 64 and Y is 109; X is 64 and Y is110; X is 64 and Y is 111; X is 64 and Y is 112; X is 64 and Y is 113; Xis 64 and Y is 114; X is 64 and Y is 115; X is 64 and Y is 116; X is 64and Y is 117; X is 64 and Y is 118; X is 64 and Y is 119; X is 64 and Yis 120; X is 64 and Y is 121; X is 64 and Y is 122; X is 64 and Y is123; X is 64 and Y is 124; X is 64 and Y is 125; X is 64 and Y is 126; Xis 64 and Y is 127; X is 64 and Y is 128; X is 64 and Y is 129; X is 64and Y is 130; X is 64 and Y is 131; X is 64 and Y is 132; X is 64 and Yis 133; X is 64 and Y is 134; X is 64 and Y is 135; X is 64 and Y is136; X is 64 and Y is 137; X is 64 and Y is 138; X is 64 and Y is 139; Xis 64 and Y is 140; X is 64 and Y is 141; X is 64 and Y is 142; X is 64and Y is 143; X is 64 and Y is 144; X is 64 and Y is 145; X is 64 and Yis 146; X is 64 and Y is 147; X is 64 and Y is 148; X is 64 and Y is149; X is 64 and Y is 150; X is 64 and Y is 151; X is 64 and Y is 152; Xis 64 and Y is 153; X is 64 and Y is 154; X is 64 and Y is 155; X is 64and Y is 156; X is 64 and Y is 157; X is 64 and Y is 158; X is 64 and Yis 159; X is 64 and Y is 160; X is 64 and Y is 161; X is 64 and Y is162; X is 64 and Y is 163; X is 64 and Y is 164; X is 64 and Y is 165; Xis 64 and Y is 166; X is 64 and Y is 167; X is 64 and Y is 168; X is 64and Y is 169; X is 64 and Y is 170; X is 64 and Y is 171; X is 64 and Yis 172; X is 64 and Y is 173; X is 64 and Y is 174; X is 64 and Y is175; X is 64 and Y is 176; X is 64 and Y is 177; X is 64 and Y is 178; Xis 64 and Y is 179; X is 64 and Y is 180; X is 64 and Y is 181; X is 64and Y is 182; X is 64 and Y is 183; X is 64 and Y is 184; X is 64 and Yis 185; X is 64 and Y is 186;X is 65 and Y is 1; X is 65 and Y is 2; X is 65 and Y is 3; X is 65 andY is 4; X is 65 and Y is 5; X is 65 and Y is 6; X is 65 and Y is 7; X is65 and Y is 8; X is 65 and Y is 9; X is 65 and Y is 10; X is 65 and Y is11; X is 65 and Y is 12; X is 65 and Y is 13; X is 65 and Y is 14; X is65 and Y is 15; X is 65 and Y is 16; X is 65 and Y is 17; X is 65 and Yis 18; X is 65 and Y is 19; X is 65 and Y is 20; X is 65 and Y is 21; Xis 65 and Y is 22; X is 65 and Y is 23; X is 65 and Y is 24; X is 65 andY is 25; X is 65 and Y is 26; X is 65 and Y is 27; X is 65 and Y is 28;X is 65 and Y is 29; X is 65 and Y is 30; X is 65 and Y is 31; X is 65and Y is 32; X is 65 and Y is 33; X is 65 and Y is 34; X is 65 and Y is35; X is 65 and Y is 36; X is 65 and Y is 37; X is 65 and Y is 38; X is65 and Y is 39; X is 65 and Y is 40; X is 65 and Y is 41; X is 65 and Yis 42; X is 65 and Y is 43; X is 65 and Y is 44; X is 65 and Y is 45; Xis 65 and Y is 46; X is 65 and Y is 47; X is 65 and Y is 48; X is 65 andY is 49; X is 65 and Y is 50; X is 65 and Y is 51; X is 65 and Y is 52;X is 65 and Y is 53; X is 65 and Y is 54; X is 65 and Y is 55; X is 65and Y is 56; X is 65 and Y is 57; X is 65 and Y is 58; X is 65 and Y is59; X is 65 and Y is 60; X is 65 and Y is 61; X is 65 and Y is 62; X is65 and Y is 63; X is 65 and Y is 64; X is 65 and Y is 65; X is 65 and Yis 66; X is 65 and Y is 67; X is 65 and Y is 68; X is 65 and Y is 69; Xis 65 and Y is 70; X is 65 and Y is 71; X is 65 and Y is 72; X is 65 andY is 73; X is 65 and Y is 74; X is 65 and Y is 75; X is 65 and Y is 76;X is 65 and Y is 77; X is 65 and Y is 78; X is 65 and Y is 79; X is 65and Y is 80; X is 65 and Y is 81; X is 65 and Y is 82; X is 65 and Y is83; X is 65 and Y is 84; X is 65 and Y is 85; X is 65 and Y is 86; X is65 and Y is 87; X is 65 and Y is 88; X is 65 and Y is 89; X is 65 and Yis 90; X is 65 and Y is 91; X is 65 and Y is 92; X is 65 and Y is 93; Xis 65 and Y is 94; X is 65 and Y is 95; X is 65 and Y is 96; X is 65 andY is 97; X is 65 and Y is 98; X is 65 and Y is 99; X is 65 and Y is 100;X is 65 and Y is 101; X is 65 and Y is 102; X is 65 and Y is 103; X is65 and Y is 104; X is 65 and Y is 105; X is 65 and Y is 106; X is 65 andY is 107; X is 65 and Y is 108; X is 65 and Y is 109; X is 65 and Y is110; X is 65 and Y is 111; X is 65 and Y is 112; X is 65 and Y is 113; Xis 65 and Y is 114; X is 65 and Y is 115; X is 65 and Y is 116; X is 65and Y is 117; X is 65 and Y is 118; X is 65 and Y is 119; X is 65 and Yis 120; X is 65 and Y is 121; X is 65 and Y is 122; X is 65 and Y is123; X is 65 and Y is 124; X is 65 and Y is 125; X is 65 and Y is 126; Xis 65 and Y is 127; X is 65 and Y is 128; X is 65 and Y is 129; X is 65and Y is 130; X is 65 and Y is 131; X is 65 and Y is 132; X is 65 and Yis 133; X is 65 and Y is 134; X is 65 and Y is 135; X is 65 and Y is136; X is 65 and Y is 137; X is 65 and Y is 138; X is 65 and Y is 139; Xis 65 and Y is 140; X is 65 and Y is 141; X is 65 and Y is 142; X is 65and Y is 143; X is 65 and Y is 144; X is 65 and Y is 145; X is 65 and Yis 146; X is 65 and Y is 147; X is 65 and Y is 148; X is 65 and Y is149; X is 65 and Y is 150; X is 65 and Y is 151; X is 65 and Y is 152; Xis 65 and Y is 153; X is 65 and Y is 154; X is 65 and Y is 155; X is 65and Y is 156; X is 65 and Y is 157; X is 65 and Y is 158; X is 65 and Yis 159; X is 65 and Y is 160; X is 65 and Y is 161; X is 65 and Y is162; X is 65 and Y is 163; X is 65 and Y is 164; X is 65 and Y is 165; Xis 65 and Y is 166; X is 65 and Y is 167; X is 65 and Y is 168; X is 65and Y is 169; X is 65 and Y is 170; X is 65 and Y is 171; X is 65 and Yis 172; X is 65 and Y is 173; X is 65 and Y is 174; X is 65 and Y is175; X is 65 and Y is 176; X is 65 and Y is 177; X is 65 and Y is 178; Xis 65 and Y is 179; X is 65 and Y is 180; X is 65 and Y is 181; X is 65and Y is 182; X is 65 and Y is 183; X is 65 and Y is 184; X is 65 and Yis 185; X is 65 and Y is 186;X is 66 and Y is 1; X is 66 and Y is 2; X is 66 and Y is 3; X is 66 andY is 4; X is 66 and Y is 5; X is 66 and Y is 6; X is 66 and Y is 7; X is66 and Y is 8; X is 66 and Y is 9; X is 66 and Y is 10; X is 66 and Y is11; X is 66 and Y is 12; X is 66 and Y is 13; X is 66 and Y is 14; X is66 and Y is 15; X is 66 and Y is 16; X is 66 and Y is 17; X is 66 and Yis 18; X is 66 and Y is 19; X is 66 and Y is 20; X is 66 and Y is 21; Xis 66 and Y is 22; X is 66 and Y is 23; X is 66 and Y is 24; X is 66 andY is 25; X is 66 and Y is 26; X is 66 and Y is 27; X is 66 and Y is 28;X is 66 and Y is 29; X is 66 and Y is 30; X is 66 and Y is 31; X is 66and Y is 32; X is 66 and Y is 33; X is 66 and Y is 34; X is 66 and Y is35; X is 66 and Y is 36; X is 66 and Y is 37; X is 66 and Y is 38; X is66 and Y is 39; X is 66 and Y is 40; X is 66 and Y is 41; X is 66 and Yis 42; X is 66 and Y is 43; X is 66 and Y is 44; X is 66 and Y is 45; Xis 66 and Y is 46; X is 66 and Y is 47; X is 66 and Y is 48; X is 66 andY is 49; X is 66 and Y is 50; X is 66 and Y is 51; X is 66 and Y is 52;X is 66 and Y is 53; X is 66 and Y is 54; X is 66 and Y is 55; X is 66and Y is 56; X is 66 and Y is 57; X is 66 and Y is 58; X is 66 and Y is59; X is 66 and Y is 60; X is 66 and Y is 61; X is 66 and Y is 62; X is66 and Y is 63; X is 66 and Y is 64; X is 66 and Y is 65; X is 66 and Yis 66; X is 66 and Y is 67; X is 66 and Y is 68; X is 66 and Y is 69; Xis 66 and Y is 70; X is 66 and Y is 71; X is 66 and Y is 72; X is 66 andY is 73; X is 66 and Y is 74; X is 66 and Y is 75; X is 66 and Y is 76;X is 66 and Y is 77; X is 66 and Y is 78; X is 66 and Y is 79; X is 66and Y is 80; X is 66 and Y is 81; X is 66 and Y is 82; X is 66 and Y is83; X is 66 and Y is 84; X is 66 and Y is 85; X is 66 and Y is 86; X is66 and Y is 87; X is 66 and Y is 88; X is 66 and Y is 89; X is 66 and Yis 90; X is 66 and Y is 91; X is 66 and Y is 92; X is 66 and Y is 93; Xis 66 and Y is 94; X is 66 and Y is 95; X is 66 and Y is 96; X is 66 andY is 97; X is 66 and Y is 98; X is 66 and Y is 99; X is 66 and Y is 100;X is 66 and Y is 101; X is 66 and Y is 102; X is 66 and Y is 103; X is66 and Y is 104; X is 66 and Y is 105; X is 66 and Y is 106; X is 66 andY is 107; X is 66 and Y is 108; X is 66 and Y is 109; X is 66 and Y is110; X is 66 and Y is 111; X is 66 and Y is 112; X is 66 and Y is 113; Xis 66 and Y is 114; X is 66 and Y is 115; X is 66 and Y is 116; X is 66and Y is 117; X is 66 and Y is 118; X is 66 and Y is 119; X is 66 and Yis 120; X is 66 and Y is 121; X is 66 and Y is 122; X is 66 and Y is123; X is 66 and Y is 124; X is 66 and Y is 125; X is 66 and Y is 126; Xis 66 and Y is 127; X is 66 and Y is 128; X is 66 and Y is 129; X is 66and Y is 130; X is 66 and Y is 131; X is 66 and Y is 132; X is 66 and Yis 133; X is 66 and Y is 134; X is 66 and Y is 135; X is 66 and Y is136; X is 66 and Y is 137; X is 66 and Y is 138; X is 66 and Y is 139; Xis 66 and Y is 140; X is 66 and Y is 141; X is 66 and Y is 142; X is 66and Y is 143; X is 66 and Y is 144; X is 66 and Y is 145; X is 66 and Yis 146; X is 66 and Y is 147; X is 66 and Y is 148; X is 66 and Y is149; X is 66 and Y is 150; X is 66 and Y is 151; X is 66 and Y is 152; Xis 66 and Y is 153; X is 66 and Y is 154; X is 66 and Y is 155; X is 66and Y is 156; X is 66 and Y is 157; X is 66 and Y is 158; X is 66 and Yis 159; X is 66 and Y is 160; X is 66 and Y is 161; X is 66 and Y is162; X is 66 and Y is 163; X is 66 and Y is 164; X is 66 and Y is 165; Xis 66 and Y is 166; X is 66 and Y is 167; X is 66 and Y is 168; X is 66and Y is 169; X is 66 and Y is 170; X is 66 and Y is 171; X is 66 and Yis 172; X is 66 and Y is 173; X is 66 and Y is 174; X is 66 and Y is175; X is 66 and Y is 176; X is 66 and Y is 177; X is 66 and Y is 178; Xis 66 and Y is 179; X is 66 and Y is 180; X is 66 and Y is 181; X is 66and Y is 182; X is 66 and Y is 183; X is 66 and Y is 184; X is 66 and Yis 185; X is 66 and Y is 186;X is 67 and Y is 1; X is 67 and Y is 2; X is 67 and Y is 3; X is 67 andY is 4; X is 67 and Y is 5; X is 67 and Y is 6; X is 67 and Y is 7; X is67 and Y is 8; X is 67 and Y is 9; X is 67 and Y is 10; X is 67 and Y is11; X is 67 and Y is 12; X is 67 and Y is 13; X is 67 and Y is 14; X is67 and Y is 15; X is 67 and Y is 16; X is 67 and Y is 17; X is 67 and Yis 18; X is 67 and Y is 19; X is 67 and Y is 20; X is 67 and Y is 21; Xis 67 and Y is 22; X is 67 and Y is 23; X is 67 and Y is 24; X is 67 andY is 25; X is 67 and Y is 26; X is 67 and Y is 27; X is 67 and Y is 28;X is 67 and Y is 29; X is 67 and Y is 30; X is 67 and Y is 31; X is 67and Y is 32; X is 67 and Y is 33; X is 67 and Y is 34; X is 67 and Y is35; X is 67 and Y is 36; X is 67 and Y is 37; X is 67 and Y is 38; X is67 and Y is 39; X is 67 and Y is 40; X is 67 and Y is 41; X is 67 and Yis 42; X is 67 and Y is 43; X is 67 and Y is 44; X is 67 and Y is 45; Xis 67 and Y is 46; X is 67 and Y is 47; X is 67 and Y is 48; X is 67 andY is 49; X is 67 and Y is 50; X is 67 and Y is 51; X is 67 and Y is 52;X is 67 and Y is 53; X is 67 and Y is 54; X is 67 and Y is 55; X is 67and Y is 56; X is 67 and Y is 57; X is 67 and Y is 58; X is 67 and Y is59; X is 67 and Y is 60; X is 67 and Y is 61; X is 67 and Y is 62; X is67 and Y is 63; X is 67 and Y is 64; X is 67 and Y is 65; X is 67 and Yis 66; X is 67 and Y is 67; X is 67 and Y is 68; X is 67 and Y is 69; Xis 67 and Y is 70; X is 67 and Y is 71; X is 67 and Y is 72; X is 67 andY is 73; X is 67 and Y is 74; X is 67 and Y is 75; X is 67 and Y is 76;X is 67 and Y is 77; X is 67 and Y is 78; X is 67 and Y is 79; X is 67and Y is 80; X is 67 and Y is 81; X is 67 and Y is 82; X is 67 and Y is83; X is 67 and Y is 84; X is 67 and Y is 85; X is 67 and Y is 86; X is67 and Y is 87; X is 67 and Y is 88; X is 67 and Y is 89; X is 67 and Yis 90; X is 67 and Y is 91; X is 67 and Y is 92; X is 67 and Y is 93; Xis 67 and Y is 94; X is 67 and Y is 95; X is 67 and Y is 96; X is 67 andY is 97; X is 67 and Y is 98; X is 67 and Y is 99; X is 67 and Y is 100;X is 67 and Y is 101; X is 67 and Y is 102; X is 67 and Y is 103; X is67 and Y is 104; X is 67 and Y is 105; X is 67 and Y is 106; X is 67 andY is 107; X is 67 and Y is 108; X is 67 and Y is 109; X is 67 and Y is110; X is 67 and Y is 111; X is 67 and Y is 112; X is 67 and Y is 113; Xis 67 and Y is 114; X is 67 and Y is 115; X is 67 and Y is 116; X is 67and Y is 117; X is 67 and Y is 118; X is 67 and Y is 119; X is 67 and Yis 120; X is 67 and Y is 121; X is 67 and Y is 122; X is 67 and Y is123; X is 67 and Y is 124; X is 67 and Y is 125; X is 67 and Y is 126; Xis 67 and Y is 127; X is 67 and Y is 128; X is 67 and Y is 129; X is 67and Y is 130; X is 67 and Y is 131; X is 67 and Y is 132; X is 67 and Yis 133; X is 67 and Y is 134; X is 67 and Y is 135; X is 67 and Y is136; X is 67 and Y is 137; X is 67 and Y is 138; X is 67 and Y is 139; Xis 67 and Y is 140; X is 67 and Y is 141; X is 67 and Y is 142; X is 67and Y is 143; X is 67 and Y is 144; X is 67 and Y is 145; X is 67 and Yis 146; X is 67 and Y is 147; X is 67 and Y is 148; X is 67 and Y is149; X is 67 and Y is 150; X is 67 and Y is 151; X is 67 and Y is 152; Xis 67 and Y is 153; X is 67 and Y is 154; X is 67 and Y is 155; X is 67and Y is 156; X is 67 and Y is 157; X is 67 and Y is 158; X is 67 and Yis 159; X is 67 and Y is 160; X is 67 and Y is 161; X is 67 and Y is162; X is 67 and Y is 163; X is 67 and Y is 164; X is 67 and Y is 165; Xis 67 and Y is 166; X is 67 and Y is 167; X is 67 and Y is 168; X is 67and Y is 169; X is 67 and Y is 170; X is 67 and Y is 171; X is 67 and Yis 172; X is 67 and Y is 173; X is 67 and Y is 174; X is 67 and Y is175; X is 67 and Y is 176; X is 67 and Y is 177; X is 67 and Y is 178; Xis 67 and Y is 179; X is 67 and Y is 180; X is 67 and Y is 181; X is 67and Y is 182; X is 67 and Y is 183; X is 67 and Y is 184; X is 67 and Yis 185; X is 67 and Y is 186;X is 68 and Y is 1; X is 68 and Y is 2; X is 68 and Y is 3; X is 68 andY is 4; X is 68 and Y is 5; X is 68 and Y is 6; X is 68 and Y is 7; X is68 and Y is 8; X is 68 and Y is 9; X is 68 and Y is 10; X is 68 and Y is11; X is 68 and Y is 12; X is 68 and Y is 13; X is 68 and Y is 14; X is68 and Y is 15; X is 68 and Y is 16; X is 68 and Y is 17; X is 68 and Yis 18; X is 68 and Y is 19; X is 68 and Y is 20; X is 68 and Y is 21; Xis 68 and Y is 22; X is 68 and Y is 23; X is 68 and Y is 24; X is 68 andY is 25; X is 68 and Y is 26; X is 68 and Y is 27; X is 68 and Y is 28;X is 68 and Y is 29; X is 68 and Y is 30; X is 68 and Y is 31; X is 68and Y is 32; X is 68 and Y is 33; X is 68 and Y is 34; X is 68 and Y is35; X is 68 and Y is 36; X is 68 and Y is 37; X is 68 and Y is 38; X is68 and Y is 39; X is 68 and Y is 40; X is 68 and Y is 41; X is 68 and Yis 42; X is 68 and Y is 43; X is 68 and Y is 44; X is 68 and Y is 45; Xis 68 and Y is 46; X is 68 and Y is 47; X is 68 and Y is 48; X is 68 andY is 49; X is 68 and Y is 50; X is 68 and Y is 51; X is 68 and Y is 52;X is 68 and Y is 53; X is 68 and Y is 54; X is 68 and Y is 55; X is 68and Y is 56; X is 68 and Y is 57; X is 68 and Y is 58; X is 68 and Y is59; X is 68 and Y is 60; X is 68 and Y is 61; X is 68 and Y is 62; X is68 and Y is 63; X is 68 and Y is 64; X is 68 and Y is 65; X is 68 and Yis 66; X is 68 and Y is 67; X is 68 and Y is 68; X is 68 and Y is 69; Xis 68 and Y is 70; X is 68 and Y is 71; X is 68 and Y is 72; X is 68 andY is 73; X is 68 and Y is 74; X is 68 and Y is 75; X is 68 and Y is 76;X is 68 and Y is 77; X is 68 and Y is 78; X is 68 and Y is 79; X is 68and Y is 80; X is 68 and Y is 81; X is 68 and Y is 82; X is 68 and Y is83; X is 68 and Y is 84; X is 68 and Y is 85; X is 68 and Y is 86; X is68 and Y is 87; X is 68 and Y is 88; X is 68 and Y is 89; X is 68 and Yis 90; X is 68 and Y is 91; X is 68 and Y is 92; X is 68 and Y is 93; Xis 68 and Y is 94; X is 68 and Y is 95; X is 68 and Y is 96; X is 68 andY is 97; X is 68 and Y is 98; X is 68 and Y is 99; X is 68 and Y is 100;X is 68 and Y is 101; X is 68 and Y is 102; X is 68 and Y is 103; X is68 and Y is 104; X is 68 and Y is 105; X is 68 and Y is 106; X is 68 andY is 107; X is 68 and Y is 108; X is 68 and Y is 109; X is 68 and Y is110; X is 68 and Y is 111; X is 68 and Y is 112; X is 68 and Y is 113; Xis 68 and Y is 114; X is 68 and Y is 115; X is 68 and Y is 116; X is 68and Y is 117; X is 68 and Y is 118; X is 68 and Y is 119; X is 68 and Yis 120; X is 68 and Y is 121; X is 68 and Y is 122; X is 68 and Y is123; X is 68 and Y is 124; X is 68 and Y is 125; X is 68 and Y is 126; Xis 68 and Y is 127; X is 68 and Y is 128; X is 68 and Y is 129; X is 68and Y is 130; X is 68 and Y is 131; X is 68 and Y is 132; X is 68 and Yis 133; X is 68 and Y is 134; X is 68 and Y is 135; X is 68 and Y is136; X is 68 and Y is 137; X is 68 and Y is 138; X is 68 and Y is 139; Xis 68 and Y is 140; X is 68 and Y is 141; X is 68 and Y is 142; X is 68and Y is 143; X is 68 and Y is 144; X is 68 and Y is 145; X is 68 and Yis 146; X is 68 and Y is 147; X is 68 and Y is 148; X is 68 and Y is149; X is 68 and Y is 150; X is 68 and Y is 151; X is 68 and Y is 152; Xis 68 and Y is 153; X is 68 and Y is 154; X is 68 and Y is 155; X is 68and Y is 156; X is 68 and Y is 157; X is 68 and Y is 158; X is 68 and Yis 159; X is 68 and Y is 160; X is 68 and Y is 161; X is 68 and Y is162; X is 68 and Y is 163; X is 68 and Y is 164; X is 68 and Y is 165; Xis 68 and Y is 166; X is 68 and Y is 167; X is 68 and Y is 168; X is 68and Y is 169; X is 68 and Y is 170; X is 68 and Y is 171; X is 68 and Yis 172; X is 68 and Y is 173; X is 68 and Y is 174; X is 68 and Y is175; X is 68 and Y is 176; X is 68 and Y is 177; X is 68 and Y is 178; Xis 68 and Y is 179; X is 68 and Y is 180; X is 68 and Y is 181; X is 68and Y is 182; X is 68 and Y is 183; X is 68 and Y is 184; X is 68 and Yis 185; X is 68 and Y is 186;X is 69 and Y is 1; X is 69 and Y is 2; X is 69 and Y is 3; X is 69 andY is 4; X is 69 and Y is 5; X is 69 and Y is 6; X is 69 and Y is 7; X is69 and Y is 8; X is 69 and Y is 9; X is 69 and Y is 10; X is 69 and Y is11; X is 69 and Y is 12; X is 69 and Y is 13; X is 69 and Y is 14; X is69 and Y is 15; X is 69 and Y is 16; X is 69 and Y is 17; X is 69 and Yis 18; X is 69 and Y is 19; X is 69 and Y is 20; X is 69 and Y is 21; Xis 69 and Y is 22; X is 69 and Y is 23; X is 69 and Y is 24; X is 69 andY is 25; X is 69 and Y is 26; X is 69 and Y is 27; X is 69 and Y is 28;X is 69 and Y is 29; X is 69 and Y is 30; X is 69 and Y is 31; X is 69and Y is 32; X is 69 and Y is 33; X is 69 and Y is 34; X is 69 and Y is35; X is 69 and Y is 36; X is 69 and Y is 37; X is 69 and Y is 38; X is69 and Y is 39; X is 69 and Y is 40; X is 69 and Y is 41; X is 69 and Yis 42; X is 69 and Y is 43; X is 69 and Y is 44; X is 69 and Y is 45; Xis 69 and Y is 46; X is 69 and Y is 47; X is 69 and Y is 48; X is 69 andY is 49; X is 69 and Y is 50; X is 69 and Y is 51; X is 69 and Y is 52;X is 69 and Y is 53; X is 69 and Y is 54; X is 69 and Y is 55; X is 69and Y is 56; X is 69 and Y is 57; X is 69 and Y is 58; X is 69 and Y is59; X is 69 and Y is 60; X is 69 and Y is 61; X is 69 and Y is 62; X is69 and Y is 63; X is 69 and Y is 64; X is 69 and Y is 65; X is 69 and Yis 66; X is 69 and Y is 67; X is 69 and Y is 68; X is 69 and Y is 69; Xis 69 and Y is 70; X is 69 and Y is 71; X is 69 and Y is 72; X is 69 andY is 73; X is 69 and Y is 74; X is 69 and Y is 75; X is 69 and Y is 76;X is 69 and Y is 77; X is 69 and Y is 78; X is 69 and Y is 79; X is 69and Y is 80; X is 69 and Y is 81; X is 69 and Y is 82; X is 69 and Y is83; X is 69 and Y is 84; X is 69 and Y is 85; X is 69 and Y is 86; X is69 and Y is 87; X is 69 and Y is 88; X is 69 and Y is 89; X is 69 and Yis 90; X is 69 and Y is 91; X is 69 and Y is 92; X is 69 and Y is 93; Xis 69 and Y is 94; X is 69 and Y is 95; X is 69 and Y is 96; X is 69 andY is 97; X is 69 and Y is 98; X is 69 and Y is 99; X is 69 and Y is 100;X is 69 and Y is 101; X is 69 and Y is 102; X is 69 and Y is 103; X is69 and Y is 104; X is 69 and Y is 105; X is 69 and Y is 106; X is 69 andY is 107; X is 69 and Y is 108; X is 69 and Y is 109; X is 69 and Y is110; X is 69 and Y is 111; X is 69 and Y is 112; X is 69 and Y is 113; Xis 69 and Y is 114; X is 69 and Y is 115; X is 69 and Y is 116; X is 69and Y is 117; X is 69 and Y is 118; X is 69 and Y is 119; X is 69 and Yis 120; X is 69 and Y is 121; X is 69 and Y is 122; X is 69 and Y is123; X is 69 and Y is 124; X is 69 and Y is 125; X is 69 and Y is 126; Xis 69 and Y is 127; X is 69 and Y is 128; X is 69 and Y is 129; X is 69and Y is 130; X is 69 and Y is 131; X is 69 and Y is 132; X is 69 and Yis 133; X is 69 and Y is 134; X is 69 and Y is 135; X is 69 and Y is136; X is 69 and Y is 137; X is 69 and Y is 138; X is 69 and Y is 139; Xis 69 and Y is 140; X is 69 and Y is 141; X is 69 and Y is 142; X is 69and Y is 143; X is 69 and Y is 144; X is 69 and Y is 145; X is 69 and Yis 146; X is 69 and Y is 147; X is 69 and Y is 148; X is 69 and Y is149; X is 69 and Y is 150; X is 69 and Y is 151; X is 69 and Y is 152; Xis 69 and Y is 153; X is 69 and Y is 154; X is 69 and Y is 155; X is 69and Y is 156; X is 69 and Y is 157; X is 69 and Y is 158; X is 69 and Yis 159; X is 69 and Y is 160; X is 69 and Y is 161; X is 69 and Y is162; X is 69 and Y is 163; X is 69 and Y is 164; X is 69 and Y is 165; Xis 69 and Y is 166; X is 69 and Y is 167; X is 69 and Y is 168; X is 69and Y is 169; X is 69 and Y is 170; X is 69 and Y is 171; X is 69 and Yis 172; X is 69 and Y is 173; X is 69 and Y is 174; X is 69 and Y is175; X is 69 and Y is 176; X is 69 and Y is 177; X is 69 and Y is 178; Xis 69 and Y is 179; X is 69 and Y is 180; X is 69 and Y is 181; X is 69and Y is 182; X is 69 and Y is 183; X is 69 and Y is 184; X is 69 and Yis 185; X is 69 and Y is 186;X is 70 and Y is 1; X is 70 and Y is 2; X is 70 and Y is 3; X is 70 andY is 4; X is 70 and Y is 5; X is 70 and Y is 6; X is 70 and Y is 7; X is70 and Y is 8; X is 70 and Y is 9; X is 70 and Y is 10; X is 70 and Y is11; X is 70 and Y is 12; X is 70 and Y is 13; X is 70 and Y is 14; X is70 and Y is 15; X is 70 and Y is 16; X is 70 and Y is 17; X is 70 and Yis 18; X is 70 and Y is 19; X is 70 and Y is 20; X is 70 and Y is 21; Xis 70 and Y is 22; X is 70 and Y is 23; X is 70 and Y is 24; X is 70 andY is 25; X is 70 and Y is 26; X is 70 and Y is 27; X is 70 and Y is 28;X is 70 and Y is 29; X is 70 and Y is 30; X is 70 and Y is 31; X is 70and Y is 32; X is 70 and Y is 33; X is 70 and Y is 34; X is 70 and Y is35; X is 70 and Y is 36; X is 70 and Y is 37; X is 70 and Y is 38; X is70 and Y is 39; X is 70 and Y is 40; X is 70 and Y is 41; X is 70 and Yis 42; X is 70 and Y is 43; X is 70 and Y is 44; X is 70 and Y is 45; Xis 70 and Y is 46; X is 70 and Y is 47; X is 70 and Y is 48; X is 70 andY is 49; X is 70 and Y is 50; X is 70 and Y is 51; X is 70 and Y is 52;X is 70 and Y is 53; X is 70 and Y is 54; X is 70 and Y is 55; X is 70and Y is 56; X is 70 and Y is 57; X is 70 and Y is 58; X is 70 and Y is59; X is 70 and Y is 60; X is 70 and Y is 61; X is 70 and Y is 62; X is70 and Y is 63; X is 70 and Y is 64; X is 70 and Y is 65; X is 70 and Yis 66; X is 70 and Y is 67; X is 70 and Y is 68; X is 70 and Y is 69; Xis 70 and Y is 70; X is 70 and Y is 71; X is 70 and Y is 72; X is 70 andY is 73; X is 70 and Y is 74; X is 70 and Y is 75; X is 70 and Y is 76;X is 70 and Y is 77; X is 70 and Y is 78; X is 70 and Y is 79; X is 70and Y is 80; X is 70 and Y is 81; X is 70 and Y is 82; X is 70 and Y is83; X is 70 and Y is 84; X is 70 and Y is 85; X is 70 and Y is 86; X is70 and Y is 87; X is 70 and Y is 88; X is 70 and Y is 89; X is 70 and Yis 90; X is 70 and Y is 91; X is 70 and Y is 92; X is 70 and Y is 93; Xis 70 and Y is 94; X is 70 and Y is 95; X is 70 and Y is 96; X is 70 andY is 97; X is 70 and Y is 98; X is 70 and Y is 99; X is 70 and Y is 100;X is 70 and Y is 101; X is 70 and Y is 102; X is 70 and Y is 103; X is70 and Y is 104; X is 70 and Y is 105; X is 70 and Y is 106; X is 70 andY is 107; X is 70 and Y is 108; X is 70 and Y is 109; X is 70 and Y is110; X is 70 and Y is 111; X is 70 and Y is 112; X is 70 and Y is 113; Xis 70 and Y is 114; X is 70 and Y is 115; X is 70 and Y is 116; X is 70and Y is 117; X is 70 and Y is 118; X is 70 and Y is 119; X is 70 and Yis 120; X is 70 and Y is 121; X is 70 and Y is 122; X is 70 and Y is123; X is 70 and Y is 124; X is 70 and Y is 125; X is 70 and Y is 126; Xis 70 and Y is 127; X is 70 and Y is 128; X is 70 and Y is 129; X is 70and Y is 130; X is 70 and Y is 131; X is 70 and Y is 132; X is 70 and Yis 133; X is 70 and Y is 134; X is 70 and Y is 135; X is 70 and Y is136; X is 70 and Y is 137; X is 70 and Y is 138; X is 70 and Y is 139; Xis 70 and Y is 140; X is 70 and Y is 141; X is 70 and Y is 142; X is 70and Y is 143; X is 70 and Y is 144; X is 70 and Y is 145; X is 70 and Yis 146; X is 70 and Y is 147; X is 70 and Y is 148; X is 70 and Y is149; X is 70 and Y is 150; X is 70 and Y is 151; X is 70 and Y is 152; Xis 70 and Y is 153; X is 70 and Y is 154; X is 70 and Y is 155; X is 70and Y is 156; X is 70 and Y is 157; X is 70 and Y is 158; X is 70 and Yis 159; X is 70 and Y is 160; X is 70 and Y is 161; X is 70 and Y is162; X is 70 and Y is 163; X is 70 and Y is 164; X is 70 and Y is 165; Xis 70 and Y is 166; X is 70 and Y is 167; X is 70 and Y is 168; X is 70and Y is 169; X is 70 and Y is 170; X is 70 and Y is 171; X is 70 and Yis 172; X is 70 and Y is 173; X is 70 and Y is 174; X is 70 and Y is175; X is 70 and Y is 176; X is 70 and Y is 177; X is 70 and Y is 178; Xis 70 and Y is 179; X is 70 and Y is 180; X is 70 and Y is 181; X is 70and Y is 182; X is 70 and Y is 183; X is 70 and Y is 184; X is 70 and Yis 185; X is 70 and Y is 186;X is 71 and Y is 1; X is 71 and Y is 2; X is 71 and Y is 3; X is 71 andY is 4; X is 71 and Y is 5; X is 71 and Y is 6; X is 71 and Y is 7; X is71 and Y is 8; X is 71 and Y is 9; X is 71 and Y is 10; X is 71 and Y is11; X is 71 and Y is 12; X is 71 and Y is 13; X is 71 and Y is 14; X is71 and Y is 15; X is 71 and Y is 16; X is 71 and Y is 17; X is 71 and Yis 18; X is 71 and Y is 19; X is 71 and Y is 20; X is 71 and Y is 21; Xis 71 and Y is 22; X is 71 and Y is 23; X is 71 and Y is 24; X is 71 andY is 25; X is 71 and Y is 26; X is 71 and Y is 27; X is 71 and Y is 28;X is 71 and Y is 29; X is 71 and Y is 30; X is 71 and Y is 31; X is 71and Y is 32; X is 71 and Y is 33; X is 71 and Y is 34; X is 71 and Y is35; X is 71 and Y is 36; X is 71 and Y is 37; X is 71 and Y is 38; X is71 and Y is 39; X is 71 and Y is 40; X is 71 and Y is 41; X is 71 and Yis 42; X is 71 and Y is 43; X is 71 and Y is 44; X is 71 and Y is 45; Xis 71 and Y is 46; X is 71 and Y is 47; X is 71 and Y is 48; X is 71 andY is 49; X is 71 and Y is 50; X is 71 and Y is 51; X is 71 and Y is 52;X is 71 and Y is 53; X is 71 and Y is 54; X is 71 and Y is 55; X is 71and Y is 56; X is 71 and Y is 57; X is 71 and Y is 58; X is 71 and Y is59; X is 71 and Y is 60; X is 71 and Y is 61; X is 71 and Y is 62; X is71 and Y is 63; X is 71 and Y is 64; X is 71 and Y is 65; X is 71 and Yis 66; X is 71 and Y is 67; X is 71 and Y is 68; X is 71 and Y is 69; Xis 71 and Y is 70; X is 71 and Y is 71; X is 71 and Y is 72; X is 71 andY is 73; X is 71 and Y is 74; X is 71 and Y is 75; X is 71 and Y is 76;X is 71 and Y is 77; X is 71 and Y is 78; X is 71 and Y is 79; X is 71and Y is 80; X is 71 and Y is 81; X is 71 and Y is 82; X is 71 and Y is83; X is 71 and Y is 84; X is 71 and Y is 85; X is 71 and Y is 86; X is71 and Y is 87; X is 71 and Y is 88; X is 71 and Y is 89; X is 71 and Yis 90; X is 71 and Y is 91; X is 71 and Y is 92; X is 71 and Y is 93; Xis 71 and Y is 94; X is 71 and Y is 95; X is 71 and Y is 96; X is 71 andY is 97; X is 71 and Y is 98; X is 71 and Y is 99; X is 71 and Y is 100;X is 71 and Y is 101; X is 71 and Y is 102; X is 71 and Y is 103; X is71 and Y is 104; X is 71 and Y is 105; X is 71 and Y is 106; X is 71 andY is 107; X is 71 and Y is 108; X is 71 and Y is 109; X is 71 and Y is110; X is 71 and Y is 111; X is 71 and Y is 112; X is 71 and Y is 113; Xis 71 and Y is 114; X is 71 and Y is 115; X is 71 and Y is 116; X is 71and Y is 117; X is 71 and Y is 118; X is 71 and Y is 119; X is 71 and Yis 120; X is 71 and Y is 121; X is 71 and Y is 122; X is 71 and Y is123; X is 71 and Y is 124; X is 71 and Y is 125; X is 71 and Y is 126; Xis 71 and Y is 127; X is 71 and Y is 128; X is 71 and Y is 129; X is 71and Y is 130; X is 71 and Y is 131; X is 71 and Y is 132; X is 71 and Yis 133; X is 71 and Y is 134; X is 71 and Y is 135; X is 71 and Y is136; X is 71 and Y is 137; X is 71 and Y is 138; X is 71 and Y is 139; Xis 71 and Y is 140; X is 71 and Y is 141; X is 71 and Y is 142; X is 71and Y is 143; X is 71 and Y is 144; X is 71 and Y is 145; X is 71 and Yis 146; X is 71 and Y is 147; X is 71 and Y is 148; X is 71 and Y is149; X is 71 and Y is 150; X is 71 and Y is 151; X is 71 and Y is 152; Xis 71 and Y is 153; X is 71 and Y is 154; X is 71 and Y is 155; X is 71and Y is 156; X is 71 and Y is 157; X is 71 and Y is 158; X is 71 and Yis 159; X is 71 and Y is 160; X is 71 and Y is 161; X is 71 and Y is162; X is 71 and Y is 163; X is 71 and Y is 164; X is 71 and Y is 165; Xis 71 and Y is 166; X is 71 and Y is 167; X is 71 and Y is 168; X is 71and Y is 169; X is 71 and Y is 170; X is 71 and Y is 171; X is 71 and Yis 172; X is 71 and Y is 173; X is 71 and Y is 174; X is 71 and Y is175; X is 71 and Y is 176; X is 71 and Y is 177; X is 71 and Y is 178; Xis 71 and Y is 179; X is 71 and Y is 180; X is 71 and Y is 181; X is 71and Y is 182; X is 71 and Y is 183; X is 71 and Y is 184; X is 71 and Yis 185; X is 71 and Y is 186;X is 72 and Y is 1; X is 72 and Y is 2; X is 72 and Y is 3; X is 72 andY is 4; X is 72 and Y is 5; X is 72 and Y is 6; X is 72 and Y is 7; X is72 and Y is 8; X is 72 and Y is 9; X is 72 and Y is 10; X is 72 and Y is11; X is 72 and Y is 12; X is 72 and Y is 13; X is 72 and Y is 14; X is72 and Y is 15; X is 72 and Y is 16; X is 72 and Y is 17; X is 72 and Yis 18; X is 72 and Y is 19; X is 72 and Y is 20; X is 72 and Y is 21; Xis 72 and Y is 22; X is 72 and Y is 23; X is 72 and Y is 24; X is 72 andY is 25; X is 72 and Y is 26; X is 72 and Y is 27; X is 72 and Y is 28;X is 72 and Y is 29; X is 72 and Y is 30; X is 72 and Y is 31; X is 72and Y is 32; X is 72 and Y is 33; X is 72 and Y is 34; X is 72 and Y is35; X is 72 and Y is 36; X is 72 and Y is 37; X is 72 and Y is 38; X is72 and Y is 39; X is 72 and Y is 40; X is 72 and Y is 41; X is 72 and Yis 42; X is 72 and Y is 43; X is 72 and Y is 44; X is 72 and Y is 45; Xis 72 and Y is 46; X is 72 and Y is 47; X is 72 and Y is 48; X is 72 andY is 49; X is 72 and Y is 50; X is 72 and Y is 51; X is 72 and Y is 52;X is 72 and Y is 53; X is 72 and Y is 54; X is 72 and Y is 55; X is 72and Y is 56; X is 72 and Y is 57; X is 72 and Y is 58; X is 72 and Y is59; X is 72 and Y is 60; X is 72 and Y is 61; X is 72 and Y is 62; X is72 and Y is 63; X is 72 and Y is 64; X is 72 and Y is 65; X is 72 and Yis 66; X is 72 and Y is 67; X is 72 and Y is 68; X is 72 and Y is 69; Xis 72 and Y is 70; X is 72 and Y is 71; X is 72 and Y is 72; X is 72 andY is 73; X is 72 and Y is 74; X is 72 and Y is 75; X is 72 and Y is 76;X is 72 and Y is 77; X is 72 and Y is 78; X is 72 and Y is 79; X is 72and Y is 80; X is 72 and Y is 81; X is 72 and Y is 82; X is 72 and Y is83; X is 72 and Y is 84; X is 72 and Y is 85; X is 72 and Y is 86; X is72 and Y is 87; X is 72 and Y is 88; X is 72 and Y is 89; X is 72 and Yis 90; X is 72 and Y is 91; X is 72 and Y is 92; X is 72 and Y is 93; Xis 72 and Y is 94; X is 72 and Y is 95; X is 72 and Y is 96; X is 72 andY is 97; X is 72 and Y is 98; X is 72 and Y is 99; X is 72 and Y is 100;X is 72 and Y is 101; X is 72 and Y is 102; X is 72 and Y is 103; X is72 and Y is 104; X is 72 and Y is 105; X is 72 and Y is 106; X is 72 andY is 107; X is 72 and Y is 108; X is 72 and Y is 109; X is 72 and Y is110; X is 72 and Y is 111; X is 72 and Y is 112; X is 72 and Y is 113; Xis 72 and Y is 114; X is 72 and Y is 115; X is 72 and Y is 116; X is 72and Y is 117; X is 72 and Y is 118; X is 72 and Y is 119; X is 72 and Yis 120; X is 72 and Y is 121; X is 72 and Y is 122; X is 72 and Y is123; X is 72 and Y is 124; X is 72 and Y is 125; X is 72 and Y is 126; Xis 72 and Y is 127; X is 72 and Y is 128; X is 72 and Y is 129; X is 72and Y is 130; X is 72 and Y is 131; X is 72 and Y is 132; X is 72 and Yis 133; X is 72 and Y is 134; X is 72 and Y is 135; X is 72 and Y is136; X is 72 and Y is 137; X is 72 and Y is 138; X is 72 and Y is 139; Xis 72 and Y is 140; X is 72 and Y is 141; X is 72 and Y is 142; X is 72and Y is 143; X is 72 and Y is 144; X is 72 and Y is 145; X is 72 and Yis 146; X is 72 and Y is 147; X is 72 and Y is 148; X is 72 and Y is149; X is 72 and Y is 150; X is 72 and Y is 151; X is 72 and Y is 152; Xis 72 and Y is 153; X is 72 and Y is 154; X is 72 and Y is 155; X is 72and Y is 156; X is 72 and Y is 157; X is 72 and Y is 158; X is 72 and Yis 159; X is 72 and Y is 160; X is 72 and Y is 161; X is 72 and Y is162; X is 72 and Y is 163; X is 72 and Y is 164; X is 72 and Y is 165; Xis 72 and Y is 166; X is 72 and Y is 167; X is 72 and Y is 168; X is 72and Y is 169; X is 72 and Y is 170; X is 72 and Y is 171; X is 72 and Yis 172; X is 72 and Y is 173; X is 72 and Y is 174; X is 72 and Y is175; X is 72 and Y is 176; X is 72 and Y is 177; X is 72 and Y is 178; Xis 72 and Y is 179; X is 72 and Y is 180; X is 72 and Y is 181; X is 72and Y is 182; X is 72 and Y is 183; X is 72 and Y is 184; X is 72 and Yis 185; X is 72 and Y is 186;X is 73 and Y is 1; X is 73 and Y is 2; X is 73 and Y is 3; X is 73 andY is 4; X is 73 and Y is 5; X is 73 and Y is 6; X is 73 and Y is 7; X is73 and Y is 8; X is 73 and Y is 9; X is 73 and Y is 10; X is 73 and Y is11; X is 73 and Y is 12; X is 73 and Y is 13; X is 73 and Y is 14; X is73 and Y is 15; X is 73 and Y is 16; X is 73 and Y is 17; X is 73 and Yis 18; X is 73 and Y is 19; X is 73 and Y is 20; X is 73 and Y is 21; Xis 73 and Y is 22; X is 73 and Y is 23; X is 73 and Y is 24; X is 73 andY is 25; X is 73 and Y is 26; X is 73 and Y is 27; X is 73 and Y is 28;X is 73 and Y is 29; X is 73 and Y is 30; X is 73 and Y is 31; X is 73and Y is 32; X is 73 and Y is 33; X is 73 and Y is 34; X is 73 and Y is35; X is 73 and Y is 36; X is 73 and Y is 37; X is 73 and Y is 38; X is73 and Y is 39; X is 73 and Y is 40; X is 73 and Y is 41; X is 73 and Yis 42; X is 73 and Y is 43; X is 73 and Y is 44; X is 73 and Y is 45; Xis 73 and Y is 46; X is 73 and Y is 47; X is 73 and Y is 48; X is 73 andY is 49; X is 73 and Y is 50; X is 73 and Y is 51; X is 73 and Y is 52;X is 73 and Y is 53; X is 73 and Y is 54; X is 73 and Y is 55; X is 73and Y is 56; X is 73 and Y is 57; X is 73 and Y is 58; X is 73 and Y is59; X is 73 and Y is 60; X is 73 and Y is 61; X is 73 and Y is 62; X is73 and Y is 63; X is 73 and Y is 64; X is 73 and Y is 65; X is 73 and Yis 66; X is 73 and Y is 67; X is 73 and Y is 68; X is 73 and Y is 69; Xis 73 and Y is 70; X is 73 and Y is 71; X is 73 and Y is 72; X is 73 andY is 73; X is 73 and Y is 74; X is 73 and Y is 75; X is 73 and Y is 76;X is 73 and Y is 77; X is 73 and Y is 78; X is 73 and Y is 79; X is 73and Y is 80; X is 73 and Y is 81; X is 73 and Y is 82; X is 73 and Y is83; X is 73 and Y is 84; X is 73 and Y is 85; X is 73 and Y is 86; X is73 and Y is 87; X is 73 and Y is 88; X is 73 and Y is 89; X is 73 and Yis 90; X is 73 and Y is 91; X is 73 and Y is 92; X is 73 and Y is 93; Xis 73 and Y is 94; X is 73 and Y is 95; X is 73 and Y is 96; X is 73 andY is 97; X is 73 and Y is 98; X is 73 and Y is 99; X is 73 and Y is 100;X is 73 and Y is 101; X is 73 and Y is 102; X is 73 and Y is 103; X is73 and Y is 104; X is 73 and Y is 105; X is 73 and Y is 106; X is 73 andY is 107; X is 73 and Y is 108; X is 73 and Y is 109; X is 73 and Y is110; X is 73 and Y is 111; X is 73 and Y is 112; X is 73 and Y is 113; Xis 73 and Y is 114; X is 73 and Y is 115; X is 73 and Y is 116; X is 73and Y is 117; X is 73 and Y is 118; X is 73 and Y is 119; X is 73 and Yis 120; X is 73 and Y is 121; X is 73 and Y is 122; X is 73 and Y is123; X is 73 and Y is 124; X is 73 and Y is 125; X is 73 and Y is 126; Xis 73 and Y is 127; X is 73 and Y is 128; X is 73 and Y is 129; X is 73and Y is 130; X is 73 and Y is 131; X is 73 and Y is 132; X is 73 and Yis 133; X is 73 and Y is 134; X is 73 and Y is 135; X is 73 and Y is136; X is 73 and Y is 137; X is 73 and Y is 138; X is 73 and Y is 139; Xis 73 and Y is 140; X is 73 and Y is 141; X is 73 and Y is 142; X is 73and Y is 143; X is 73 and Y is 144; X is 73 and Y is 145; X is 73 and Yis 146; X is 73 and Y is 147; X is 73 and Y is 148; X is 73 and Y is149; X is 73 and Y is 150; X is 73 and Y is 151; X is 73 and Y is 152; Xis 73 and Y is 153; X is 73 and Y is 154; X is 73 and Y is 155; X is 73and Y is 156; X is 73 and Y is 157; X is 73 and Y is 158; X is 73 and Yis 159; X is 73 and Y is 160; X is 73 and Y is 161; X is 73 and Y is162; X is 73 and Y is 163; X is 73 and Y is 164; X is 73 and Y is 165; Xis 73 and Y is 166; X is 73 and Y is 167; X is 73 and Y is 168; X is 73and Y is 169; X is 73 and Y is 170; X is 73 and Y is 171; X is 73 and Yis 172; X is 73 and Y is 173; X is 73 and Y is 174; X is 73 and Y is175; X is 73 and Y is 176; X is 73 and Y is 177; X is 73 and Y is 178; Xis 73 and Y is 179; X is 73 and Y is 180; X is 73 and Y is 181; X is 73and Y is 182; X is 73 and Y is 183; X is 73 and Y is 184; X is 73 and Yis 185; X is 73 and Y is 186;X is 74 and Y is 1; X is 74 and Y is 2; X is 74 and Y is 3; X is 74 andY is 4; X is 74 and Y is 5; X is 74 and Y is 6; X is 74 and Y is 7; X is74 and Y is 8; X is 74 and Y is 9; X is 74 and Y is 10; X is 74 and Y is11; X is 74 and Y is 12; X is 74 and Y is 13; X is 74 and Y is 14; X is74 and Y is 15; X is 74 and Y is 16; X is 74 and Y is 17; X is 74 and Yis 18; X is 74 and Y is 19; X is 74 and Y is 20; X is 74 and Y is 21; Xis 74 and Y is 22; X is 74 and Y is 23; X is 74 and Y is 24; X is 74 andY is 25; X is 74 and Y is 26; X is 74 and Y is 27; X is 74 and Y is 28;X is 74 and Y is 29; X is 74 and Y is 30; X is 74 and Y is 31; X is 74and Y is 32; X is 74 and Y is 33; X is 74 and Y is 34; X is 74 and Y is35; X is 74 and Y is 36; X is 74 and Y is 37; X is 74 and Y is 38; X is74 and Y is 39; X is 74 and Y is 40; X is 74 and Y is 41; X is 74 and Yis 42; X is 74 and Y is 43; X is 74 and Y is 44; X is 74 and Y is 45; Xis 74 and Y is 46; X is 74 and Y is 47; X is 74 and Y is 48; X is 74 andY is 49; X is 74 and Y is 50; X is 74 and Y is 51; X is 74 and Y is 52;X is 74 and Y is 53; X is 74 and Y is 54; X is 74 and Y is 55; X is 74and Y is 56; X is 74 and Y is 57; X is 74 and Y is 58; X is 74 and Y is59; X is 74 and Y is 60; X is 74 and Y is 61; X is 74 and Y is 62; X is74 and Y is 63; X is 74 and Y is 64; X is 74 and Y is 65; X is 74 and Yis 66; X is 74 and Y is 67; X is 74 and Y is 68; X is 74 and Y is 69; Xis 74 and Y is 70; X is 74 and Y is 71; X is 74 and Y is 72; X is 74 andY is 73; X is 74 and Y is 74; X is 74 and Y is 75; X is 74 and Y is 76;X is 74 and Y is 77; X is 74 and Y is 78; X is 74 and Y is 79; X is 74and Y is 80; X is 74 and Y is 81; X is 74 and Y is 82; X is 74 and Y is83; X is 74 and Y is 84; X is 74 and Y is 85; X is 74 and Y is 86; X is74 and Y is 87; X is 74 and Y is 88; X is 74 and Y is 89; X is 74 and Yis 90; X is 74 and Y is 91; X is 74 and Y is 92; X is 74 and Y is 93; Xis 74 and Y is 94; X is 74 and Y is 95; X is 74 and Y is 96; X is 74 andY is 97; X is 74 and Y is 98; X is 74 and Y is 99; X is 74 and Y is 100;X is 74 and Y is 101; X is 74 and Y is 102; X is 74 and Y is 103; X is74 and Y is 104; X is 74 and Y is 105; X is 74 and Y is 106; X is 74 andY is 107; X is 74 and Y is 108; X is 74 and Y is 109; X is 74 and Y is110; X is 74 and Y is 111; X is 74 and Y is 112; X is 74 and Y is 113; Xis 74 and Y is 114; X is 74 and Y is 115; X is 74 and Y is 116; X is 74and Y is 117; X is 74 and Y is 118; X is 74 and Y is 119; X is 74 and Yis 120; X is 74 and Y is 121; X is 74 and Y is 122; X is 74 and Y is123; X is 74 and Y is 124; X is 74 and Y is 125; X is 74 and Y is 126; Xis 74 and Y is 127; X is 74 and Y is 128; X is 74 and Y is 129; X is 74and Y is 130; X is 74 and Y is 131; X is 74 and Y is 132; X is 74 and Yis 133; X is 74 and Y is 134; X is 74 and Y is 135; X is 74 and Y is136; X is 74 and Y is 137; X is 74 and Y is 138; X is 74 and Y is 139; Xis 74 and Y is 140; X is 74 and Y is 141; X is 74 and Y is 142; X is 74and Y is 143; X is 74 and Y is 144; X is 74 and Y is 145; X is 74 and Yis 146; X is 74 and Y is 147; X is 74 and Y is 148; X is 74 and Y is149; X is 74 and Y is 150; X is 74 and Y is 151; X is 74 and Y is 152; Xis 74 and Y is 153; X is 74 and Y is 154; X is 74 and Y is 155; X is 74and Y is 156; X is 74 and Y is 157; X is 74 and Y is 158; X is 74 and Yis 159; X is 74 and Y is 160; X is 74 and Y is 161; X is 74 and Y is162; X is 74 and Y is 163; X is 74 and Y is 164; X is 74 and Y is 165; Xis 74 and Y is 166; X is 74 and Y is 167; X is 74 and Y is 168; X is 74and Y is 169; X is 74 and Y is 170; X is 74 and Y is 171; X is 74 and Yis 172; X is 74 and Y is 173; X is 74 and Y is 174; X is 74 and Y is175; X is 74 and Y is 176; X is 74 and Y is 177; X is 74 and Y is 178; Xis 74 and Y is 179; X is 74 and Y is 180; X is 74 and Y is 181; X is 74and Y is 182; X is 74 and Y is 183; X is 74 and Y is 184; X is 74 and Yis 185; X is 74 and Y is 186;X is 75 and Y is 1; X is 75 and Y is 2; X is 75 and Y is 3; X is 75 andY is 4; X is 75 and Y is 5; X is 75 and Y is 6; X is 75 and Y is 7; X is75 and Y is 8; X is 75 and Y is 9; X is 75 and Y is 10; X is 75 and Y is11; X is 75 and Y is 12; X is 75 and Y is 13; X is 75 and Y is 14; X is75 and Y is 15; X is 75 and Y is 16; X is 75 and Y is 17; X is 75 and Yis 18; X is 75 and Y is 19; X is 75 and Y is 20; X is 75 and Y is 21; Xis 75 and Y is 22; X is 75 and Y is 23; X is 75 and Y is 24; X is 75 andY is 25; X is 75 and Y is 26; X is 75 and Y is 27; X is 75 and Y is 28;X is 75 and Y is 29; X is 75 and Y is 30; X is 75 and Y is 31; X is 75and Y is 32; X is 75 and Y is 33; X is 75 and Y is 34; X is 75 and Y is35; X is 75 and Y is 36; X is 75 and Y is 37; X is 75 and Y is 38; X is75 and Y is 39; X is 75 and Y is 40; X is 75 and Y is 41; X is 75 and Yis 42; X is 75 and Y is 43; X is 75 and Y is 44; X is 75 and Y is 45; Xis 75 and Y is 46; X is 75 and Y is 47; X is 75 and Y is 48; X is 75 andY is 49; X is 75 and Y is 50; X is 75 and Y is 51; X is 75 and Y is 52;X is 75 and Y is 53; X is 75 and Y is 54; X is 75 and Y is 55; X is 75and Y is 56; X is 75 and Y is 57; X is 75 and Y is 58; X is 75 and Y is59; X is 75 and Y is 60; X is 75 and Y is 61; X is 75 and Y is 62; X is75 and Y is 63; X is 75 and Y is 64; X is 75 and Y is 65; X is 75 and Yis 66; X is 75 and Y is 67; X is 75 and Y is 68; X is 75 and Y is 69; Xis 75 and Y is 70; X is 75 and Y is 71; X is 75 and Y is 72; X is 75 andY is 73; X is 75 and Y is 74; X is 75 and Y is 75; X is 75 and Y is 76;X is 75 and Y is 77; X is 75 and Y is 78; X is 75 and Y is 79; X is 75and Y is 80; X is 75 and Y is 81; X is 75 and Y is 82; X is 75 and Y is83; X is 75 and Y is 84; X is 75 and Y is 85; X is 75 and Y is 86; X is75 and Y is 87; X is 75 and Y is 88; X is 75 and Y is 89; X is 75 and Yis 90; X is 75 and Y is 91; X is 75 and Y is 92; X is 75 and Y is 93; Xis 75 and Y is 94; X is 75 and Y is 95; X is 75 and Y is 96; X is 75 andY is 97; X is 75 and Y is 98; X is 75 and Y is 99; X is 75 and Y is 100;X is 75 and Y is 101; X is 75 and Y is 102; X is 75 and Y is 103; X is75 and Y is 104; X is 75 and Y is 105; X is 75 and Y is 106; X is 75 andY is 107; X is 75 and Y is 108; X is 75 and Y is 109; X is 75 and Y is110; X is 75 and Y is 111; X is 75 and Y is 112; X is 75 and Y is 113; Xis 75 and Y is 114; X is 75 and Y is 115; X is 75 and Y is 116; X is 75and Y is 117; X is 75 and Y is 118; X is 75 and Y is 119; X is 75 and Yis 120; X is 75 and Y is 121; X is 75 and Y is 122; X is 75 and Y is123; X is 75 and Y is 124; X is 75 and Y is 125; X is 75 and Y is 126; Xis 75 and Y is 127; X is 75 and Y is 128; X is 75 and Y is 129; X is 75and Y is 130; X is 75 and Y is 131; X is 75 and Y is 132; X is 75 and Yis 133; X is 75 and Y is 134; X is 75 and Y is 135; X is 75 and Y is136; X is 75 and Y is 137; X is 75 and Y is 138; X is 75 and Y is 139; Xis 75 and Y is 140; X is 75 and Y is 141; X is 75 and Y is 142; X is 75and Y is 143; X is 75 and Y is 144; X is 75 and Y is 145; X is 75 and Yis 146; X is 75 and Y is 147; X is 75 and Y is 148; X is 75 and Y is149; X is 75 and Y is 150; X is 75 and Y is 151; X is 75 and Y is 152; Xis 75 and Y is 153; X is 75 and Y is 154; X is 75 and Y is 155; X is 75and Y is 156; X is 75 and Y is 157; X is 75 and Y is 158; X is 75 and Yis 159; X is 75 and Y is 160; X is 75 and Y is 161; X is 75 and Y is162; X is 75 and Y is 163; X is 75 and Y is 164; X is 75 and Y is 165; Xis 75 and Y is 166; X is 75 and Y is 167; X is 75 and Y is 168; X is 75and Y is 169; X is 75 and Y is 170; X is 75 and Y is 171; X is 75 and Yis 172; X is 75 and Y is 173; X is 75 and Y is 174; X is 75 and Y is175; X is 75 and Y is 176; X is 75 and Y is 177; X is 75 and Y is 178; Xis 75 and Y is 179; X is 75 and Y is 180; X is 75 and Y is 181; X is 75and Y is 182; X is 75 and Y is 183; X is 75 and Y is 184; X is 75 and Yis 185; X is 75 and Y is 186;X is 76 and Y is 1; X is 76 and Y is 2; X is 76 and Y is 3; X is 76 andY is 4; X is 76 and Y is 5; X is 76 and Y is 6; X is 76 and Y is 7; X is76 and Y is 8; X is 76 and Y is 9; X is 76 and Y is 10; X is 76 and Y is11; X is 76 and Y is 12; X is 76 and Y is 13; X is 76 and Y is 14; X is76 and Y is 15; X is 76 and Y is 16; X is 76 and Y is 17; X is 76 and Yis 18; X is 76 and Y is 19; X is 76 and Y is 20; X is 76 and Y is 21; Xis 76 and Y is 22; X is 76 and Y is 23; X is 76 and Y is 24; X is 76 andY is 25; X is 76 and Y is 26; X is 76 and Y is 27; X is 76 and Y is 28;X is 76 and Y is 29; X is 76 and Y is 30; X is 76 and Y is 31; X is 76and Y is 32; X is 76 and Y is 33; X is 76 and Y is 34; X is 76 and Y is35; X is 76 and Y is 36; X is 76 and Y is 37; X is 76 and Y is 38; X is76 and Y is 39; X is 76 and Y is 40; X is 76 and Y is 41; X is 76 and Yis 42; X is 76 and Y is 43; X is 76 and Y is 44; X is 76 and Y is 45; Xis 76 and Y is 46; X is 76 and Y is 47; X is 76 and Y is 48; X is 76 andY is 49; X is 76 and Y is 50; X is 76 and Y is 51; X is 76 and Y is 52;X is 76 and Y is 53; X is 76 and Y is 54; X is 76 and Y is 55; X is 76and Y is 56; X is 76 and Y is 57; X is 76 and Y is 58; X is 76 and Y is59; X is 76 and Y is 60; X is 76 and Y is 61; X is 76 and Y is 62; X is76 and Y is 63; X is 76 and Y is 64; X is 76 and Y is 65; X is 76 and Yis 66; X is 76 and Y is 67; X is 76 and Y is 68; X is 76 and Y is 69; Xis 76 and Y is 70; X is 76 and Y is 71; X is 76 and Y is 72; X is 76 andY is 73; X is 76 and Y is 74; X is 76 and Y is 75; X is 76 and Y is 76;X is 76 and Y is 77; X is 76 and Y is 78; X is 76 and Y is 79; X is 76and Y is 80; X is 76 and Y is 81; X is 76 and Y is 82; X is 76 and Y is83; X is 76 and Y is 84; X is 76 and Y is 85; X is 76 and Y is 86; X is76 and Y is 87; X is 76 and Y is 88; X is 76 and Y is 89; X is 76 and Yis 90; X is 76 and Y is 91; X is 76 and Y is 92; X is 76 and Y is 93; Xis 76 and Y is 94; X is 76 and Y is 95; X is 76 and Y is 96; X is 76 andY is 97; X is 76 and Y is 98; X is 76 and Y is 99; X is 76 and Y is 100;X is 76 and Y is 101; X is 76 and Y is 102; X is 76 and Y is 103; X is76 and Y is 104; X is 76 and Y is 105; X is 76 and Y is 106; X is 76 andY is 107; X is 76 and Y is 108; X is 76 and Y is 109; X is 76 and Y is110; X is 76 and Y is 111; X is 76 and Y is 112; X is 76 and Y is 113; Xis 76 and Y is 114; X is 76 and Y is 115; X is 76 and Y is 116; X is 76and Y is 117; X is 76 and Y is 118; X is 76 and Y is 119; X is 76 and Yis 120; X is 76 and Y is 121; X is 76 and Y is 122; X is 76 and Y is123; X is 76 and Y is 124; X is 76 and Y is 125; X is 76 and Y is 126; Xis 76 and Y is 127; X is 76 and Y is 128; X is 76 and Y is 129; X is 76and Y is 130; X is 76 and Y is 131; X is 76 and Y is 132; X is 76 and Yis 133; X is 76 and Y is 134; X is 76 and Y is 135; X is 76 and Y is136; X is 76 and Y is 137; X is 76 and Y is 138; X is 76 and Y is 139; Xis 76 and Y is 140; X is 76 and Y is 141; X is 76 and Y is 142; X is 76and Y is 143; X is 76 and Y is 144; X is 76 and Y is 145; X is 76 and Yis 146; X is 76 and Y is 147; X is 76 and Y is 148; X is 76 and Y is149; X is 76 and Y is 150; X is 76 and Y is 151; X is 76 and Y is 152; Xis 76 and Y is 153; X is 76 and Y is 154; X is 76 and Y is 155; X is 76and Y is 156; X is 76 and Y is 157; X is 76 and Y is 158; X is 76 and Yis 159; X is 76 and Y is 160; X is 76 and Y is 161; X is 76 and Y is162; X is 76 and Y is 163; X is 76 and Y is 164; X is 76 and Y is 165; Xis 76 and Y is 166; X is 76 and Y is 167; X is 76 and Y is 168; X is 76and Y is 169; X is 76 and Y is 170; X is 76 and Y is 171; X is 76 and Yis 172; X is 76 and Y is 173; X is 76 and Y is 174; X is 76 and Y is175; X is 76 and Y is 176; X is 76 and Y is 177; X is 76 and Y is 178; Xis 76 and Y is 179; X is 76 and Y is 180; X is 76 and Y is 181; X is 76and Y is 182; X is 76 and Y is 183; X is 76 and Y is 184; X is 76 and Yis 185; X is 76 and Y is 186;X is 77 and Y is 1; X is 77 and Y is 2; X is 77 and Y is 3; X is 77 andY is 4; X is 77 and Y is 5; X is 77 and Y is 6; X is 77 and Y is 7; X is77 and Y is 8; X is 77 and Y is 9; X is 77 and Y is 10; X is 77 and Y is11; X is 77 and Y is 12; X is 77 and Y is 13; X is 77 and Y is 14; X is77 and Y is 15; X is 77 and Y is 16; X is 77 and Y is 17; X is 77 and Yis 18; X is 77 and Y is 19; X is 77 and Y is 20; X is 77 and Y is 21; Xis 77 and Y is 22; X is 77 and Y is 23; X is 77 and Y is 24; X is 77 andY is 25; X is 77 and Y is 26; X is 77 and Y is 27; X is 77 and Y is 28;X is 77 and Y is 29; X is 77 and Y is 30; X is 77 and Y is 31; X is 77and Y is 32; X is 77 and Y is 33; X is 77 and Y is 34; X is 77 and Y is35; X is 77 and Y is 36; X is 77 and Y is 37; X is 77 and Y is 38; X is77 and Y is 39; X is 77 and Y is 40; X is 77 and Y is 41; X is 77 and Yis 42; X is 77 and Y is 43; X is 77 and Y is 44; X is 77 and Y is 45; Xis 77 and Y is 46; X is 77 and Y is 47; X is 77 and Y is 48; X is 77 andY is 49; X is 77 and Y is 50; X is 77 and Y is 51; X is 77 and Y is 52;X is 77 and Y is 53; X is 77 and Y is 54; X is 77 and Y is 55; X is 77and Y is 56; X is 77 and Y is 57; X is 77 and Y is 58; X is 77 and Y is59; X is 77 and Y is 60; X is 77 and Y is 61; X is 77 and Y is 62; X is77 and Y is 63; X is 77 and Y is 64; X is 77 and Y is 65; X is 77 and Yis 66; X is 77 and Y is 67; X is 77 and Y is 68; X is 77 and Y is 69; Xis 77 and Y is 70; X is 77 and Y is 71; X is 77 and Y is 72; X is 77 andY is 73; X is 77 and Y is 74; X is 77 and Y is 75; X is 77 and Y is 76;X is 77 and Y is 77; X is 77 and Y is 78; X is 77 and Y is 79; X is 77and Y is 80; X is 77 and Y is 81; X is 77 and Y is 82; X is 77 and Y is83; X is 77 and Y is 84; X is 77 and Y is 85; X is 77 and Y is 86; X is77 and Y is 87; X is 77 and Y is 88; X is 77 and Y is 89; X is 77 and Yis 90; X is 77 and Y is 91; X is 77 and Y is 92; X is 77 and Y is 93; Xis 77 and Y is 94; X is 77 and Y is 95; X is 77 and Y is 96; X is 77 andY is 97; X is 77 and Y is 98; X is 77 and Y is 99; X is 77 and Y is 100;X is 77 and Y is 101; X is 77 and Y is 102; X is 77 and Y is 103; X is77 and Y is 104; X is 77 and Y is 105; X is 77 and Y is 106; X is 77 andY is 107; X is 77 and Y is 108; X is 77 and Y is 109; X is 77 and Y is110; X is 77 and Y is 111; X is 77 and Y is 112; X is 77 and Y is 113; Xis 77 and Y is 114; X is 77 and Y is 115; X is 77 and Y is 116; X is 77and Y is 117; X is 77 and Y is 118; X is 77 and Y is 119; X is 77 and Yis 120; X is 77 and Y is 121; X is 77 and Y is 122; X is 77 and Y is123; X is 77 and Y is 124; X is 77 and Y is 125; X is 77 and Y is 126; Xis 77 and Y is 127; X is 77 and Y is 128; X is 77 and Y is 129; X is 77and Y is 130; X is 77 and Y is 131; X is 77 and Y is 132; X is 77 and Yis 133; X is 77 and Y is 134; X is 77 and Y is 135; X is 77 and Y is136; X is 77 and Y is 137; X is 77 and Y is 138; X is 77 and Y is 139; Xis 77 and Y is 140; X is 77 and Y is 141; X is 77 and Y is 142; X is 77and Y is 143; X is 77 and Y is 144; X is 77 and Y is 145; X is 77 and Yis 146; X is 77 and Y is 147; X is 77 and Y is 148; X is 77 and Y is149; X is 77 and Y is 150; X is 77 and Y is 151; X is 77 and Y is 152; Xis 77 and Y is 153; X is 77 and Y is 154; X is 77 and Y is 155; X is 77and Y is 156; X is 77 and Y is 157; X is 77 and Y is 158; X is 77 and Yis 159; X is 77 and Y is 160; X is 77 and Y is 161; X is 77 and Y is162; X is 77 and Y is 163; X is 77 and Y is 164; X is 77 and Y is 165; Xis 77 and Y is 166; X is 77 and Y is 167; X is 77 and Y is 168; X is 77and Y is 169; X is 77 and Y is 170; X is 77 and Y is 171; X is 77 and Yis 172; X is 77 and Y is 173; X is 77 and Y is 174; X is 77 and Y is175; X is 77 and Y is 176; X is 77 and Y is 177; X is 77 and Y is 178; Xis 77 and Y is 179; X is 77 and Y is 180; X is 77 and Y is 181; X is 77and Y is 182; X is 77 and Y is 183; X is 77 and Y is 184; X is 77 and Yis 185; X is 77 and Y is 186;X is 78 and Y is 1; X is 78 and Y is 2; X is 78 and Y is 3; X is 78 andY is 4; X is 78 and Y is 5; X is 78 and Y is 6; X is 78 and Y is 7; X is78 and Y is 8; X is 78 and Y is 9; X is 78 and Y is 10; X is 78 and Y is11; X is 78 and Y is 12; X is 78 and Y is 13; X is 78 and Y is 14; X is78 and Y is 15; X is 78 and Y is 16; X is 78 and Y is 17; X is 78 and Yis 18; X is 78 and Y is 19; X is 78 and Y is 20; X is 78 and Y is 21; Xis 78 and Y is 22; X is 78 and Y is 23; X is 78 and Y is 24; X is 78 andY is 25; X is 78 and Y is 26; X is 78 and Y is 27; X is 78 and Y is 28;X is 78 and Y is 29; X is 78 and Y is 30; X is 78 and Y is 31; X is 78and Y is 32; X is 78 and Y is 33; X is 78 and Y is 34; X is 78 and Y is35; X is 78 and Y is 36; X is 78 and Y is 37; X is 78 and Y is 38; X is78 and Y is 39; X is 78 and Y is 40; X is 78 and Y is 41; X is 78 and Yis 42; X is 78 and Y is 43; X is 78 and Y is 44; X is 78 and Y is 45; Xis 78 and Y is 46; X is 78 and Y is 47; X is 78 and Y is 48; X is 78 andY is 49; X is 78 and Y is 50; X is 78 and Y is 51; X is 78 and Y is 52;X is 78 and Y is 53; X is 78 and Y is 54; X is 78 and Y is 55; X is 78and Y is 56; X is 78 and Y is 57; X is 78 and Y is 58; X is 78 and Y is59; X is 78 and Y is 60; X is 78 and Y is 61; X is 78 and Y is 62; X is78 and Y is 63; X is 78 and Y is 64; X is 78 and Y is 65; X is 78 and Yis 66; X is 78 and Y is 67; X is 78 and Y is 68; X is 78 and Y is 69; Xis 78 and Y is 70; X is 78 and Y is 71; X is 78 and Y is 72; X is 78 andY is 73; X is 78 and Y is 74; X is 78 and Y is 75; X is 78 and Y is 76;X is 78 and Y is 77; X is 78 and Y is 78; X is 78 and Y is 79; X is 78and Y is 80; X is 78 and Y is 81; X is 78 and Y is 82; X is 78 and Y is83; X is 78 and Y is 84; X is 78 and Y is 85; X is 78 and Y is 86; X is78 and Y is 87; X is 78 and Y is 88; X is 78 and Y is 89; X is 78 and Yis 90; X is 78 and Y is 91; X is 78 and Y is 92; X is 78 and Y is 93; Xis 78 and Y is 94; X is 78 and Y is 95; X is 78 and Y is 96; X is 78 andY is 97; X is 78 and Y is 98; X is 78 and Y is 99; X is 78 and Y is 100;X is 78 and Y is 101; X is 78 and Y is 102; X is 78 and Y is 103; X is78 and Y is 104; X is 78 and Y is 105; X is 78 and Y is 106; X is 78 andY is 107; X is 78 and Y is 108; X is 78 and Y is 109; X is 78 and Y is110; X is 78 and Y is 111; X is 78 and Y is 112; X is 78 and Y is 113; Xis 78 and Y is 114; X is 78 and Y is 115; X is 78 and Y is 116; X is 78and Y is 117; X is 78 and Y is 118; X is 78 and Y is 119; X is 78 and Yis 120; X is 78 and Y is 121; X is 78 and Y is 122; X is 78 and Y is123; X is 78 and Y is 124; X is 78 and Y is 125; X is 78 and Y is 126; Xis 78 and Y is 127; X is 78 and Y is 128; X is 78 and Y is 129; X is 78and Y is 130; X is 78 and Y is 131; X is 78 and Y is 132; X is 78 and Yis 133; X is 78 and Y is 134; X is 78 and Y is 135; X is 78 and Y is136; X is 78 and Y is 137; X is 78 and Y is 138; X is 78 and Y is 139; Xis 78 and Y is 140; X is 78 and Y is 141; X is 78 and Y is 142; X is 78and Y is 143; X is 78 and Y is 144; X is 78 and Y is 145; X is 78 and Yis 146; X is 78 and Y is 147; X is 78 and Y is 148; X is 78 and Y is149; X is 78 and Y is 150; X is 78 and Y is 151; X is 78 and Y is 152; Xis 78 and Y is 153; X is 78 and Y is 154; X is 78 and Y is 155; X is 78and Y is 156; X is 78 and Y is 157; X is 78 and Y is 158; X is 78 and Yis 159; X is 78 and Y is 160; X is 78 and Y is 161; X is 78 and Y is162; X is 78 and Y is 163; X is 78 and Y is 164; X is 78 and Y is 165; Xis 78 and Y is 166; X is 78 and Y is 167; X is 78 and Y is 168; X is 78and Y is 169; X is 78 and Y is 170; X is 78 and Y is 171; X is 78 and Yis 172; X is 78 and Y is 173; X is 78 and Y is 174; X is 78 and Y is175; X is 78 and Y is 176; X is 78 and Y is 177; X is 78 and Y is 178; Xis 78 and Y is 179; X is 78 and Y is 180; X is 78 and Y is 181; X is 78and Y is 182; X is 78 and Y is 183; X is 78 and Y is 184; X is 78 and Yis 185; X is 78 and Y is 186;X is 79 and Y is 1; X is 79 and Y is 2; X is 79 and Y is 3; X is 79 andY is 4; X is 79 and Y is 5; X is 79 and Y is 6; X is 79 and Y is 7; X is79 and Y is 8; X is 79 and Y is 9; X is 79 and Y is 10; X is 79 and Y is11; X is 79 and Y is 12; X is 79 and Y is 13; X is 79 and Y is 14; X is79 and Y is 15; X is 79 and Y is 16; X is 79 and Y is 17; X is 79 and Yis 18; X is 79 and Y is 19; X is 79 and Y is 20; X is 79 and Y is 21; Xis 79 and Y is 22; X is 79 and Y is 23; X is 79 and Y is 24; X is 79 andY is 25; X is 79 and Y is 26; X is 79 and Y is 27; X is 79 and Y is 28;X is 79 and Y is 29; X is 79 and Y is 30; X is 79 and Y is 31; X is 79and Y is 32; X is 79 and Y is 33; X is 79 and Y is 34; X is 79 and Y is35; X is 79 and Y is 36; X is 79 and Y is 37; X is 79 and Y is 38; X is79 and Y is 39; X is 79 and Y is 40; X is 79 and Y is 41; X is 79 and Yis 42; X is 79 and Y is 43; X is 79 and Y is 44; X is 79 and Y is 45; Xis 79 and Y is 46; X is 79 and Y is 47; X is 79 and Y is 48; X is 79 andY is 49; X is 79 and Y is 50; X is 79 and Y is 51; X is 79 and Y is 52;X is 79 and Y is 53; X is 79 and Y is 54; X is 79 and Y is 55; X is 79and Y is 56; X is 79 and Y is 57; X is 79 and Y is 58; X is 79 and Y is59; X is 79 and Y is 60; X is 79 and Y is 61; X is 79 and Y is 62; X is79 and Y is 63; X is 79 and Y is 64; X is 79 and Y is 65; X is 79 and Yis 66; X is 79 and Y is 67; X is 79 and Y is 68; X is 79 and Y is 69; Xis 79 and Y is 70; X is 79 and Y is 71; X is 79 and Y is 72; X is 79 andY is 73; X is 79 and Y is 74; X is 79 and Y is 75; X is 79 and Y is 76;X is 79 and Y is 77; X is 79 and Y is 78; X is 79 and Y is 79; X is 79and Y is 80; X is 79 and Y is 81; X is 79 and Y is 82; X is 79 and Y is83; X is 79 and Y is 84; X is 79 and Y is 85; X is 79 and Y is 86; X is79 and Y is 87; X is 79 and Y is 88; X is 79 and Y is 89; X is 79 and Yis 90; X is 79 and Y is 91; X is 79 and Y is 92; X is 79 and Y is 93; Xis 79 and Y is 94; X is 79 and Y is 95; X is 79 and Y is 96; X is 79 andY is 97; X is 79 and Y is 98; X is 79 and Y is 99; X is 79 and Y is 100;X is 79 and Y is 101; X is 79 and Y is 102; X is 79 and Y is 103; X is79 and Y is 104; X is 79 and Y is 105; X is 79 and Y is 106; X is 79 andY is 107; X is 79 and Y is 108; X is 79 and Y is 109; X is 79 and Y is110; X is 79 and Y is 111; X is 79 and Y is 112; X is 79 and Y is 113; Xis 79 and Y is 114; X is 79 and Y is 115; X is 79 and Y is 116; X is 79and Y is 117; X is 79 and Y is 118; X is 79 and Y is 119; X is 79 and Yis 120; X is 79 and Y is 121; X is 79 and Y is 122; X is 79 and Y is123; X is 79 and Y is 124; X is 79 and Y is 125; X is 79 and Y is 126; Xis 79 and Y is 127; X is 79 and Y is 128; X is 79 and Y is 129; X is 79and Y is 130; X is 79 and Y is 131; X is 79 and Y is 132; X is 79 and Yis 133; X is 79 and Y is 134; X is 79 and Y is 135; X is 79 and Y is136; X is 79 and Y is 137; X is 79 and Y is 138; X is 79 and Y is 139; Xis 79 and Y is 140; X is 79 and Y is 141; X is 79 and Y is 142; X is 79and Y is 143; X is 79 and Y is 144; X is 79 and Y is 145; X is 79 and Yis 146; X is 79 and Y is 147; X is 79 and Y is 148; X is 79 and Y is149; X is 79 and Y is 150; X is 79 and Y is 151; X is 79 and Y is 152; Xis 79 and Y is 153; X is 79 and Y is 154; X is 79 and Y is 155; X is 79and Y is 156; X is 79 and Y is 157; X is 79 and Y is 158; X is 79 and Yis 159; X is 79 and Y is 160; X is 79 and Y is 161; X is 79 and Y is162; X is 79 and Y is 163; X is 79 and Y is 164; X is 79 and Y is 165; Xis 79 and Y is 166; X is 79 and Y is 167; X is 79 and Y is 168; X is 79and Y is 169; X is 79 and Y is 170; X is 79 and Y is 171; X is 79 and Yis 172; X is 79 and Y is 173; X is 79 and Y is 174; X is 79 and Y is175; X is 79 and Y is 176; X is 79 and Y is 177; X is 79 and Y is 178; Xis 79 and Y is 179; X is 79 and Y is 180; X is 79 and Y is 181; X is 79and Y is 182; X is 79 and Y is 183; X is 79 and Y is 184; X is 79 and Yis 185; X is 79 and Y is 186;X is 80 and Y is 1; X is 80 and Y is 2; X is 80 and Y is 3; X is 80 andY is 4; X is 80 and Y is 5; X is 80 and Y is 6; X is 80 and Y is 7; X is80 and Y is 8; X is 80 and Y is 9; X is 80 and Y is 10; X is 80 and Y is11; X is 80 and Y is 12; X is 80 and Y is 13; X is 80 and Y is 14; X is80 and Y is 15; X is 80 and Y is 16; X is 80 and Y is 17; X is 80 and Yis 18; X is 80 and Y is 19; X is 80 and Y is 20; X is 80 and Y is 21; Xis 80 and Y is 22; X is 80 and Y is 23; X is 80 and Y is 24; X is 80 andY is 25; X is 80 and Y is 26; X is 80 and Y is 27; X is 80 and Y is 28;X is 80 and Y is 29; X is 80 and Y is 30; X is 80 and Y is 31; X is 80and Y is 32; X is 80 and Y is 33; X is 80 and Y is 34; X is 80 and Y is35; X is 80 and Y is 36; X is 80 and Y is 37; X is 80 and Y is 38; X is80 and Y is 39; X is 80 and Y is 40; X is 80 and Y is 41; X is 80 and Yis 42; X is 80 and Y is 43; X is 80 and Y is 44; X is 80 and Y is 45; Xis 80 and Y is 46; X is 80 and Y is 47; X is 80 and Y is 48; X is 80 andY is 49; X is 80 and Y is 50; X is 80 and Y is 51; X is 80 and Y is 52;X is 80 and Y is 53; X is 80 and Y is 54; X is 80 and Y is 55; X is 80and Y is 56; X is 80 and Y is 57; X is 80 and Y is 58; X is 80 and Y is59; X is 80 and Y is 60; X is 80 and Y is 61; X is 80 and Y is 62; X is80 and Y is 63; X is 80 and Y is 64; X is 80 and Y is 65; X is 80 and Yis 66; X is 80 and Y is 67; X is 80 and Y is 68; X is 80 and Y is 69; Xis 80 and Y is 70; X is 80 and Y is 71; X is 80 and Y is 72; X is 80 andY is 73; X is 80 and Y is 74; X is 80 and Y is 75; X is 80 and Y is 76;X is 80 and Y is 77; X is 80 and Y is 78; X is 80 and Y is 79; X is 80and Y is 80; X is 80 and Y is 81; X is 80 and Y is 82; X is 80 and Y is83; X is 80 and Y is 84; X is 80 and Y is 85; X is 80 and Y is 86; X is80 and Y is 87; X is 80 and Y is 88; X is 80 and Y is 89; X is 80 and Yis 90; X is 80 and Y is 91; X is 80 and Y is 92; X is 80 and Y is 93; Xis 80 and Y is 94; X is 80 and Y is 95; X is 80 and Y is 96; X is 80 andY is 97; X is 80 and Y is 98; X is 80 and Y is 99; X is 80 and Y is 100;X is 80 and Y is 101; X is 80 and Y is 102; X is 80 and Y is 103; X is80 and Y is 104; X is 80 and Y is 105; X is 80 and Y is 106; X is 80 andY is 107; X is 80 and Y is 108; X is 80 and Y is 109; X is 80 and Y is110; X is 80 and Y is 111; X is 80 and Y is 112; X is 80 and Y is 113; Xis 80 and Y is 114; X is 80 and Y is 115; X is 80 and Y is 116; X is 80and Y is 117; X is 80 and Y is 118; X is 80 and Y is 119; X is 80 and Yis 120; X is 80 and Y is 121; X is 80 and Y is 122; X is 80 and Y is123; X is 80 and Y is 124; X is 80 and Y is 125; X is 80 and Y is 126; Xis 80 and Y is 127; X is 80 and Y is 128; X is 80 and Y is 129; X is 80and Y is 130; X is 80 and Y is 131; X is 80 and Y is 132; X is 80 and Yis 133; X is 80 and Y is 134; X is 80 and Y is 135; X is 80 and Y is136; X is 80 and Y is 137; X is 80 and Y is 138; X is 80 and Y is 139; Xis 80 and Y is 140; X is 80 and Y is 141; X is 80 and Y is 142; X is 80and Y is 143; X is 80 and Y is 144; X is 80 and Y is 145; X is 80 and Yis 146; X is 80 and Y is 147; X is 80 and Y is 148; X is 80 and Y is149; X is 80 and Y is 150; X is 80 and Y is 151; X is 80 and Y is 152; Xis 80 and Y is 153; X is 80 and Y is 154; X is 80 and Y is 155; X is 80and Y is 156; X is 80 and Y is 157; X is 80 and Y is 158; X is 80 and Yis 159; X is 80 and Y is 160; X is 80 and Y is 161; X is 80 and Y is162; X is 80 and Y is 163; X is 80 and Y is 164; X is 80 and Y is 165; Xis 80 and Y is 166; X is 80 and Y is 167; X is 80 and Y is 168; X is 80and Y is 169; X is 80 and Y is 170; X is 80 and Y is 171; X is 80 and Yis 172; X is 80 and Y is 173; X is 80 and Y is 174; X is 80 and Y is175; X is 80 and Y is 176; X is 80 and Y is 177; X is 80 and Y is 178; Xis 80 and Y is 179; X is 80 and Y is 180; X is 80 and Y is 181; X is 80and Y is 182; X is 80 and Y is 183; X is 80 and Y is 184; X is 80 and Yis 185; X is 80 and Y is 186;X is 81 and Y is 1; X is 81 and Y is 2; X is 81 and Y is 3; X is 81 andY is 4; X is 81 and Y is 5; X is 81 and Y is 6; X is 81 and Y is 7; X is81 and Y is 8; X is 81 and Y is 9; X is 81 and Y is 10; X is 81 and Y is11; X is 81 and Y is 12; X is 81 and Y is 13; X is 81 and Y is 14; X is81 and Y is 15; X is 81 and Y is 16; X is 81 and Y is 17; X is 81 and Yis 18; X is 81 and Y is 19; X is 81 and Y is 20; X is 81 and Y is 21; Xis 81 and Y is 22; X is 81 and Y is 23; X is 81 and Y is 24; X is 81 andY is 25; X is 81 and Y is 26; X is 81 and Y is 27; X is 81 and Y is 28;X is 81 and Y is 29; X is 81 and Y is 30; X is 81 and Y is 31; X is 81and Y is 32; X is 81 and Y is 33; X is 81 and Y is 34; X is 81 and Y is35; X is 81 and Y is 36; X is 81 and Y is 37; X is 81 and Y is 38; X is81 and Y is 39; X is 81 and Y is 40; X is 81 and Y is 41; X is 81 and Yis 42; X is 81 and Y is 43; X is 81 and Y is 44; X is 81 and Y is 45; Xis 81 and Y is 46; X is 81 and Y is 47; X is 81 and Y is 48; X is 81 andY is 49; X is 81 and Y is 50; X is 81 and Y is 51; X is 81 and Y is 52;X is 81 and Y is 53; X is 81 and Y is 54; X is 81 and Y is 55; X is 81and Y is 56; X is 81 and Y is 57; X is 81 and Y is 58; X is 81 and Y is59; X is 81 and Y is 60; X is 81 and Y is 61; X is 81 and Y is 62; X is81 and Y is 63; X is 81 and Y is 64; X is 81 and Y is 65; X is 81 and Yis 66; X is 81 and Y is 67; X is 81 and Y is 68; X is 81 and Y is 69; Xis 81 and Y is 70; X is 81 and Y is 71; X is 81 and Y is 72; X is 81 andY is 73; X is 81 and Y is 74; X is 81 and Y is 75; X is 81 and Y is 76;X is 81 and Y is 77; X is 81 and Y is 78; X is 81 and Y is 79; X is 81and Y is 80; X is 81 and Y is 81; X is 81 and Y is 82; X is 81 and Y is83; X is 81 and Y is 84; X is 81 and Y is 85; X is 81 and Y is 86; X is81 and Y is 87; X is 81 and Y is 88; X is 81 and Y is 89; X is 81 and Yis 90; X is 81 and Y is 91; X is 81 and Y is 92; X is 81 and Y is 93; Xis 81 and Y is 94; X is 81 and Y is 95; X is 81 and Y is 96; X is 81 andY is 97; X is 81 and Y is 98; X is 81 and Y is 99; X is 81 and Y is 100;X is 81 and Y is 101; X is 81 and Y is 102; X is 81 and Y is 103; X is81 and Y is 104; X is 81 and Y is 105; X is 81 and Y is 106; X is 81 andY is 107; X is 81 and Y is 108; X is 81 and Y is 109; X is 81 and Y is110; X is 81 and Y is 111; X is 81 and Y is 112; X is 81 and Y is 113; Xis 81 and Y is 114; X is 81 and Y is 115; X is 81 and Y is 116; X is 81and Y is 117; X is 81 and Y is 118; X is 81 and Y is 119; X is 81 and Yis 120; X is 81 and Y is 121; X is 81 and Y is 122; X is 81 and Y is123; X is 81 and Y is 124; X is 81 and Y is 125; X is 81 and Y is 126; Xis 81 and Y is 127; X is 81 and Y is 128; X is 81 and Y is 129; X is 81and Y is 130; X is 81 and Y is 131; X is 81 and Y is 132; X is 81 and Yis 133; X is 81 and Y is 134; X is 81 and Y is 135; X is 81 and Y is136; X is 81 and Y is 137; X is 81 and Y is 138; X is 81 and Y is 139; Xis 81 and Y is 140; X is 81 and Y is 141; X is 81 and Y is 142; X is 81and Y is 143; X is 81 and Y is 144; X is 81 and Y is 145; X is 81 and Yis 146; X is 81 and Y is 147; X is 81 and Y is 148; X is 81 and Y is149; X is 81 and Y is 150; X is 81 and Y is 151; X is 81 and Y is 152; Xis 81 and Y is 153; X is 81 and Y is 154; X is 81 and Y is 155; X is 81and Y is 156; X is 81 and Y is 157; X is 81 and Y is 158; X is 81 and Yis 159; X is 81 and Y is 160; X is 81 and Y is 161; X is 81 and Y is162; X is 81 and Y is 163; X is 81 and Y is 164; X is 81 and Y is 165; Xis 81 and Y is 166; X is 81 and Y is 167; X is 81 and Y is 168; X is 81and Y is 169; X is 81 and Y is 170; X is 81 and Y is 171; X is 81 and Yis 172; X is 81 and Y is 173; X is 81 and Y is 174; X is 81 and Y is175; X is 81 and Y is 176; X is 81 and Y is 177; X is 81 and Y is 178; Xis 81 and Y is 179; X is 81 and Y is 180; X is 81 and Y is 181; X is 81and Y is 182; X is 81 and Y is 183; X is 81 and Y is 184; X is 81 and Yis 185; X is 81 and Y is 186;X is 82 and Y is 1; X is 82 and Y is 2; X is 82 and Y is 3; X is 82 andY is 4; X is 82 and Y is 5; X is 82 and Y is 6; X is 82 and Y is 7; X is82 and Y is 8; X is 82 and Y is 9; X is 82 and Y is 10; X is 82 and Y is11; X is 82 and Y is 12; X is 82 and Y is 13; X is 82 and Y is 14; X is82 and Y is 15; X is 82 and Y is 16; X is 82 and Y is 17; X is 82 and Yis 18; X is 82 and Y is 19; X is 82 and Y is 20; X is 82 and Y is 21; Xis 82 and Y is 22; X is 82 and Y is 23; X is 82 and Y is 24; X is 82 andY is 25; X is 82 and Y is 26; X is 82 and Y is 27; X is 82 and Y is 28;X is 82 and Y is 29; X is 82 and Y is 30; X is 82 and Y is 31; X is 82and Y is 32; X is 82 and Y is 33; X is 82 and Y is 34; X is 82 and Y is35; X is 82 and Y is 36; X is 82 and Y is 37; X is 82 and Y is 38; X is82 and Y is 39; X is 82 and Y is 40; X is 82 and Y is 41; X is 82 and Yis 42; X is 82 and Y is 43; X is 82 and Y is 44; X is 82 and Y is 45; Xis 82 and Y is 46; X is 82 and Y is 47; X is 82 and Y is 48; X is 82 andY is 49; X is 82 and Y is 50; X is 82 and Y is 51; X is 82 and Y is 52;X is 82 and Y is 53; X is 82 and Y is 54; X is 82 and Y is 55; X is 82and Y is 56; X is 82 and Y is 57; X is 82 and Y is 58; X is 82 and Y is59; X is 82 and Y is 60; X is 82 and Y is 61; X is 82 and Y is 62; X is82 and Y is 63; X is 82 and Y is 64; X is 82 and Y is 65; X is 82 and Yis 66; X is 82 and Y is 67; X is 82 and Y is 68; X is 82 and Y is 69; Xis 82 and Y is 70; X is 82 and Y is 71; X is 82 and Y is 72; X is 82 andY is 73; X is 82 and Y is 74; X is 82 and Y is 75; X is 82 and Y is 76;X is 82 and Y is 77; X is 82 and Y is 78; X is 82 and Y is 79; X is 82and Y is 80; X is 82 and Y is 81; X is 82 and Y is 82; X is 82 and Y is83; X is 82 and Y is 84; X is 82 and Y is 85; X is 82 and Y is 86; X is82 and Y is 87; X is 82 and Y is 88; X is 82 and Y is 89; X is 82 and Yis 90; X is 82 and Y is 91; X is 82 and Y is 92; X is 82 and Y is 93; Xis 82 and Y is 94; X is 82 and Y is 95; X is 82 and Y is 96; X is 82 andY is 97; X is 82 and Y is 98; X is 82 and Y is 99; X is 82 and Y is 100;X is 82 and Y is 101; X is 82 and Y is 102; X is 82 and Y is 103; X is82 and Y is 104; X is 82 and Y is 105; X is 82 and Y is 106; X is 82 andY is 107; X is 82 and Y is 108; X is 82 and Y is 109; X is 82 and Y is110; X is 82 and Y is 111; X is 82 and Y is 112; X is 82 and Y is 113; Xis 82 and Y is 114; X is 82 and Y is 115; X is 82 and Y is 116; X is 82and Y is 117; X is 82 and Y is 118; X is 82 and Y is 119; X is 82 and Yis 120; X is 82 and Y is 121; X is 82 and Y is 122; X is 82 and Y is123; X is 82 and Y is 124; X is 82 and Y is 125; X is 82 and Y is 126; Xis 82 and Y is 127; X is 82 and Y is 128; X is 82 and Y is 129; X is 82and Y is 130; X is 82 and Y is 131; X is 82 and Y is 132; X is 82 and Yis 133; X is 82 and Y is 134; X is 82 and Y is 135; X is 82 and Y is136; X is 82 and Y is 137; X is 82 and Y is 138; X is 82 and Y is 139; Xis 82 and Y is 140; X is 82 and Y is 141; X is 82 and Y is 142; X is 82and Y is 143; X is 82 and Y is 144; X is 82 and Y is 145; X is 82 and Yis 146; X is 82 and Y is 147; X is 82 and Y is 148; X is 82 and Y is149; X is 82 and Y is 150; X is 82 and Y is 151; X is 82 and Y is 152; Xis 82 and Y is 153; X is 82 and Y is 154; X is 82 and Y is 155; X is 82and Y is 156; X is 82 and Y is 157; X is 82 and Y is 158; X is 82 and Yis 159; X is 82 and Y is 160; X is 82 and Y is 161; X is 82 and Y is162; X is 82 and Y is 163; X is 82 and Y is 164; X is 82 and Y is 165; Xis 82 and Y is 166; X is 82 and Y is 167; X is 82 and Y is 168; X is 82and Y is 169; X is 82 and Y is 170; X is 82 and Y is 171; X is 82 and Yis 172; X is 82 and Y is 173; X is 82 and Y is 174; X is 82 and Y is175; X is 82 and Y is 176; X is 82 and Y is 177; X is 82 and Y is 178; Xis 82 and Y is 179; X is 82 and Y is 180; X is 82 and Y is 181; X is 82and Y is 182; X is 82 and Y is 183; X is 82 and Y is 184; X is 82 and Yis 185; X is 82 and Y is 186;X is 83 and Y is 1; X is 83 and Y is 2; X is 83 and Y is 3; X is 83 andY is 4; X is 83 and Y is 5; X is 83 and Y is 6; X is 83 and Y is 7; X is83 and Y is 8; X is 83 and Y is 9; X is 83 and Y is 10; X is 83 and Y is11; X is 83 and Y is 12; X is 83 and Y is 13; X is 83 and Y is 14; X is83 and Y is 15; X is 83 and Y is 16; X is 83 and Y is 17; X is 83 and Yis 18; X is 83 and Y is 19; X is 83 and Y is 20; X is 83 and Y is 21; Xis 83 and Y is 22; X is 83 and Y is 23; X is 83 and Y is 24; X is 83 andY is 25; X is 83 and Y is 26; X is 83 and Y is 27; X is 83 and Y is 28;X is 83 and Y is 29; X is 83 and Y is 30; X is 83 and Y is 31; X is 83and Y is 32; X is 83 and Y is 33; X is 83 and Y is 34; X is 83 and Y is35; X is 83 and Y is 36; X is 83 and Y is 37; X is 83 and Y is 38; X is83 and Y is 39; X is 83 and Y is 40; X is 83 and Y is 41; X is 83 and Yis 42; X is 83 and Y is 43; X is 83 and Y is 44; X is 83 and Y is 45; Xis 83 and Y is 46; X is 83 and Y is 47; X is 83 and Y is 48; X is 83 andY is 49; X is 83 and Y is 50; X is 83 and Y is 51; X is 83 and Y is 52;X is 83 and Y is 53; X is 83 and Y is 54; X is 83 and Y is 55; X is 83and Y is 56; X is 83 and Y is 57; X is 83 and Y is 58; X is 83 and Y is59; X is 83 and Y is 60; X is 83 and Y is 61; X is 83 and Y is 62; X is83 and Y is 63; X is 83 and Y is 64; X is 83 and Y is 65; X is 83 and Yis 66; X is 83 and Y is 67; X is 83 and Y is 68; X is 83 and Y is 69; Xis 83 and Y is 70; X is 83 and Y is 71; X is 83 and Y is 72; X is 83 andY is 73; X is 83 and Y is 74; X is 83 and Y is 75; X is 83 and Y is 76;X is 83 and Y is 77; X is 83 and Y is 78; X is 83 and Y is 79; X is 83and Y is 80; X is 83 and Y is 81; X is 83 and Y is 82; X is 83 and Y is83; X is 83 and Y is 84; X is 83 and Y is 85; X is 83 and Y is 86; X is83 and Y is 87; X is 83 and Y is 88; X is 83 and Y is 89; X is 83 and Yis 90; X is 83 and Y is 91; X is 83 and Y is 92; X is 83 and Y is 93; Xis 83 and Y is 94; X is 83 and Y is 95; X is 83 and Y is 96; X is 83 andY is 97; X is 83 and Y is 98; X is 83 and Y is 99; X is 83 and Y is 100;X is 83 and Y is 101; X is 83 and Y is 102; X is 83 and Y is 103; X is83 and Y is 104; X is 83 and Y is 105; X is 83 and Y is 106; X is 83 andY is 107; X is 83 and Y is 108; X is 83 and Y is 109; X is 83 and Y is110; X is 83 and Y is 111; X is 83 and Y is 112; X is 83 and Y is 113; Xis 83 and Y is 114; X is 83 and Y is 115; X is 83 and Y is 116; X is 83and Y is 117; X is 83 and Y is 118; X is 83 and Y is 119; X is 83 and Yis 120; X is 83 and Y is 121; X is 83 and Y is 122; X is 83 and Y is123; X is 83 and Y is 124; X is 83 and Y is 125; X is 83 and Y is 126; Xis 83 and Y is 127; X is 83 and Y is 128; X is 83 and Y is 129; X is 83and Y is 130; X is 83 and Y is 131; X is 83 and Y is 132; X is 83 and Yis 133; X is 83 and Y is 134; X is 83 and Y is 135; X is 83 and Y is136; X is 83 and Y is 137; X is 83 and Y is 138; X is 83 and Y is 139; Xis 83 and Y is 140; X is 83 and Y is 141; X is 83 and Y is 142; X is 83and Y is 143; X is 83 and Y is 144; X is 83 and Y is 145; X is 83 and Yis 146; X is 83 and Y is 147; X is 83 and Y is 148; X is 83 and Y is149; X is 83 and Y is 150; X is 83 and Y is 151; X is 83 and Y is 152; Xis 83 and Y is 153; X is 83 and Y is 154; X is 83 and Y is 155; X is 83and Y is 156; X is 83 and Y is 157; X is 83 and Y is 158; X is 83 and Yis 159; X is 83 and Y is 160; X is 83 and Y is 161; X is 83 and Y is162; X is 83 and Y is 163; X is 83 and Y is 164; X is 83 and Y is 165; Xis 83 and Y is 166; X is 83 and Y is 167; X is 83 and Y is 168; X is 83and Y is 169; X is 83 and Y is 170; X is 83 and Y is 171; X is 83 and Yis 172; X is 83 and Y is 173; X is 83 and Y is 174; X is 83 and Y is175; X is 83 and Y is 176; X is 83 and Y is 177; X is 83 and Y is 178; Xis 83 and Y is 179; X is 83 and Y is 180; X is 83 and Y is 181; X is 83and Y is 182; X is 83 and Y is 183; X is 83 and Y is 184; X is 83 and Yis 185; X is 83 and Y is 186;X is 84 and Y is 1; X is 84 and Y is 2; X is 84 and Y is 3; X is 84 andY is 4; X is 84 and Y is 5; X is 84 and Y is 6; X is 84 and Y is 7; X is84 and Y is 8; X is 84 and Y is 9; X is 84 and Y is 10; X is 84 and Y is11; X is 84 and Y is 12; X is 84 and Y is 13; X is 84 and Y is 14; X is84 and Y is 15; X is 84 and Y is 16; X is 84 and Y is 17; X is 84 and Yis 18; X is 84 and Y is 19; X is 84 and Y is 20; X is 84 and Y is 21; Xis 84 and Y is 22; X is 84 and Y is 23; X is 84 and Y is 24; X is 84 andY is 25; X is 84 and Y is 26; X is 84 and Y is 27; X is 84 and Y is 28;X is 84 and Y is 29; X is 84 and Y is 30; X is 84 and Y is 31; X is 84and Y is 32; X is 84 and Y is 33; X is 84 and Y is 34; X is 84 and Y is35; X is 84 and Y is 36; X is 84 and Y is 37; X is 84 and Y is 38; X is84 and Y is 39; X is 84 and Y is 40; X is 84 and Y is 41; X is 84 and Yis 42; X is 84 and Y is 43; X is 84 and Y is 44; X is 84 and Y is 45; Xis 84 and Y is 46; X is 84 and Y is 47; X is 84 and Y is 48; X is 84 andY is 49; X is 84 and Y is 50; X is 84 and Y is 51; X is 84 and Y is 52;X is 84 and Y is 53; X is 84 and Y is 54; X is 84 and Y is 55; X is 84and Y is 56; X is 84 and Y is 57; X is 84 and Y is 58; X is 84 and Y is59; X is 84 and Y is 60; X is 84 and Y is 61; X is 84 and Y is 62; X is84 and Y is 63; X is 84 and Y is 64; X is 84 and Y is 65; X is 84 and Yis 66; X is 84 and Y is 67; X is 84 and Y is 68; X is 84 and Y is 69; Xis 84 and Y is 70; X is 84 and Y is 71; X is 84 and Y is 72; X is 84 andY is 73; X is 84 and Y is 74; X is 84 and Y is 75; X is 84 and Y is 76;X is 84 and Y is 77; X is 84 and Y is 78; X is 84 and Y is 79; X is 84and Y is 80; X is 84 and Y is 81; X is 84 and Y is 82; X is 84 and Y is83; X is 84 and Y is 84; X is 84 and Y is 85; X is 84 and Y is 86; X is84 and Y is 87; X is 84 and Y is 88; X is 84 and Y is 89; X is 84 and Yis 90; X is 84 and Y is 91; X is 84 and Y is 92; X is 84 and Y is 93; Xis 84 and Y is 94; X is 84 and Y is 95; X is 84 and Y is 96; X is 84 andY is 97; X is 84 and Y is 98; X is 84 and Y is 99; X is 84 and Y is 100;X is 84 and Y is 101; X is 84 and Y is 102; X is 84 and Y is 103; X is84 and Y is 104; X is 84 and Y is 105; X is 84 and Y is 106; X is 84 andY is 107; X is 84 and Y is 108; X is 84 and Y is 109; X is 84 and Y is110; X is 84 and Y is 111; X is 84 and Y is 112; X is 84 and Y is 113; Xis 84 and Y is 114; X is 84 and Y is 115; X is 84 and Y is 116; X is 84and Y is 117; X is 84 and Y is 118; X is 84 and Y is 119; X is 84 and Yis 120; X is 84 and Y is 121; X is 84 and Y is 122; X is 84 and Y is123; X is 84 and Y is 124; X is 84 and Y is 125; X is 84 and Y is 126; Xis 84 and Y is 127; X is 84 and Y is 128; X is 84 and Y is 129; X is 84and Y is 130; X is 84 and Y is 131; X is 84 and Y is 132; X is 84 and Yis 133; X is 84 and Y is 134; X is 84 and Y is 135; X is 84 and Y is136; X is 84 and Y is 137; X is 84 and Y is 138; X is 84 and Y is 139; Xis 84 and Y is 140; X is 84 and Y is 141; X is 84 and Y is 142; X is 84and Y is 143; X is 84 and Y is 144; X is 84 and Y is 145; X is 84 and Yis 146; X is 84 and Y is 147; X is 84 and Y is 148; X is 84 and Y is149; X is 84 and Y is 150; X is 84 and Y is 151; X is 84 and Y is 152; Xis 84 and Y is 153; X is 84 and Y is 154; X is 84 and Y is 155; X is 84and Y is 156; X is 84 and Y is 157; X is 84 and Y is 158; X is 84 and Yis 159; X is 84 and Y is 160; X is 84 and Y is 161; X is 84 and Y is162; X is 84 and Y is 163; X is 84 and Y is 164; X is 84 and Y is 165; Xis 84 and Y is 166; X is 84 and Y is 167; X is 84 and Y is 168; X is 84and Y is 169; X is 84 and Y is 170; X is 84 and Y is 171; X is 84 and Yis 172; X is 84 and Y is 173; X is 84 and Y is 174; X is 84 and Y is175; X is 84 and Y is 176; X is 84 and Y is 177; X is 84 and Y is 178; Xis 84 and Y is 179; X is 84 and Y is 180; X is 84 and Y is 181; X is 84and Y is 182; X is 84 and Y is 183; X is 84 and Y is 184; X is 84 and Yis 185; X is 84 and Y is 186;X is 85 and Y is 1; X is 85 and Y is 2; X is 85 and Y is 3; X is 85 andY is 4; X is 85 and Y is 5; X is 85 and Y is 6; X is 85 and Y is 7; X is85 and Y is 8; X is 85 and Y is 9; X is 85 and Y is 10; X is 85 and Y is11; X is 85 and Y is 12; X is 85 and Y is 13; X is 85 and Y is 14; X is85 and Y is 15; X is 85 and Y is 16; X is 85 and Y is 17; X is 85 and Yis 18; X is 85 and Y is 19; X is 85 and Y is 20; X is 85 and Y is 21; Xis 85 and Y is 22; X is 85 and Y is 23; X is 85 and Y is 24; X is 85 andY is 25; X is 85 and Y is 26; X is 85 and Y is 27; X is 85 and Y is 28;X is 85 and Y is 29; X is 85 and Y is 30; X is 85 and Y is 31; X is 85and Y is 32; X is 85 and Y is 33; X is 85 and Y is 34; X is 85 and Y is35; X is 85 and Y is 36; X is 85 and Y is 37; X is 85 and Y is 38; X is85 and Y is 39; X is 85 and Y is 40; X is 85 and Y is 41; X is 85 and Yis 42; X is 85 and Y is 43; X is 85 and Y is 44; X is 85 and Y is 45; Xis 85 and Y is 46; X is 85 and Y is 47; X is 85 and Y is 48; X is 85 andY is 49; X is 85 and Y is 50; X is 85 and Y is 51; X is 85 and Y is 52;X is 85 and Y is 53; X is 85 and Y is 54; X is 85 and Y is 55; X is 85and Y is 56; X is 85 and Y is 57; X is 85 and Y is 58; X is 85 and Y is59; X is 85 and Y is 60; X is 85 and Y is 61; X is 85 and Y is 62; X is85 and Y is 63; X is 85 and Y is 64; X is 85 and Y is 65; X is 85 and Yis 66; X is 85 and Y is 67; X is 85 and Y is 68; X is 85 and Y is 69; Xis 85 and Y is 70; X is 85 and Y is 71; X is 85 and Y is 72; X is 85 andY is 73; X is 85 and Y is 74; X is 85 and Y is 75; X is 85 and Y is 76;X is 85 and Y is 77; X is 85 and Y is 78; X is 85 and Y is 79; X is 85and Y is 80; X is 85 and Y is 81; X is 85 and Y is 82; X is 85 and Y is83; X is 85 and Y is 84; X is 85 and Y is 85; X is 85 and Y is 86; X is85 and Y is 87; X is 85 and Y is 88; X is 85 and Y is 89; X is 85 and Yis 90; X is 85 and Y is 91; X is 85 and Y is 92; X is 85 and Y is 93; Xis 85 and Y is 94; X is 85 and Y is 95; X is 85 and Y is 96; X is 85 andY is 97; X is 85 and Y is 98; X is 85 and Y is 99; X is 85 and Y is 100;X is 85 and Y is 101; X is 85 and Y is 102; X is 85 and Y is 103; X is85 and Y is 104; X is 85 and Y is 105; X is 85 and Y is 106; X is 85 andY is 107; X is 85 and Y is 108; X is 85 and Y is 109; X is 85 and Y is110; X is 85 and Y is 111; X is 85 and Y is 112; X is 85 and Y is 113; Xis 85 and Y is 114; X is 85 and Y is 115; X is 85 and Y is 116; X is 85and Y is 117; X is 85 and Y is 118; X is 85 and Y is 119; X is 85 and Yis 120; X is 85 and Y is 121; X is 85 and Y is 122; X is 85 and Y is123; X is 85 and Y is 124; X is 85 and Y is 125; X is 85 and Y is 126; Xis 85 and Y is 127; X is 85 and Y is 128; X is 85 and Y is 129; X is 85and Y is 130; X is 85 and Y is 131; X is 85 and Y is 132; X is 85 and Yis 133; X is 85 and Y is 134; X is 85 and Y is 135; X is 85 and Y is136; X is 85 and Y is 137; X is 85 and Y is 138; X is 85 and Y is 139; Xis 85 and Y is 140; X is 85 and Y is 141; X is 85 and Y is 142; X is 85and Y is 143; X is 85 and Y is 144; X is 85 and Y is 145; X is 85 and Yis 146; X is 85 and Y is 147; X is 85 and Y is 148; X is 85 and Y is149; X is 85 and Y is 150; X is 85 and Y is 151; X is 85 and Y is 152; Xis 85 and Y is 153; X is 85 and Y is 154; X is 85 and Y is 155; X is 85and Y is 156; X is 85 and Y is 157; X is 85 and Y is 158; X is 85 and Yis 159; X is 85 and Y is 160; X is 85 and Y is 161; X is 85 and Y is162; X is 85 and Y is 163; X is 85 and Y is 164; X is 85 and Y is 165; Xis 85 and Y is 166; X is 85 and Y is 167; X is 85 and Y is 168; X is 85and Y is 169; X is 85 and Y is 170; X is 85 and Y is 171; X is 85 and Yis 172; X is 85 and Y is 173; X is 85 and Y is 174; X is 85 and Y is175; X is 85 and Y is 176; X is 85 and Y is 177; X is 85 and Y is 178; Xis 85 and Y is 179; X is 85 and Y is 180; X is 85 and Y is 181; X is 85and Y is 182; X is 85 and Y is 183; X is 85 and Y is 184; X is 85 and Yis 185; X is 85 and Y is 186;X is 86 and Y is 1; X is 86 and Y is 2; X is 86 and Y is 3; X is 86 andY is 4; X is 86 and Y is 5; X is 86 and Y is 6; X is 86 and Y is 7; X is86 and Y is 8; X is 86 and Y is 9; X is 86 and Y is 10; X is 86 and Y is11; X is 86 and Y is 12; X is 86 and Y is 13; X is 86 and Y is 14; X is86 and Y is 15; X is 86 and Y is 16; X is 86 and Y is 17; X is 86 and Yis 18; X is 86 and Y is 19; X is 86 and Y is 20; X is 86 and Y is 21; Xis 86 and Y is 22; X is 86 and Y is 23; X is 86 and Y is 24; X is 86 andY is 25; X is 86 and Y is 26; X is 86 and Y is 27; X is 86 and Y is 28;X is 86 and Y is 29; X is 86 and Y is 30; X is 86 and Y is 31; X is 86and Y is 32; X is 86 and Y is 33; X is 86 and Y is 34; X is 86 and Y is35; X is 86 and Y is 36; X is 86 and Y is 37; X is 86 and Y is 38; X is86 and Y is 39; X is 86 and Y is 40; X is 86 and Y is 41; X is 86 and Yis 42; X is 86 and Y is 43; X is 86 and Y is 44; X is 86 and Y is 45; Xis 86 and Y is 46; X is 86 and Y is 47; X is 86 and Y is 48; X is 86 andY is 49; X is 86 and Y is 50; X is 86 and Y is 51; X is 86 and Y is 52;X is 86 and Y is 53; X is 86 and Y is 54; X is 86 and Y is 55; X is 86and Y is 56; X is 86 and Y is 57; X is 86 and Y is 58; X is 86 and Y is59; X is 86 and Y is 60; X is 86 and Y is 61; X is 86 and Y is 62; X is86 and Y is 63; X is 86 and Y is 64; X is 86 and Y is 65; X is 86 and Yis 66; X is 86 and Y is 67; X is 86 and Y is 68; X is 86 and Y is 69; Xis 86 and Y is 70; X is 86 and Y is 71; X is 86 and Y is 72; X is 86 andY is 73; X is 86 and Y is 74; X is 86 and Y is 75; X is 86 and Y is 76;X is 86 and Y is 77; X is 86 and Y is 78; X is 86 and Y is 79; X is 86and Y is 80; X is 86 and Y is 81; X is 86 and Y is 82; X is 86 and Y is83; X is 86 and Y is 84; X is 86 and Y is 85; X is 86 and Y is 86; X is86 and Y is 87; X is 86 and Y is 88; X is 86 and Y is 89; X is 86 and Yis 90; X is 86 and Y is 91; X is 86 and Y is 92; X is 86 and Y is 93; Xis 86 and Y is 94; X is 86 and Y is 95; X is 86 and Y is 96; X is 86 andY is 97; X is 86 and Y is 98; X is 86 and Y is 99; X is 86 and Y is 100;X is 86 and Y is 101; X is 86 and Y is 102; X is 86 and Y is 103; X is86 and Y is 104; X is 86 and Y is 105; X is 86 and Y is 106; X is 86 andY is 107; X is 86 and Y is 108; X is 86 and Y is 109; X is 86 and Y is110; X is 86 and Y is 111; X is 86 and Y is 112; X is 86 and Y is 113; Xis 86 and Y is 114; X is 86 and Y is 115; X is 86 and Y is 116; X is 86and Y is 117; X is 86 and Y is 118; X is 86 and Y is 119; X is 86 and Yis 120; X is 86 and Y is 121; X is 86 and Y is 122; X is 86 and Y is123; X is 86 and Y is 124; X is 86 and Y is 125; X is 86 and Y is 126; Xis 86 and Y is 127; X is 86 and Y is 128; X is 86 and Y is 129; X is 86and Y is 130; X is 86 and Y is 131; X is 86 and Y is 132; X is 86 and Yis 133; X is 86 and Y is 134; X is 86 and Y is 135; X is 86 and Y is136; X is 86 and Y is 137; X is 86 and Y is 138; X is 86 and Y is 139; Xis 86 and Y is 140; X is 86 and Y is 141; X is 86 and Y is 142; X is 86and Y is 143; X is 86 and Y is 144; X is 86 and Y is 145; X is 86 and Yis 146; X is 86 and Y is 147; X is 86 and Y is 148; X is 86 and Y is149; X is 86 and Y is 150; X is 86 and Y is 151; X is 86 and Y is 152; Xis 86 and Y is 153; X is 86 and Y is 154; X is 86 and Y is 155; X is 86and Y is 156; X is 86 and Y is 157; X is 86 and Y is 158; X is 86 and Yis 159; X is 86 and Y is 160; X is 86 and Y is 161; X is 86 and Y is162; X is 86 and Y is 163; X is 86 and Y is 164; X is 86 and Y is 165; Xis 86 and Y is 166; X is 86 and Y is 167; X is 86 and Y is 168; X is 86and Y is 169; X is 86 and Y is 170; X is 86 and Y is 171; X is 86 and Yis 172; X is 86 and Y is 173; X is 86 and Y is 174; X is 86 and Y is175; X is 86 and Y is 176; X is 86 and Y is 177; X is 86 and Y is 178; Xis 86 and Y is 179; X is 86 and Y is 180; X is 86 and Y is 181; X is 86and Y is 182; X is 86 and Y is 183; X is 86 and Y is 184; X is 86 and Yis 185; X is 86 and Y is 186;X is 87 and Y is 1; X is 87 and Y is 2; X is 87 and Y is 3; X is 87 andY is 4; X is 87 and Y is 5; X is 87 and Y is 6; X is 87 and Y is 7; X is87 and Y is 8; X is 87 and Y is 9; X is 87 and Y is 10; X is 87 and Y is11; X is 87 and Y is 12; X is 87 and Y is 13; X is 87 and Y is 14; X is87 and Y is 15; X is 87 and Y is 16; X is 87 and Y is 17; X is 87 and Yis 18; X is 87 and Y is 19; X is 87 and Y is 20; X is 87 and Y is 21; Xis 87 and Y is 22; X is 87 and Y is 23; X is 87 and Y is 24; X is 87 andY is 25; X is 87 and Y is 26; X is 87 and Y is 27; X is 87 and Y is 28;X is 87 and Y is 29; X is 87 and Y is 30; X is 87 and Y is 31; X is 87and Y is 32; X is 87 and Y is 33; X is 87 and Y is 34; X is 87 and Y is35; X is 87 and Y is 36; X is 87 and Y is 37; X is 87 and Y is 38; X is87 and Y is 39; X is 87 and Y is 40; X is 87 and Y is 41; X is 87 and Yis 42; X is 87 and Y is 43; X is 87 and Y is 44; X is 87 and Y is 45; Xis 87 and Y is 46; X is 87 and Y is 47; X is 87 and Y is 48; X is 87 andY is 49; X is 87 and Y is 50; X is 87 and Y is 51; X is 87 and Y is 52;X is 87 and Y is 53; X is 87 and Y is 54; X is 87 and Y is 55; X is 87and Y is 56; X is 87 and Y is 57; X is 87 and Y is 58; X is 87 and Y is59; X is 87 and Y is 60; X is 87 and Y is 61; X is 87 and Y is 62; X is87 and Y is 63; X is 87 and Y is 64; X is 87 and Y is 65; X is 87 and Yis 66; X is 87 and Y is 67; X is 87 and Y is 68; X is 87 and Y is 69; Xis 87 and Y is 70; X is 87 and Y is 71; X is 87 and Y is 72; X is 87 andY is 73; X is 87 and Y is 74; X is 87 and Y is 75; X is 87 and Y is 76;X is 87 and Y is 77; X is 87 and Y is 78; X is 87 and Y is 79; X is 87and Y is 80; X is 87 and Y is 81; X is 87 and Y is 82; X is 87 and Y is83; X is 87 and Y is 84; X is 87 and Y is 85; X is 87 and Y is 86; X is87 and Y is 87; X is 87 and Y is 88; X is 87 and Y is 89; X is 87 and Yis 90; X is 87 and Y is 91; X is 87 and Y is 92; X is 87 and Y is 93; Xis 87 and Y is 94; X is 87 and Y is 95; X is 87 and Y is 96; X is 87 andY is 97; X is 87 and Y is 98; X is 87 and Y is 99; X is 87 and Y is 100;X is 87 and Y is 101; X is 87 and Y is 102; X is 87 and Y is 103; X is87 and Y is 104; X is 87 and Y is 105; X is 87 and Y is 106; X is 87 andY is 107; X is 87 and Y is 108; X is 87 and Y is 109; X is 87 and Y is110; X is 87 and Y is 111; X is 87 and Y is 112; X is 87 and Y is 113; Xis 87 and Y is 114; X is 87 and Y is 115; X is 87 and Y is 116; X is 87and Y is 117; X is 87 and Y is 118; X is 87 and Y is 119; X is 87 and Yis 120; X is 87 and Y is 121; X is 87 and Y is 122; X is 87 and Y is123; X is 87 and Y is 124; X is 87 and Y is 125; X is 87 and Y is 126; Xis 87 and Y is 127; X is 87 and Y is 128; X is 87 and Y is 129; X is 87and Y is 130; X is 87 and Y is 131; X is 87 and Y is 132; X is 87 and Yis 133; X is 87 and Y is 134; X is 87 and Y is 135; X is 87 and Y is136; X is 87 and Y is 137; X is 87 and Y is 138; X is 87 and Y is 139; Xis 87 and Y is 140; X is 87 and Y is 141; X is 87 and Y is 142; X is 87and Y is 143; X is 87 and Y is 144; X is 87 and Y is 145; X is 87 and Yis 146; X is 87 and Y is 147; X is 87 and Y is 148; X is 87 and Y is149; X is 87 and Y is 150; X is 87 and Y is 151; X is 87 and Y is 152; Xis 87 and Y is 153; X is 87 and Y is 154; X is 87 and Y is 155; X is 87and Y is 156; X is 87 and Y is 157; X is 87 and Y is 158; X is 87 and Yis 159; X is 87 and Y is 160; X is 87 and Y is 161; X is 87 and Y is162; X is 87 and Y is 163; X is 87 and Y is 164; X is 87 and Y is 165; Xis 87 and Y is 166; X is 87 and Y is 167; X is 87 and Y is 168; X is 87and Y is 169; X is 87 and Y is 170; X is 87 and Y is 171; X is 87 and Yis 172; X is 87 and Y is 173; X is 87 and Y is 174; X is 87 and Y is175; X is 87 and Y is 176; X is 87 and Y is 177; X is 87 and Y is 178; Xis 87 and Y is 179; X is 87 and Y is 180; X is 87 and Y is 181; X is 87and Y is 182; X is 87 and Y is 183; X is 87 and Y is 184; X is 87 and Yis 185; X is 87 and Y is 186;X is 88 and Y is 1; X is 88 and Y is 2; X is 88 and Y is 3; X is 88 andY is 4; X is 88 and Y is 5; X is 88 and Y is 6; X is 88 and Y is 7; X is88 and Y is 8; X is 88 and Y is 9; X is 88 and Y is 10; X is 88 and Y is11; X is 88 and Y is 12; X is 88 and Y is 13; X is 88 and Y is 14; X is88 and Y is 15; X is 88 and Y is 16; X is 88 and Y is 17; X is 88 and Yis 18; X is 88 and Y is 19; X is 88 and Y is 20; X is 88 and Y is 21; Xis 88 and Y is 22; X is 88 and Y is 23; X is 88 and Y is 24; X is 88 andY is 25; X is 88 and Y is 26; X is 88 and Y is 27; X is 88 and Y is 28;X is 88 and Y is 29; X is 88 and Y is 30; X is 88 and Y is 31; X is 88and Y is 32; X is 88 and Y is 33; X is 88 and Y is 34; X is 88 and Y is35; X is 88 and Y is 36; X is 88 and Y is 37; X is 88 and Y is 38; X is88 and Y is 39; X is 88 and Y is 40; X is 88 and Y is 41; X is 88 and Yis 42; X is 88 and Y is 43; X is 88 and Y is 44; X is 88 and Y is 45; Xis 88 and Y is 46; X is 88 and Y is 47; X is 88 and Y is 48; X is 88 andY is 49; X is 88 and Y is 50; X is 88 and Y is 51; X is 88 and Y is 52;X is 88 and Y is 53; X is 88 and Y is 54; X is 88 and Y is 55; X is 88and Y is 56; X is 88 and Y is 57; X is 88 and Y is 58; X is 88 and Y is59; X is 88 and Y is 60; X is 88 and Y is 61; X is 88 and Y is 62; X is88 and Y is 63; X is 88 and Y is 64; X is 88 and Y is 65; X is 88 and Yis 66; X is 88 and Y is 67; X is 88 and Y is 68; X is 88 and Y is 69; Xis 88 and Y is 70; X is 88 and Y is 71; X is 88 and Y is 72; X is 88 andY is 73; X is 88 and Y is 74; X is 88 and Y is 75; X is 88 and Y is 76;X is 88 and Y is 77; X is 88 and Y is 78; X is 88 and Y is 79; X is 88and Y is 80; X is 88 and Y is 81; X is 88 and Y is 82; X is 88 and Y is83; X is 88 and Y is 84; X is 88 and Y is 85; X is 88 and Y is 86; X is88 and Y is 87; X is 88 and Y is 88; X is 88 and Y is 89; X is 88 and Yis 90; X is 88 and Y is 91; X is 88 and Y is 92; X is 88 and Y is 93; Xis 88 and Y is 94; X is 88 and Y is 95; X is 88 and Y is 96; X is 88 andY is 97; X is 88 and Y is 98; X is 88 and Y is 99; X is 88 and Y is 100;X is 88 and Y is 101; X is 88 and Y is 102; X is 88 and Y is 103; X is88 and Y is 104; X is 88 and Y is 105; X is 88 and Y is 106; X is 88 andY is 107; X is 88 and Y is 108; X is 88 and Y is 109; X is 88 and Y is110; X is 88 and Y is 111; X is 88 and Y is 112; X is 88 and Y is 113; Xis 88 and Y is 114; X is 88 and Y is 115; X is 88 and Y is 116; X is 88and Y is 117; X is 88 and Y is 118; X is 88 and Y is 119; X is 88 and Yis 120; X is 88 and Y is 121; X is 88 and Y is 122; X is 88 and Y is123; X is 88 and Y is 124; X is 88 and Y is 125; X is 88 and Y is 126; Xis 88 and Y is 127; X is 88 and Y is 128; X is 88 and Y is 129; X is 88and Y is 130; X is 88 and Y is 131; X is 88 and Y is 132; X is 88 and Yis 133; X is 88 and Y is 134; X is 88 and Y is 135; X is 88 and Y is136; X is 88 and Y is 137; X is 88 and Y is 138; X is 88 and Y is 139; Xis 88 and Y is 140; X is 88 and Y is 141; X is 88 and Y is 142; X is 88and Y is 143; X is 88 and Y is 144; X is 88 and Y is 145; X is 88 and Yis 146; X is 88 and Y is 147; X is 88 and Y is 148; X is 88 and Y is149; X is 88 and Y is 150; X is 88 and Y is 151; X is 88 and Y is 152; Xis 88 and Y is 153; X is 88 and Y is 154; X is 88 and Y is 155; X is 88and Y is 156; X is 88 and Y is 157; X is 88 and Y is 158; X is 88 and Yis 159; X is 88 and Y is 160; X is 88 and Y is 161; X is 88 and Y is162; X is 88 and Y is 163; X is 88 and Y is 164; X is 88 and Y is 165; Xis 88 and Y is 166; X is 88 and Y is 167; X is 88 and Y is 168; X is 88and Y is 169; X is 88 and Y is 170; X is 88 and Y is 171; X is 88 and Yis 172; X is 88 and Y is 173; X is 88 and Y is 174; X is 88 and Y is175; X is 88 and Y is 176; X is 88 and Y is 177; X is 88 and Y is 178; Xis 88 and Y is 179; X is 88 and Y is 180; X is 88 and Y is 181; X is 88and Y is 182; X is 88 and Y is 183; X is 88 and Y is 184; X is 88 and Yis 185; X is 88 and Y is 186;X is 89 and Y is 1; X is 89 and Y is 2; X is 89 and Y is 3; X is 89 andY is 4; X is 89 and Y is 5; X is 89 and Y is 6; X is 89 and Y is 7; X is89 and Y is 8; X is 89 and Y is 9; X is 89 and Y is 10; X is 89 and Y is11; X is 89 and Y is 12; X is 89 and Y is 13; X is 89 and Y is 14; X is89 and Y is 15; X is 89 and Y is 16; X is 89 and Y is 17; X is 89 and Yis 18; X is 89 and Y is 19; X is 89 and Y is 20; X is 89 and Y is 21; Xis 89 and Y is 22; X is 89 and Y is 23; X is 89 and Y is 24; X is 89 andY is 25; X is 89 and Y is 26; X is 89 and Y is 27; X is 89 and Y is 28;X is 89 and Y is 29; X is 89 and Y is 30; X is 89 and Y is 31; X is 89and Y is 32; X is 89 and Y is 33; X is 89 and Y is 34; X is 89 and Y is35; X is 89 and Y is 36; X is 89 and Y is 37; X is 89 and Y is 38; X is89 and Y is 39; X is 89 and Y is 40; X is 89 and Y is 41; X is 89 and Yis 42; X is 89 and Y is 43; X is 89 and Y is 44; X is 89 and Y is 45; Xis 89 and Y is 46; X is 89 and Y is 47; X is 89 and Y is 48; X is 89 andY is 49; X is 89 and Y is 50; X is 89 and Y is 51; X is 89 and Y is 52;X is 89 and Y is 53; X is 89 and Y is 54; X is 89 and Y is 55; X is 89and Y is 56; X is 89 and Y is 57; X is 89 and Y is 58; X is 89 and Y is59; X is 89 and Y is 60; X is 89 and Y is 61; X is 89 and Y is 62; X is89 and Y is 63; X is 89 and Y is 64; X is 89 and Y is 65; X is 89 and Yis 66; X is 89 and Y is 67; X is 89 and Y is 68; X is 89 and Y is 69; Xis 89 and Y is 70; X is 89 and Y is 71; X is 89 and Y is 72; X is 89 andY is 73; X is 89 and Y is 74; X is 89 and Y is 75; X is 89 and Y is 76;X is 89 and Y is 77; X is 89 and Y is 78; X is 89 and Y is 79; X is 89and Y is 80; X is 89 and Y is 81; X is 89 and Y is 82; X is 89 and Y is83; X is 89 and Y is 84; X is 89 and Y is 85; X is 89 and Y is 86; X is89 and Y is 87; X is 89 and Y is 88; X is 89 and Y is 89; X is 89 and Yis 90; X is 89 and Y is 91; X is 89 and Y is 92; X is 89 and Y is 93; Xis 89 and Y is 94; X is 89 and Y is 95; X is 89 and Y is 96; X is 89 andY is 97; X is 89 and Y is 98; X is 89 and Y is 99; X is 89 and Y is 100;X is 89 and Y is 101; X is 89 and Y is 102; X is 89 and Y is 103; X is89 and Y is 104; X is 89 and Y is 105; X is 89 and Y is 106; X is 89 andY is 107; X is 89 and Y is 108; X is 89 and Y is 109; X is 89 and Y is110; X is 89 and Y is 111; X is 89 and Y is 112; X is 89 and Y is 113; Xis 89 and Y is 114; X is 89 and Y is 115; X is 89 and Y is 116; X is 89and Y is 117; X is 89 and Y is 118; X is 89 and Y is 119; X is 89 and Yis 120; X is 89 and Y is 121; X is 89 and Y is 122; X is 89 and Y is123; X is 89 and Y is 124; X is 89 and Y is 125; X is 89 and Y is 126; Xis 89 and Y is 127; X is 89 and Y is 128; X is 89 and Y is 129; X is 89and Y is 130; X is 89 and Y is 131; X is 89 and Y is 132; X is 89 and Yis 133; X is 89 and Y is 134; X is 89 and Y is 135; X is 89 and Y is136; X is 89 and Y is 137; X is 89 and Y is 138; X is 89 and Y is 139; Xis 89 and Y is 140; X is 89 and Y is 141; X is 89 and Y is 142; X is 89and Y is 143; X is 89 and Y is 144; X is 89 and Y is 145; X is 89 and Yis 146; X is 89 and Y is 147; X is 89 and Y is 148; X is 89 and Y is149; X is 89 and Y is 150; X is 89 and Y is 151; X is 89 and Y is 152; Xis 89 and Y is 153; X is 89 and Y is 154; X is 89 and Y is 155; X is 89and Y is 156; X is 89 and Y is 157; X is 89 and Y is 158; X is 89 and Yis 159; X is 89 and Y is 160; X is 89 and Y is 161; X is 89 and Y is162; X is 89 and Y is 163; X is 89 and Y is 164; X is 89 and Y is 165; Xis 89 and Y is 166; X is 89 and Y is 167; X is 89 and Y is 168; X is 89and Y is 169; X is 89 and Y is 170; X is 89 and Y is 171; X is 89 and Yis 172; X is 89 and Y is 173; X is 89 and Y is 174; X is 89 and Y is175; X is 89 and Y is 176; X is 89 and Y is 177; X is 89 and Y is 178; Xis 89 and Y is 179; X is 89 and Y is 180; X is 89 and Y is 181; X is 89and Y is 182; X is 89 and Y is 183; X is 89 and Y is 184; X is 89 and Yis 185; X is 89 and Y is 186;X is 90 and Y is 1; X is 90 and Y is 2; X is 90 and Y is 3; X is 90 andY is 4; X is 90 and Y is 5; X is 90 and Y is 6; X is 90 and Y is 7; X is90 and Y is 8; X is 90 and Y is 9; X is 90 and Y is 10; X is 90 and Y is11; X is 90 and Y is 12; X is 90 and Y is 13; X is 90 and Y is 14; X is90 and Y is 15; X is 90 and Y is 16; X is 90 and Y is 17; X is 90 and Yis 18; X is 90 and Y is 19; X is 90 and Y is 20; X is 90 and Y is 21; Xis 90 and Y is 22; X is 90 and Y is 23; X is 90 and Y is 24; X is 90 andY is 25; X is 90 and Y is 26; X is 90 and Y is 27; X is 90 and Y is 28;X is 90 and Y is 29; X is 90 and Y is 30; X is 90 and Y is 31; X is 90and Y is 32; X is 90 and Y is 33; X is 90 and Y is 34; X is 90 and Y is35; X is 90 and Y is 36; X is 90 and Y is 37; X is 90 and Y is 38; X is90 and Y is 39; X is 90 and Y is 40; X is 90 and Y is 41; X is 90 and Yis 42; X is 90 and Y is 43; X is 90 and Y is 44; X is 90 and Y is 45; Xis 90 and Y is 46; X is 90 and Y is 47; X is 90 and Y is 48; X is 90 andY is 49; X is 90 and Y is 50; X is 90 and Y is 51; X is 90 and Y is 52;X is 90 and Y is 53; X is 90 and Y is 54; X is 90 and Y is 55; X is 90and Y is 56; X is 90 and Y is 57; X is 90 and Y is 58; X is 90 and Y is59; X is 90 and Y is 60; X is 90 and Y is 61; X is 90 and Y is 62; X is90 and Y is 63; X is 90 and Y is 64; X is 90 and Y is 65; X is 90 and Yis 66; X is 90 and Y is 67; X is 90 and Y is 68; X is 90 and Y is 69; Xis 90 and Y is 70; X is 90 and Y is 71; X is 90 and Y is 72; X is 90 andY is 73; X is 90 and Y is 74; X is 90 and Y is 75; X is 90 and Y is 76;X is 90 and Y is 77; X is 90 and Y is 78; X is 90 and Y is 79; X is 90and Y is 80; X is 90 and Y is 81; X is 90 and Y is 82; X is 90 and Y is83; X is 90 and Y is 84; X is 90 and Y is 85; X is 90 and Y is 86; X is90 and Y is 87; X is 90 and Y is 88; X is 90 and Y is 89; X is 90 and Yis 90; X is 90 and Y is 91; X is 90 and Y is 92; X is 90 and Y is 93; Xis 90 and Y is 94; X is 90 and Y is 95; X is 90 and Y is 96; X is 90 andY is 97; X is 90 and Y is 98; X is 90 and Y is 99; X is 90 and Y is 100;X is 90 and Y is 101; X is 90 and Y is 102; X is 90 and Y is 103; X is90 and Y is 104; X is 90 and Y is 105; X is 90 and Y is 106; X is 90 andY is 107; X is 90 and Y is 108; X is 90 and Y is 109; X is 90 and Y is110; X is 90 and Y is 111; X is 90 and Y is 112; X is 90 and Y is 113; Xis 90 and Y is 114; X is 90 and Y is 115; X is 90 and Y is 116; X is 90and Y is 117; X is 90 and Y is 118; X is 90 and Y is 119; X is 90 and Yis 120; X is 90 and Y is 121; X is 90 and Y is 122; X is 90 and Y is123; X is 90 and Y is 124; X is 90 and Y is 125; X is 90 and Y is 126; Xis 90 and Y is 127; X is 90 and Y is 128; X is 90 and Y is 129; X is 90and Y is 130; X is 90 and Y is 131; X is 90 and Y is 132; X is 90 and Yis 133; X is 90 and Y is 134; X is 90 and Y is 135; X is 90 and Y is136; X is 90 and Y is 137; X is 90 and Y is 138; X is 90 and Y is 139; Xis 90 and Y is 140; X is 90 and Y is 141; X is 90 and Y is 142; X is 90and Y is 143; X is 90 and Y is 144; X is 90 and Y is 145; X is 90 and Yis 146; X is 90 and Y is 147; X is 90 and Y is 148; X is 90 and Y is149; X is 90 and Y is 150; X is 90 and Y is 151; X is 90 and Y is 152; Xis 90 and Y is 153; X is 90 and Y is 154; X is 90 and Y is 155; X is 90and Y is 156; X is 90 and Y is 157; X is 90 and Y is 158; X is 90 and Yis 159; X is 90 and Y is 160; X is 90 and Y is 161; X is 90 and Y is162; X is 90 and Y is 163; X is 90 and Y is 164; X is 90 and Y is 165; Xis 90 and Y is 166; X is 90 and Y is 167; X is 90 and Y is 168; X is 90and Y is 169; X is 90 and Y is 170; X is 90 and Y is 171; X is 90 and Yis 172; X is 90 and Y is 173; X is 90 and Y is 174; X is 90 and Y is175; X is 90 and Y is 176; X is 90 and Y is 177; X is 90 and Y is 178; Xis 90 and Y is 179; X is 90 and Y is 180; X is 90 and Y is 181; X is 90and Y is 182; X is 90 and Y is 183; X is 90 and Y is 184; X is 90 and Yis 185; X is 90 and Y is 186;X is 91 and Y is 1; X is 91 and Y is 2; X is 91 and Y is 3; X is 91 andY is 4; X is 91 and Y is 5; X is 91 and Y is 6; X is 91 and Y is 7; X is91 and Y is 8; X is 91 and Y is 9; X is 91 and Y is 10; X is 91 and Y is11; X is 91 and Y is 12; X is 91 and Y is 13; X is 91 and Y is 14; X is91 and Y is 15; X is 91 and Y is 16; X is 91 and Y is 17; X is 91 and Yis 18; X is 91 and Y is 19; X is 91 and Y is 20; X is 91 and Y is 21; Xis 91 and Y is 22; X is 91 and Y is 23; X is 91 and Y is 24; X is 91 andY is 25; X is 91 and Y is 26; X is 91 and Y is 27; X is 91 and Y is 28;X is 91 and Y is 29; X is 91 and Y is 30; X is 91 and Y is 31; X is 91and Y is 32; X is 91 and Y is 33; X is 91 and Y is 34; X is 91 and Y is35; X is 91 and Y is 36; X is 91 and Y is 37; X is 91 and Y is 38; X is91 and Y is 39; X is 91 and Y is 40; X is 91 and Y is 41; X is 91 and Yis 42; X is 91 and Y is 43; X is 91 and Y is 44; X is 91 and Y is 45; Xis 91 and Y is 46; X is 91 and Y is 47; X is 91 and Y is 48; X is 91 andY is 49; X is 91 and Y is 50; X is 91 and Y is 51; X is 91 and Y is 52;X is 91 and Y is 53; X is 91 and Y is 54; X is 91 and Y is 55; X is 91and Y is 56; X is 91 and Y is 57; X is 91 and Y is 58; X is 91 and Y is59; X is 91 and Y is 60; X is 91 and Y is 61; X is 91 and Y is 62; X is91 and Y is 63; X is 91 and Y is 64; X is 91 and Y is 65; X is 91 and Yis 66; X is 91 and Y is 67; X is 91 and Y is 68; X is 91 and Y is 69; Xis 91 and Y is 70; X is 91 and Y is 71; X is 91 and Y is 72; X is 91 andY is 73; X is 91 and Y is 74; X is 91 and Y is 75; X is 91 and Y is 76;X is 91 and Y is 77; X is 91 and Y is 78; X is 91 and Y is 79; X is 91and Y is 80; X is 91 and Y is 81; X is 91 and Y is 82; X is 91 and Y is83; X is 91 and Y is 84; X is 91 and Y is 85; X is 91 and Y is 86; X is91 and Y is 87; X is 91 and Y is 88; X is 91 and Y is 89; X is 91 and Yis 90; X is 91 and Y is 91; X is 91 and Y is 92; X is 91 and Y is 93; Xis 91 and Y is 94; X is 91 and Y is 95; X is 91 and Y is 96; X is 91 andY is 97; X is 91 and Y is 98; X is 91 and Y is 99; X is 91 and Y is 100;X is 91 and Y is 101; X is 91 and Y is 102; X is 91 and Y is 103; X is91 and Y is 104; X is 91 and Y is 105; X is 91 and Y is 106; X is 91 andY is 107; X is 91 and Y is 108; X is 91 and Y is 109; X is 91 and Y is110; X is 91 and Y is 111; X is 91 and Y is 112; X is 91 and Y is 113; Xis 91 and Y is 114; X is 91 and Y is 115; X is 91 and Y is 116; X is 91and Y is 117; X is 91 and Y is 118; X is 91 and Y is 119; X is 91 and Yis 120; X is 91 and Y is 121; X is 91 and Y is 122; X is 91 and Y is123; X is 91 and Y is 124; X is 91 and Y is 125; X is 91 and Y is 126; Xis 91 and Y is 127; X is 91 and Y is 128; X is 91 and Y is 129; X is 91and Y is 130; X is 91 and Y is 131; X is 91 and Y is 132; X is 91 and Yis 133; X is 91 and Y is 134; X is 91 and Y is 135; X is 91 and Y is136; X is 91 and Y is 137; X is 91 and Y is 138; X is 91 and Y is 139; Xis 91 and Y is 140; X is 91 and Y is 141; X is 91 and Y is 142; X is 91and Y is 143; X is 91 and Y is 144; X is 91 and Y is 145; X is 91 and Yis 146; X is 91 and Y is 147; X is 91 and Y is 148; X is 91 and Y is149; X is 91 and Y is 150; X is 91 and Y is 151; X is 91 and Y is 152; Xis 91 and Y is 153; X is 91 and Y is 154; X is 91 and Y is 155; X is 91and Y is 156; X is 91 and Y is 157; X is 91 and Y is 158; X is 91 and Yis 159; X is 91 and Y is 160; X is 91 and Y is 161; X is 91 and Y is162; X is 91 and Y is 163; X is 91 and Y is 164; X is 91 and Y is 165; Xis 91 and Y is 166; X is 91 and Y is 167; X is 91 and Y is 168; X is 91and Y is 169; X is 91 and Y is 170; X is 91 and Y is 171; X is 91 and Yis 172; X is 91 and Y is 173; X is 91 and Y is 174; X is 91 and Y is175; X is 91 and Y is 176; X is 91 and Y is 177; X is 91 and Y is 178; Xis 91 and Y is 179; X is 91 and Y is 180; X is 91 and Y is 181; X is 91and Y is 182; X is 91 and Y is 183; X is 91 and Y is 184; X is 91 and Yis 185; X is 91 and Y is 186;X is 92 and Y is 1; X is 92 and Y is 2; X is 92 and Y is 3; X is 92 andY is 4; X is 92 and Y is 5; X is 92 and Y is 6; X is 92 and Y is 7; X is92 and Y is 8; X is 92 and Y is 9; X is 92 and Y is 10; X is 92 and Y is11; X is 92 and Y is 12; X is 92 and Y is 13; X is 92 and Y is 14; X is92 and Y is 15; X is 92 and Y is 16; X is 92 and Y is 17; X is 92 and Yis 18; X is 92 and Y is 19; X is 92 and Y is 20; X is 92 and Y is 21; Xis 92 and Y is 22; X is 92 and Y is 23; X is 92 and Y is 24; X is 92 andY is 25; X is 92 and Y is 26; X is 92 and Y is 27; X is 92 and Y is 28;X is 92 and Y is 29; X is 92 and Y is 30; X is 92 and Y is 31; X is 92and Y is 32; X is 92 and Y is 33; X is 92 and Y is 34; X is 92 and Y is35; X is 92 and Y is 36; X is 92 and Y is 37; X is 92 and Y is 38; X is92 and Y is 39; X is 92 and Y is 40; X is 92 and Y is 41; X is 92 and Yis 42; X is 92 and Y is 43; X is 92 and Y is 44; X is 92 and Y is 45; Xis 92 and Y is 46; X is 92 and Y is 47; X is 92 and Y is 48; X is 92 andY is 49; X is 92 and Y is 50; X is 92 and Y is 51; X is 92 and Y is 52;X is 92 and Y is 53; X is 92 and Y is 54; X is 92 and Y is 55; X is 92and Y is 56; X is 92 and Y is 57; X is 92 and Y is 58; X is 92 and Y is59; X is 92 and Y is 60; X is 92 and Y is 61; X is 92 and Y is 62; X is92 and Y is 63; X is 92 and Y is 64; X is 92 and Y is 65; X is 92 and Yis 66; X is 92 and Y is 67; X is 92 and Y is 68; X is 92 and Y is 69; Xis 92 and Y is 70; X is 92 and Y is 71; X is 92 and Y is 72; X is 92 andY is 73; X is 92 and Y is 74; X is 92 and Y is 75; X is 92 and Y is 76;X is 92 and Y is 77; X is 92 and Y is 78; X is 92 and Y is 79; X is 92and Y is 80; X is 92 and Y is 81; X is 92 and Y is 82; X is 92 and Y is83; X is 92 and Y is 84; X is 92 and Y is 85; X is 92 and Y is 86; X is92 and Y is 87; X is 92 and Y is 88; X is 92 and Y is 89; X is 92 and Yis 90; X is 92 and Y is 91; X is 92 and Y is 92; X is 92 and Y is 93; Xis 92 and Y is 94; X is 92 and Y is 95; X is 92 and Y is 96; X is 92 andY is 97; X is 92 and Y is 98; X is 92 and Y is 99; X is 92 and Y is 100;X is 92 and Y is 101; X is 92 and Y is 102; X is 92 and Y is 103; X is92 and Y is 104; X is 92 and Y is 105; X is 92 and Y is 106; X is 92 andY is 107; X is 92 and Y is 108; X is 92 and Y is 109; X is 92 and Y is110; X is 92 and Y is 111; X is 92 and Y is 112; X is 92 and Y is 113; Xis 92 and Y is 114; X is 92 and Y is 115; X is 92 and Y is 116; X is 92and Y is 117; X is 92 and Y is 118; X is 92 and Y is 119; X is 92 and Yis 120; X is 92 and Y is 121; X is 92 and Y is 122; X is 92 and Y is123; X is 92 and Y is 124; X is 92 and Y is 125; X is 92 and Y is 126; Xis 92 and Y is 127; X is 92 and Y is 128; X is 92 and Y is 129; X is 92and Y is 130; X is 92 and Y is 131; X is 92 and Y is 132; X is 92 and Yis 133; X is 92 and Y is 134; X is 92 and Y is 135; X is 92 and Y is136; X is 92 and Y is 137; X is 92 and Y is 138; X is 92 and Y is 139; Xis 92 and Y is 140; X is 92 and Y is 141; X is 92 and Y is 142; X is 92and Y is 143; X is 92 and Y is 144; X is 92 and Y is 145; X is 92 and Yis 146; X is 92 and Y is 147; X is 92 and Y is 148; X is 92 and Y is149; X is 92 and Y is 150; X is 92 and Y is 151; X is 92 and Y is 152; Xis 92 and Y is 153; X is 92 and Y is 154; X is 92 and Y is 155; X is 92and Y is 156; X is 92 and Y is 157; X is 92 and Y is 158; X is 92 and Yis 159; X is 92 and Y is 160; X is 92 and Y is 161; X is 92 and Y is162; X is 92 and Y is 163; X is 92 and Y is 164; X is 92 and Y is 165; Xis 92 and Y is 166; X is 92 and Y is 167; X is 92 and Y is 168; X is 92and Y is 169; X is 92 and Y is 170; X is 92 and Y is 171; X is 92 and Yis 172; X is 92 and Y is 173; X is 92 and Y is 174; X is 92 and Y is175; X is 92 and Y is 176; X is 92 and Y is 177; X is 92 and Y is 178; Xis 92 and Y is 179; X is 92 and Y is 180; X is 92 and Y is 181; X is 92and Y is 182; X is 92 and Y is 183; X is 92 and Y is 184; X is 92 and Yis 185; or X is 92 and Y is 186.

In one embodiment, X is 3 and Y is 5.

The term “one or more CDRs”, as used in connection with the aboveembodiments, refers to one of the CDRs HCDR1, HCDR2, HCDR3, LCDR1, LCDR2and LCDR3 (e.g., HCDR3), or several (i.e., 2, 3, 4, 5 or 6) of the CDRs,such as a set of HCDR1, HCDR2 and HCDR3 or a set of LCDR1, LCDR2 andLCDR3. In a preferred embodiment, the term “one or more CDRs” refers toall six CDRs, i.e., HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 and LCDR3.

The term “one or more variable domains”, as used in connection with theabove embodiments, preferably refers to one of the VH domain and the VLdomain or, more preferably, to both the VH domain and the VL domain.

The term “nucleic acid molecule”, as used herein, is intended to includeDNA and RNA, such as genomic DNA, cDNA, mRNA, recombinantly produced andchemically synthesized molecules.

A nucleic acid molecule may be single-stranded or double-stranded. RNAincludes in vitro transcribed RNA (IVT RNA) or synthetic RNA.

In the context of the present invention, the term “DNA” relates to amolecule which comprises deoxyribonucleotide residues and preferably isentirely or substantially composed of deoxyribonucleotide residues.“Deoxyribonucleotide” relates to a nucleotide which lacks a hydroxylgroup at the 2′-position of a β-D-ribofuranosyl group. The term “DNA”comprises isolated DNA such as partially or completely purified DNA,essentially pure DNA, synthetic DNA, and recombinantly generated DNA andincludes modified DNA which differs from naturally occurring DNA byaddition, deletion, substitution and/or alteration of one or morenucleotides. Such alterations can include addition of non-nucleotidematerial, such as to the end(s) of a DNA or internally, for example atone or more nucleotides of the DNA. Nucleotides in DNA molecules canalso comprise non-standard nucleotides, such as non-naturally occurringnucleotides or chemically synthesized nucleotides. These altered DNAscan be referred to as analogs or analogs of naturally-occurring DNA.

In the context of the present invention, the term “RNA” relates to amolecule which comprises ribonucleotide residues and preferably beingentirely or substantially composed of ribonucleotide residues.“Ribonucleotide” relates to a nucleotide with a hydroxyl group at the2′-position of a β-D-ribofuranosyl group. The term includes doublestranded RNA, single stranded RNA, isolated RNA such as partiallypurified RNA, essentially pure RNA, synthetic RNA, recombinantlyproduced RNA, as well as modified RNA that differs from naturallyoccurring RNA by the addition, deletion, substitution and/or alterationof one or more nucleotides. Such alterations can include addition ofnon-nucleotide material, such as to the end(s) of a RNA or internally,for example at one or more nucleotides of the RNA. Nucleotides in RNAmolecules can also comprise non-standard nucleotides, such asnon-naturally occurring nucleotides or chemically synthesizednucleotides or deoxynucleotides. These altered RNAs can be referred toas analogs or analogs of naturally-occurring RNA. According to thepresent invention, the term “RNA” includes and preferably relates to“mRNA” which means “messenger RNA” and relates to a transcript which maybe produced using DNA as template and encodes a peptide or protein. mRNAtypically comprises a 5′ non translated region (5′-UTR), a protein orpeptide coding region and a 3′ non translated region (3′-UTR). mRNA hasa limited halftime in cells and in vitro. Preferably, mRNA is producedby in vitro transcription using a DNA template. In one embodiment of theinvention, the RNA is obtained by in vitro transcription or chemicalsynthesis. The in vitro transcription methodology is known to theskilled person. For example, there is a variety of in vitrotranscription kits commercially available.

The nucleic acid molecule according to the present invention may becontained/comprised in a vector. The term “vector”, as used herein,includes any vectors known to the skilled person, including plasmidvectors, cosmid vectors, phage vectors, such as lambda phage, viralvectors, such as adenoviral or baculoviral vectors, or artificialchromosome vectors such as bacterial artificial chromosomes (BAC), yeastartificial chromosomes (YAC), or P1 artificial chromosomes (PAC). Saidvectors include expression as well as cloning vectors. Expressionvectors comprise plasmids as well as viral vectors and generally containa desired coding sequence and appropriate DNA sequences necessary forthe expression of the operably linked coding sequence in a particularhost organism (e.g., bacteria, yeast, plant, insect, or mammal) or in invitro expression systems. Cloning vectors are generally used to engineerand amplify a certain desired DNA fragment and may lack functionalsequences needed for expression of the desired DNA fragments.

The term “cell” or “host cell” preferably relates to an intact cell,i.e. a cell with an intact membrane that has not released its normalintracellular components such as enzymes, organelles, or geneticmaterial. An intact cell preferably is a viable cell, i.e. a living cellcapable of carrying out its normal metabolic functions. Preferably saidterm relates according to the invention to any cell which can betransfected with an exogenous nucleic acid. Preferably, the cell whentransfected with an exogenous nucleic acid and transferred to arecipient can express the nucleic acid in the recipient. The term “cell”includes bacterial cells; other useful cells are yeast cells, fungalcells or mammalian cells. Suitable bacterial cells include cells fromgram-negative bacterial strains such as strains of Escherichia coli,Proteus, and Pseudomonas, and gram-positive bacterial strains such asstrains of Bacillus, Streptomyces, Staphylococcus, and Lactococcus.Suitable fungal cell include cells from species of Trichoderma,Neurospora, and Aspergillus. Suitable yeast cells include cells fromspecies of Saccharomyces (Tor example Saccharomyces cerevisiae),Schizosaccharomyces (for example Schizosaccharomyces pombe), Pichia (forexample Pichia pastoris and Pichia methanolica), and Hansenula. Suitablemammalian cells include for example CHO cells, BHK cells, HeLa cells,COS cells, 293 HEK and the like. However, amphibian cells, insect cells,plant cells, and any other cells used in the art for the expression ofheterologous proteins can be used as well. Mammalian cells areparticularly preferred for adoptive transfer, such as cells from humans,mice, hamsters, pigs, goats, and primates. The cells may be derived froma large number of tissue types and include primary cells and cell linessuch as cells of the immune system, in particular antigen-presentingcells (APCs), such as dendritic cells, and T cells, stem cells, such ashematopoietic stem cells and mesenchymal stem cells, and other celltypes. An antigen-presenting cell is a cell that displays antigen in thecontext of major histocompatibility complex on its surface. T cells mayrecognize this complex using their T cell receptor (TCR).

The binding agents of the invention can be produced eitherintracellularly (e.g. in the cytosol, in the periplasma or in inclusionbodies) and then isolated from the host cells and optionally furtherpurified; or they can be produced extracellularly (e.g. in the medium inwhich the host cells are cultured) and then isolated from the culturemedium and optionally further purified. Methods and reagents used forthe recombinant production of polypeptides, such as specific suitableexpression vectors, transformation or transfection methods, selectionmarkers, methods of induction of protein expression, culture conditions,and the like, are known in the art. Similarly, protein isolation andpurification techniques are well known to the skilled person.

The binding agents, nucleic acid molecules or cells described herein maybe administered in the form of any suitable pharmaceutical composition.

The pharmaceutical compositions of the invention are preferably sterileand contain an effective amount of the binding agents, nucleic acidmolecules or cells described herein to generate the desired reaction orthe desired effect.

Pharmaceutical compositions are usually provided in a uniform dosageform and may be prepared in a manner known per se. A pharmaceuticalcomposition may, e.g., be in the form of a solution or suspension.

A pharmaceutical composition may further comprise one or more carriersand/or excipients, all of which are preferably pharmaceuticallyacceptable. The term “pharmaceutically acceptable”, as used herein,refers to the non-toxicity of a material which, preferably, does notinteract with the action of the active agent of the pharmaceuticalcomposition.

The term “carrier” refers to an organic or inorganic component, of anatural or synthetic nature, in which the active component is combinedin order to facilitate, enhance or enable application. According to theinvention, the term “carrier” also includes one or more compatible solidor liquid fillers, diluents or encapsulating substances, which aresuitable for administration to a subject.

Possible carrier substances for parenteral administration are, e.g.,sterile water, Ringer, Ringer lactate, sterile sodium chloride solution,polyalkylene glycols, hydrogenated naphthalenes and, in particular,biocompatible lactide polymers, lactide/glycolide copolymers orpolyoxyethylene/polyoxy-propylene copolymers.

The term “excipient”, as used herein, is intended to include allsubstances which may be present in a pharmaceutical composition andwhich are not active ingredients, such as salts, binders, lubricants,thickeners, surface active agents, preservatives, emulsifiers, buffersubstances, flavouring agents, or colorants.

Salts, which are not pharmaceutically acceptable, may be used forpreparing pharmaceutically acceptable salts and are included in theinvention. Pharmaceutically acceptable salts of this kind comprise in anon limiting way those prepared from the following acids: hydrochloric,hydrobromic, sulfuric, nitric, phosphoric, maleic, acetic, salicylic,citric, formic, malonic, succinic acids, and the like. Pharmaceuticallyacceptable salts may also be prepared as alkali metal salts or alkalineearth metal salts, such as sodium salts, potassium salts or calciumsalts.

Suitable preservatives for use in a pharmaceutical composition includebenzalkonium chloride, chlorobutanol, paraben and thimerosal.

Suitable buffer substances for use in a pharmaceutical compositioninclude acetic acid in a salt, citric acid in a salt, boric acid in asalt and phosphoric acid in a salt.

The agents and compositions described herein may be administered via anyconventional route, such as by parenteral administration including byinjection or infusion. Administration is preferably parenterally, e.g.intravenously, intraarterially, subcutaneously, intradermally orintramuscularly.

Pharmaceutical compositions suitable for parenteral administrationusually comprise a sterile aqueous or non-aqueous preparation of theactive compound, which is preferably isotonic to the blood of therecipient. Examples of compatible carriers/solvents/diluents are Ringersolution and isotonic sodium chloride solution. In addition, usuallysterile, fixed oils are used as solution or suspension medium.

The agents and compositions described herein are administered ineffective amounts. An “effective amount” refers to the amount, whichachieves a desired reaction or a desired effect alone or together withfurther doses. In the case of treatment of a particular disease or of aparticular condition, the desired reaction preferably relates toinhibition of the course of the disease. This comprises slowing down theprogress of the disease and, in particular, interrupting or reversingthe progress of the disease. The desired reaction in a treatment of adisease or of a condition may also be delay of the onset or a preventionof the onset of said disease or said condition. An effective amount ofan agent or composition described herein will depend on the condition tobe treated, the severeness of the disease, the individual parameters ofthe patient, including age, physiological condition, size and weight,the duration of treatment, the type of an accompanying therapy (ifpresent), the specific route of administration and similar factors.Accordingly, the doses administered of the agents described herein maydepend on various of such parameters. In the case that a reaction in apatient is insufficient with an initial dose, higher doses (oreffectively higher doses achieved by a different, more localized routeof administration) may be used.

As used herein, the term “kit of parts (in short: kit)” refers to anarticle of manufacture comprising one or more containers and,optionally, a data carrier. Said one or more containers may be filledwith one or more of the above mentioned means or reagents. Additionalcontainers may be included in the kit that contain, e.g., diluents,buffers and further reagents. Said data carrier may be anon-electronical data carrier, e.g., a graphical data carrier such as aninformation leaflet, an information sheet, a bar code or an access code,or an electronical data carrier such as a floppy disk, a compact disk(CD), a digital versatile disk (DVD), a microchip or anothersemiconductor-based electronical data carrier. The access code may allowthe access to a database, e.g., an internet database, a centralized, ora decentralized database. Said data carrier may comprise instructionsfor the use of the binding agent, nucleic acid molecule, cell and/orpharmaceutical composition of the present invention.

The agents and compositions described herein can be administered topatients, e.g., in vivo, to treat or prevent a variety of disorders suchas those described herein.

The term “medicament”, as used herein, refers to a substance/compositionused in therapy, i.e., in the treatment of a disease.

According to the invention, the term “disease” refers to anypathological state, in particular cancer, infectious diseases,inflammatory diseases, metabolic diseases, autoimmune disorders,degenerative diseases, apoptosis-associated diseases and transplantrejections.

As used herein, the term “cancer” includes a disease characterized byaberrantly regulated cellular growth, proliferation, differentiation,adhesion, and/or migration. By “cancer cell” is meant an abnormal cellthat grows by a rapid, uncontrolled cellular proliferation and continuesto grow after the stimuli that initiated the new growth cease. The term“cancer” according to the invention comprises leukemias, seminomas,melanomas, teratomas, lymphomas, neuroblastomas, gliomas, rectal cancer,endometrial cancer, kidney cancer, adrenal cancer, thyroid cancer, bloodcancer, skin cancer, cancer of the brain, cervical cancer, intestinalcancer, liver cancer, colon cancer, stomach cancer, intestine cancer,head and neck cancer, gastrointestinal cancer, lymph node cancer,esophagus cancer, colorectal cancer, pancreas cancer, ear, nose andthroat (ENT) cancer, breast cancer, prostate cancer, cancer of theuterus, ovarian cancer and lung cancer and the metastases thereof.Examples thereof are lung carcinomas, mamma carcinomas, prostatecarcinomas, colon carcinomas, renal cell carcinomas, cervicalcarcinomas, or metastases of the cancer types or tumors described above.

The term “cancer” according to the invention also comprises cancermetastases. By “metastasis” is meant the spread of cancer cells from itsoriginal site to another part of the body. The formation of metastasisis a very complex process and depends on detachment of malignant cellsfrom the primary tumor, invasion of the extracellular matrix,penetration of the endothelial basement membranes to enter the bodycavity and vessels, and then, after being transported by the blood,infiltration of target organs. Finally, the growth of a new tumor, i.e.a secondary tumor or metastatic tumor, at the target site depends onangiogenesis. Tumor metastasis often occurs even after the removal ofthe primary tumor because tumor cells or components may remain anddevelop metastatic potential. In one embodiment, the term “metastasis”according to the invention relates to “distant metastasis” which relatesto a metastasis which is remote from the primary tumor and the regionallymph node system.

The term “infectious disease” refers to any disease which can betransmitted from individual to individual or from organism to organism,and is caused by a microbial agent (e.g. common cold). Examples ofinfectious diseases include viral infectious diseases, such as AIDS(HIV), hepatitis A, B or C, herpes, herpes zoster (chicken-pox), Germanmeasles (rubella virus), yellow fever, dengue etc. flaviviruses,influenza viruses, hemorrhagic infectious diseases (Marburg or Ebolaviruses), and severe acute respiratory syndrome (SARS), bacterialinfectious diseases, such as Legionnaire's disease (Legionella),sexually transmitted diseases (e.g. chlamydia or gonorrhea), gastriculcer (Helicobacter), cholera (Vibrio), tuberculosis, diphtheria,infections by E. coli, Staphylococci, Salmonella or Streptococci(tetanus); infections by protozoan pathogens such as malaria, sleepingsickness, leishmaniasis; toxoplasmosis, i.e. infections by Plasmodium,Trypanosoma, Leishmania and Toxoplasma; or fungal infections, which arecaused, e.g., by Cryptococcus neoformans, Histoplasma capsulatum,Coccidioides immitis, Blastomyces dermatitidis or Candida albicans.

The term “inflammatory disease” refers to any disease, which ischaracterized by or associated with high levels of inflammation intissues, in particular connective tissues, or degeneration of thesetissues. A chronic inflammatory disease is a medical condition which ischaracterized by persistent inflammation. Examples of (chronic)inflammatory diseases include celiac disease, vasculitis, lupus, chronicobstructive pulmonary disease (COPD), irritable bowel disease,atherosclerosis, arthritis, ankylosing spondylitis, Crohn's disease,colitis, chronic active hepatitis, dermatitis and psoriasis.

The term “metabolic disease” refers to any disease or disorder thatdisrupts normal metabolism. Examples include cystinosis, diabetes,dyslipidemia, hyperthyroidism, hypothyroidism, hyperlipidemia,hypolipidemia, galactosemia, Gaucher's disease, obesity andphenylketonuria.

The term “autoimmune disorder” refers to any disease/disorder in whichthe body produces an immunogenic (i.e. immune system) response to someconstituent of its own tissue. In other words, the immune system losesits ability to recognize some tissue or system within the body as selfand targets and attacks it as if it were foreign. Autoimmune diseasescan be classified into those in which predominantly one organ isaffected (e.g. hemolytic anemia and anti-immune thyroiditis), and thosein which the autoimmune disease process is diffused through many tissues(e.g. systemic lupus erythematosus). For example, multiple sclerosis isthought to be caused by T cells attacking the sheaths that surround thenerve fibers of the brain and spinal cord. This results in loss ofcoordination, weakness, and blurred vision. Autoimmune diseases areknown in the art and include, for instance, Hashimoto's thyroiditis,Grave's disease, lupus, multiple sclerosis, rheumatic arthritis,hemolytic anemia, anti-immune thyroiditis, systemic lupus erythematosus,celiac disease, Crohn's disease, colitis, diabetes, scleroderma,psoriasis, and the like.

The term “degenerative disease” refers to any disease in which thefunction or structure of the affected tissues or organs willincreasingly deteriorate over time. Examples include Alzheimer'sdisease, Parkinson's disease, amyotrophic lateral sclerosis (ALS),Huntington's disease, macular degeneration, multiple sclerosis, musculardystrophy, Niemann Pick disease, osteoporosis and rheumatoid arthritis.

The term “apoptosis-associated diseases” refers to any disease in whichalterations of apoptosis are involved. Examples include cancer,neurological disorders, such as Alzheimer's disease, Parkinson'sdisease, Huntington's disease, amyotrophic lateral sclerosis (ALS) andstroke, heart diseases, such as ischemia reperfusion and chronic heartfailure, infectious diseases and autoimmune diseases.

The term “transplant rejection” refers to the rejection of atransplanted tissue or organ by the recipient's immune system, whichmay, ultimately, destroy the transplanted tissue or organ.

By “treat” is meant to administer a compound or composition or acombination of compounds or compositions to a subject in order toprevent or eliminate a disease, including reducing the size of a tumoror the number of tumors in a subject; arrest or slow a disease in asubject; inhibit or slow the development of a new disease in a subject;decrease the frequency or severity of symptoms and/or recurrences in asubject who currently has or who previously has had a disease; and/orprolong, i.e. increase the lifespan of the subject.

In particular, the term “treatment of a disease” includes curing,shortening the duration, ameliorating, preventing, slowing down orinhibiting progression or worsening, or preventing or delaying the onsetof a disease or the symptoms thereof.

The term “subject” means according to the invention a subject fortreatment, in particular a diseased subject (also referred to as“patient”), including human beings, non-human primates or other animals,in particular mammals, such as cows, horses, pigs, sheep, goats, dogs,cats, rabbits, guinea pigs, hamsters or rodents, such as mice and rats.In a particularly preferred embodiment, the subject/patient is a humanbeing.

The agents and compositions provided herein may be used alone or incombination with therapeutic regimens.

EXAMPLES Example 1: Generation of Agonistic anti-CD27, anti-CD134 andanti-CD137 Antibodies 1.1 Immunization and Collection of B-Cell Clones

9 rabbits were immunized with a mixture of human CD27 (Enzo LifeSciences, ALX-522-031-0000), human CD134 (OX40; AdipoGen, AG-40B-0014)and human CD137 (4-1BB; Enzo Life Sciences, ALX-522-029-0000), whereineach protein was fused to the Fc portion of human IgG1. Blood was takenat 4 different time points and enriched for B-lymphocytes (also referredto as B-cells). Single B-cells were sorted by fluorescence-activatedcell sorting (FACS) into wells of a 96-well microtiter plate andcultivated for 8 days, releasing antibodies into the cultivation medium.The B-cell supernatants were removed and prepared for testing.

1.2 Screening for Target-Binding Antibodies by ELISA

In order to identify antibodies that bind to human CD27, CD134 andCD137, respectively, an enzyme-linked immunosorbent assay (ELISA) wasestablished. For this purpose, CD27 protein (His-tagged, Sino BiologicalInc. 10039-H08B1), CD134 protein (His-tagged, Sino Biological Inc.10481-H08H) and CD137 protein (His-tagged, Sino Biological Inc.10041-H08H), respectively, were coated onto microtiter plates. PBScontaining 2% BSA and 0.05% Tween was used for blocking. Afterincubation with B-cell supernatants, bound antibodies were detected byusing a peroxidase-labeled anti-rabbit-Fc antibody.

Commercially available antibodies were used as reference antibodies forassay development. FIG. 1A shows binding curves of reference anti-CD27antibodies (Armenian hamster monoclonal anti-human CD27 clone LG7F9 andmouse monoclonal anti-human CD27 clone 0323, both purchased fromeBiosciences) to recombinant protein. FIG. 1B shows binding curves of areference anti-CD134 antibody (mouse monoclonal anti-human CD134 cloneBer-ACT35, purchased from eBiosciences) to recombinant protein. FIG. 1Cshows binding curves of reference anti-CD137 antibodies (mouseanti-human CD137 clone 4B4-1 from Biolegend and rat monoclonalanti-human CD137 from Biozol BZL06614) to recombinant protein. For allthree ELISAs, OD 450 nm/620 nm values >0.5 indicated binding, and themaximum value was at about 3.6.

In total, 47.471 B-cells were sorted, cultivated and screened forbinding to CD27, CD134 and CD137 by ELISA. 5.096 antibodies wereidentified to bind to at least to one of the three targets.

1.3 Identification of Cell-Binding Antibodies

The 5.096 ELISA hits were then tested in a cellular binding assay forbinding to cell surface expressed CD27, CD134 and CD137, respectively.For this purpose, the following stable transfectants of the HT1080 cellline were used: HT1080_CD27, HT1080_OX40 and HT1080_4-1BB. Cells werecultivated in RPMI 1640 GlutaMAX supplemented with 5% FCS, 100 IU/mLpenicillin, and 100 μg/mL streptomycin. Cell surface expression of TNFreceptors on HT1080-transfectants was analyzed by FACS, wherein cellswere stained using antibodies against CD27-PE (BD), OX40-PE (BD) and4-1BB-PE (BD) (FIGS. 2A-2C).

In order to test cellular binding of the antibodies, HT1080 cellsoverexpressing the respective target (1.000 cells per well of a 384-wellmicrotiter plate) were incubated together with samples for 18 hours.After gentle washing, an Alexa-labeled detection antibody and Hoechstdye were added, and fluorescence intensity was read in the cell imagerCellInsight (Thermo). Data analysis was based on the calculation of themean object spot average intensity.

Commercially available antibodies were used as reference antibodies forassay development. FIG. 3A shows binding curves of reference anti-CD27antibodies (Armenian hamster monoclonal anti-human CD27 clone LG7F9) toHT1080_CD27 cells. FIG. 3B shows binding curves of reference anti-CD134antibodies (mouse monoclonal anti-human CD134 clone Ber-ACT35) toHT1080_OX40 cells. FIG. 3C shows binding curves of reference anti-CD137antibodies (mouse anti-human CD137 clone 4B4-1) to HT1080_4-1BB cells.For all three cell lines, a mean spot intensity >25 indicated binding,and the maximum values were at about 300. 3.176 antibodies out of the5.096 ELISA hits were identified to bind at least to one of the threecell surface expressed targets by the cellular binding assay.

1.4 Recombinant Antibody Production

644 antibody hits, identified by ELISA and the cellular binding assay asdescribed above, were selected. These hits were picked, their RNA wasextracted, and sequencing was performed. 582 unique sequences wereidentified, and the corresponding variable regions of heavy and lightchains were gene synthesized. The variable regions were cloned in frontof human immunoglobulin constant parts (Ig HEK293 cell transienttransfections protocols were executed by a Tecan Freedom Evo device on aDionex Ultimate 3000 with a plate auto-sampler. After normalization, 531antibodies were available for confirmation of the primary screening dataset (ELISA, cellular binding) and for functional assays.

1.5 Analysis of Recombinantly Expressed Antibodies

In order to confirm the primary screening data set, all 531recombinantly produced antibodies were retested (i) for their binding tothe corresponding recombinant protein in the ELISA and (ii) for theirbinding to the corresponding target expressed on the cell surface ofHT1080 cells in the cellular binding assay (both assays as describedabove).

Furthermore, for the analysis of agonistic antibody functions,target-overexpressing HT1080 cells were used, wherein stimulation of thetargets (CD27, CD134 and CD137, respectively) induced IL-8 release fromthese cell lines. The recombinant CD27-, CD134- and CD137-overexpressingHT1080 cells (5.000 cells per well of a 384-well microtiter plate) wereincubated for 6 hours at 37° C. with the antibody samples. IL-8concentrations in the supernatants were then determined by using an IL-8ELISA kit (BD Bioscience). In a second approach, antibodies werecross-linked. Therefor, the target-overexpressing HT1080 cells wereincubated with a mixture of the antibody sample and a F(ab′)2 fragmentgoat anti-human IgG (Dianova). An agonistic reference anti-CD27 antibody[described in US 2013/0183316 A1 (sequences 3 and 4, hCD27.15)] was usedfor assay development. FIG. 4 shows results of the IL-8 ELISA uponantibody titration with and without cross-linking. For all three IL-8ELISAs, OD 450 nm/620 nm values >0.5 indicated agonistic antibodyactivities, the maximum values being at about 3.

Altogether, 186 agonistic anti-CD27 antibodies, 92 agonistic anti-CD134antibodies and 12 agonistic anti-CD137 antibodies were identified by thefunctional assay under cross-linking conditions. To some extent,antibodies already showed agonistic activity without cross-linking. Thedata of the ELISAs, the cellular binding assays and the functionalassays are summarized in Table 1 for the agonistic anti-CD27 antibodies,in Table 2 for the agonistic anti-CD134 antibodies and in Table 3 forthe agonistic anti-CD137 antibodies.

EC50 values of the agonistic function of anti-CD27, anti-CD134 andanti-CD137, respectively, upon cross-linking were determined bymeasuring IL-8 release values of 12 different antibody concentrationsapplied in the above-described functional assay. The EC50 value wascalculated using Xlfit-analysis tools (Fit Models 205). Resultingtypical sigmoidal curve progression is exemplarily shown in FIGS. 5A-5Cfor one anti-CD27 antibody (P018.S09.A.A06; EC50: 387.2 ng/mL), for oneanti-CD134 antibody (P018.S02.A.H03; EC50: 214.9 ng/mL) and for oneanti-CD137 antibody (P018.S08.A.E03; EC50: 4963.8 ng/mL). EC50 values ofthe antibodies are listed in Table 4 (anti-CD27), Table 5 (anti-CD134)and Table 6 (anti-CD137).

Sequence information of the tested antibodies are listed in Table 7(anti-CD27), Table 8 (anti-CD134) as well as Table 9 (anti-CD137),wherein the sequences of the CDR regions are given according to the IMGTunique numbering scheme for V- and V-like-domains (Lefranc, M.-P., TheImmunologist, 7, 132-136 (1999)).

TABLE 1 Binding and functional activity properties of agonisticanti-CD27 antibodies Functional assay Cellular Cross-linked bindingbyF(ab′)2 Anti-CD27 ELISA assay IL-8 fragment IL-8 Antibody ID [abs.corr.] [RFU] [abs. corr.] [abs. corr.] P018.S.01.A.G04 3.765 388 0.2731.145 P018.S.04.A.D04 3.696 365 0.486 1.322 P018.S.01.A.G02 3.673 3630.848 1.878 P018.S.07.A.B04 3.635 382 0.304 1.667 P018.S.06.A.B03 3.594424 0.566 1.220 P018.S.03.A.H04 3.589 334 0.211 1.226 P018.S.08.A.H023.576 352 0.328 1.909 P018.S.09.A.H03 3.536 268 0.578 2.130P018.S.09.A.E06 3.535 307 1.228 1.733 P018.S.09.A.C03 3.533 319 0.4642.253 P018.S.07.A.F03 3.528 380 0.444 1.413 P018.S.03.A.C04 3.524 3370.394 1.483 P018.S.09.A.E05 3.523 353 0.872 2.169 P018.S.04.A.E02 3.516463 0.676 1.911 P018.S.01.A.B05 3.503 376 0.453 1.882 P018.S.04.A.B053.502 414 0.308 1.084 P018.S.01.A.G03 3.495 358 −0.105 1.214P018.S.10.A.F05 3.491 335 0.267 1.341 P018.S.02.A.B05 3.485 374 0.2011.761 P018.S.04.A.G04 3.479 335 0.451 1.571 P018.S.07.A.H02 3.471 2830.107 1.222 P018.S.05.A.H02 3.469 336 0.369 1.899 P018.S.03.A.F02 3.464276 0.736 1.221 P018.S.04.A.H04 3.463 291 0.579 1.982 P018.S.07.A.C043.453 300 0.302 1.645 P018.S.09.A.C06 3.452 219 1.943 2.304P018.S.01.A.E06 3.446 291 0.448 1.401 P018.S.01.A.H06 3.445 422 0.2702.181 P018.S.07.A.A05 3.441 379 0.408 1.033 P018.S.02.A.F05 3.440 3070.395 1.165 P018.S.03.A.A02 3.438 373 0.651 2.203 P018.S.03.A.G02 3.435275 0.412 1.280 P018.S.10.A.G05 3.424 408 0.137 1.249 P018.S.08.A.D013.421 394 −0.001 1.120 P018.S.01.A.F02 3.420 326 0.495 2.052P018.S.07.A.B05 3.418 295 0.203 1.407 P018.S.10.A.H01 3.418 443 0.4122.288 P018.S.08.A.A01 3.417 448 0.876 1.570 P018.S.04.A.D02 3.416 3350.294 1.346 P018.S.03.A.B02 3.411 308 0.366 1.489 P018.S.06.A.A03 3.411387 0.576 1.861 P018.S.02.A.G01 3.408 332 0.127 1.518 P018.S.01.A.D043.405 341 0.175 2.199 P018.S.07.A.H04 3.403 386 0.158 1.864P018.S.03.A.G06 3.402 302 0.560 1.364 P018.S.06.A.F01 3.402 310 0.4051.082 P018.S.10.A.C06 3.390 395 0.280 1.175 P018.S.04.A.B01 3.383 3300.508 1.670 P018.S.04.A.E04 3.381 283 0.641 1.344 P018.S.02.A.H05 3.375252 0.067 1.403 P018.S.04.A.C02 3.373 415 0.235 1.534 P018.S.09.A.D023.373 337 1.013 1.746 P018.S.08.A.D02 3.372 407 0.534 1.668P018.S.05.A.D04 3.372 317 0.246 1.527 P018.S.03.A.D02 3.370 397 0.4631.469 P018.S.07.A.B03 3.369 346 0.612 1.340 P018.S.02.A.C06 3.366 3480.418 1.590 P018.S.01.A.B04 3.362 382 0.582 2.121 P018.S.03.A.C02 3.362317 0.373 1.582 P018.S.03.A.H05 3.359 294 0.401 1.391 P018.S.09.A.H043.356 314 0.274 1.399 P018.S.04.A.F04 3.355 320 1.600 2.494P018.S.05.A.E04 3.354 332 0.813 1.329 P018.S.07.A.B06 3.353 372 0.2181.074 P018.S.05.A.C06 3.351 351 0.539 1.111 P018.S.07.A.F04 3.351 2960.424 1.582 P018.S.01.A.F05 3.350 369 0.559 1.180 P018.S.05.A.G04 3.349375 0.393 1.191 P018.S.09.A.D04 3.348 376 0.688 1.660 P018.S.07.A.H063.345 327 0.422 1.228 P018.S.06.A.E01 3.345 354 0.525 1.551P018.S.07.A.D03 3.340 409 0.569 1.676 P018.S.07.A.D04 3.335 393 0.4491.810 P018.S.08.A.E02 3.333 387 0.315 1.555 P018.S.04.A.D05 3.331 2920.241 1.081 P018.S.07.A.G02 3.330 453 0.725 2.408 P018.S.02.A.E06 3.324331 0.308 1.292 P018.S.03.A.C05 3.321 303 0.544 1.630 P018.S.04.A.A013.319 297 0.176 1.471 P018.S.05.A.B02 3.318 259 0.633 1.954P018.S.08.A.G02 3.316 315 0.598 2.483 P018.S.03.A.F04 3.307 299 0.2531.593 P018.S.10.A.F01 3.306 329 −0.011 1.052 P018.S.10.A.G03 3.306 386−0.180 1.300 P018.S.01.A.B03 3.304 387 0.060 1.699 P018.S.05.A.A02 3.301334 0.212 1.534 P018.S.05.A.A04 3.301 369 0.226 1.371 P018.S.06.A.E023.299 357 0.582 1.223 P018.S.10.A.E01 3.298 227 0.257 2.544P018.S.01.A.E03 3.297 335 0.436 1.220 P018.S.01.A.H02 3.296 317 0.3002.536 P018.S.01.A.C06 3.296 369 0.325 1.788 P018.S.05.A.F02 3.294 4720.526 1.913 P018.S.03.A.E04 3.294 356 0.200 1.193 P018.S.04.A.A05 3.294206 1.666 2.238 P018.S.07.A.C06 3.293 336 0.408 1.044 P018.S.09.A.D053.282 400 0.187 2.109 P018.S.10.A.E06 3.281 215 0.262 2.061P018.S.06.A.D04 3.280 394 0.444 1.064 P018.S.01.A.E04 3.280 295 0.2641.149 P018.S.07.A.E03 3.276 227 0.123 1.513 P018.S.04.A.B03 3.276 3380.394 1.971 P018.S.09.A.E03 3.272 334 0.099 1.545 P018.S.02.A.D04 3.269390 0.569 1.369 P018.S.01.A.D02 3.258 323 0.675 1.667 P018.S.10.A.B063.254 308 0.455 1.461 P018.S.10.A.H02 3.252 144 1.573 2.104P018.S.02.A.B03 3.251 332 0.120 1.161 P018.S.01.A.C02 3.250 324 0.3951.478 P018.S.07.A.H05 3.248 256 −0.160 1.186 P018.S.01.A.A04 3.244 3150.236 1.030 P018.S.01.A.C04 3.243 368 0.383 1.081 P018.S.02.A.F06 3.240294 0.094 1.728 P018.S.06.A.H04 3.234 331 0.173 1.692 P018.S.06.A.C023.232 283 0.519 1.610 P018.S.06.A.A02 3.232 366 0.737 1.811P018.S.02.A.A01 3.225 350 0.400 1.616 P018.S.01.A.E05 3.222 420 0.2091.332 P018.S.03.A.D03 3.216 320 0.281 1.051 P018.S.08.A.A03 3.214 3420.276 1.639 P018.S.10.A.C03 3.214 360 0.079 1.561 P018.S.03.A.G03 3.207292 0.546 1.585 P018.S.07.A.E05 3.198 317 0.055 1.151 P018.S.03.A.D063.194 360 0.245 1.053 P018.S.01.A.C05 3.189 349 0.327 1.400P018.S.02.A.G04 3.188 196 0.205 1.674 P018.S.10.A.B01 3.187 333 0.0801.037 P018.S.10.A.A06 3.181 414 −0.130 1.121 P018.S.06.A.F04 3.176 3380.678 1.160 P018.S.09.A.A05 3.173 214 0.504 1.953 P018.S.04.A.C05 3.173292 0.382 1.429 P018.S.01.A.G06 3.171 313 0.491 1.088 P018.S.06.A.F063.170 326 0.700 1.030 P018.S.09.A.A03 3.160 360 0.263 1.542P018.S.06.A.E04 3.160 281 0.327 1.223 P018.S.06.A.F03 3.157 304 0.0631.082 P018.S.07.A.G04 3.156 177 0.274 1.741 P018.S.10.A.E04 3.154 2800.339 2.287 P018.S.03.A.H02 3.152 395 0.130 1.071 P018.S.03.A.H03 3.152289 0.588 1.093 P018.S.03.A.F03 3.151 223 0.106 1.355 P018.S.01.A.A053.148 300 0.328 1.086 P018.S.06.A.C03 3.143 269 0.272 1.131P018.S.10.A.C05 3.143 11 0.206 2.098 P018.S.01.A.D05 3.140 273 0.0891.101 P018.S.03.A.B05 3.137 206 0.325 1.213 P018.S.10.A.A04 3.132 1751.778 2.159 P018.S.06.A.C06 3.132 379 0.128 1.078 P018.S.02.A.G03 3.129357 −0.061 1.484 P018.S.07.A.C02 3.128 380 0.735 2.020 P018.S.02.A.A063.126 293 0.299 1.476 P018.S.01.A.E02 3.126 360 0.276 1.172P018.S.09.A.F05 3.125 400 0.158 1.683 P018.S.09.A.G06 3.120 338 0.4671.338 P018.S.03.A.D05 3.118 324 0.500 1.504 P018.S.10.A.B02 3.114 2490.470 1.907 P018.S.04.A.E05 3.111 319 0.747 1.766 P018.S.05.A.A06 3.107374 0.324 1.582 P018.S.05.A.D03 3.105 321 0.100 1.278 P018.S.08.A.F013.102 395 0.211 1.113 P018.S.05.A.B06 3.098 309 0.220 1.700P018.S.03.A.D04 3.098 270 0.513 1.230 P018.S.01.A.A06 3.091 287 0.5661.919 P018.S.09.A.A06 3.088 113 2.192 2.251 P018.S.07.A.A02 3.081 3140.059 1.852 P018.S.07.A.D05 3.080 329 −0.032 1.639 P018.S.05.A.E03 3.069322 0.208 1.915 P018.S.10.A.E02 3.016 395 0.230 1.389 P018.S.03.A.G052.981 269 0.031 1.272 P018.S.09.A.E02 2.981 305 0.172 1.610P018.S.09.A.F06 2.980 218 0.580 2.032 P018.S.06.A.H05 2.977 308 0.2781.557 P018.S.10.A.H05 2.961 313 −0.155 1.108 P018.S.06.A.A05 2.954 1400.433 1.086 P018.S.09.A.A02 2.949 155 0.839 2.458 P018.S.09.A.C02 2.943323 0.070 1.068 P018.S.06.A.B01 2.943 279 0.106 1.176 P018.S.10.A.C012.934 266 −0.046 1.104 P018.S.05.A.D06 2.931 323 0.338 1.228P018.S.02.A.B01 2.930 332 0.538 1.423 P018.S.10.A.C02 2.905 238 0.6312.284 P018.S.10.A.F04 2.889 133 0.273 2.324 P018.S.10.A.A03 2.806 1981.021 2.063 P018.S.05.A.F05 2.310 11 0.189 2.212 P018.S.10.A.B03 2.24319 −0.032 2.074

TABLE 2 Binding and functional activity properties of agonisticanti-CD134 antibodies Functional assay Cellular Cross-linked binding byF(ab′)2 Anti-CD134 ELISA assay IL-8 fragment IL-8 Antibody ID [abs.corr.] [RFU] [abs. corr.] [abs. corr.] P018.S.03.A.E03 2.718 419 0.3142.544 P018.S.04.A.G05 2.865 451 −0.022 2.414 P018.S.04.A.F05 2.439 3680.181 2.397 P018.S.05.A.G03 0.056 40 0.032 2.391 P018.S.05.A.G05 2.619463 2.616 2.387 P018.S.04.A.H05 2.972 451 0.356 2.386 P018.S.04.A.E060.206 140 0.135 2.381 P018.S.02.A.F01 2.690 498 0.115 2.341P018.S.04.A.D06 2.493 510 1.009 2.302 P018.S.04.A.B06 2.638 482 1.8242.271 P018.S.12.A.E04 2.208 659 0.455 2.234 P018.S.04.A.A06 2.853 4860.879 2.211 P018.S.04.A.F06 2.358 402 2.071 2.210 P018.S.11.A.C04 1.963406 0.253 2.195 P018.S.12.A.H05 2.373 527 0.348 2.190 P018.S.12.A.G052.045 570 0.130 2.190 P018.S.11.A.C03 1.535 507 0.586 2.189P018.S.12.A.D06 0.865 180 0.832 2.171 P018.S.12.A.F05 2.124 511 0.3412.165 P018.S.11.A.A06 1.845 537 0.732 2.164 P018.S.11.A.F05 1.669 3960.330 2.155 P018.S.12.A.F03 2.450 485 0.527 2.153 P018.S.12.A.D05 2.130451 −0.007 2.152 P018.S.11.A.A05 1.898 550 0.260 2.149 P018.S.12.A.B052.103 536 0.960 2.147 P018.S.12.A.C02 2.052 571 0.936 2.143P018.S.12.A.A01 2.414 600 0.071 2.137 P018.S.11.A.F04 2.251 486 0.5682.113 P018.S.04.A.B04 3.208 331 1.990 2.112 P018.S.12.A.C03 1.956 4830.238 2.108 P018.S.12.A.B01 2.341 607 0.396 2.107 P018.S.12.A.E05 1.933523 0.132 2.107 P018.S.12.A.G03 2.521 452 0.209 2.105 P018.S.11.A.B062.133 441 0.403 2.105 P018.S.11.A.B03 2.660 527 −0.075 2.104P018.S.12.A.C06 2.346 525 0.881 2.101 P018.S.11.A.G03 2.112 450 1.5732.101 P018.S.12.A.B06 1.404 451 1.845 2.071 P018.S.11.A.G02 1.070 3570.270 2.061 P018.S.12.A.C01 2.493 496 −0.026 2.058 P018.S.12.A.B03 1.182446 1.074 2.054 P018.S.11.A.G05 2.363 531 0.031 2.053 P018.S.12.A.F061.645 500 0.374 2.052 P018.S.12.A.A06 1.613 515 0.062 2.043P018.S.11.A.D04 2.070 530 0.380 2.043 P018.S.11.A.E02 2.652 525 0.2142.043 P018.S.12.A.E01 2.547 463 0.439 2.038 P018.S.11.A.A03 1.930 4591.381 2.011 P018.S.11.A.H05 1.691 478 1.207 2.010 P018.S.04.A.C06 2.501458 0.538 2.005 P018.S.12.A.E03 2.043 482 0.461 2.005 P018.S.12.A.G042.082 534 0.407 1.994 P018.S.11.A.A04 2.105 582 0.533 1.993P018.S.12.A.F02 2.074 549 0.185 1.991 P018.S.11.A.D06 0.744 130 0.0191.966 P018.S.12.A.B02 2.208 560 −0.167 1.966 P018.S.02.A.H03 0.468 1982.557 1.954 P018.S.11.A.H06 2.516 498 0.567 1.949 P018.S.12.A.F04 2.109551 0.289 1.946 P018.S.12.A.A03 1.440 493 0.393 1.945 P018.S.11.A.F031.852 522 0.380 1.936 P018.S.08.A.B03 2.661 477 0.709 1.935P018.S.12.A.H04 1.984 295 −0.121 1.889 P018.S.12.A.E06 2.302 493 0.0541.866 P018.S.12.A.D04 2.227 488 0.139 1.865 P018.S.12.A.G01 1.560 5261.326 1.862 P018.S.11.A.D03 1.993 482 2.243 1.861 P018.S.11.A.E04 1.314416 −0.194 1.834 P018.S.12.A.H01 1.888 523 0.430 1.834 P018.S.12.A.D031.345 559 0.707 1.830 P018.S.12.A.C04 2.044 509 0.215 1.829P018.S.11.A.B05 1.651 456 1.360 1.826 P018.S.12.A.G02 2.331 530 0.2121.806 P018.S.11.A.H02 2.802 515 0.783 1.803 P018.S.11.A.E03 0.276 3180.481 1.791 P018.S.12.A.D02 2.642 472 0.333 1.773 P018.S.11.A.G04 2.128482 0.014 1.752 P018.S.02.A.F03 2.851 140 0.090 1.732 P018.S.11.A.E062.047 554 0.278 1.722 P018.S.05.A.F05 2.411 392 0.187 1.711P018.S.11.A.B04 1.426 444 −0.087 1.657 P018.S.12.A.C05 2.941 494 0.2281.653 P018.S.12.A.E02 2.589 497 0.355 1.629 P018.S.11.A.H04 2.648 3820.610 1.612 P018.S.13.A.G06 0.002 0 −0.114 1.585 P018.S.12.A.A02 1.577502 0.145 1.569 P018.S.12.A.A05 2.862 503 0.267 1.526 P018.S.11.A.E051.660 407 −0.265 1.422 P018.S.04.A.E01 2.876 22 0.084 1.405P018.S.12.A.A04 1.985 514 −0.007 1.401 P018.S.11.A.F02 2.426 503 −0.0111.382 P018.S.12.A.H03 2.477 496 −0.074 1.275 P018.S.04.A.F04 0.000 11−0.129 1.132

TABLE 3 Binding and functional activity properties of agonisticanti-CD137 antibodies Functional assay Cellular Cross-linked binding byF(ab′)2 Anti-CD137 ELISA assay IL-8 fragment IL-8 Antibody ID [abs.corr.] [RFU] [abs. corr.] [abs. corr.] P018.S.13.A.A05 0.687 0 0.5592.570 P018.S.14.A.H01 2.968 6 2.015 2.193 P018.S.08.A.E03 3.047 9 −0.3042.019 P018.S.13.A.G04 0.577 1 −0.179 1.801 P018.S.13.A.A06 3.388 38−0.153 1.712 P018.S.08.A.A04 3.418 46 0.368 1.546 P018.S.14.A.D06 2.8961 −0.011 1.523 P018.S.13.A.C02 2.551 8 0.113 1.399 P018.S.08.A.F03 2.3307 −0.346 1.356 P018.S.14.A.G03 2.072 19 0.222 1.140 P018.S.14.A.A043.440 81 0.785 0.972 P018.S.13.A.G03 1.725 13 −0.164 0.789

TABLE 4 EC50 values of agonistic anti-CD27 antibodies Anti-CD27 AntibodyID EC 50 [ng/mL] P018.S.10.A.H02 122.2 P018.S.09.A.A02 144.1P018.S.09.A.C06 220.9 P018.S.10.A.E04 233.6 P018.S.09.A.H06 329.1P018.S.10.A.A04 334.7 P018.S.10.A.C05 340.1 P018.S.05.A.F05 376.4P018.S.09.A.H03 387.0 P018.S.09.A.A06 387.2 P018.S.04.A.A05 407.7P018.S.10.A.C02 414.3 P018.S.07.A.G02 430.4 P018.S.10.A.H01 431.0P018.S.09.A.E05 502.0 P018.S.10.A.A03 512.8 P018.S.02.A.G03 526.1P018.S.09.A.D05 561.2 P018.S.06.A.A02 575.3 P018.S.10.A.E01 721.5P018.S.07.A.C04 801.5 P018.S.04.A.A04 819.8 P018.S.03.A.A02 834.9P018.S.01.A.B04 855.7 P018.S.09.A.C03 1022.1 P018.S.01.A.H02 1109.2P018.S.10.A.F04 1266.5 P018.S.01.A.D04 1302.2 P018.S.01.A.F05 1322.3P018.S.04.A.F04 1444.2 P018.S.08.A.G02 1935.4 P018.S.10.A.B03 1936.1P018.S.01.A.H06 2346.5

TABLE 5 EC50 values of agonistic anti-CD134 antibodies Anti-CD134Antibody ID EC 50 [ng/mL] P018.S.12.A.B05 102.1 P018.S.11.A.D03 175.8P018.S.02.A.H03 214.9 P018.S.11.A.C03 217.2 P018.S.04.A.F05 224.6P018.S.04.A.D06 354.6 P018.S.12.A.C01 431.5 P018.S.04.A.F06 440.1P018.S.04.A.B06 460.8 P018.S.03.A.E03 528.9 P018.S.04.A.A06 629.9P018.S.04.A.G05 669.5 P018.S.12.A.F05 732.5 P018.S.12.A.G05 745.0P018.S.11.A.C04 785.3 P018.S.11.A.A05 865.3 P018.S.11.A.G03 893.9P018.S.05.A.G03 966.4 P018.S.05.A.G05 974.5 P018.S.12.A.E04 1005.0P018.S.04.A.H05 1167.0 P018.S.04.A.E06 1390.5 P018.S.12.A.F03 1630.3P018.S.11.A.A06 2094.9 P018.S.12.A.D05 2401.8 P018.S.12.A.D06 2773.7P018.S.05.A.F05 7119.8

TABLE 6 EC50 values of agonistic anti-CD137 antibodies Anti-CD137Antibody ID EC 50 [ng/mL] P018.S.08.A.F03 2710.1 P018.S.13.A.C02 3498.0P018.S.14.A.G03 3499.7 P018.S.13.A.A05 3722.8 P018.S.13.A.G03 4776.3P018.S.08.A.E03 4963.8 P018.S.08.A.A04 5152.8 P018.S.14.A.H01 5818.0P018.S.14.A.A04 6789.0 P018.S.13.A.A06 7785.1 P018.S.14.A.D06 10208.0P018.S.13.A.G04 255179.8

TABLE 7 Sequence information of agonistic anti-CD27 antibodies (variabledomains and CDRs) SEQ ID NOs of Variable SEQ ID NOs of CDRs Anti-CD27Domains HCDR1/HCDR2/HCDR3 Short ID Antibody ID VH/VL LCDR1/LCDR2/LCDR3AB27_1 P018.S.01.A.A04 1/2 373/374/375 376/377/378 AB27_2P018.S.01.A.A05 3/4 379/380/381 382/383/384 AB27_3 P018.S.01.A.A06 5/6385/386/387 388/389/390 AB27_4 P018.S.01.A.B03 7/8 391/392/393394/395/396 AB27_5 P018.S.01.A.B04  9/10 397/398/399 400/401/402 AB27_6P018.S.01.A.B05 11/12 403/404/405 406/407/408 AB27_7 P018.S.01.A.C0213/14 409/410/411 412/413/414 AB27_8 P018.S.01.A.C04 15/16 415/416/417418/419/420 AB27_9 P018.S.01.A.C05 17/18 421/422/423 424/425/426 AB27_10P018.S.01.A.C06 19/20 427/428/429 430/431/432 AB27_11 P018.S.01.A.D0221/22 433/434/435 436/437/438 AB27_12 P018.S.01.A.D04 23/24 439/440/441442/443/444 AB27_13 P018.S.01.A.D05 25/26 445/446/447 448/449/450AB27_14 P018.S.01.A.E02 27/28 451/452/453 454/455/456 AB27_15P018.S.01.A.E03 29/30 457/458/459 460/461/462 AB27_16 P018.S.01.A.E0431/32 463/464/465 466/467/468 AB27_17 P018.S.01.A.E05 33/34 469/470/471472/473/474 AB27_18 P018.S.01.A.E06 35/36 475/476/477 478/479/480AB27_19 P018.S.01.A.F02 37/38 481/482/483 484/485/486 AB27_20P018.S.01.A.F05 39/40 487/488/489 490/491/492 AB27_21 P018.S.01.A.G0241/42 493/494/495 496/497/498 AB27_22 P018.S.01.A.G03 43/44 499/500/501502/503/504 AB27_23 P018.S.01.A.G04 45/46 505/506/507 508/509/510AB27_24 P018.S.01.A.G06 47/48 511/512/513 514/515/516 AB27_25P018.S.01.A.H02 49/50 517/518/519 520/521/522 AB27_26 P018.S.01.A.H0651/52 523/524/525 526/527/528 AB27_27 P018.S.02.A.A01 53/54 529/530/531532/533/534 AB27_28 P018.S.02.A.A06 55/56 535/536/537 538/539/540AB27_29 P018.S.02.A.B01 57/58 541/542/543 544/545/546 AB27_30P018.S.02.A.B03 59/60 547/548/549 550/551/552 AB27_31 P018.S.02.A.B0561/62 553/554/555 556/557/558 AB27_32 P018.S.02.A.C06 63/64 559/560/561562/563/564 AB27_33 P018.S.02.A.D04 65/66 565/566/567 568/569/570AB27_34 P018.S.02.A.E06 67/68 571/572/573 574/575/576 AB27_35P018.S.02.A.F05 69/70 577/578/579 580/581/582 AB27_36 P018.S.02.A.F0671/72 583/584/585 586/587/588 AB27_37 P018.S.02.A.G01 73/74 589/590/591592/593/594 AB27_38 P018.S.02.A.G03 75/76 595/596/597 598/599/600AB27_39 P018.S.02.A.G04 77/78 601/602/603 604/605/606 AB27_40P018.S.02.A.H05 79/80 607/608/609 610/611/612 AB27_41 P018.S.03.A.A0281/82 613/614/615 616/617/618 AB27_42 P018.S.03.A.B02 83/84 619/620/621622/623/624 AB27_43 P018.S.03.A.B05 85/86 625/626/627 628/629/630AB27_44 P018.S.03.A.C02 87/88 631/632/633 634/635/636 AB27_45P018.S.03.A.C04 89/90 637/638/639 640/641/642 AB27_46 P018.S.03.A.C0591/92 643/644/645 646/647/648 AB27_47 P018.S.03.A.D02 93/94 649/650/651652/653/654 AB27_48 P018.S.03.A.D03 95/96 655/656/657 658/659/660AB27_49 P018.S.03.A.D04 97/98 661/662/663 664/665/666 AB27_50P018.S.03.A.D05  99/100 667/668/669 670/671/672 AB27_51 P018.S.03.A.D06101/102 673/674/675 676/677/678 AB27_52 P018.S.03.A.E04 103/104679/680/681 682/683/684 AB27_53 P018.S.03.A.F02 105/106 685/686/687688/689/690 AB27_54 P018.S.03.A.F03 107/108 691/692/693 694/695/696AB27_55 P018.S.03.A.F04 109/110 697/698/699 700/701/702 AB27_56P018.S.03.A.G02 111/112 703/704/705 706/707/708 AB27_57 P018.S.03.A.G03113/114 709/710/711 712/713/714 AB27_58 P018.S.03.A.G05 115/116715/716/717 718/719/720 AB27_59 P018.S.03.A.G06 117/118 721/722/723724/725/726 AB27_60 P018.S.03.A.H02 119/120 727/728/729 730/731/732AB27_61 P018.S.03.A.H03 121/122 733/734/735 736/737/738 AB27_62P018.S.03.A.H04 123/124 739/740/741 742/743/744 AB27_63 P018.S.03.A.H05125/126 745/746/747 748/749/750 AB27_64 P018.S.04.A.A01 127/128751/752/753 754/755/756 AB27_65 P018.S.04.A.A05 129/130 757/758/759760/761/762 AB27_66 P018.S.04.A.B01 131/132 763/764/765 766/767/768AB27_67 P018.S.04.A.B03 133/134 769/770/771 772/773/774 AB27_68P018.S.04.A.B05 135/136 775/776/777 778/779/780 AB27_69 P018.S.04.A.C02137/138 781/782/783 784/785/786 AB27_70 P018.S.04.A.C05 139/140787/788/789 790/791/792 AB27_71 P018.S.04.A.D02 141/142 793/794/795796/797/798 AB27_72 P018.S.04.A.D04 143/144 799/800/801 802/803/804AB27_73 P018.S.04.A.D05 145/146 805/806/807 808/809/810 AB27_74P018.S.04.A.E02 147/148 811/812/813 814/815/816 AB27_75 P018.S.04.A.E04149/150 817/818/819 820/821/822 AB27_76 P018.S.04.A.E05 151/152823/824/825 826/827/828 AB27_77 P018.S.04.A.F04 153/154 829/830/831832/833/834 AB27_78 P018.S.04.A.G04 155/156 835/836/837 838/839/840AB27_79 P018.S.04.A.H04 157/158 841/842/843 844/845/846 AB27_80P018.S.05.A.A02 159/160 847/848/849 850/851/852 AB27_81 P018.S.05.A.A04161/162 853/854/855 856/857/858 AB27_82 P018.S.05.A.A06 163/164859/860/861 862/863/864 AB27_83 P018.S.05.A.B02 165/166 865/866/867868/869/870 AB27_84 P018.S.05.A.B06 167/168 871/872/873 874/875/876AB27_85 P018.S.05.A.C06 169/170 877/878/879 880/881/882 AB27_86P018.S.05.A.D03 171/172 883/884/885 886/887/888 AB27_87 P018.S.05.A.D04173/174 889/890/891 892/893/894 AB27_88 P018.S.05.A.D06 175/176895/896/897 898/899/900 AB27_89 P018.S.05.A.E03 177/178 901/902/903904/905/906 AB27_90 P018.S.05.A.E04 179/180 907/908/909 910/911/912AB27_91 P018.S.05.A.F02 181/182 913/914/915 916/917/918 AB27_92P018.S.05.A.F05 183/184 919/920/921 922/923/924 AB27_93 P018.S.05.A.G04185/186 925/926/927 928/929/930 AB27_94 P018.S.05.A.H02 187/188931/932/933 934/935/936 AB27_95 P018.S.06.A.A02 189/190 937/938/939940/941/942 AB27_96 P018.S.06.A.A03 191/192 943/944/945 946/947/948AB27_97 P018.S.06.A.A05 193/194 949/950/951 952/953/954 AB27_98P018.S.06.A.B01 195/196 955/956/957 958/959/960 AB27_99 P018.S.06.A.B03197/198 961/962/963 964/965/966 AB27_100 P018.S.06.A.C02 199/200967/968/969 970/971/972 AB27_101 P018.S.06.A.C03 201/202 973/974/975976/977/978 AB27_102 P018.S.06.A.C06 203/204 979/980/981 982/983/984AB27_103 P018.S.06.A.D04 205/206 985/986/987 988/989/990 AB27_104P018.S.06.A.E01 207/208 991/992/993 994/995/996 AB27_105 P018.S.06.A.E02209/210 997/998/999 1000/1001/1002 AB27_106 P018.S.06.A.E04 211/2121003/1004/1005 1006/1007/1008 AB27_107 P018.S.06.A.F01 213/2141009/1010/1011 1012/1013/1014 AB27_108 P018.S.06.A.F03 215/2161015/1016/1017 1018/1019/1020 AB27_109 P018.S.06.A.F04 217/2181021/1022/1023 1024/1025/1026 AB27_110 P018.S.06.A.F06 219/2201027/1028/1029 1030/1031/1032 AB27_111 P018.S.06.A.H04 221/2221033/1034/1035 1036/1037/1038 AB27_112 P018.S.06.A.H05 223/2241039/1040/1041 1042/1043/1044 AB27_113 P018.S.07.A.A02 225/2261045/1046/1047 1048/1049/1050 AB27_114 P018.S.07.A.A05 227/2281051/1052/1053 1054/1055/1056 AB27_115 P018.S.07.A.B03 229/2301057/1058/1059 1060/1061/1062 AB27_116 P018.S.07.A.B04 231/2321063/1064/1065 1066/1067/1068 AB27_117 P018.S.07.A.B05 233/2341069/1070/1071 1072/1073/1074 AB27_118 P018.S.07.A.B06 235/2361075/1076/1077 1078/1079/1080 AB27_119 P018.S.07.A.C02 237/2381081/1082/1083 1084/1085/1086 AB27_120 P018.S.07.A.C04 239/2401087/1088/1089 1090/1091/1092 AB27_121 P018.S.07.A.C06 241/2421093/1094/1095 1096/1097/1098 AB27_122 P018.S.07.A.D03 243/2441099/1100/1101 1102/1103/1104 AB27_123 P018.S.07.A.D04 245/2461105/1106/1107 1108/1109/1110 AB27_124 P018.S.07.A.D05 247/2481111/1112/1113 1114/1115/1116 AB27_125 P018.S.07.A.E03 249/2501117/1118/1119 1120/1121/1122 AB27_126 P018.S.07.A.E05 251/2521123/1124/1125 1126/1127/1128 AB27_127 P018.S.07.A.F03 253/2541129/1130/1131 1132/1133/1134 AB27_128 P018.S.07.A.F04 255/2561135/1136/1137 1138/1139/1140 AB27_129 P018.S.07.A.G02 257/2581141/1142/1143 1144/1145/1146 AB27_130 P018.S.07.A.G04 259/2601147/1148/1149 1150/1151/1152 AB27_131 P018.S.07.A.H02 261/2621153/1154/1155 1156/1157/1158 AB27_132 P018.S.07.A.H04 263/2641159/1160/1161 1162/1163/1164 AB27_133 P018.S.07.A.H05 265/2661165/1166/1167 1168/1169/1170 AB27_134 P018.S.07.A.H06 267/2681171/1172/1173 1174/1175/1176 AB27_135 P018.S.08.A.A01 269/2701177/1178/1179 1180/1181/1182 AB27_136 P018.S.08.A.A03 271/2721183/1184/1185 1186/1187/1188 AB27_137 P018.S.08.A.D01 273/2741189/1190/1191 1192/1193/1194 AB27_138 P018.S.08.A.D02 275/2761195/1196/1197 1198/1199/1200 AB27_139 P018.S.08.A.E02 277/2781201/1202/1203 1204/1205/1206 AB27_140 P018.S.08.A.F01 279/2801207/1208/1209 1210/1211/1212 AB27_141 P018.S.08.A.G02 281/2821213/1214/1215 1216/1217/1218 AB27_142 P018.S.08.A.H02 283/2841219/1220/1221 1222/1223/1224 AB27_143 P018.S.09.A.A02 285/2861225/1226/1227 1228/1229/1230 AB27_144 P018.S.09.A.A03 287/2881231/1232/1233 1234/1235/1236 AB27_145 P018.S.09.A.A05 289/2901237/1238/1239 1240/1241/1242 AB27_146 P018.S.09.A.A06 291/2921243/1244/1245 1246/1247/1248 AB27_147 P018.S.09.A.C02 293/2941249/1250/1251 1252/1253/1254 AB27_148 P018.S.09.A.C03 295/2961255/1256/1257 1258/1259/1260 AB27_149 P018.S.09.A.C06 297/2981261/1262/1263 1264/1265/1266 AB27_150 P018.S.09.A.D02 299/3001267/1268/1269 1270/1271/1272 AB27_151 P018.S.09.A.D04 301/3021273/1274/1275 1276/1277/1278 AB27_152 P018.S.09.A.D05 303/3041279/1280/1281 1282/1283/1284 AB27_153 P018.S.09.A.E02 305/3061285/1286/1287 1288/1289/1290 AB27_154 P018.S.09.A.E03 307/3081291/1292/1293 1294/1295/1296 AB27_155 P018.S.09.A.E05 309/3101297/1298/1299 1300/1301/1302 AB27_156 P018.S.09.A.E06 311/3121303/1304/1305 1306/1307/1308 AB27_157 P018.S.09.A.F05 313/3141309/1310/1311 1312/1313/1314 AB27_158 P018.S.09.A.F06 315/3161315/1316/1317 1318/1319/1320 AB27_159 P018.S.09.A.G06 317/3181321/1322/1323 1324/1325/1326 AB27_160 P018.S.09.A.H03 319/3201327/1328/1329 1330/1331/1332 AB27_161 P018.S.09.A.H04 321/3221333/1334/1335 1336/1337/1338 AB27_162 P018.S.09.A.H06 323/3241339/1340/1341 1342/1343/1344 AB27_163 P018.S.10.A.A03 325/3261345/1346/1347 1348/1349/1350 AB27_164 P018.S.10.A.A04 327/3281351/1352/1353 1354/1355/1356 AB27_165 P018.S.10.A.A06 329/3301357/1358/1359 1360/1361/1362 AB27_166 P018.S.10.A.B01 331/3321363/1364/1365 1366/1367/1368 AB27_167 P018.S.10.A.B02 333/3341369/1370/1371 1372/1373/1374 AB27_168 P018.S.10.A.B03 335/3361375/1376/1377 1378/1379/1380 AB27_169 P018.S.10.A.B06 337/3381381/1382/1383 1384/1385/1386 AB27_170 P018.S.10.A.C01 339/3401387/1388/1389 1390/1391/1392 AB27_171 P018.S.10.A.C02 341/3421393/1394/1395 1396/1397/1398 AB27_172 P018.S.10.A.C03 343/3441399/1400/1401 1402/1403/1404 AB27_173 P018.S.10.A.C05 345/3461405/1406/1407 1408/1409/1410 AB27_174 P018.S.10.A.C06 347/3481411/1412/1413 1414/1415/1416 AB27_175 P018.S.10.A.E01 349/3501417/1418/1419 1420/1421/1422 AB27_176 P018.S.10.A.E02 351/3521423/1424/1425 1426/1427/1428 AB27_177 P018.S.10.A.E04 353/3541429/1430/1431 1432/1433/1434 AB27_178 P018.S.10.A.E06 355/3561435/1436/1437 1438/1439/1440 AB27_179 P018.S.10.A.F01 357/3581441/1442/1443 1444/1445/1446 AB27_180 P018.S.10.A.F04 359/3601447/1448/1449 1450/1451/1452 AB27_181 P018.S.10.A.F05 361/3621453/1454/1455 1456/1457/1458 AB27_182 P018.S.10.A.G03 363/3641459/1460/1461 1462/1463/1464 AB27_183 P018.S.10.A.G05 365/3661465/1466/1467 1468/1469/1470 AB27_184 P018.S.10.A.H01 367/3681471/1472/1473 1474/1475/1476 AB27_185 P018.S.10.A.H02 369/3701477/1478/1479 1480/1481/1482 AB27_186 P018.S.10.A.H05 371/3721483/1484/1485 1486/1487/1488

TABLE 8 Sequence information of agonistic anti-CD134 antibodies(variable domains and CDRs) SEQ ID NOs of Variable SEQ ID NOs of CDRsAnti-CD134 Domains HCDR1/HCDR2/HCDR3 Short ID Antibody ID VH/VLLCDR1/LCDR2/LCDR3 AB134_1 P018.S.02.A.F01 1489/1490 1673/1674/16751676/1677/1678 AB134_2 P018.S.02.A.F03 1491/1492 1679/1680/16811682/1683/1684 AB134_3 P018.S.02.A.H03 1493/1494 1685/1686/16871688/1689/1690 AB134_4 P018.S.03.A.E03 1495/1496 1691/1692/16931694/1695/1696 AB134_5 P018.S.04.A.A06 1497/1498 1697/1698/16991700/1701/1702 AB134_6 P018.S.04.A.B04 1499/1500 1703/1704/17051706/1707/1708 AB134_7 P018.S.04.A.B06 1501/1502 1709/1710/17111712/1713/1714 AB134_8 P018.S.04.A.C06 1503/1504 1715/1716/17171718/1719/1720 AB134_9 P018.S.04.A.D06 1505/1506 1721/1722/17231724/1725/1726 AB134_10 P018.S.04.A.E01 1507/1508 1727/1728/17291730/1731/1732 AB134_11 P018.S.04.A.E06 1509/1510 1733/1734/17351736/1737/1738 AB134_12 P018.S.04.A.F05 1511/1512 1739/1740/17411742/1743/1744 AB134_13 P018.S.04.A.F06 1513/1514 1745/1746/17471748/1749/1750 AB134_14 P018.S.04.A.G05 1515/1516 1751/1752/17531754/1755/1756 AB134_15 P018.S.04.A.H05 1517/1518 1757/1758/17591760/1761/1762 AB134_16 P018.S.05.A.F05 1519/1520 1763/1764/17651766/1767/1768 AB134_17 P018.S.05.A.G03 1521/1522 1769/1770/17711772/1773/1774 AB134_18 P018.S.05.A.G05 1523/1524 1775/1776/17771778/1779/1780 AB134_19 P018.S.08.A.B03 1525/1526 1781/1782/17831784/1785/1786 AB134_20 P018.S.11.A.A03 1527/1528 1787/1788/17891790/1791/1792 AB134_21 P018.S.11.A.A04 1529/1530 1793/1794/17951796/1797/1798 AB134_22 P018.S.11.A.A05 1531/1532 1799/1800/18011802/1803/1804 AB134_23 P018.S.11.A.A06 1533/1534 1805/1806/18071808/1809/1810 AB134_24 P018.S.11.A.B03 1535/1536 1811/1812/18131814/1815/1816 AB134_25 P018.S.11.A.B04 1537/1538 1817/1818/18191820/1821/1822 AB134_26 P018.S.11.A.B05 1539/1540 1823/1824/18251826/1827/1828 AB134_27 P018.S.11.A.B06 1541/1542 1829/1830/18311832/1833/1834 AB134_28 P018.S.11.A.C03 1543/1544 1835/1836/18371838/1839/1840 AB134_29 P018.S.11.A.C04 1545/1546 1841/1842/18431844/1845/1846 AB134_30 P018.S.11.A.D03 1547/1548 1847/1848/18491850/1851/1852 AB134_31 P018.S.11.A.D04 1549/1550 1853/1854/18551856/1857/1858 AB134_32 P018.S.11.A.D06 1551/1552 1859/1860/18611862/1863/1864 AB134_33 P018.S.11.A.E02 1553/1554 1865/1866/18671868/1869/1870 AB134_34 P018.S.11.A.E03 1555/1556 1871/1872/18731874/1875/1876 AB134_35 P018.S.11.A.E04 1557/1558 1877/1878/18791880/1881/1882 AB134_36 P018.S.11.A.E05 1559/1560 1883/1884/18851886/1887/1888 AB134_37 P018.S.11.A.E06 1561/1562 1889/1890/18911892/1893/1894 AB134_38 P018.S.11.A.F02 1563/1564 1895/1896/18971898/1899/1900 AB134_39 P018.S.11.A.F03 1565/1566 1901/1902/19031904/1905/1906 AB134_40 P018.S.11.A.F04 1567/1568 1907/1908/19091910/1911/1912 AB134_41 P018.S.11.A.F05 1569/1570 1913/1914/19151916/1917/1918 AB134_42 P018.S.11.A.G02 1571/1572 1919/1920/19211922/1923/1924 AB134_43 P018.S.11.A.G03 1573/1574 1925/1926/19271928/1929/1930 AB134_44 P018.S.11.A.G04 1575/1576 1931/1932/19331934/1935/1936 AB134_45 P018.S.11.A.G05 1577/1578 1937/1938/19391940/1941/1942 AB134_46 P018.S.11.A.H02 1579/1580 1943/1944/19451946/1947/1948 AB134_47 P018.S.11.A.H04 1581/1582 1949/1950/19511952/1953/1954 AB134_48 P018.S.11.A.H05 1583/1584 1955/1956/19571958/1959/1960 AB134_49 P018.S.11.A.H06 1585/1586 1961/1962/19631964/1965/1966 AB134_50 P018.S.12.A.A01 1587/1588 1967/1968/19691970/1971/1972 AB134_51 P018.S.12.A.A02 1589/1590 1973/1974/19751976/1977/1978 AB134_52 P018.S.12.A.A03 1591/1592 1979/1980/19811982/1983/1984 AB134_53 P018.S.12.A.A04 1593/1594 1985/1986/19871988/1989/1990 AB134_54 P018.S.12.A.A05 1595/1596 1991/1992/19931994/1995/1996 AB134_55 P018.S.12.A.A06 1597/1598 1997/1998/19992000/2001/2002 AB134_56 P018.S.12.A.B01 1599/1600 2003/2004/20052006/2007/2008 AB134_57 P018.S.12.A.B02 1601/1602 2009/2010/20112012/2013/2014 AB134_58 P018.S.12.A.B03 1603/1604 2015/2016/20172018/2019/2020 AB134_59 P018.S.12.A.B05 1605/1606 2021/2022/20232024/2025/2026 AB134_60 P018.S.12.A.B06 1607/1608 2027/2028/20292030/2031/2032 AB134_61 P018.S.12.A.C01 1609/1610 2033/2034/20352036/2037/2038 AB134_62 P018.S.12.A.C02 1611/1612 2039/2040/20412042/2043/2044 AB134_63 P018.S.12.A.C03 1613/1614 2045/2046/20472048/2049/2050 AB134_64 P018.S.12.A.C04 1615/1616 2051/2052/20532054/2055/2056 AB134_65 P018.S.12.A.C05 1617/1618 2057/2058/20592060/2061/2062 AB134_66 P018.S.12.A.C06 1619/1620 2063/2064/20652066/2067/2068 AB134_67 P018.S.12.A.D02 1621/1622 2069/2070/20712072/2073/2074 AB134_68 P018.S.12.A.D03 1623/1624 2075/2076/20772078/2079/2080 AB134_69 P018.S.12.A.D04 1625/1626 2081/2082/20832084/2085/2086 AB134_70 P018.S.12.A.D05 1627/1628 2087/2088/20892090/2091/2092 AB134_71 P018.S.12.A.D06 1629/1630 2093/2094/20952096/2097/2098 AB134_72 P018.S.12.A.E01 1631/1632 2099/2100/21012102/2103/2104 AB134_73 P018.S.12.A.E02 1633/1634 2105/2106/21072108/2109/2110 AB134_74 P018.S.12.A.E03 1635/1636 2111/2112/21132114/2115/2116 AB134_75 P018.S.12.A.E04 1637/1638 2117/2118/21192120/2121/2122 AB134_76 P018.S.12.A.E05 1639/1640 2123/2124/21252126/2127/2128 AB134_77 P018.S.12.A.E06 1641/1642 2129/2130/21312132/2133/2134 AB134_78 P018.S.12.A.F02 1643/1644 2135/2136/21372138/2139/2140 AB134_79 P018.S.12.A.F03 1645/1646 2141/2142/21432144/2145/2146 AB134_80 P018.S.12.A.F04 1647/1648 2147/2148/21492150/2151/2152 AB134_81 P018.S.12.A.F05 1649/1650 2153/2154/21552156/2157/2158 AB134_82 P018.S.12.A.F06 1651/1652 2159/2160/21612162/2163/2164 AB134_83 P018.S.12.A.G01 1653/1654 2165/2166/21672168/2169/2170 AB134_84 P018.S.12.A.G02 1655/1656 2171/2172/21732174/2175/2176 AB134_85 P018.S.12.A.G03 1657/1658 2177/2178/21792180/2181/2182 AB134_86 P018.S.12.A.G04 1659/1660 2183/2184/21852186/2187/2188 AB134_87 P018.S.12.A.G05 1661/1662 2189/2190/21912192/2193/2194 AB134_88 P018.S.12.A.H01 1663/1664 2195/2196/21972198/2199/2200 AB134_89 P018.S.12.A.H03 1665/1666 2201/2202/22032204/2205/2206 AB134_90 P018.S.12.A.H04 1667/1668 2207/2208/22092210/2211/2212 AB134_91 P018.S.12.A.H05 1669/1670 2213/2214/22152216/2217/2218 AB134_92 P018.S.13.A.G06 1671/1672 2219/2220/22212222/2223/2224

TABLE 9 Sequence information of agonistic anti-CD137 antibodies(variable domains and CDRs) SEQ ID NOs of Variable SEQ ID NOs of CDRsAnti-CD137 Domains HCDR1/HCDR2/HCDR3 Short ID Antibody ID VH/VLLCDR1/LCDR2/LCDR3 AB137_1 P018.S.08.A.A04 2225/2226 2249/2250/22512252/2253/2254 AB137_2 P018.S.08.A.E03 2227/2228 2255/2256/22572258/2259/2260 AB137_3 P018.S.08.A.F03 2229/2230 2261/2262/22632264/2265/2266 AB137_4 P018.S.13.A.A05 2231/2232 2267/2268/22692270/2271/2272 AB137_5 P018.S.13.A.A06 2233/2234 2273/2274/22752276/2277/2278 AB137_6 P018.S.13.A.C02 2235/2236 2279/2280/22812282/2283/2284 AB137_7 P018.S.13.A.G03 2237/2238 2285/2286/22872288/2289/2290 AB137_8 P018.S.13.A.G04 2239/2240 2291/2292/22932294/2295/2296 AB137_9 P018.S.14.A.A04 2241/2242 2297/2298/22992300/2301/2302 AB137_10 P018.S.14.A.D06 2243/2244 2303/2304/23052306/2307/2308 AB137_11 P018.S.14.A.G03 2245/2246 2309/2310/23112312/2313/2314 AB137_12 P018.S.14.A.H01 2247/2248 2315/2316/23172318/2319/2320

Example 2: Bispecific Antibodies Targeting CD40 and CD27, CD40 and CD137or CD40 and CD134 2.1 Reporter Assay Measuring Trans-Activation

CD40 is predominantly expressed on antigen-presenting cells (APCs), suchas dendritic cells, whereas CD27, CD134 and CD137 are predominantlyexpressed on T cells. Thus, bispecific antibodies binding to CD40 andCD27, to CD40 and CD137 or to CD40 and CD134 are able to bindsimultaneously to APCs and T cells expressing these receptors. Thereby,these bispecific antibodies are able (i) to mediate cell-to-cellinteraction between APCs and T cells by receptor binding and (ii) toactivate both indicated receptors at once, which is primarily induced bycross-linking and receptor clustering upon cell-to-cell interaction andnot necessarily dependent on agonistic activity of the parentalmonospecific bivalent antibodies. Thus, these trans-activatingbispecific antibodies exert costimulatory activity in the context ofAPC: T cell interactions.

A corresponding reporter assay system was established. To that end,HEK293_NFK_gfp_luc cells were stably transduced with humanTNF-receptors, CD27, CD40, CD134 and CD137, respectively.HEK293_NFK_gfp_luc (NF-κB/293/GFP-Luc™ Transcriptional Reporter CellLine obtained from System Biosciences) is a reporter cell line whichallows to monitor the NF-κB pathway by the detection of GFP fluorescenceas well as luciferase activity for quantitative transcription activationreporter assays. Additionally, K562 cells were stably transduced withhuman TNF-receptors, CD27, CD40, CD134 and CD137, as well, in order togenerate cell lines mediating trans-presentation of the indicatedreceptors. Cell surface expression of the receptors onHEK293_NFK_gfp_luc cells and K562 cells was analyzed by flow cytometrydepicted in FIG. 6A and FIG. 6B.

The reporter assay measuring trans-activation was set up as follows:HEK293_NFK_gfp_luc cells expressing one of the 4 indicated TNF-receptorswere seeded in multi-well culture plates. Bispecific antibodies andcorresponding monospecific control antibodies were added inconcentrations from 100 ng/ml to 10.000 ng/ml. K562 cells expressing thesecond TNF-receptor or wildtype K562 (K562_wt) were added to indicatedwells. Thus, the bispecific antibodies are able to bind to the firstTNF-receptor on the HEK293_NFK_gfp_luc cell line and, at the same time,to the second TNF-receptor on the K562 cell line mediatingtrans-presentation. Only receptor activation of the first TNF receptoron HEK293_NFK_gfp_luc cells is measured by luciferase activity inducedupon NF-κB-signaling. Thus, bispecific antibodies targeting CD40 andCD27, CD40 and CD137 or CD40 and CD134 were analyzed by two reporterassays: (i) the first assay measuring CD27-, CD134- or CD137-activationupon cross-presentation by K562_CD40 and (ii) the second assay measuringCD40-activation upon cross-presentation by K562_CD27, K562_CD134 orK562_CD137, respectively.

2.2 Analysis of CD40×CD137 Bispecific Antibodies

Bispecific antibodies binding with one arm to CD40 and with the secondarm to CD137 were produced and analyzed by the two Trans-reporter assaysusing HEK293_NFK_CD40_gfp_luc+K562_CD137 andHEK293_NFK_CD137_gfp_luc+K562_CD40. Two different bispecific antibodiesas well as the control antibodies, the parental monospecific bivalentanti-CD40 and anti-CD137 antibodies and corresponding monovalentantibodies with one irrelevant arm, were tested (FIGS. 7A-7D). Allantibodies were tested under the indicated trans-presentation conditionsusing K562 cells expressing the second TNF-receptor and for controlwithout trans-presentation using K562_wt. None of the controlantibodies, neither the parental monospecific bivalent antibodies northe monovalent antibodies with one irrelevant arm, induced luciferaseactivity in HEK293_NFK_CD40_gfp_luc cells or in HEK293_NFK_CD137_gfp_luccells. Only the two bispecific CD40×CD137 antibodies resulted inluciferase activity upon addition of antibodies (100 ng/ml and higherconcentrations) to HEK293_NFK_CD40_gfp_luc or HEK293_NFK_CD137_gfp_luccells under trans-presentation conditions. Thus, even if the parentalmonospecific, bivalent anti-CD40 and anti-CD137 IgG1 antibodies do notshow agonistic activity, the bispecific CD40×CD137 antibody is able toinduce activation of both receptors resulting in intracellular signalingand NF-κB pathway activation.

2.3 Analysis of CD40×CD27 Bispecific Antibodies

A bispecific antibody binding with one arm to CD40 and with the secondarm to CD27 was produced and analyzed by the two Trans-reporter assaysusing HEK293_NFK_CD40_gfp_luc+K562_CD27 andHEK293_NFK_CD27_gfp_luc+K562_CD40. The bispecific antibody as well asthe control antibodies, the parental monospecific bivalent anti-CD40 andanti-CD27 antibodies and corresponding monovalent antibodies with oneirrelevant arm, were tested (FIGS. 8A-8B). All antibodies were testedunder the indicated trans-presentation conditions using K562 cellsexpressing the second TNF-receptor and for control withouttrans-presentation using K562_wt. The bispecific antibody (100 ng/ml andhigher concentrations) induced strong luciferase activity inHEK293_NFK_CD40gfp_luc and in HEK293_NFK_CD27_gfp_luc cell lines,respectively, under trans-presentation conditions. Thus, the bispecificCD40×CD27 antibody is able to induce activation of both receptorsresulting in strong intracellular signaling and NF-κB pathwayactivation.

2.4 Analysis of CD40×CD134 Bispecific Antibodies

Bispecific antibodies binding with one arm to CD40 and with the secondarm to CD134 were produced and analyzed by the two Trans-reporter assaysusing HEK293_NFK_CD40_gfp_luc+K562_CD134 andHEK293_NFK_CD134_gfp_luc+K562_CD40. Two different bispecific antibodiesas well as the control antibodies, the parental monospecific bivalentanti-CD40 and anti-CD134 antibodies and the corresponding monovalentantibodies with one irrelevant arm, were tested (FIGS. 9A-9D). Allantibodies were tested under the indicated trans-presentation conditionsusing K562 cells expressing the second TNF-receptor and for controlwithout trans-presentation using K562_wt. The parental monospecificbivalent anti-CD134 antibodies induced only very weak luciferaseactivity. However, the bispecific antibodies (100 ng/ml and higherconcentrations) induced strong luciferase activity inHEK293_NFK_CD40_gfp_luc and in HEK293_NFK_CD134_gfp_luc cell lines,respectively, under trans-presentation conditions. Thus, even if theparental monospecific, bivalent anti-CD40 and anti-CD134 IgG1 antibodiesshow only slight agonistic activity the bispecific CD40×CD134 antibodyis able to induce activation of both receptors resulting in strongintracellular signaling and NF-κB pathway activation.

Example 3: Bispecific Antibodies Targeting CD134 and CD27, CD134 andCD137 or CD27 and CD137 3.1 Reporter Assay Measuring Cis-Activation

CD27, CD134 and CD137 are predominantly expressed on T cells. While CD27is constitutively expressed and CD27 expression density only varies uponT cell activation, CD134 and CD137 expression is only induced upon Tcell activation. Thereby, bispecific antibodies binding to CD134 andCD27, to CD134 and CD137 or to CD27 and CD137 most probably target tworeceptors expressed on the same T cell. However, the activity of thesebispecific antibodies depends on the co-expression of the two receptorsand thereby on the activation status of the T cells. Activation of theseTNF-receptors is dependent on receptor cross-linking and receptorclustering, respectively, which can be achieved by binding agentssimultaneously binding to different receptors. If T cells co-express theindicated receptors, these bispecific antibodies can act ascostimulatory agents mediating receptor-induced signaling in T cellsupon binding of two different TNF-receptors on the same T cell.

A corresponding reporter assay system was established using TNF-receptordouble transfectants. To that end, HEK293_NFK_gfp_luc cells were stablytransduced with two of the indicated human TNF-receptors, CD27, CD134and CD137, respectively. Cell surface expression of the receptors wasanalyzed by flow cytometry depicted in FIG. 10A and FIG. 10B.

3.2 Analysis of CD134×CD27 Bispecific Antibodies

A bispecific antibody binding with one arm to CD134 and with the secondarm to CD27 was produced and analyzed by a Cis-reporter assay usingHEK293_NFK_CD27_CD134_gfp_luc cells. The bispecific antibody as well asthe control antibodies, the parental monospecific bivalent anti-CD134and anti-CD27 antibodies and the corresponding monovalent antibodieswith one irrelevant arm, were tested (FIG. 11). The bispecific antibodyinduced the strongest luciferase activity inHEK293_NFK_CD27_CD134_gfp_luc cells. Thus, the bispecific CD134×CD27antibody is able to induce a strong activation of cells expressing bothreceptors resulting in strong NF-κB signaling.

3.3 Analysis of CD134×CD137 Bispecific Antibodies

Bispecific antibodies binding with one arm to CD134 and with the secondarm to CD137 were produced and analyzed by a Cis-reporter assay usingthe HEK293_NFK_CD134_CD137_gfp_luc cell line. Two different bispecificantibodies as well as the control antibodies, the parental monospecificbivalent anti-CD134 and anti-CD137 antibodies and correspondingmonovalent antibodies with one irrelevant arm, were tested (FIG. 12A andFIG. 12B). None of the control antibodies, neither the parentalmonospecific bivalent antibodies nor the monovalent antibodies with oneirrelevant arm, induced luciferase activity in theHEK293_NFK_CD134_CD137_gfp_luc. Only the bispecific CD134×CD137 antibodyresulted in luciferase activity. Thus, even if the parentalmonospecific, bivalent anti-CD134 and anti-CD137 IgG1 antibodies do notshow any agonistic activity, the bispecific CD134×CD137 antibody is ableto induce activation in the cell line expressing both receptorsresulting in NF-κB pathway activation.

3.3 Analysis of CD27×CD137 Bispecific Antibodies

Bispecific antibodies binding with one arm to CD137 and with the secondarm to CD27 were produced and analyzed by a Cis-reporter assay usingHEK293_NFK_CD27_CD137_gfp_luc cells. Two different bispecific antibodiesas well as the control antibodies, the parental monospecific bivalentanti-CD137 and anti-CD27 antibodies and corresponding monospecificantibodies with one irrelevant arm, were tested (FIG. 13A and FIG. 13B).In this case, the parental monospecific bivalent anti-CD27 antibodiesinduced luciferase activity, whereas the parental monospecific bivalentanti-CD137 resulted only in extremely weak maximum activation signals.Both control monovalent antibodies consisting of one irrelevant arminduced very weak activation of HEK293_NFK_CD27_CD137_gfp_luc cells.However, the bispecific antibodies induced stronger luciferase activityin HEK293_NFK_CD27_CD137_gfp_luc cells than the control antibodies withone irrelevant arm.

1-25. (canceled)
 26. A nucleic acid molecule encoding a binding agentcomprising at least two binding domains, wherein a first binding domainbinds to a first receptor of the tumor necrosis factor (TNF) superfamilyand a second binding domain binds to a second receptor of the TNFsuperfamily, wherein the first receptor and the second receptor aredifferent, wherein: the first binding domain binds to CD40 and isselected from a first group consisting of: (a) light and heavy chaincomplementarity determining regions wherein the heavy chaincomplementary determining region 1 (HCDR1) includes the amino acidsequence of SEQ ID NO: 2323, the HCDR2 includes the amino acid sequenceof SEQ ID NO: 2324 and the HCDR3 includes the amino acid sequence of SEQID NO: 2325, and the light chain complementarity determining region 1(LCDR1) includes the amino acid sequence of SEQ ID NO: 2326, the LCDR2includes the amino acid sequence of SEQ ID NO: 2327 and the LCDR3includes the amino acid sequence of SEQ ID NO: 2328; and (b) a heavychain variable domain (VH) having the amino acid sequence of SEQ ID NO:2321, and a light chain variable domain (VL) having the amino acidsequence of SEQ ID NO: 2322; and the second binding domain binds to4-1BB (CD137) and is selected from a second group consisting of: (a)light and heavy chain complementarity determining regions wherein theheavy chain complementary determining region 1 (HCDR1) includes theamino acid sequence of SEQ ID NO: 2297, the HCDR2 includes the aminoacid sequence of SEQ ID NO: 2298 and the HCDR3 includes the amino acidsequence of SEQ ID NO: 2299, and the light chain complementaritydetermining region 1 (LCDR1) includes the amino acid sequence of SEQ IDNO: 2300, the LCDR2 includes the amino acid sequence of SEQ ID NO: 2301and the LCDR3 includes the amino acid sequence of SEQ ID NO: 2302; (b) aheavy chain variable domain (VH) having the amino acid sequence of SEQID NO: 2241 and a light chain variable domain (VL) having the amino acidsequence of SEQ ID NO: 2242; (c) light and heavy chain complementaritydetermining regions wherein the heavy chain complementarity determiningregion HCDR1 includes the amino acid sequence of SEQ ID NO: 2255, theHCDR2 includes the amino acid sequence of SEQ ID NO: 2256 and the HCDR3includes the amino acid sequence of SEQ ID NO: 2257, and the light chaincomplementarity determining region LCDR1 includes the amino acidsequence of SEQ ID NO: 2258, the LCDR2 includes the amino acid sequenceof SEQ ID NO: 2259 and the LCDR3 includes the amino acid sequence of SEQID NO: 2260; (d) a heavy chain variable domain (VH) having the aminoacid sequence of SEQ ID NO: 2227 and a light chain variable domain (VL)having the amino acid sequence of SEQ ID NO: 2228; (e) light and heavychain complementarity determining regions wherein the heavy chaincomplementarity determining region HCDR1 includes the amino acidsequence of SEQ ID NO: 2315, the HCDR2 includes the amino acid sequenceof SEQ ID NO: 2316 and the HCDR3 includes the amino acid sequence of SEQID NO: 2317, and the light chain complementarity determining regionLCDR1 includes the amino acid sequence of SEQ ID NO: 2318, the LCDR2includes the amino acid sequence of SEQ ID NO: 2319 and the LCDR3includes the amino acid sequence of SEQ ID NO: 2320; and (f) a heavychain variable domain (VH) having the amino acid sequence of SEQ ID NO:2247 and a light chain variable domain (VL) having the amino acidsequence of SEQ ID NO:
 2248. 27. A cell comprising the nucleic acidmolecule according to claim
 26. 28. The nucleic acid molecule of claim26, wherein the first binding domain of the binding agent comprises: theHCDR1 having the amino acid sequence of SEQ ID NO: 2323; the HCDR2having the amino acid sequence of SEQ ID NO: 2324; the HCDR3 having theamino acid sequence of SEQ ID NO: 2325; the LCDR1 having the amino acidsequence of SEQ ID NO: 2326; the LCDR2 having the amino acid sequence ofSEQ ID NO: 2327; and the LCDR3 having the amino acid sequence of SEQ IDNO:
 2328. 29. The nucleic acid molecule of claim 26, wherein the firstbinding domain of the binding agent comprises: the VH having the aminoacid sequence of SEQ ID NO: 2321 and the VL having the amino acidsequence of SEQ ID NO:
 2322. 30. The nucleic acid molecule of claim 26,wherein the second binding domain of the binding agent comprises: theHCDR1 having the amino acid sequence of SEQ ID NO: 2297; the HCDR2having the amino acid sequence of SEQ ID NO: 2298; the HCDR3 having theamino acid sequence of SEQ ID NO: 2299, and the LCDR1 having the aminoacid sequence of SEQ ID NO: 2300; the LCDR2 having the amino acidsequence of SEQ ID NO: 2301; and the LCDR3 having the amino acidsequence of SEQ ID NO:
 2302. 31. The nucleic acid molecule of claim 26,wherein the second binding domain of the binding agent comprises the VHhaving the amino acid sequence of SEQ ID NO: 2241 and the VL having theamino acid sequence of SEQ ID NO:
 2242. 32. The nucleic acid molecule ofclaim 26, wherein the second binding domain of the binding agentcomprises: the HCDR1 having the amino acid sequence of SEQ ID NO: 2255;the HCDR2 having the amino acid sequence of SEQ ID NO: 2256; the HCDR3having the amino acid sequence of SEQ ID NO: 2257; the LCDR1 having theamino acid sequence of SEQ ID NO: 2258; the LCDR2 having the amino acidsequence of SEQ ID NO: 2259; and the LCDR3 having the amino acidsequence of SEQ ID NO:
 2260. 33. The nucleic acid molecule of claim 26,wherein the second binding domain of the binding agent comprises the VHhaving the amino acid sequence of SEQ ID NO: 2227 and the VL having theamino acid sequence of SEQ ID NO:
 2228. 34. The nucleic acid molecule ofclaim 26, wherein the second binding domain of the binding agentcomprises: the HCDR1 having the amino acid sequence of SEQ ID NO: 2315;the HCDR2 having the amino acid sequence of SEQ ID NO: 2316; the HCDR3having the amino acid sequence of SEQ ID NO: 2317; the LCDR1 having theamino acid sequence of SEQ ID NO: 2318; the LCDR2 having the amino acidsequence of SEQ ID NO: 2319; and the LCDR3 having the amino acidsequence of SEQ ID NO:
 2320. 35. The nucleic acid molecule of claim 26,wherein the second binding domain of the binding agent comprises the VHhaving the amino acid sequence of SEQ ID NO: 2247 and the VL having theamino acid sequence of SEQ ID NO:
 2248. 36. A nucleic acid moleculeencoding a bispecific antibody comprising a first binding arm to CD40and a second binding arm to CD137, wherein: the first binding armcomprises a VH having the amino acid sequence of SEQ ID NO: 2321 and aVL having the amino acid sequence of SEQ ID NO: 2322; and the secondbinding arm comprises a VH having the amino acid sequence of SEQ ID NO:2247 and a VL having the amino acid sequence of SEQ ID NO:
 2248. 37. Acell comprising the nucleic acid molecule to claim
 36. 38. A nucleicacid molecule encoding a bispecific antibody comprising a first bindingarm to CD40 and a second binding arm to CD137, wherein: the firstbinding arm comprises a VH having the amino acid sequence of SEQ ID NO:2321 and a VL having the amino acid sequence of SEQ ID NO: 2322; and thesecond binding arm comprises a VH having the amino acid sequence of SEQID NO: 2227 and a VL having the amino acid sequence of SEQ ID NO: 2228.39. A cell comprising the nucleic acid molecule according to claim 38.